Glutamate decarboxylase 1 (Q21140783)

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mammalian protein found in Homo sapiens

• GAD-67
• glutamate decarboxylase 1
• GAD1
• 67 kDa glutamic acid decarboxylase
• glutamate decarboxylase 67 kDa isoform
• glutamate decarboxylase 1 (brain, 67kDa)

edit

Language	Label	Description	Also known as
English	Glutamate decarboxylase 1	mammalian protein found in Homo sapiens	GAD-67 glutamate decarboxylase 1 GAD1 67 kDa glutamic acid decarboxylase glutamate decarboxylase 67 kDa isoform glutamate decarboxylase 1 (brain, 67kDa)

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q99259

subclass of

protein

1 reference

stated in

UniProt

retrieved

1 December 2016

UniProt protein ID

Q99259

part of

Pyridoxal phosphate-dependent transferase, major domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q99259

Pyridoxal phosphate-dependent decarboxylase

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q99259

Pyridoxal phosphate-dependent transferase

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q99259

Pyridoxal-phosphate binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q99259

encoded by

GAD1

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q99259

molecular function

protein binding

determination method or standard

IPI

6 references

retrieved

8 April 2019

stated in

Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues

GOA

curator

UniProt

UniProt protein ID

Q99259

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IPI

retrieved

8 April 2019

stated in

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IPI

retrieved

8 April 2019

stated in

Next-generation sequencing to generate interactome datasets

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IPI

retrieved

8 April 2019

stated in

Towards a proteome-scale map of the human protein–protein interaction network

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IPI

retrieved

8 April 2019

stated in

A proteome-scale map of the human interactome network

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IPI

retrieved

8 April 2019

stated in

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IPI

catalytic activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IEA

lyase activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q99259

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IEA

protein heterodimerization activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IEA

pyridoxal phosphate binding

determination method or standard

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IEA

carboxy-lyase activity

determination method or standard

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q99259

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IEA

glutamate binding

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IEA

glutamate decarboxylase activity

determination method or standard

IEA

IDA

TAS

4 references

retrieved

5 June 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99259&geneProductId=UniProtKB:Q99259

determination method or standard

TAS

retrieved

5 June 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q99259

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99259&geneProductId=UniProtKB:Q99259

determination method or standard

IEA

retrieved

5 June 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99259&geneProductId=UniProtKB:Q99259

determination method or standard

IEA

retrieved

5 June 2018

stated in

Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues

GOA

curator

UniProt

UniProt protein ID

Q99259

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99259&geneProductId=UniProtKB:Q99259

determination method or standard

IDA

protein N-terminus binding

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IEA

glutamate decarboxylase activity

determination method or standard

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q99259

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IEA

retrieved

8 April 2019

stated in

Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues

GOA

curator

UniProt

UniProt protein ID

Q99259

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IDA

cell component

vesicle membrane

determination method or standard

NAS

1 reference

retrieved

8 April 2019

stated in

Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues

GOA

curator

UniProt

UniProt protein ID

Q99259

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

NAS

plasma membrane

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

TAS

clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

TAS

intracellular anatomical structure

determination method or standard

IDA

1 reference

retrieved

5 June 2018

stated in

Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues

GOA

curator

UniProt

UniProt protein ID

Q99259

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99259&geneProductId=UniProtKB:Q99259

determination method or standard

IDA

presynaptic active zone

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IEA

cytoplasm

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IEA

cell cortex

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IEA

axon

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IEA

axon terminus

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IEA

neuron projection terminus

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IEA

synapse

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IEA

inhibitory synapse

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IEA

biological process

gamma-aminobutyric acid biosynthetic process

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IEA

glutamate catabolic process

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues

GOA

curator

UniProt

UniProt protein ID

Q99259

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

TAS

carboxylic acid metabolic process

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IEA

neurotransmitter biosynthetic process

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q99259

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IEA

protein-pyridoxal-5-phosphate linkage

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues

GOA

curator

UniProt

UniProt protein ID

Q99259

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

TAS

glutamate decarboxylation to succinate

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

TAS

chemical synaptic transmission

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

TAS

social behavior

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IEA

locomotory exploration behavior

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

IEA

neurotransmitter secretion

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99259

determination method or standard

TAS

has part(s)

Pyridoxal-phosphate binding site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q99259

Identifiers

RefSeq protein ID

NP_000808

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2571

NP_038473

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2571

XP_005246501

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2571

XP_011509224

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2571

XP_016859245

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2571

XP_016859246

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2571

XP_016859247

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2571

XP_024308551

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2571

UniProt protein ID

Q99259

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q99259

Ensembl protein ID

ENSP00000341167

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000341167

ENSP00000350928

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000350928

ENSP00000364421

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000364421

ENSP00000434696

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000434696

ENSP00000486612

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000486612

ENSP00000394255

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000394255

ENSP00000394948

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000394948

ENSP00000402366

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000402366

ENSP00000403849

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000403849

ENSP00000405917

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000405917

ENSP00000476147

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000476147

PDB structure ID

2OKJ

1 reference

stated in

UniProt

UniProt protein ID

Q99259

retrieved

30 June 2016

language of work or name

English

3VP6

1 reference

stated in

UniProt

UniProt protein ID

Q99259

retrieved

30 June 2016

language of work or name

English

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q21140783&oldid=2023031636"