Papers by Rajendra D Badgaiyan
NeuroImage, Dec 1, 1997
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Annals of the New York Academy of Sciences, Aug 1, 2005
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Journal of Neurology and Neurophysiology, Sep 13, 2016
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NeuroImage, Dec 1, 1997
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Elsevier eBooks, 2019
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Elsevier eBooks, 2019
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Elsevier eBooks, 2019
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Journal of Addiction Research and Therapy, Aug 13, 2013
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HAL (Le Centre pour la Communication Scientifique Directe), 2021
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International Journal of Mental Health & Psychiatry, 2018
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Journal of Cell Science and Therapy, Nov 2, 2015
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Journal of Systems and Integrative Neuroscience, 2020
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Journal of Alzheimer’s Disease & Parkinsonism, 2017
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Neuroscience of the Nonconscious Mind, 2019
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Neuroscience of the Nonconscious Mind, 2019
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Scientific Reports, 2021
Treatment of severe chronic and acute pain in sickle cell disease (SCD) remains challenging due t... more Treatment of severe chronic and acute pain in sickle cell disease (SCD) remains challenging due to the interdependence of pain and psychosocial modulation. We examined whether modulation of the descending pain pathway through an enriched diet and companionship could alleviate pain in transgenic sickle mice. Mechanical and thermal hyperalgesia were reduced significantly with enriched diet and/or companionship. Upon withdrawal of both conditions, analgesic effects observed prior to withdrawal were diminished. Serotonin (5-hydroxytryptamine, 5-HT) was found to be increased in the spinal cords of mice provided both treatments. Additionally, 5-HT production improved at the rostral ventromedial medulla and 5-HT accumulated at the dorsal horn of the spinal cord of sickle mice, suggesting the involvement of the descending pain pathway in the analgesic response. Modulation of 5-HT and its effect on hyperalgesia was also investigated through pharmaceutical approaches. Duloxetine, a serotonin-...
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Blood, 2016
Pain in sickle cell disease (SCD) often requires chronic opioid use and remains a major challenge... more Pain in sickle cell disease (SCD) often requires chronic opioid use and remains a major challenge to treat, necessitating a need for alternate strategies to manage pain. We examined whether altering the activity of descending anti-nociceptive pathway could produce analgesia in sickle mice. Strategies tested included dietary modification, mating and the use of a serotonergic agent. We used homozygous HbSS-BERK (sickle) mice, fed customized Sickle Mouse Diet (SD; 59M3, TestDiet) and Rodent Diet (RD; 2018, Harlan). SD contains 26.4% protein, 11.1% fat and 27.5% and 26% kcal/g from each, respectively. RD contains 18.6% protein and 6.2% fat, and 24% and 18% kcal/g from each, respectively. SD also contains higher minerals, vitamins and omega-3 fatty acids compared to RD. Male and female sickle mice on RD show tonic hyperalgesia as compared to "control" mice expressing normal human hemoglobin A (Kohli et al., Blood 2010). Mice were treated as follows: [A] SD with mating for 6 - 8...
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Journal of Personalized Medicine, Oct 27, 2022
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PubMed, 2018
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Papers by Rajendra D Badgaiyan