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Volume 6, Number 2—April 2000
Synopsis

Vaccines for Mucosal Immunity to Combat Emerging Infectious Diseases

Frederik W. van GinkelComments to Author , Huan H. Nguyen, and Jerry R. McGhee
Author affiliations: The University of Alabama at Birmingham, Birmingham, Alabama, USA

Main Article

Figure 3

Pathways of intracellular pathogen clearance from infected cells by cytotoxic cells. Intracellular pathogen-derived antigens complexed to MHC class I molecules are recognized by CTLs, while NK cells recognize the absence or suppressed levels of MHC class I molecules on infected cells. Activated cytotoxic cells deliver apoptotic signals through Fas ligand and perforin to infected cells. They also secrete cytokines (IFN-gð, TNF-að) and chemokines (Rantes, MIP-1að, MIP-1bð) to inhibit or suppress i

Figure 3. Pathways of intracellular pathogen clearance from infected cells by cytotoxic cells. Intracellular pathogen-derived antigens complexed to MHC class I molecules are recognized by CTLs, while NK cells recognize the absence or suppressed levels of MHC class I molecules on infected cells. Activated cytotoxic cells deliver apoptotic signals through Fas ligand and perforin to infected cells. They also secrete cytokines (IFN-gð, TNF-að) and chemokines (Rantes, MIP-1að, MIP-1bð) to inhibit or suppress intracellular pathogen replication.

Main Article

Page created: December 16, 2010
Page updated: December 16, 2010
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The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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