Abstract
Haemodynamics, and in particular wall shear stress, is thought to play a critical role in the progression and rupture of intracranial aneurysms. A novel method is presented that combines image-based wall motion estimation obtained through non-rigid registration with computational fluid dynamics (CFD) simulations in order to provide realistic intra-aneurysmal flow patterns and understand the effects of deforming walls on the haemodynamic patterns. In contrast to previous approaches, which assume rigid walls or ad hoc elastic parameters to perform the CFD simulations, wall compliance has been included in this study through the imposition of measured wall motions. This circumvents the difficulties in estimating personalized elasticity properties. Although variations in the aneurysmal haemodynamics were observed when incorporating the wall motion, the overall characteristics of the wall shear stress distribution do not seem to change considerably. Further experiments with more cases will be required to establish the clinical significance of the observed variations.
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Keywords
- Computational Fluid Dynamic
- Wall Motion
- Wall Shear Stress
- Intracranial Aneurysm
- Computational Fluid Dynamic Simulation
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Wiebers, D.O., Whisnant, J.P., Huston 3rd, J., Meissner, I., Brown Jr, R.D., Piepgras, D.G., Forbes, G.S., Thielen, K., Nichols, D., O’Fallon, W.M., Peacock, J., Jaeger, L., Kassell, N.F., Kongable-Beckman, G.L., Torner, J.C.: International Study of Unruptured Intracranial Aneurysms Investigators. Unruptured Intracranial Aneurysms: Natural History, Clinical Outcome, and Risks of Surgical and Endovascular Treatment. Lancet 362(9378), 103–110 (2003)
Meyer, F.B., Huston 3rd, J., Riederer, S.S.: Pulsatile increases in aneurysm size determined by cine phase-contrast MR angiography. J. Neurosurg 78(6), 879–883 (1993)
Ishida, F., Ogawa, H., Simizu, T., Kojima, T., Taki, W.: Visualizing the Dynamics of Cerebral Aneurysms with Four-Dimensional Computed Tomographic Angiography. Neurosurgery 57, 460–471 (2005)
Hayakawa, M., Katada, K., Anno, H., Imizu, S., Hayashi, J., Irie, K., Negoro, M., Kato, Y., Kanno, T., Sano, H.: CT Angiography with Electrocardiographically Gated Reconstruction for Visualizing Pulsation of Intracranial Aneurysms: Identification of Aneurysmal Protuberance Presumably Associated with Wall Thinning. Am. J. Neuroradiol. 26, 1366–1369 (2005)
Cebral, J.R., Castro, M.A., Appanaboyina, S., Putman, C., Millan, D., Frangi, A.F.: Efficient Pipeline for Image-Based Patient-Specific Analysis of Cerebral Aneurysm Haemodynamics: Technique and Sensitivity. IEEE T. Med. Imaging 24(4), 457–467 (2005)
Liou, T.M., Liou, S.N.: A review of in vitro studies of hemodynamic characteristics in terminal and lateral aneurysm models. Proc. Nat. Sci. Council (B) 23(4), 133–148 (1999)
Rueckert, D., Sonoda, L.I., Hayes, C., Hill, D.L.G., Leach, M.O., Hawkes, D.J.: Non-rigid registration using free-form deformations: Application to breast MR images. IEEE T. Med. Imaging 18(8), 712–721 (1999)
Studholme, C., Hill, D.L.G., Hawkes, D.J.: An overlap invariant entropy measure of 3D medical image alignment. Pattern Recogn. 32(1), 71–86 (1999)
Löhner, R.: Automatic unstructured grid generators. Finite Elem. Anal. Des. 25, 111–134 (1997)
Löhner, R., Yang, C.: Improved ALE Mesh Velocities for Moving Bodies. Comm. Numer. Meth. En. 12, 599–608 (1996)
Shojima, M., Oshima, M., Takagi, K., Torii, R., Hayakawa, M., Katada, K., Morita, A., Kirino, T.: Magnitude and role of wall shear stress on cerebral aneurysm. Computational fluid dynamic study of 20 middle cerebral artery aneurysms. Stroke 35, 2500–2505 (2004)
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Dempere-Marco, L., Oubel, E., Castro, M., Putman, C., Frangi, A., Cebral, J. (2006). CFD Analysis Incorporating the Influence of Wall Motion: Application to Intracranial Aneurysms. In: Larsen, R., Nielsen, M., Sporring, J. (eds) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2006. MICCAI 2006. Lecture Notes in Computer Science, vol 4191. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11866763_54
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DOI: https://doi.org/10.1007/11866763_54
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