Tumor suppressor ARF (Q7117832)

http://www.ebi.ac.uk/interpro/protein/Q8N726

1 reference

16 September 2016

1 reference

9 August 2016

language of work or name

English

molecular function

DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

1 reference

8 April 2019

p53 binding

1 reference

27 February 2018

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N726&geneProductId=UniProtKB:Q8N726

transcription factor binding

1 reference

8 April 2019

PTEN regulation by Akt-EGR1-ARF-PTEN axis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

MDM2/MDM4 family protein binding

ubiquitin-protein transferase inhibitor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

protein binding

18 references

8 April 2019

Tumor suppressor ARF promotes non-classic proteasome-independent polyubiquitination of COMMD1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

8 April 2019

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

8 April 2019

GLTSCR2 promotes the nucleoplasmic translocation and subsequent degradation of nucleolar ARF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

8 April 2019

EBV-encoded EBNA-5 associates with P14ARF in extranucleolar inclusions and prolongs the survival of P14ARF-expressing cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

8 April 2019

The autophagic inducer smARF interacts with and is stabilized by the mitochondrial p32 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

8 April 2019

Antiviral action of the tumor suppressor ARF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

8 April 2019

Bidirectional autoregulatory mechanism of metastasis-associated protein 1-alternative reading frame pathway in oncogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

8 April 2019

p14ARF interacts with N-Myc and inhibits its transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

8 April 2019

14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2--Potential interplay with the PKB/Akt pathway and p14(ARF)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

8 April 2019

p14ARF interacts with DAXX: effects on HDM2 and p53

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

8 April 2019

ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

8 April 2019

A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

8 April 2019

ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

8 April 2019

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

8 April 2019

PTEN regulation by Akt-EGR1-ARF-PTEN axis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

8 April 2019

A novel putative collaborator of p19ARF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

8 April 2019

A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

SUMO transferase activity

EXP

1 reference

8 April 2019

p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

disordered domain specific binding

EXP

1 reference

8 April 2019

Peptides derived from two dynamically disordered proteins self-assemble into amyloid-like fibrils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

ubiquitin ligase inhibitor activity

1 reference

8 April 2019

Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

cell component

nuclear body

1 reference

27 February 2018

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N726&geneProductId=UniProtKB:Q8N726

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

8 April 2019

8 April 2019

Tumor suppressor ARF promotes non-classic proteasome-independent polyubiquitination of COMMD1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

8 April 2019

A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

nucleolus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

6 references

8 April 2019

8 April 2019

Tumor suppressor ARF promotes non-classic proteasome-independent polyubiquitination of COMMD1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

8 April 2019

GLTSCR2 promotes the nucleoplasmic translocation and subsequent degradation of nucleolar ARF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

8 April 2019

A novel proapoptotic gene PANO encodes a post-translational modulator of the tumor suppressor p14ARF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

8 April 2019

8 April 2019

A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

protein-containing complex

1 reference

27 February 2018

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N726&geneProductId=UniProtKB:Q8N726

mitochondrion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

1 reference

8 April 2019

regulation of G2/M transition of mitotic cell cycle

biological process

1 reference

8 April 2019

p14ARF induces G2 cell cycle arrest in p53- and p21-deficient cells by down-regulating p34cdc2 kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N726&geneProductId=UniProtKB:Q8N726

1 reference

27 February 2018

regulation of protein stability

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

negative regulation of immature T cell proliferation in thymus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

regulation of protein export from nucleus

1 reference

27 February 2018

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N726&geneProductId=UniProtKB:Q8N726

negative regulation of protein kinase activity

1 reference

8 April 2019

p14ARF induces G2 cell cycle arrest in p53- and p21-deficient cells by down-regulating p34cdc2 kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

negative regulation of proteolysis involved in cellular protein catabolic process

1 reference

27 February 2018

Short mitochondrial ARF triggers Parkin/PINK1-dependent mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N726&geneProductId=UniProtKB:Q8N726

protein K63-linked ubiquitination

1 reference

8 April 2019

Tumor suppressor ARF promotes non-classic proteasome-independent polyubiquitination of COMMD1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

positive regulation of signal transduction by p53 class mediator

1 reference

27 February 2018

A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N726&geneProductId=UniProtKB:Q8N726

somatic stem cell division

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

protein stabilization

1 reference

8 April 2019

Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

protein polyubiquitination

1 reference

8 April 2019

Tumor suppressor ARF promotes non-classic proteasome-independent polyubiquitination of COMMD1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

positive regulation of protein sumoylation

1 reference

8 April 2019

PTEN regulation by Akt-EGR1-ARF-PTEN axis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N726&geneProductId=UniProtKB:Q8N726

1 reference

27 February 2018

positive regulation of transcription, DNA-templated

1 reference

8 April 2019

Activation of p53 by MEG3 non-coding RNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

cellular senescence

1 reference

8 April 2019

Immortalization of human mammary epithelial cells is associated with inactivation of the p14ARF-p53 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

autophagy of mitochondrion

1 reference

27 February 2018

Short mitochondrial ARF triggers Parkin/PINK1-dependent mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N726&geneProductId=UniProtKB:Q8N726

apoptotic mitochondrial changes

1 reference

8 April 2019

Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

regulation of protein targeting to mitochondrion

1 reference

27 February 2018

Short mitochondrial ARF triggers Parkin/PINK1-dependent mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N726&geneProductId=UniProtKB:Q8N726

protein destabilization

1 reference

8 April 2019

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

negative regulation of ubiquitin-protein transferase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

positive regulation of apoptotic process

1 reference

8 April 2019

A novel proapoptotic gene PANO encodes a post-translational modulator of the tumor suppressor p14ARF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

rRNA processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

1 reference

8 April 2019

negative regulation of ubiquitin-dependent protein catabolic process

1 reference

8 April 2019

Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

1 reference

8 April 2019

mitochondrial depolarization

1 reference

27 February 2018

Short mitochondrial ARF triggers Parkin/PINK1-dependent mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N726&geneProductId=UniProtKB:Q8N726

positive regulation of DNA damage response, signal transduction by p53 class mediator

1 reference

27 February 2018

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N726&geneProductId=UniProtKB:Q8N726

negative regulation of B cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

activation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

8 April 2019

Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

regulation of apoptotic DNA fragmentation

1 reference

8 April 2019

Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Activation of p53 by MEG3 non-coding RNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

positive regulation of protein localization to nucleus

1 reference

27 February 2018

A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N726&geneProductId=UniProtKB:Q8N726

protein sumoylation

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

positive regulation of gene expression

1 reference

8 April 2019

Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

negative regulation of ubiquitin protein ligase activity

1 reference

8 April 2019

Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

amyloid fibril formation

1 reference

8 April 2019

Peptides derived from two dynamically disordered proteins self-assemble into amyloid-like fibrils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726

negative regulation of protein neddylation

1 reference

8 April 2019

Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N726