Targeting polo-like kinase 1 for cancer therapy. (Q53348000)

13 May 2018

review article

1 reference

title

Targeting polo-like kinase 1 for cancer therapy. (English)

1 reference

13 May 2018

author name string

Klaus Strebhardt

series ordinal

1 reference

13 May 2018

Axel Ullrich

series ordinal

1 reference

13 May 2018

language of work or name

English

0 references

publication date

1 April 2006

1 reference

13 May 2018

published in

Nature Reviews Cancer

1 reference

13 May 2018

volume

1 reference

13 May 2018

issue

1 reference

13 May 2018

page(s)

321-330

1 reference

13 May 2018

A conserved mitotic kinase active at late anaphase-telophase in syncytial Drosophila embryos

cites work

1 reference

Polo-like kinases: a team that plays throughout mitosis

31 March 2020

1 reference

Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila

31 March 2020

1 reference

Cell cycle- and terminal differentiation-associated regulation of the mouse mRNA encoding a conserved mitotic protein kinase

31 March 2020

1 reference

Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors

31 March 2020

1 reference

Identification of an early-growth-response gene encoding a novel putative protein kinase

31 March 2020

1 reference

Human Prk Is a Conserved Protein Serine/Threonine Kinase Involved in Regulating M Phase Functions

31 March 2020

1 reference

Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages

31 March 2020

1 reference

Sak, a murine protein-serine/threonine kinase that is related to the Drosophila polo kinase and involved in cell proliferation

31 March 2020

1 reference

On the Regulation and Function of Human Polo-like Kinase 1 (PLK1): Effects of Overexpression on Cell Cycle Progression

31 March 2020

1 reference

Malignant transformation of mammalian cells initiated by constitutive expression of the polo-like kinase

31 March 2020

1 reference

Polo-like kinases and oncogenesis

31 March 2020

1 reference

Scytonemin--a marine natural product inhibitor of kinases key in hyperproliferative inflammatory diseases

31 March 2020

1 reference

The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore

31 March 2020

1 reference

Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase.

31 March 2020

1 reference

ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent.

31 March 2020

1 reference

Polo-like kinases and the orchestration of cell division

31 March 2020

1 reference

Regulation of cell cycle checkpoints by polo-like kinases

31 March 2020

1 reference

Getting in and out of mitosis with Polo-like kinase-1.

31 March 2020

1 reference

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function

31 March 2020

1 reference

Plk is an M-phase-specific protein kinase and interacts with a kinesin-like protein, CHO1/MKLP-1

31 March 2020

1 reference

A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5

31 March 2020

1 reference

The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.

31 March 2020

1 reference

GFP tagging reveals human Polo-like kinase 1 at the kinetochore/centromere region of mitotic chromosomes

31 March 2020

1 reference

Mouse polo-like kinase 1 associates with the acentriolar spindle poles, meiotic chromosomes and spindle midzone during oocyte maturation.

31 March 2020

1 reference

Plk is a functional homolog of Saccharomyces cerevisiae Cdc5, and elevated Plk activity induces multiple septation structures

31 March 2020

1 reference

Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA.

31 March 2020

1 reference

Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells

31 March 2020

1 reference

Functional studies on the role of the C-terminal domain of mammalian polo-like kinase

31 March 2020

1 reference

Polo-like kinase-1 is a target of the DNA damage checkpoint

31 March 2020

1 reference

Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells

31 March 2020

1 reference

Restarting the cell cycle when the checkpoint comes to a halt

31 March 2020

1 reference

Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation

31 March 2020

1 reference

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

31 March 2020

1 reference

Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members

31 March 2020

1 reference

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

31 March 2020

1 reference

Structural basis of Aurora-A activation by TPX2 at the mitotic spindle

31 March 2020

1 reference

Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography

31 March 2020

1 reference

Crystal structure of aurora-2, an oncogenic serine/threonine kinase

31 March 2020

1 reference

Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

31 March 2020

1 reference

Structure and function of Polo-like kinases

31 March 2020

1 reference

Polo-like Kinase Is a Cell Cycle-regulated Kinase Activated during Mitosis

31 March 2020

1 reference

Hot lips and phosphorylation of protein kinases

31 March 2020

1 reference

Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

31 March 2020

1 reference

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

31 March 2020

1 reference

Ste20-like kinase (SLK), a regulatory kinase for polo-like kinase (Plk) during the G2/M transition in somatic cells

31 March 2020

1 reference

Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue

31 March 2020

1 reference

Cell cycle-regulated phosphorylation of the Xenopus polo-like kinase Plx1.

31 March 2020

1 reference

The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain

31 March 2020

1 reference

The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex

31 March 2020

1 reference

Mapping specificity determinants for protein-protein association using protein fusions and random peptide libraries

31 March 2020

1 reference

Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates

31 March 2020

1 reference

Mutation of the polo-box disrupts localization and mitotic functions of the mammalian polo kinase Plk.

31 March 2020

1 reference

Assembly of Cell Regulatory Systems Through Protein Interaction Domains

31 March 2020

1 reference

Peripheral Golgi protein GRASP65 is a target of mitotic polo-like kinase (Plk) and Cdc2

31 March 2020

1 reference

Plk phosphorylation regulates the microtubule-stabilizing protein TCTP.

