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Fully unsupervised low-dimensional representation of adverse drug reaction events through distributional semantics

Alicia Pérez, Arantza Casillas, Koldo Gojenola


Abstract
Electronic health records show great variability since the same concept is often expressed with different terms, either scientific latin forms, common or lay variants and even vernacular naming. Deep learning enables distributional representation of terms in a vector-space, and therefore, related terms tend to be close in the vector space. Accordingly, embedding words through these vectors opens the way towards accounting for semantic relatedness through classical algebraic operations. In this work we propose a simple though efficient unsupervised characterization of Adverse Drug Reactions (ADRs). This approach exploits the embedding representation of the terms involved in candidate ADR events, that is, drug-disease entity pairs. In brief, the ADRs are represented as vectors that link the drug with the disease in their context through a recursive additive model. We discovered that a low-dimensional representation that makes use of the modulus and argument of the embedded representation of the ADR event shows correlation with the manually annotated class. Thus, it can be derived that this characterization results in to be beneficial for further classification tasks as predictive features.
Anthology ID:
W16-5106
Volume:
Proceedings of the Fifth Workshop on Building and Evaluating Resources for Biomedical Text Mining (BioTxtM2016)
Month:
December
Year:
2016
Address:
Osaka, Japan
Editors:
Sophia Ananiadou, Riza Batista-Navarro, Kevin Bretonnel Cohen, Dina Demner-Fushman, Paul Thompson
Venue:
WS
SIG:
Publisher:
The COLING 2016 Organizing Committee
Note:
Pages:
50–59
Language:
URL:
https://aclanthology.org/W16-5106
DOI:
Bibkey:
Cite (ACL):
Alicia Pérez, Arantza Casillas, and Koldo Gojenola. 2016. Fully unsupervised low-dimensional representation of adverse drug reaction events through distributional semantics. In Proceedings of the Fifth Workshop on Building and Evaluating Resources for Biomedical Text Mining (BioTxtM2016), pages 50–59, Osaka, Japan. The COLING 2016 Organizing Committee.
Cite (Informal):
Fully unsupervised low-dimensional representation of adverse drug reaction events through distributional semantics (Pérez et al., 2016)
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PDF:
https://aclanthology.org/W16-5106.pdf