Abstract
We present a neural network clustering approach to the analysis of dynamic contrast-enhanced magnetic resonance imaging (MRI) mammography time-series. In contrast to conventional extraction of a few voxel-based perfusion parameters, neural network clustering does not discard information contained in the complete signal dynamics time-series data. We performed exploratory data analysis in patients with breast lesions classified as indeterminate from clinical findings and conventional X-ray mammography. Minimal free energy vector quantization provided a self-organized segmentation of voxels w.r.t. fine-grained differences of signal amplitude and dynamics, thus identifying the lesions from surrounding tissue and enabling a subclassification within the lesions with regard to regions characterized by different MRI signal time-courses. We conclude that neural network clustering can provide a useful extension to the conventional visual inspection of interactively defined regions-of-interest. Thus, it can contribute to the diagnosis of indeterminate breast lesions by non-invasive imaging.
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Wismüller, A., Lange, O., Dersch, D.R., Hahn, K., Leinsinger, G.L. (2001). Neural Network Analysis of Dynamic Contrast-Enhanced MRI Mammography. In: Dorffner, G., Bischof, H., Hornik, K. (eds) Artificial Neural Networks — ICANN 2001. ICANN 2001. Lecture Notes in Computer Science, vol 2130. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-44668-0_138
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DOI: https://doi.org/10.1007/3-540-44668-0_138
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