Abstract
Most cardiac diseases are related to non-uniformities in contractile function. Such regional non- uniformities can be recognized conventionally, but transmural gradients in mechanical function cannot be determined that easily. We propose a method to assess transmural differences in myofiber shortening, using MRI- tagging of the heart. Midwall motion of 5 short-axis slices of the left ventricle was determined non-invasively. Using a model of cardiac motion, the transmural distribution of deformation of the left ventricular wall was determined. On the basis of remodeling rules, the transmural course of myofiber orientation was estimated. From deformation and fiber orientation data transmural differences in myofiber shortening were calculated. The method appears sensitive to distinguish patients with aortic stenosis from healthy volunteers.
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Arts, T., Delhaas, T., van Susteren, A., Snoep, G., Prinzen, F.W. (2003). Left Ventricular Flow Dynamics and Transmural Gradients in Myofiber Shortening with MRI-Tagging. In: Magnin, I.E., Montagnat, J., Clarysse, P., Nenonen, J., Katila, T. (eds) Functional Imaging and Modeling of the Heart. FIMH 2003. Lecture Notes in Computer Science, vol 2674. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-44883-7_24
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DOI: https://doi.org/10.1007/3-540-44883-7_24
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