ZHX3

ZHX3
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2DA5, 2DN0
Identifikatori
Aliasi	ZHX3
Vanjski ID-jevi	OMIM: 609598 MGI: 2444772 HomoloGene: 9000 GeneCards: ZHX3
Lokacija gena (čovjek)
Hrom.	Hromosom 20 (čovjek)
Kraj	41,317,672 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	160,714,918 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • vezivanje sa DNK; • GO:0001948, GO:0016582 vezivanje za proteine; • protein homodimerization activity; • GO:0001106 transcription corepressor activity; • vezivanje iona metala; • protein heterodimerization activity; • nucleic acid binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• jedro; • nukleoplazma;
Biološki proces	• Ćelijska diferencijacija; • positive regulation of osteoblast differentiation; • GO:0045996 negative regulation of transcription, DNA-templated; • GO:0009373 regulation of transcription, DNA-templated; • GO:1901227 negative regulation of transcription by RNA polymerase II; • transcription, DNA-templated;
	Izvori:Amigo / QuickGO
Ortolozi
	23051
	320799
	ENSG00000174306
	ENSMUSG00000035877
	Q9H4I2
	Q8C0Q2
	NM_015035
	NM_177263
	NP_055850
	NP_796237
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Cinkov prst i homeoboksni protein 3 je protein koji je kod ljudi kodiran genom ZHX3.^[5]^[6]

Ovaj gen kodira člana porodice cinkovih prstiju i homeoboksova (ZHX). Kodirani protein sadrži dva cinkova prsta tipa C2H2 i pet homeodomena i čini imer sa sobom ili sa članom porodice cinkovih prstiju i homeoboksova 1. U jedru, dimerizirani protein djeluje u interakciji s A podjedinicom sveprisutnog jedarnog faktora transkripcionog faktora-Y i može funkcionirati kao transkripcijski represor.^[6]

Ontologija

Molekulska funkcija

GO: 0001131, GO: 0001151, GO: 0001130, GO: 0001204
aktivnost transkripcijskog faktora koji veže DNK
vezanje DNK
GO: 0001948 vezanje za proteine
aktivnost homodimerizacije proteina
GO: 0001106 aktivnost transpresorskog korepresora
vezanje metalnih Iona
aktivnost heterodimerizacije proteina
vezanje nukleinske kiseline
vezanje DNK za regulatorno područje transkripcije RNK-polimeraze II specifično
GO: 0001200, GO: 0001133, GO: 0001201
aktivnost transkripcionog faktora koji veže DNK, specifična za RNK-polimerazu II

Ćelijska komponenta

Biološki proces

ćelijska diferencijacija
pozitivna regulacija diferencijacije osteoblasta
negativna regulacija transkripcije, sa predloškom DNK
regulacija transkripcije, sa predloškom DNK
negativna regulacija transkripcije RNK-polimeraze II
transkripcija, DNK predložak

Izvori: Amigo / QuickGO

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MASKRKSTTP	CMIPVKTVVL	QDASMEAQPA	ETLPEGPQQD	LPPEASAASS
EAAQNPSSTD	GSTLANGHRS	TLDGYLYSCK	YCDFRSHDMT	QFVGHMNSEH
TDFNKDPTFV	CSGCSFLAKT	PEGLSLHNAT	CHSGEASFVW	NVAKPDNHVV
VEQSIPESTS	TPDLAGEPSA	EGADGQAEII	ITKTPIMKIM	KGKAEAKKIH
TLKENVPSQP	VGEALPKLST	GEMEVREGDH	SFINGAVPVS	QASASSAKNP
HAANGPLIGT	VPVLPAGIAQ	FLSLQQQPPV	HAQHHVHQPL	PTAKALPKVM
IPLSSIPTYN	AAMDSNSFLK	NSFHKFPYPT	KAELCYLTVV	TKYPEEQLKI
WFTAQRLKQG	ISWSPEEIED	ARKKMFNTVI	QSVPQPTITV	LNTPLVASAG
NVQHLIQAAL	PGHVVGQPEG	TGGGLLVTQP	LMANGLQATS	SPLPLTVTSV
PKQPGVAPIN	TVCSNTTSAV	KVVNAAQSLL	TACPSITSQA	FLDASIYKNK
KSHEQLSALK	GSFCRNQFPG	QSEVEHLTKV	TGLSTREVRK	WFSDRRYHCR
NLKGSRAMIP	GDHSSIIIDS	VPEVSFSPSS	KVPEVTCIPT	TATLATHPSA
KRQSWHQTPD	FTPTKYKERA	PEQLRALESS	FAQNPLPLDE	ELDRLRSETK
MTRREIDSWF	SERRKKVNAE	ETKKAEENAS	QEEEEAAEDE	GGEEDLASEL
RVSGENGSLE	MPSSHILAER	KVSPIKINLK	NLRVTEANGR	NEIPGLGACD
PEDDESNKLA	EQLPGKVSCK	KTAQQRHLLR	QLFVQTQWPS	NQDYDSIMAQ
TGLPRPEVVR	WFGDSRYALK	NGQLKWYEDY	KRGNFPPGLL	VIAPGNRELL
QDYYMTHKML	YEEDLQNLCD	KTQMSSQQVK	QWFAEKMGEE	TRAVADTGSE
DQGPGTGELT	AVHKGMGDTY	SEVSENSESW	EPRVPEASSE	PFDTSSPQAG
RQLETD

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174306 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035877 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
^ ^a ^b "Entrez Gene: ZHX3 zinc fingers and homeoboxes 3".

Dopunska literatura

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Liu G, Clement LC, Kanwar YS, et al. (2007). "ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome". J. Biol. Chem. 281 (51): 39681–92. doi:10.1074/jbc.M606664200. PMID 17056598.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kawata H, Yamada K, Shou Z, et al. (2004). "The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3". Gene. 323: 133–40. doi:10.1016/j.gene.2003.09.013. PMID 14659886.
Yamada K, Kawata H, Shou Z, et al. (2003). "Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3". Biochem. J. 373 (Pt 1): 167–78. doi:10.1042/BJ20021866. PMC 1223464. PMID 12659632.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jia L, Young MF, Powell J, et al. (2002). "Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis". Genomics. 79 (1): 7–17. doi:10.1006/geno.2001.6683. PMID 11827452.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174306 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035877 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9455477-5] Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.

[entrez-6] "Entrez Gene: ZHX3 zinc fingers and homeoboxes 3".

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