DLGAP4

DLGAP4
Identifikatori
Aliasi	DLGAP4
Vanjski ID-jevi	OMIM: 616191 MGI: 2138865 HomoloGene: 8935 GeneCards: DLGAP4
Lokacija gena (čovjek)
Hrom.	Hromosom 20 (čovjek)
Kraj	36,528,637 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	156,606,283 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • protein domain specific binding;
Ćelijska komponenta	• membrana; • ćelijska membrana; • sinapsa; • Nervno-mišićna veza; • glutamatergic synapse; • cholinergic synapse; • postsynaptic specialization;
Biološki proces	• signaling;
	Izvori:Amigo / QuickGO
Ortolozi
	22839
	228836
	ENSG00000080845
	ENSMUSG00000061689
	Q9Y2H0
	B1AZP2
	NM_001042486; NM_014902; NM_183006; NM_001365621
	NM_001042487; NM_001042488; NM_001277186; NM_001277187; NM_146128
	NP_001035951; NP_055717; NP_892118; NP_001352550
	NP_001035952; NP_001035953; NP_001264115; NP_001264116; NP_666240
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Velikodiskni pridruženi protein 4 (DAP-4), poznat i kao SAP90/ PSD-95-združeni protein 4 (SAPAP-4) je protein koji je kod ljudi kodiran genom DLGAP4.^[5]^[6]

Funkcija

DAP-4 je gvanilat-kinaza povezana s membranom koja se nalazi u postsinapsnoj gustoći u nervnih ćelija. To je signalna molekula, koja može stupiti u interakciju s kalijevim kanalom i receptorima, kao i drugim signalnim molekulama. DAP-4 može komunicirati sa PSD-95 preko svog domena gvanilat-kinaze i može biti uključen u klasteriranje PSD-95, u regiji postsinapsne gustoće. Kodirani protein je jedan od najmanje četiri slična proteina koja su pronađena. Za ovaj gen pronađene su alternativno prerađene varijante transkripata, koje kodiraju različite izoforme.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000080845 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061689 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takeuchi M, Hata Y, Hirao K, Toyoda A, Irie M, Takai Y (Jun 1997). "SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density". J Biol Chem. 272 (18): 11943–51. doi:10.1074/jbc.272.18.11943. PMID 9115257.
^ ^a ^b "Entrez Gene: DLGAP4 discs, large (Drosophila) homolog-associated protein 4".

Dopunska literatura

Kim JH, Liao D, Lau LF, Huganir RL (1998). "SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family". Neuron. 20 (4): 683–91. doi:10.1016/S0896-6273(00)81008-9. PMID 9581761.
Chen HJ, Rojas-Soto M, Oguni A, Kennedy MB (1998). "A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II". Neuron. 20 (5): 895–904. doi:10.1016/S0896-6273(00)80471-7. PMID 9620694.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
Kawabe H, Hata Y, Takeuchi M, et al. (1999). "nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that interacts with synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP)". J. Biol. Chem. 274 (43): 30914–8. doi:10.1074/jbc.274.43.30914. PMID 10521485.
Husi H, Ward MA, Choudhary JS, et al. (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nat. Neurosci. 3 (7): 661–9. doi:10.1038/76615. hdl:1842/742. PMID 10862698. S2CID 14392630.
Pei L, Teves RL, Wallace MC, Gurd JW (2001). "Transient cerebral ischemia increases tyrosine phosphorylation of the synaptic RAS-GTPase activating protein, SynGAP". J. Cereb. Blood Flow Metab. 21 (8): 955–63. doi:10.1097/00004647-200108000-00008. PMID 11487731.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Riefler GM, Balasingam G, Lucas KG, et al. (2003). "Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor)". Biochem. J. 373 (Pt 1): 49–55. doi:10.1042/BJ20021838. PMC 1223477. PMID 12675619.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Song B, Yan XB, Zhang GY (2004). "PSD-95 promotes CaMKII-catalyzed serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP after transient brain ischemia in rat hippocampus". Brain Res. 1005 (1–2): 44–50. doi:10.1016/j.brainres.2004.01.032. PMID 15044063.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000080845 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000061689 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9115257-5] Takeuchi M, Hata Y, Hirao K, Toyoda A, Irie M, Takai Y (Jun 1997). "SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density". J Biol Chem. 272 (18): 11943–51. doi:10.1074/jbc.272.18.11943. PMID 9115257.

[entrez-6] "Entrez Gene: DLGAP4 discs, large (Drosophila) homolog-associated protein 4".

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