Papers by Kobkan Thongprasom
Journal of Medical & Surgical Pathology, 2016
Drug-induced lichenoid reaction is quite common in the oral cavity. Patients with oral lichenoid ... more Drug-induced lichenoid reaction is quite common in the oral cavity. Patients with oral lichenoid lesions (OLL) may increase risk of developing epithelial dysplasia and squamous cell carcinoma. Although this subject remains controversial, several studies suggested that the overall rate of malignant transformation of OLL was greater than that of general population or patients with oral lichen planus (OLP). In the present article, we report a 66-year-old female Thai patient with OLL associated with many medications including simvastatin. She also had a history of hypertension, osteoarthritis and hepatitis B virus infection. Her physician treated her with amlodipine, etoricoxib, glucosamine and chondroitin sulfate for more than 20 years. Simvastatin had been prescribed for the treatment of dyslipidemia for 2 years. Notably, the patient reported that oral symptoms and lesions arose after taking this medication. This patient later developed epithelial dysplasia and carcinoma in situ within areas of OLL approximately 7 and 8 years, respectively after its initial presentation. This case report will be useful for clinicians to become aware of the possible adverse outcome of long-standing drug-induced OLL.
Bookmarks Related papers MentionsView impact
Asian Biomedicine, 2014
Bookmarks Related papers MentionsView impact
Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, Jul 1, 2006
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
Journal of Investigative and Clinical Dentistry, Jun 20, 2019
Bookmarks Related papers MentionsView impact
Oral Diseases, Feb 26, 2018
Bookmarks Related papers MentionsView impact
The Cochrane library, Jul 6, 2011
Bookmarks Related papers MentionsView impact
International Journal of Experimental Dental Science, 2014
Bookmarks Related papers MentionsView impact
Asian Biomedicine, Dec 1, 2014
Bookmarks Related papers MentionsView impact
Journal of Oral Pathology & Medicine, May 13, 2013
Bookmarks Related papers MentionsView impact
Journal of Dentistry Indonesia, Aug 31, 2019
Bookmarks Related papers MentionsView impact
Acta stomatologica Croatica, Sep 15, 2016
Bookmarks Related papers MentionsView impact
Journal of Oral Pathology & Medicine, Oct 6, 2008
Bookmarks Related papers MentionsView impact
Oral Diseases, Jul 13, 2012
Oral Diseases (2012)Lichen planus (LP) is a common disorder affecting the oral cavity (OLP) and s... more Oral Diseases (2012)Lichen planus (LP) is a common disorder affecting the oral cavity (OLP) and skin. Despite intensive research, LP/OLP etiology and treatment remain controversial. We investigated four controversial topics: (i) Is hepatitis C virus (HCV) infection associated with LP and involved in its pathogenesis? (ii) Should all patients with LP be screened for HCV? (iii) Should patients with OLP have all their amalgam restorations removed? (iv) Are there any new treatments for OLP? Results from extensive literature searches suggested that: (i) Robust evidence from three meta‐analyses indicate that HCV is associated with LP and might be involved in OLP pathogenesis (ii) It would be prudent to screen patients with LP/OLP at significant risk with an ELISA for HCV antibodies using country‐specific screening strategies (iii) There is no evidence that either OLP or oral lichenoid lesions patients would routinely benefit from having all their amalgam restorations replaced. Weak evidence from potentially very biased, small, non‐randomized, unblinded studies suggests that a small fraction of patients may benefit from targeted amalgam replacement. (iv) There is weak evidence that, among new OLP treatments, topical pimecrolimus, aloe vera, and oral curcuminoids may be useful. The development of specific formulations for oral delivery of topical medications is a promising field.
Bookmarks Related papers MentionsView impact
HAL (Le Centre pour la Communication Scientifique Directe), 2017
Recurrent aphthous ulceration (RAU) is considered to be the most common oral mucosal lesion that ... more Recurrent aphthous ulceration (RAU) is considered to be the most common oral mucosal lesion that presents initially in childhood or adolescence. Recurrent aphthous-like lesions occurring in middle-aged patients over many years is uncommon. A 46-year-old male with a history of RAU of more than 10 years is reported. The histopathologic appearance of his buccal mucosa biopsy was diagnosed as an intraepithelial bullous lesion. Indirect immunofluorescence evaluation of the biopsy specimen was IgG and C3 positive at the intercellular epithelium space. The definitive diagnosis was oral pemphigus. Long-term aphthous-like lesions in the middle-aged patient together with desquamative gingivitis should be carefully considered.
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
วารสารเภสัชวิทยา (Thai Journal of Pharmacology), 1996
A 46-year-old Indian woman had been treated with methyldopa for three months, had the erosive les... more A 46-year-old Indian woman had been treated with methyldopa for three months, had the erosive lesions on the buccal mucosa. This patient was then treated with amoxycillin in concomitant with the antihypertensive drug, methyldopa. However, the erosive lesions were still there. She was referred to the Oral Medicine Department, Faculty of Dentistry, Chulalongkorn University by her physician. The lesions were diagnosed to be erosive lichen planus and were treated with 0.1 percent solution of fluocinolone acetonide. It has been documented that methyldopa could induce intraoral membrane reactions; therefore the recommendation to change the antihypertensive drug from methyldopa to be a beta adrenergic blocking drug, atenolol, was given to her physician. After this treatment regime, the erosive lichen planus was gradually disappeared within a period of 2 months. Later, the same patient underwent medical treatment with the oral hypoglycemic drug, chlorpropamide. Following 3 months after treatment, the marked intraoral lesions with generalized skin lesions of lichen planus were aggressively flared up. Together with a dermatologist of Chulalongkorn hospital, both skin and oral lesions were treated and improved within one year. It is suggested, therefore, that the precaution should be taken on the treatment of hypertensive and diabetic patient with methyldopa and chlorpropamide. If it is possible, the changing of these drugs to the others is recommended whenever the oral lesions occur from their side effects. Moreover, lichenoid eruption of oral mucosa due to methyldopa and chlorpropamide has never been reported in Thai patients.
Bookmarks Related papers MentionsView impact
Clinical Oral Investigations, May 17, 2019
Bookmarks Related papers MentionsView impact
Journal of Oral Pathology & Medicine, Apr 8, 2016
Bookmarks Related papers MentionsView impact
Uploads
Papers by Kobkan Thongprasom