EP 4093373 A1 20221130 - LIPID NANOPARTICLES
Title (en)
LIPID NANOPARTICLES
Title (de)
LIPIDNANOPARTIKEL
Title (fr)
NANOPARTICULES LIPIDIQUES
Publication
Application
Priority
- EP 20152938 A 20200121
- EP 20152995 A 20200121
- EP 20179434 A 20200611
- EP 2021051290 W 20210121
Abstract (en)
[origin: WO2021148511A1] The present invention relates to the field of lipid nanoparticles (LNP); more specifically comprising an ionizable lipid, a phospholipid, a sterol, a PEG lipid and one or more nucleic acids. The LNP's of the present invention are characterized in comprising less than about 1 mol% of a C18-PEG2000 lipid. The present invention provides use of the LNP's for immunogenic delivery of nucleic acid molecules, specifically mRNA; thereby making them highly suitable for use in vaccines, such as for the treatment of cancer or infectious diseases. Finally, methods are provided for preparing such LNP's.
IPC 8 full level
A61K 9/00 (2006.01); A61K 9/127 (2006.01); A61K 9/51 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61K 47/14 (2017.01); A61K 47/24 (2006.01)
CPC (source: EP IL KR US)
A61K 9/127 (2013.01 - EP IL); A61K 9/51 (2013.01 - EP IL); A61K 9/5123 (2013.01 - KR US); A61K 9/5146 (2013.01 - US); A61K 39/39 (2013.01 - EP IL KR US); A61K 47/14 (2013.01 - EP IL KR); A61K 47/24 (2013.01 - EP IL KR); A61P 31/00 (2017.12 - KR); A61P 35/00 (2017.12 - KR US); A61P 37/04 (2017.12 - US); A61K 2039/53 (2013.01 - EP IL KR US); A61K 2039/55555 (2013.01 - EP IL KR US)
Citation (search report)
See references of WO 2021148511A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2021148511 A1 20210729; AU 2021211894 A1 20220901; BR 112022013837 A2 20220913; CA 3168696 A1 20210729; CN 115697298 A 20230203; EP 4093373 A1 20221130; IL 294624 A 20220901; JP 2023517275 A 20230425; KR 20230002300 A 20230105; MX 2022009018 A 20220811; TW 202139975 A 20211101; US 2023067722 A1 20230302
DOCDB simple family (application)
EP 2021051290 W 20210121; AU 2021211894 A 20210121; BR 112022013837 A 20210121; CA 3168696 A 20210121; CN 202180010449 A 20210121; EP 21701492 A 20210121; IL 29462422 A 20220709; JP 2022544069 A 20210121; KR 20227028916 A 20210121; MX 2022009018 A 20210121; TW 110102316 A 20210121; US 202117794087 A 20210121