31 March 2020

1 reference

Plk1 docking to GRASP65 phosphorylated by Cdk1 suggests a mechanism for Golgi checkpoint signalling.

31 March 2020

1 reference

The polo-box-dependent induction of ectopic septal structures by a mammalian polo kinase, plk, in Saccharomyces cerevisiae

31 March 2020

1 reference

A spindle checkpoint arrest and a cytokinesis failure by the dominant-negative polo-box domain of Plk1 in U-2 OS cells.

31 March 2020

1 reference

Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer

31 March 2020

1 reference

PLK (polo-like kinase), a new prognostic marker for oropharyngeal carcinomas

31 March 2020

1 reference

Prognostic value of pololike kinase expression in melanomas

31 March 2020

1 reference

Expression of polo-like kinase (PLK1) in thin melanomas: a novel marker of metastatic disease

31 March 2020

1 reference

Polo‐like kinase 1 (PLK1) is overexpressed in primary colorectal cancers

31 March 2020

1 reference

Comparative expression of the mitotic regulators SAK and PLK in colorectal cancer

31 March 2020

1 reference

Polo-like kinase 1 expression is a prognostic factor in human colon cancer

31 March 2020

1 reference

Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas

31 March 2020

1 reference

Identification of high risk breast-cancer patients by gene expression profiling

31 March 2020

1 reference

Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines

31 March 2020

1 reference

polo encodes a protein kinase homolog required for mitosis in Drosophila

31 March 2020

1 reference

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes

31 March 2020

1 reference

Downregulation of human polo-like kinase activity by antisense oligonucleotides induces growth inhibition in cancer cells

31 March 2020

1 reference

Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles

31 March 2020

1 reference

Effect of RNA silencing of polo-like kinase-1 (PLK1) on apoptosis and spindle formation in human cancer cells

31 March 2020

1 reference

Silencing of polo-like kinase (Plk) 1 via siRNA causes induction of apoptosis and impairment of mitosis machinery in human prostate cancer cells: implications for the treatment of prostate cancer.

31 March 2020

1 reference

Intravesical administration of small interfering RNA targeting PLK-1 successfully prevents the growth of bladder cancer.

31 March 2020

1 reference

Cancer inhibition in nude mice after systemic application of U6 promoter-driven short hairpin RNAs against PLK1.

31 March 2020

1 reference

Expression profiling reveals off-target gene regulation by RNAi

31 March 2020

1 reference

Strategies to overcome resistance to targeted protein kinase inhibitors

31 March 2020

1 reference

Smart drugs: tyrosine kinase inhibitors in cancer therapy

31 March 2020

1 reference

Progress in the discovery of polo-like kinase inhibitors.

31 March 2020

1 reference

The development and application of methods for activity-based protein profiling

31 March 2020

1 reference

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

31 March 2020

1 reference

Aurora-kinase inhibitors as anticancer agents

31 March 2020

1 reference

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

31 March 2020

1 reference

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

31 March 2020

1 reference

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

31 March 2020

1 reference

Roles of polo-like kinase 1 in the assembly of functional mitotic spindles

31 March 2020

1 reference

Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation

31 March 2020

1 reference

31 March 2020

Recycling the Cell Cycle

1 reference

Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase

31 March 2020

1 reference

Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1.

31 March 2020

1 reference

Active cyclin B1-Cdk1 first appears on centrosomes in prophase

31 March 2020

1 reference

Activated polo-like kinase Plx1 is required at multiple points during mitosis in Xenopus laevis

31 March 2020

1 reference

Plk1 promotes nuclear translocation of human Cdc25C during prophase

31 March 2020

1 reference

Anaphase-promoting complex-dependent proteolysis of cell cycle regulators and genomic instability of cancer cells

31 March 2020

1 reference

The anaphase-promoting complex: a key factor in the regulation of cell cycle

31 March 2020

1 reference

Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome

31 March 2020

1 reference

Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1

31 March 2020

1 reference

Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores

31 March 2020

1 reference

Molecular interactions of Polo-like-kinase 1 with the mitotic kinesin-like protein CHO1/MKLP-1

31 March 2020

1 reference

Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis

31 March 2020

1 reference

A role for Plk1 phosphorylation of NudC in cytokinesis

31 March 2020

1 reference

Polo-like kinase: a novel marker of proliferation: correlation with estrogen-receptor expression in human breast cancer

31 March 2020

1 reference

Polo-like kinase isoforms in breast cancer: expression patterns and prognostic implications

31 March 2020

1 reference

Expression of polo-like kinase in ovarian cancer is associated with histological grade and clinical stage

31 March 2020

1 reference

Polo-like kinase (PLK) expression in endometrial carcinoma

31 March 2020

1 reference

Increased human polo-like kinase-1 expression in gliomas

31 March 2020

1 reference

Polo-like kinase 1 overexpression is an early event in the progression of papillary carcinoma

31 March 2020

1 reference

Overexpression of Polo-like kinase 1 is a common and early event in pancreatic cancer.

31 March 2020

1 reference

Polo-like kinase 1 is overexpressed in prostate cancer and linked to higher tumor grades

31 March 2020

1 reference

Expression of Polo-Like Kinase (PLK1) in non-Hodgkin's lymphomas

31 March 2020

1 reference

Chemistry and biology of wortmannin

31 March 2020

1 reference

Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRC1841

1 reference

13 May 2018

1 reference

13 May 2018