MHC 클래스 I 폴리펩타이드 관련 배열 B

MICB
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1JE6, 2WY3
식별자
에일리어스	MICB, PERB11.2, MHC 클래스 I 폴리펩타이드 관련 배열 B
외부 ID	OMIM: 602436 MGI: 2179999 HomoloGene: 88329 GeneCard: MICB
유전자 위치(인간)
크르.	6번 염색체(인간)
끝.	31,511,120 bp
유전자 위치(마우스)
크르.	7번 염색체(쥐)
끝.	18,599,327 bp
RNA발현패턴
	상단 표시 위치:
	단구; ; 피; ; 자궁내막간질세포; ; 림프절; ; 골수; ; 골수 세포; ; 비장; ; 부록; ; 좌폐 상엽; ; 오른쪽 폐;
	상단 표시 위치:
	방광; ; 자궁; ; 폐; ; 난소; ; 백색 지방 조직; ; 부신; ; 피부대; ; 식도; ; 근육 조직; ; 골격근 조직;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	천연킬러세포렉틴수용체결합;
셀룰러 컴포넌트	막의 적분 성분; 세포 표면; 혈장막; 막; 세포외 공간; 혈장막외측;
생물학적 과정	면역계 과정; 감마델타T세포활성화; 바이러스 과정; 열에 대한 반응; 세포 분해; 적응 면역 반응; 산화 스트레스에 대한 반응; 레티노인산에 대한 반응; T세포 매개세포독성; 자연 킬러 세포 매개 세포독성; 면역 반응 조절; 면역반응활성화세포표면수용체신호경로; 면역 반응; 자연킬러세포활성화; 자연 킬러 세포 매개 세포 독성에 대한 감수성;
	출처:아미고 / QuickGO
맞춤법
	4277
	243864
ENSG00000231179; ENSG00000224378; ENSG00000206449; ENSG0000022772; ENSG00000238289;
	ENSG00000231372; ENSG00000234218; ENSG00000204516
	ENSMUSG000040987
	문제 29980
	Q8HWE5
	NM_001289160; NM_001289161; NM_005931
	NM_153760; NM_153761
	NP_001276089; NP_001276090; NP_005922
	NP_715641; NP_715642
	위키데이터
인간 보기/편집	마우스 표시/편집

MHC 클래스 I 폴리펩타이드 관련 배열 B(MICB)는 MHC ^[5]궤적 내에 위치한 MICB 유전자에 의해 암호화되는 단백질이다.MICB는 MHC 클래스 I와 관련이 있으며 외부 α1α2α3 도메인, 막 통과 세그먼트 및 C 말단 세포질 ^[5]꼬리로 구성된 유사한 도메인 구조를 가지고 있습니다.MICB는 NKG2D ^[6]수용체에 대한 스트레스 유도 리간드이다.MICB의 전사는 프로모터 열충격 ^[7]요소에 의해 조절되므로 열충격 응력 경로는 MICB 발현 조절에 관여한다.

「」를 참조해 주세요.

마이카

레퍼런스

^ ^a ^b ^c ENSG00000224378, ENSG0000022772, ENSG00000238289, ENSG00000231372, ENSG00000234218, ENSG00204516 GRCh38: Ensubbl 릴리스 89: ENSG0000011,7972
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000040987 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Bahram S, Bresnahan M, Geraghty DE, Spies T (Jul 1994). "A second lineage of mammalian major histocompatibility complex class I genes". Proceedings of the National Academy of Sciences of the United States of America. 91 (14): 6259–63. Bibcode:1994PNAS...91.6259B. doi:10.1073/pnas.91.14.6259. PMC 44180. PMID 8022771.
^ Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T (Jul 1999). "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA". Science. 285 (5428): 727–9. doi:10.1126/science.285.5428.727. PMID 10426993.
^ Groh V, Bahram S, Bauer S, Herman A, Beauchamp M, Spies T (Oct 1996). "Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium". Proceedings of the National Academy of Sciences of the United States of America. 93 (22): 12445–50. Bibcode:1996PNAS...9312445G. doi:10.1073/pnas.93.22.12445. PMC 38011. PMID 8901601.

