Cytomegalovirus retinitis

Cytomegalovirus retinitis
Cytomegalovirus retinitis
Other names	CMV retinitis
	Fundus photograph of CMV retinitis
Specialty	Ophthalmology, infectious diseases
Symptoms	Blurred vision
Causes	Bone marrow transplant, HIV/AIDS
Diagnostic method	Ophthalmologic exam, blood test
Medication	Antivirals (oral or intraocular injection)

Cytomegalovirus retinitis, also known as CMV retinitis, is an inflammation of the retina of the eye that can lead to blindness.^[1] Caused by human cytomegalovirus, it occurs predominantly in people whose immune system has been compromised, including 15-40% of those with AIDS.^[3]

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Thumb — The typical "pizza pie" appearance of the fundus in CMV retinitis^[4]^[5]^[6]^[7]

The symptoms of cytomegalovirus retinitis have it usually starting in one eye (and also have the possibility of retinal detachment), presenting as:^[1]

Blurred vision
Blind spots
Specks in your vision

Cytomegalovirus (a type of herpes virus) is what causes cytomegalovirus retinitis. Other types of herpes viruses include herpes simplex viruses and Epstein-Barr virus. Once an individual is infected with these viruses they stay in the body for life.^[8] What triggers the virus to reactivate are the following (though CMV can also be congenital).^[7]

Leukemia
AIDS
Immunosuppressive chemotherapy

Human cytomegalovirus (HCMV or CMV) is a DNA virus in the family Herpesviridae known for producing large cells with nuclear and cytoplasmic inclusions,^[9] CMV infects around 40% of the population worldwide.^[10]

Those areas infected by cytomegalovirus have cells evolve to necrosis, though inflammation within the retina is not great. Rhegmatogenous retinal detachments can occur following the development of holes in areas of healed retinitis (retina may be atrophic).^[11]^[12] Proliferative vitreoretinopathy has been observed in cases of retinal detachment.^[13]

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The diagnosis of CMV retinitis can be done via the following:^[7]^[14]

Ophthalmic screening frequency is based on CD4 count,(CD4 < 50 cells/mL, 0- 35% possibility of CMV retinitis)
BUN
CD8+ T-lymphocyte count
CMV DNA capture ( polymerase chain reaction (PCR) test)
DNA PCR ( ocular fluids)
Viral load
Complete blood count

In terms of the treatment of cytomegalovirus retinitis, oral valganciclovir, intravenous ganciclovir, IV foscarnet, and IV cidofovir are all efficient in the treatment of this condition. Also intravitreal injections, an injection of medicine into the vitreous near the retina, of foscarnet in concomitance with oral valganciclovir can be used for treatment as well.^[15]^[2]^[16]

Often individuals with CMV retinitis will need surgery for either retinal detachment or intravitreal instillation of ganciclovir. Retinal detachment occurs in up to 29% of affected eyes, repair being most effective with endolaser and silicone oil endotamponade. Intravitreal ganciclovir implant has the benefit of less systemic toxicity. An adverse effect of this is retinal detachment (and vitreous hemorrhage), also there is no systemic beneficial effect for cytomegalovirus organ disease.^[7]

