Carbamoyl phosphate
Chemical compound From Wikipedia, the free encyclopedia
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Chemical compound From Wikipedia, the free encyclopedia
Carbamoyl phosphate is an anion of biochemical significance. In land-dwelling animals, it is an intermediary metabolite in nitrogen disposal through the urea cycle and the synthesis of pyrimidines. Its enzymatic counterpart, carbamoyl phosphate synthetase I (CPS I), interacts with a class of molecules called sirtuins, NAD dependent protein deacetylases, and ATP to form carbamoyl phosphate. CP then enters the urea cycle in which it reacts with ornithine (a process catalyzed by the enzyme ornithine transcarbamylase) to form citrulline.
Names | |
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IUPAC name
(Carbamoyloxy)phosphonic acid | |
Identifiers | |
3D model (JSmol) |
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ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.230.975 |
KEGG | |
MeSH | Carbamoyl+phosphate |
PubChem CID |
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UNII | |
CompTox Dashboard (EPA) |
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Properties | |
CH2NO5P2− | |
Molar mass | 141.020 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Carbamoyl phosphate is a metabolic intermediate in a pathway that involves nitrogen disposal through the urea cycle and the biosynthesis of pyrimidines.[1]
It is produced from bicarbonate, ammonia (derived from amino acids), and phosphate (from ATP).[2] The synthesis is catalyzed by the enzyme carbamoyl phosphate synthetase.[2] This uses three reactions as follows:
A defect in the CPS I enzyme, and a subsequent deficiency in the production of carbamoyl phosphate has been linked to hyperammonemia in humans.[3]
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