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1.
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Measurement of $^{12}$C Fragmentation Cross Sections on C, O, and H in the Energy Range of Interest for Particle Therapy Applications
/ Mattei, I ; Alexandrov, A ; Alunni Solestizi, L ; Ambrosi, G ; Argiro, S ; Bartosik, N ; Battistoni, G ; Belcari, N ; Biondi, S ; Bisogni, M G et al.
In a carbon ion treatment the nuclear fragmentation of both target and beam projectiles impacts on the dose released on the tumor and on the surrounding healthy tissues. Carbon ion fragmentation occurring inside the patient body has to be studied in order to take into account this contribution. [...]
2020 - 14 p.
- Published in : IEEE Trans. Rad. Plasma Med. Sci. 4 (2020) 269-282
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2.
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Ion charge separation with new generation of nuclear emulsion films
/ Montesi, M.C. (Naples U. ; INFN, Naples) ; Lauria, A. (Naples U. ; INFN, Naples) ; Alexandrov, A. (INFN, Naples ; Naples U. ; Natl. U. Sci. Tech., Moscow ; Lebedev Inst.) ; Solestizi, L. Alunni (INFN, Perugia ; Perugia U.) ; Giovanni, Ambrosi (INFN, Perugia) ; Argirò, S. (Turin U. ; INFN, Turin) ; Diaz, R. (Havana, CEADEN) ; Bartosik, N. (INFN, Turin) ; Battistoni, G. (INFN, Milan) ; Belcari, N. (Pisa U. ; INFN, Pisa) et al.
In hadron therapy, the accelerated ions, interacting with the body of the patient, cause the fragmentation of both projectile and target nuclei. The fragments interact with the human tissues depositing energy both in the entrance channel and in the volume surrounding the tumor. [...]
2019 - 8 p.
- Published in : Open Physics 17 (2019) 233-240
Fulltext: PDF;
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3.
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The FOOT FragmentatiOn Of Target Experiment
/ Alexandrov, Andrey (INFN, Naples) ; Alpat, Behcet (INFN, Perugia) ; Ambrosi, Giovanni (INFN, Perugia) ; Argirò, Stefano (Turin U. ; INFN, Turin) ; Battistoni, Giuseppe (INFN, Milan) ; Bisogni, Maria Giuseppina (Pisa U. ; INFN, Pisa) ; Belcari, Nicola (Pisa U. ; INFN, Pisa) ; Biondi, Silvia (INFN, Bologna ; Bologna U.) ; Bruni, Graziano (INFN, Bologna) ; Camarlinghi, Niccolò (Pisa U. ; INFN, Pisa) et al.
In proton-therapy clinical practice a constant RBE equal to 1.1 is adopted, regardless of the demonstrated RBE variations, which depends on physical and biological parameters. Among other mechanisms, nuclear interactions might influence the proton-RBE due to secondary heavier particles produced by target fragmentation that can significantly contribute to the total dose: an un-wanted and undetermined increase of normal tissues complications probability may occur. [...]
Geneva : CERN, 2019 - 8 p.
- Published in : CERN Proc.: 1 (2019) , pp. 305-312
Fulltext: PDF;
In : 15th International Conference on Nuclear Reaction Mechanisms, Varenna, Italy, 11 - 15 Jun 2018, pp.305-312
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4.
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The Application of the Monte Carlo Code FLUKA in Radiation Protection Studies for the Large Hadron Collider
/ Battistoni, Giuseppe (INFN, Milan) ; Broggi, Francesco (INFN, Milan) ; Brugger, Markus (CERN) ; Campanella, Mauro (INFN, Milan) ; Carboni, Massimo (INFN, Legnaro) ; Empl, Anton (Houston U.) ; Fassò, Alberto (Jefferson Lab) ; Gadioli, Ettore (INFN, Milan) ; Cerutti, Francesco (CERN) ; Ferrari, Alfredo (CERN) et al.
2011
- Published in : Prog. Nucl. Sci. Tech. 2 (2011) 358-364
Fulltext: PDF; External link: Fulltext
In : Joint International Conference of the 7th Supercomputing in Nuclear Application and the 3rd Monte Carlo, Tokyo, Japan, 17 - 21 Oct 2010, pp.358-364
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5.
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Measurement of charged particle yields from therapeutic beams in view of the design of an innovative hadrontherapy dose monitor
/ Battistoni, G (INFN, Milan) ; Bellini, F (Rome U. ; INFN, Rome) ; Bini, F (U. Rome La Sapienza (main)) ; Collamati, F (Rome U. ; INFN, Rome) ; Collini, F (INFN, Milan) ; De Lucia, E (Frascati) ; Durante, M (Darmstadt, GSI) ; Faccini, R (Rome U. ; INFN, Rome) ; Ferroni, F (Rome U. ; INFN, Rome) ; Frallicciardi, P M (Enrico Fermi Ctr., Rome) et al.
Particle Therapy (PT) is an emerging technique, which makes use of charged particles to efficiently cure different kinds of solid tumors. The high precision in the hadrons dose deposition requires an accurate monitoring to prevent the risk of under-dosage of the cancer region or of over-dosage of healthy tissues. [...]
2015
- Published in : JINST 10 (2015) C02032
IOP Open Access article: PDF;
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6.