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[1]
"Cytomegalovirus retinitis". MedlinePlus Medical Encyclopedia. U.S. National Library of Medicine. Archived from the original on 2016-03-15. Retrieved 2016-03-14.
[2]
Tidy C (12 March 2014). Huinsn H (ed.). "Inflammatory Retinal Diseases". Patient. Leeds, UK: Egton Medical Information Systems Limited. Archived from the original on 2016-03-22. Retrieved 2016-03-16.
[3]
Narendran V, Kothari A (2014-05-30). Principles and Practice of Vitreoretinal Surgery. JP Medical Ltd. p. 571. ISBN 978-9-351-52097-9.
[4]
To K, Friedman AH (December 1989). "Cytomegalovirus retinitis". JAMA. 262 (23): 3337. doi:10.1001/jama.1989.03430230122038. ISSN 0098-7484. PMID 2555576. Archived from the original on 2023-03-07. Retrieved 2023-03-07.
[5]
Sudharshan S, Ganesh SK, Biswas J (January 2010). "Current approach in the diagnosis and management of posterior uveitis". Indian Journal of Ophthalmology. 58 (1): 29–43. doi:10.4103/0301-4738.58470. ISSN 0301-4738. PMC 2841371. PMID 20029144.
[6]
Weiner G (February 2014). "HIV-Related CMV Retinitis in the Developing World" (PDF). EyeNet Magazine - American Academy of Ophthalmology. pp. 27–29. Archived from the original (PDF) on 2023-03-07.
[7]
Cytomegalovirus (CMV) Retinitis~clinical at eMedicine. "Archived copy". Archived from the original on 7 March 2023. Retrieved 8 September 2023.{{cite web}}: CS1 maint: archived copy as title (link) CS1 maint: bot: original URL status unknown (link)
[8]
"CMV | Overview | Cytomegalovirus and Congenital CMV Infection". U.S. Centers for Disease Control and Prevention. Archived from the original on 2017-10-16. Retrieved 2016-03-16.
[9]
Ray K, Bala M (February 2014). "Human Cytomegalovirus Infection". In Kumar B, Gupta S (eds.). Sexually Transmitted Infections (2nd ed.). Elsevier Health Sciences. p. 399. ISBN 978-8-131-22978-1. Archived from the original on 2023-01-12. Retrieved 2016-03-16.
[10]
Offermanns S, Rosenthal W (2008). Encyclopedia of Molecular Pharmacology (2nd ed.). Springer. pp. 437–438. ISBN 978-3-540-38916-3.
[11]
Wu L, Pakalnis VA (8 October 2019). Law SK, Charles S, Dahl AA (eds.). "Rhegmatogenous Retinal Detachment Clinical Presentation: History, Physical, Causes". Medscape. Archived from the original on 2016-04-27. Retrieved 2016-03-16.
[12]
Cheeran MC, Lokensgard JR, Schleiss MR (January 2009). "Neuropathogenesis of congenital cytomegalovirus infection: disease mechanisms and prospects for intervention". Clinical Microbiology Reviews. 22 (1): 99–126, Table of Contents. doi:10.1128/CMR.00023-08. ISSN 0893-8512. PMC 2620634. PMID 19136436.
[13]
Sadaka A, Giuliari GP (January 2012). "Proliferative vitreoretinopathy: current and emerging treatments". Clinical Ophthalmology. 6: 1325–1333. doi:10.2147/OPTH.S27896. ISSN 1177-5467. PMC 3429288. PMID 22942638.
[14]
Foster CS, Vitale AT (2013-03-30). Diagnosis & Treatment of Uveitis. JP Medical Ltd. p. 449. ISBN 978-9-350-25572-8. Archived from the original on 2023-01-12. Retrieved 2016-03-16.
[15]
"Cytomegalovirus Disease | Adult and Adolescent OI Prevention and Treatment Guidelines". AIDSinfo. U.S. National Institutes of Health. Archived from the original on 2016-03-23. Retrieved 2016-03-16.
[16]
"Intravitreal injection". MedlinePlus Medical Encyclopedia. U.S. National Library of Medicine. Archived from the original on 2016-03-23. Retrieved 2016-03-16.

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Ljungman P, Griffiths P, Paya C (April 2002). "Definitions of cytomegalovirus infection and disease in transplant recipients". Clinical Infectious Diseases. 34 (8): 1094–1097. doi:10.1086/339329. ISSN 1058-4838. PMID 11914998.
Heiden D, Ford N, Wilson D, Rodriguez WR, Margolis T, Janssens B, et al. (December 2007). "Cytomegalovirus retinitis: the neglected disease of the AIDS pandemic". PLOS Medicine. 4 (12): e334. doi:10.1371/journal.pmed.0040334. ISSN 1549-1676. PMC 2100142. PMID 18052600.
Campbell RJ, Chow B, Victor G, Kravcik S, Hodge WG (September 2001). "Treatment of CMV retinitis with intravitral ganciclovir in the HAART era". The Canadian Journal of Infectious Diseases. 12 (5): 300–304. doi:10.1155/2001/851845. ISSN 1180-2332. PMC 2094829. PMID 18159353.

"Eye Implant Effective in Treating CMV Retinitis". National Eye Institute. Archived from the original on 2015-09-10. Retrieved 2016-03-17.

Scholia has a topic profile for Cytomegalovirus retinitis.

