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Perflubron (INN/USAN, or perfluorooctyl bromide; brand name Imagent) is a contrast medium for magnetic resonance imaging, computer tomography and sonography.[1] It was approved for this use in the United States by the Food and Drug Administration in 1993.[2]

Quick Facts Clinical data, ATC code ...
Perflubron
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Clinical data
ATC code
Identifiers
  • 1-Bromo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.006.391 Edit this at Wikidata
Chemical and physical data
FormulaC8BrF17
Molar mass498.965 g·mol−1
3D model (JSmol)
Density1.93 g/cm3
Melting point6 °C (43 °F)
Boiling point142 °C (288 °F)
  • FC(F)(C(F)(F)C(Br)(F)F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F
  • InChI=1S/C8BrF17/c9-7(22,23)5(18,19)3(14,15)1(10,11)2(12,13)4(16,17)6(20,21)8(24,25)26
  • Key:WTWWXOGTJWMJHI-UHFFFAOYSA-N
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Experimental research

Perflubron has also been tested experimentally for use in liquid breathing in premature infants with respiratory distress.[3][4]

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This molecular model of Perflubron is color-coded by electron density to illustrate the positive polarisation of the large bromine atom by the inductively electron-withdrawing perfluorooctyl chain.

References

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