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Measurements of secondary particles emitted by $^{12}$C, $^{4}$He and $^{16}$O ion beams in view of innovative dose profiling technique in Particle Therapy
/ Rucinski, A (INFN, Rome ; U. Rome La Sapienza (main)) ; Battistoni, G (INFN, Milan) ; Collamati, F (Rome U. ; INFN, Rome) ; De Lucia, E (Frascati) ; Faccini, R (Rome U. ; INFN, Rome) ; Marafini, M (Rome U. ; INFN, Rome) ; Mattei, I (INFN, Milan) ; Muraro, S (INFN, Milan) ; Paramatti, R (INFN, Rome) ; Patera, V (INFN, Rome ; U. Rome La Sapienza (main) ; Enrico Fermi Ctr., Rome) et al.
Geneva : CERN, 2015
Published version from CERN: PDF;
In : 14th International Conference on Nuclear Reaction Mechanisms, Villa Monastero, Varenna, Italy, 15 - 19 Jun 2015, pp.355
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7.
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Measurement of charged particle yields from PMMA irradiated by a 220 MeV/u12Cbeam
/ Piersanti, L (Frascati ; U. Rome La Sapienza (main)) ; Bellini, F (Rome U. ; INFN, Rome) ; Bini, FU. Rome La Sapienza (main) ; Collamati, F (Rome U. ; INFN, Rome) ; De Lucia, E (Frascati) ; Durante, M (Darmstadt, GSI) ; Faccini, R (Rome U. ; INFN, Rome) ; Ferroni, F (Rome U. ; INFN, Rome) ; Fiore, S (Rome U.) ; Iarocci, E (Frascati ; U. Rome La Sapienza (main)) et al.
The radiation used in hadrontherapy treatments interacts with the patient body producing secondary particles, either neutral or charged, that can be used for dose and Bragg peak monitoring and to provide a fast feedback on the treatment plans. Recent results obtained from the authors on simplified setups (mono-energetic primary beams interacting with homogeneous tissue like target) have already indicated the correlation that exists between the flux of these secondaries coming from the target (e.g. [...]
2014 - 16.
- Published in : Phys. Med. Biol. 59 (2014) 1857-1872
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8.
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Performance of the reconstruction algorithms of the FIRST experiment pixel sensors vertex detector
/ Rescigno, R (Strasbourg, IPHC) ; Finck, Ch (Strasbourg, IPHC) ; Juliani, D (Strasbourg, IPHC) ; Spiriti, E (Frascati ; INFN, Rome3) ; Baudot, J (Strasbourg, IPHC) ; Abou-Haidar, Z (CNA, Seville) ; Agodi, C (INFN, LNS) ; Alvarez, M A G (CNA, Seville) ; Aumann, T (Darmstadt, GSI) ; Battistoni, G (INFN, Milan) et al.
Hadrontherapy treatments use charged particles (e.g. protons and carbon ions) to treat tumors. [...]
2014 - 7 p.
- Published in : Nucl. Instrum. Methods Phys. Res., A 767 (2014) 34-40
Elsevier Open Access article: PDF;
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9.
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Investigating the robustness of ion beam therapy treatment plans to uncertainties in biological treatment parameters
/ Boehlen, T T (CERN ; Stockholm U. ; Karolinska Inst., Stockholm) ; Brons, S (Ion Beam Therapy Ctr, Heidelberg) ; Dosanjh, M (CERN) ; Ferrari, A (CERN) ; Fossati, P (CNAO, Pavia, Italy. ; U. Milan ; Eur. Inst. Oncol., Milan) ; Haberer, T (Ion Beam Therapy Ctr, Heidelberg) ; Mairani, A (Fdn CNAO, Pavia) ; Patera, V (U. Rome La Sapienza (main) ; Frascati)
Uncertainties in determining clinically used relative biological effectiveness (RBE) values for ion beam therapy carry the risk of absolute and relative misestimations of RBE-weighted doses for clinical scenarios. This study assesses the consequences of hypothetical misestimations of input parameters to the RBE modelling for carbon ion treatment plans by a variational approach. [...]
2012
- Published in : Phys. Med. Biol. 57 (2012) 7983-8004
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10.
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A Monte Carlo-based treatment-planning tool for ion beam therapy
/ Böhlen, T T (CERN ; Stockholm U. ; Karolinska Inst., Stockholm) ; Bauer, J (Heidelberg Ion-Beam Therapy Center, Heidelberg ; Heidelberg University Clinic) ; Dosanjh, M (CERN) ; Ferrari, A (CERN) ; Haberer, T (Heidelberg Ion-Beam Therapy Center, Heidelberg) ; Parodi, K (Heidelberg Ion-Beam Therapy Center, Heidelberg ; Heidelberg University Clinic ; Munich U.) ; Patera, V (U. Rome La Sapienza) ; Mairan, A (CNAO, Pavia)
Ion beam therapy, as an emerging radiation therapy modality, requires continuous efforts to develop and improve tools for patient treatment planning (TP) and research applications. Dose and fluence computation algorithms using the Monte Carlo (MC) technique have served for decades as reference tools for accurate dose computations for radiotherapy. [...]
2013
- Published in : J. Radiat. Res. 54 (2013) i77-i81
Oxford Univ. Press Open Access article: PDF;
In : PARTNER, pp.i77-i81
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