[nih-1] [1]
"Cytomegalovirus retinitis". MedlinePlus Medical Encyclopedia. U.S. National Library of Medicine. Archived from the original on 2016-03-15. Retrieved 2016-03-14.

[pat-2] [2]
Tidy C (12 March 2014). Huinsn H (ed.). "Inflammatory Retinal Diseases". Patient. Leeds, UK: Egton Medical Information Systems Limited. Archived from the original on 2016-03-22. Retrieved 2016-03-16.

[3] [3]
Narendran V, Kothari A (2014-05-30). Principles and Practice of Vitreoretinal Surgery. JP Medical Ltd. p. 571. ISBN 978-9-351-52097-9.

[JAMA-4] [4]
To K, Friedman AH (December 1989). "Cytomegalovirus retinitis". JAMA. 262 (23): 3337. doi:10.1001/jama.1989.03430230122038. ISSN 0098-7484. PMID 2555576. Archived from the original on 2023-03-07. Retrieved 2023-03-07.

[5] [5]
Sudharshan S, Ganesh SK, Biswas J (January 2010). "Current approach in the diagnosis and management of posterior uveitis". Indian Journal of Ophthalmology. 58 (1): 29–43. doi:10.4103/0301-4738.58470. ISSN 0301-4738. PMC 2841371. PMID 20029144.

[6] [6]
Weiner G (February 2014). "HIV-Related CMV Retinitis in the Developing World" (PDF). EyeNet Magazine - American Academy of Ophthalmology. pp. 27–29. Archived from the original (PDF) on 2023-03-07.

[emed-7] [7]
Cytomegalovirus (CMV) Retinitis~clinical at eMedicine. "Archived copy". Archived from the original on 7 March 2023. Retrieved 8 September 2023.{{cite web}}: CS1 maint: archived copy as title (link) CS1 maint: bot: original URL status unknown (link)

[8] [8]
"CMV | Overview | Cytomegalovirus and Congenital CMV Infection". U.S. Centers for Disease Control and Prevention. Archived from the original on 2017-10-16. Retrieved 2016-03-16.

[9] [9]
Ray K, Bala M (February 2014). "Human Cytomegalovirus Infection". In Kumar B, Gupta S (eds.). Sexually Transmitted Infections (2nd ed.). Elsevier Health Sciences. p. 399. ISBN 978-8-131-22978-1. Archived from the original on 2023-01-12. Retrieved 2016-03-16.

[10] [10]
Offermanns S, Rosenthal W (2008). Encyclopedia of Molecular Pharmacology (2nd ed.). Springer. pp. 437–438. ISBN 978-3-540-38916-3.

[11] [11]
Wu L, Pakalnis VA (8 October 2019). Law SK, Charles S, Dahl AA (eds.). "Rhegmatogenous Retinal Detachment Clinical Presentation: History, Physical, Causes". Medscape. Archived from the original on 2016-04-27. Retrieved 2016-03-16.

[12] [12]
Cheeran MC, Lokensgard JR, Schleiss MR (January 2009). "Neuropathogenesis of congenital cytomegalovirus infection: disease mechanisms and prospects for intervention". Clinical Microbiology Reviews. 22 (1): 99–126, Table of Contents. doi:10.1128/CMR.00023-08. ISSN 0893-8512. PMC 2620634. PMID 19136436.

[13] [13]
Sadaka A, Giuliari GP (January 2012). "Proliferative vitreoretinopathy: current and emerging treatments". Clinical Ophthalmology. 6: 1325–1333. doi:10.2147/OPTH.S27896. ISSN 1177-5467. PMC 3429288. PMID 22942638.

[14] [14]
Foster CS, Vitale AT (2013-03-30). Diagnosis & Treatment of Uveitis. JP Medical Ltd. p. 449. ISBN 978-9-350-25572-8. Archived from the original on 2023-01-12. Retrieved 2016-03-16.

[15] [15]
"Cytomegalovirus Disease | Adult and Adolescent OI Prevention and Treatment Guidelines". AIDSinfo. U.S. National Institutes of Health. Archived from the original on 2016-03-23. Retrieved 2016-03-16.

[16] [16]
"Intravitreal injection". MedlinePlus Medical Encyclopedia. U.S. National Library of Medicine. Archived from the original on 2016-03-23. Retrieved 2016-03-16.

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Cytomegalovirus retinitis

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Mechanism

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