Abstract
To improve the efficiency of DNA computing, we need to prevent hybridization errors. In this paper, we focus on the bulge loop structures, which cannot be prevented by current sequence design methods. To estimate the formation of bulge loop structure, we measured the melting temperature (TM) and the binding intensity of sequences with a single bulge loop in some simple experiments. Based on the experimental results, we mainly discuss the effect of the base type and the position of the loops. We also discuss the possibilities for modeling the formation of bulge loops based on these experimental results.
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Tanaka, F., Kameda, A., Yamamoto, M., Ohuchi, A. (2003). The Effect of the Bulge Loop upon the Hybridization Process in DNA Computing. In: Tyrrell, A.M., Haddow, P.C., Torresen, J. (eds) Evolvable Systems: From Biology to Hardware. ICES 2003. Lecture Notes in Computer Science, vol 2606. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-36553-2_40
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DOI: https://doi.org/10.1007/3-540-36553-2_40
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