Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage (Q28609754)

3 February 2017

title

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage (English)

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3 February 2017

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N. H. Chehab

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3 February 2017

A. Malikzay

series ordinal

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3 February 2017

E. S. Stavridi

series ordinal

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3 February 2017

T. D. Halazonetis

series ordinal

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3 February 2017

language of work or name

English

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publication date

23 November 1999

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Proceedings of the National Academy of Sciences of the United States of America

3 February 2017

published in

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3 February 2017

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3 February 2017

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3 February 2017

page(s)

13777–13782

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Raster3D: photorealistic molecular graphics

3 February 2017

cites work

2 references

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Regulation of p53 function and stability by phosphorylation

17 March 2017

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A role for ATR in the DNA damage-induced phosphorylation of p53

17 March 2017

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p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

17 March 2017

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A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

17 March 2017

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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

17 March 2017

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The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor

17 March 2017

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

17 March 2017

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

17 March 2017

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ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

17 March 2017

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p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner

17 March 2017

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

17 March 2017

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Regulation of p53 stability by Mdm2

17 March 2017

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Mdm2 promotes the rapid degradation of p53

17 March 2017

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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

17 March 2017

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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

17 March 2017

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A single ataxia telangiectasia gene with a product similar to PI-3 kinase

17 March 2017

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UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

17 March 2017

1 reference

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p53 mutations in human cancers

17 March 2017

1 reference

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

17 March 2017

1 reference

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Cell cycle checkpoints: preventing an identity crisis

17 March 2017

1 reference

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24141

DNA damage activates p53 through a phosphorylation-acetylation cascade

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24141

Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24141

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24141

p53 is required for radiation-induced apoptosis in mouse thymocytes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24141

Participation of p53 protein in the cellular response to DNA damage

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24141

An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs

7 April 2017

1 reference

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DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

29 September 2017

1 reference

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Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24141

ATM associates with and phosphorylates p53: mapping the region of interaction

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24141

Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24141

Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24141

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24141

DNA damage induces phosphorylation of the amino terminus of p53

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24141

p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24141

p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24141

Participation of the human p53 3′UTR in translational repression and activation following γ-irradiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24141

p53 transactivation and protein accumulation are independently regulated by UV light in different phases of the cell cycle

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24141

Wild-type p53 is a cell cycle checkpoint determinant following irradiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24141

Change in oligomerization specificity of the p53 tetramerization domain by hydrophobic amino acid substitutions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24141

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24141

Analysis of fission yeast DNA structure checkpoints

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24141

Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24141

Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24141

Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24141

Thymocyte apoptosis induced by p53-dependent and independent pathways.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24141

Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1

27 November 2018

1 reference

12 December 2020

p53 status and the efficacy of cancer therapy in vivo

1 reference

12 December 2020

Comparative study of the p53-mdm2 and p53-MDMX interfaces

1 reference

12 December 2020

The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia

1 reference

12 December 2020

The p53 activation and apoptosis induced by DNA damage are reversibly inhibited by salicylate

1 reference

12 December 2020

A subset of p53-deficient embryos exhibit exencephaly

1 reference

12 December 2020

A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation

1 reference

12 December 2020

Structure-based rescue of common tumor-derived p53 mutants

1 reference

12 December 2020

DNA damage triggers DRB-resistant phosphorylation of human p53 at the CK2 site

1 reference

12 December 2020

DNA damage and checkpoint pathways: molecular anatomy and interactions with repair

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.96.24.13777

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ADS bibcode

1999PNAS...9613777C

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