추가 정보

Braud VM, Allan DS, McMichael AJ (Feb 1999). "Functions of nonclassical MHC and non-MHC-encoded class I molecules". Current Opinion in Immunology. 11 (1): 100–8. doi:10.1016/S0952-7915(99)80018-1. PMID 10047540.
Borrego F, Kabat J, Kim DK, Lieto L, Maasho K, Peña J, Solana R, Coligan JE (Feb 2002). "Structure and function of major histocompatibility complex (MHC) class I specific receptors expressed on human natural killer (NK) cells". Molecular Immunology. 38 (9): 637–60. doi:10.1016/S0161-5890(01)00107-9. PMID 11858820.
Leelayuwat C, Townend DC, Degli-Esposti MA, Abraham LJ, Dawkins RL (1994). "A new polymorphic and multicopy MHC gene family related to nonmammalian class I". Immunogenetics. 40 (5): 339–51. doi:10.1007/BF01246675. PMID 7927538. S2CID 10504768.
Bahram S, Spies T (1996). "Nucleotide sequence of a human MHC class I MICB cDNA". Immunogenetics. 43 (4): 230–3. doi:10.1007/s002510050051. PMID 8575823.
Nalabolu SR, Shukla H, Nallur G, Parimoo S, Weissman SM (Jan 1996). "Genes in a 220-kb region spanning the TNF cluster in human MHC". Genomics. 31 (2): 215–22. doi:10.1006/geno.1996.0034. PMID 8824804.
Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Groh V, Bahram S, Bauer S, Herman A, Beauchamp M, Spies T (Oct 1996). "Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium". Proceedings of the National Academy of Sciences of the United States of America. 93 (22): 12445–50. Bibcode:1996PNAS...9312445G. doi:10.1073/pnas.93.22.12445. PMC 38011. PMID 8901601.
Bahram S, Shiina T, Oka A, Tamiya G, Inoko H (1997). "Genomic structure of the human MHC class I MICB gene". Immunogenetics. 45 (2): 161–2. doi:10.1007/s002510050184. PMID 8952966. S2CID 26270690.
Gaudieri S, Leelayuwat C, Townend DC, Mullberg J, Cosman D, Dawkins RL (1997). "Allelic and interlocus comparison of the PERB11 multigene family in the MHC". Immunogenetics. 45 (3): 209–16. doi:10.1007/s002510050191. PMID 8995188. S2CID 6658841.
Pellet P, Renaud M, Fodil N, Laloux L, Inoko H, Hauptmann G, Debré P, Bahram S, Theodorou I (1997). "Allelic repertoire of the human MICB gene". Immunogenetics. 46 (5): 434–6. doi:10.1007/s002510050299. PMID 9271635. S2CID 7799593.
Ando H, Mizuki N, Ota M, Yamazaki M, Ohno S, Goto K, Miyata Y, Wakisaka K, Bahram S, Inoko H (1997). "Allelic variants of the human MHC class I chain-related B gene (MICB)". Immunogenetics. 46 (6): 499–508. doi:10.1007/s002510050311. PMID 9321430. S2CID 1912407.
Groh V, Steinle A, Bauer S, Spies T (Mar 1998). "Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells". Science. 279 (5357): 1737–40. doi:10.1126/science.279.5357.1737. PMID 9497295.
Visser CJ, Tilanus MG, Schaeffer V, Tatari Z, Tamouza R, Janin A, Charron D (Jun 1998). "Sequencing-based typing reveals six novel MHC class I chain-related gene B (MICB) alleles". Tissue Antigens. 51 (6): 649–52. doi:10.1111/j.1399-0039.1998.tb03008.x. PMID 9694358.
Steinle A, Groh V, Spies T (Oct 1998). "Diversification, expression, and gamma delta T cell recognition of evolutionarily distant members of the MIC family of major histocompatibility complex class I-related molecules". Proceedings of the National Academy of Sciences of the United States of America. 95 (21): 12510–5. Bibcode:1998PNAS...9512510S. doi:10.1073/pnas.95.21.12510. PMC 22861. PMID 9770516.
Groh V, Rhinehart R, Secrist H, Bauer S, Grabstein KH, Spies T (Jun 1999). "Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB". Proceedings of the National Academy of Sciences of the United States of America. 96 (12): 6879–84. Bibcode:1999PNAS...96.6879G. doi:10.1073/pnas.96.12.6879. PMC 22010. PMID 10359807.
Tay GK, Hui J, Gaudieri S, Schmitt-Egenolf M, Martinez OP, Leelayuwat C, Williamson JF, Eiermann TH, Dawkins RL (Mar 2000). "PERB11 (MIC): a polymorphic MHC gene is expressed in skin and single nucleotide polymorphisms are associated with psoriasis". Clinical and Experimental Immunology. 119 (3): 553–8. doi:10.1046/j.1365-2249.2000.01140.x. PMC 1905592. PMID 10691930.
Fischer G, Pérez-Rodríguez M, Argüello JR, Cox ST, McWhinnie A, Travers PJ, Madrigal JA (Feb 2000). "Three novel MICB alleles". Tissue Antigens. 55 (2): 166–70. doi:10.1034/j.1399-0039.2000.550210.x. PMID 10746790.
Cerwenka A, Bakker AB, McClanahan T, Wagner J, Wu J, Phillips JH, Lanier LL (Jun 2000). "Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice". Immunity. 12 (6): 721–7. doi:10.1016/S1074-7613(00)80222-8. PMID 10894171.

이 단백질 관련 기사는 스텁입니다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] ENSG00000224378, ENSG0000022772, ENSG00000238289, ENSG00000231372, ENSG00000234218, ENSG00204516 GRCh38: Ensubbl 릴리스 89: ENSG0000011,7972

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000040987 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8022771-5] Bahram S, Bresnahan M, Geraghty DE, Spies T (Jul 1994). "A second lineage of mammalian major histocompatibility complex class I genes". Proceedings of the National Academy of Sciences of the United States of America. 91 (14): 6259–63. Bibcode:1994PNAS...91.6259B. doi:10.1073/pnas.91.14.6259. PMC 44180. PMID 8022771.

[6] Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T (Jul 1999). "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA". Science. 285 (5428): 727–9. doi:10.1126/science.285.5428.727. PMID 10426993.

[7] Groh V, Bahram S, Bauer S, Herman A, Beauchamp M, Spies T (Oct 1996). "Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium". Proceedings of the National Academy of Sciences of the United States of America. 93 (22): 12445–50. Bibcode:1996PNAS...9312445G. doi:10.1073/pnas.93.22.12445. PMC 38011. PMID 8901601.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

Search

MHC 클래스 I 폴리펩타이드 관련 배열 B

네임스페이스

더

「」를 참조해 주세요.

레퍼런스

추가 정보

Search

MHC 클래스 I 폴리펩타이드 관련 배열 B

「 」를 참조해 주세요.

레퍼런스

추가 정보

「」를 참조해 주세요.