SPP1

SPP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3CXD, 3DSF
Dynodwyr
Cyfenwau	SPP1, BNSP, BSPI, ETA-1, OPN, secreted phosphoprotein 1, Osteopontin
Dynodwyr allanol	OMIM: 166490 HomoloGene: 20156 GeneCards: SPP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cytokine activity • GO:0001948, GO:0016582 protein binding • extracellular matrix binding Cydrannau o'r gell • cell projection • extracellular region • perinuclear region of cytoplasm • extracellular exosome • extracellular space • Golgi apparatus • fesigl • endoplasmic reticulum lumen Prosesau biolegol • cell differentiation • response to vitamin D • ossification • biomineral tissue development • response to steroid hormone • extracellular matrix disassembly • extracellular matrix organization • response to organic substance • negative regulation of collateral sprouting of intact axon in response to injury • decidualization • inflammatory response • embryo implantation • osteoblast differentiation • positive regulation of bone resorption • cell adhesion • androgen catabolic process • post-translational protein modification • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • cellular response to testosterone stimulus • positive regulation of estradiol secretion • regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6696	n/a
Ensembl	ENSG00000118785	n/a
UniProt	P10451	n/a
RefSeq (mRNA)	NM_001251830 NM_000582 NM_001040058 NM_001040060 NM_001251829	n/a
RefSeq (protein)	NP_000573 NP_001035147 NP_001035149 NP_001238758 NP_001238759 NP_001035147.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SPP1 yw SPP1 a elwir hefyd yn Secreted phosphoprotein 1 (Osteopontin, bone sialoprotein I, early T-lymphocyte activation 1), isoform CRA_b a Secreted phosphoprotein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4q22.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SPP1.

• "Role of osteopontin and its regulation in pancreatic islet. ". Biochem Biophys Res Commun. 2018. PMID 29180017.
• "SPP1 rs4754 and its epistatic interactions with SPARC polymorphisms in gastric cancer susceptibility. ". Gene. 2018. PMID 28962925.
• "Osteopontin plays a unique role in resistance of CD34+/CD123+ human leukemia cell lines KG1a to parthenolide. ". Life Sci. 2017. PMID 28935249.
• "OPN-a Splicing Variant Expression in Non-small Cell Lung Cancer and its Effects on the Bone Metastatic Abilities of Lung Cancer Cells In Vitro. ". Anticancer Res. 2017. PMID 28476789.
• "Effect of Phosphorylation on a Human-like Osteopontin Peptide.". Biophys J. 2017. PMID 28445750.