콜린거 수용체 라고도 알려진 무스카린 아세틸콜린 수용체 M4 ( Muscarinic Acetylcholin receptor, Muscarinic 4 (CHRM4)은 인간에게 있어 CHRM4 유전자 에 의해 암호화된 단백질 이다.[4] [5]
함수 M4 사카린 수용체는 G 이질i/o 단백질과 결합된다.[6]
그것들은 아세틸콜린에 대한 억제 자각제로 기능한다. M4 수용체의 활성화는 선조체 에서 아세틸콜린 분비를 억제한다. 아세틸콜린 수용체의 M2 하위형은 주로 해마 와 대뇌피질 에서 활발하게 기능하지만 아세틸콜린 방출에 대한 억제 자동수용기와 유사하게 기능한다.
무스카린 아세틸콜린 수용체 는 도파민성 신경전달 에 대한 규제 효과를 가지고 있다. 선조체 에서 M4 수용체가 활성화되면 마우스 에서 D 유도1 보행자 자극 을 억제한다. M4 수용체 결핍 마우스는 D1 작용제 , 암페타민 , 코카인 에 반응하여 기관차 시뮬레이션을 증가시킨다.[7] [8] [9] 선조체 내 신경전달은 외사적 운동 조절 에 영향을 미치기 때문에 M4 활성의 변화가 파킨슨병 과 같은 질환에 기여할 수 있다.[10] [11] [12]
리간즈 정형외과적 작용제 포지티브 알로스테리릭 변조기 LY-2033298 [13] VU-0152100(ML-108) VU-0152099 [14] 반목자 AFDX-384 (mixed M2/M4 antagonist, N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide, CAS# 118290-27-0)디시클로바인 [20] 힘바신 맘바 독소[21] PD-102,807 (3,6a,11,14-테트라하이드로-9-메톡시-2-메틸-(12H)-isoquino[1,2-b]피롤로[3,3]벤조사진-1-카복시산 에틸에스테르, CAS# 23062-91-1)PD-0298029 트로피카미드 - 다른 무스카린 하위 유형보다 적당한 선택성(2-5배 정도)[22] 참고 항목 참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000180720 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: CHRM4 cholinergic receptor, muscarinic 4" .^ Grewal RP, Martinez M, Hoehe M, Bonner TI, Gershon ES, Detera-Wadleigh S (May 1992). "Genetic linkage mapping of the m4 human muscarinic receptor (CHRM4)" . 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