Growth factor receptor bound protein 2 (Q5514416)

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mammalian protein found in Homo sapiens
  • growth factor receptor-bound protein 3
  • protein Ash
  • epididymis secretory sperm binding protein
  • abundant SRC homology
  • HT027
  • SH2/SH3 adapter GRB2
  • GRB2
  • epidermal growth factor receptor-binding protein GRB2
  • growth factor receptor-bound protein 2
  • Adapter protein GRB2
edit
Language Label Description Also known as
English
Growth factor receptor bound protein 2
mammalian protein found in Homo sapiens
  • growth factor receptor-bound protein 3
  • protein Ash
  • epididymis secretory sperm binding protein
  • abundant SRC homology
  • HT027
  • SH2/SH3 adapter GRB2
  • GRB2
  • epidermal growth factor receptor-binding protein GRB2
  • growth factor receptor-bound protein 2
  • Adapter protein GRB2

Statements

molecular function
protein binding
determination method or standard
IPI
129 references
retrieved
1 January 2018
stated in
unc-53 controls longitudinal migration in C. elegans
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling
GOA
curator
UniProt
UniProt protein ID
P62993
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL
GOA
curator
UniProt
UniProt protein ID
P62993
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
FCRL6 receptor: expression and associated proteins.
GOA
curator
UniProt
UniProt protein ID
P62993
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development
GOA
curator
UniProt
UniProt protein ID
P62993
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling
GOA
curator
UniProt
UniProt protein ID
P62993
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck
GOA
curator
UniProt
UniProt protein ID
P62993
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Generation of novel cytoplasmic forms of protein tyrosine phosphatase epsilon by proteolytic processing and translational control
GOA
curator
UniProt
UniProt protein ID
P62993
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling
GOA
curator
UniProt
UniProt protein ID
P62993
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein
GOA
curator
UniProt
UniProt protein ID
P62993
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development
GOA
curator
UniProt
UniProt protein ID
P62993
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Shc phosphotyrosine-binding domain dominantly interacts with epidermal growth factor receptors and mediates Ras activation in intact cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Charting the molecular network of the drug target Bcr-Abl
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
The central proline rich region of POB1/REPS2 plays a regulatory role in epidermal growth factor receptor endocytosis by binding to 14-3-3 and SH3 domain-containing proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Functional interaction between c-Src and its mitotic target, Sam 68
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
A single PXXP motif in the C-terminal region of srGAP3 mediates binding to multiple SH3 domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Characterization of VIK-1: a new Vav-interacting Kruppel-like protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Co-expression with BCR induces activation of the FES tyrosine kinase and phosphorylation of specific N-terminal BCR tyrosine residues
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Characterization of interactions of Nck with Sos and dynamin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Subsets of epidermal growth factor receptors during activation and endocytosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using Extended Range Proteomic Analysis (ERPA)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
T Cell Receptor (TCR)-induced Tyrosine Phosphorylation Dynamics Identifies THEMIS as a New TCR Signalosome Component
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
SnoN/SkiL expression is modulated via arsenic trioxide-induced activation of the PI3K/AKT pathway in ovarian cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Pooled-matrix protein interaction screens using Barcode Fusion Genetics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Weak binding to E3 ubiquitin ligase c-Cbl increases EGFRvA protein stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
A novel proteomic screen for peptide-protein interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
A directed protein interaction network for investigating intracellular signal transduction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
A THEMIS:SHP1 complex promotes T-cell survival
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Rapid identification of phosphopeptide ligands for SH2 domains. Screening of peptide libraries by fluorescence-activated bead sorting
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Sos-mediated activation of rac1 by p66shc
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Threshold-controlled ubiquitination of the EGFR directs receptor fate
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Two mechanistically distinct forms of endocytosis in adrenal chromaffin cells: Differential effects of SH3 domains and amphiphysin antagonism
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Regulation of Sos Activity by Intramolecular Interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Differential interactions of human Sos1 and Sos2 with Grb2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Phospho-tyrosine dependent protein-protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Thermodynamic and structural analysis of phosphotyrosine polypeptide binding to Grb2-SH2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
The Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling in response to EGF
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Novel Src homology 3 domain-binding motifs identified from proteomic screen of a Pro-rich region
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Novel peptide inhibitors for Grb2 SH2 domain and their detection by surface plasmon resonance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Activation of Src and transformation by an RPTPα splice mutant found in human tumours
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
A quantitative protein interaction network for the ErbB receptors using protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
The elucidation of novel SH2 binding sites on PLD2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
A human MAP kinase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
An alternative to phosphotyrosine-containing motifs for binding to an SH2 domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Defining the human deubiquitinating enzyme interaction landscape
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Bcr phosphorylated on tyrosine 177 binds Grb2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Inhibition of basal FGF receptor signaling by dimeric Grb2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Bivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
A protein domain-based interactome network for C. elegans early embryogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
retrieved
1 January 2018
stated in
Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993
determination method or standard
IPI
cell component
biological process

Identifiers

MeSH descriptor ID
D051380
subject named as
GRB2 Adaptor Protein
0 references
PDB structure ID
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q5514416&oldid=2022908013"