INTRODUCTION ABOUT LASIX 40MG TABLET
LASIX 40MG TABLET contains frusemide (furosemide) which belongs to the group of medicines called Diuretics. It is used to manage edema (fluid retention) due to problems with your heart, lungs, kidneys, liver, blood vessels or high blood pressure. Generally, accumulation of excess fluid in the body adds extra pressure on your heart, blood vessels, lungs, kidneys or liver and can cause swelling of the ankles, breathing difficulties or even make you feel more tired than usual.
During the course of management with LASIX 40MG TABLET, your doctor will recommend you take several blood tests to monitor your blood sugar and uric acid levels as a precaution to avoid unwanted side effects. They may also monitor your blood potassium and sodium levels carefully, especially if you have vomiting or diarrhea.
Before taking this medicine, inform your doctor if you have any kidney, liver or heart problems. LASIX 40MG TABLET is not recommended for use in pregnant and breast-feeding women. LASIX 40MG TABLET should be used with caution in children over 12 years of age. Also, it should be used with caution in elderly patients. The most common side effects of taking LASIX 40MG TABLET are dehydration, electrolyte imbalance and decreased blood volume. Consult your doctor if any of the side effect worsens or persist for a long period of time.
USES OF LASIX 40MG TABLET
- Manage edema (fluid retention)
HOW LASIX 40MG TABLET WORKS
LASIX 40MG TABLET contains frusemide which is a loop diuretic. It works by inhibiting the reabsorption of sodium and chloride in the proximal and distal tubules and in the thick ascending loop of Henle by inhibiting the sodium-chloride cotransport system. As a result, it promotes diuresis (urine output) by enhancing the excretion of water along with sodium, chloride, magnesium and calcium.
DIRECTIONS FOR USE
Take LASIX 40MG TABLET as directed by your physician. Swallow LASIX 40MG TABLET as whole with a sip of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. Continue to take LASIX 40MG TABLET, as long as your doctor tells you to do so, to obtain better results.
SIDE EFFECTS OF LASIX 40MG TABLET
COMMON
- Signs of dehydration, altered fluid and electrolyte balance in the body (such as nausea, vomiting, dry mouth, weakness, drowsiness, fits, restlessness, muscle pain, low blood pressure, difficulty in urination or irregular heartbeat)
UNCOMMON
- Anaemia (causing tiredness, breathlessness, unusual bleeding or bruising)
- Gout
- Changes in vision including blurred or yellow vision
- Light-headedness, sensations of pressure in the head, headache, drowsiness, weakness, dizziness when standing
- Irregular heartbeat
- Muscle cramps or weakness
- Changes in the amount or need to urinate
- Tiredness
- Dry mouth, thirst
- Nausea or vomiting
- Changes in bowel movements including diarrhoea and constipation
- Deafness
RARE
- Delusions, hallucinations, disorganized speech
- Tingling or prickling sensation often in arms or legs
- Confusion, headache
- Generally feeling unwell, fever
- Ringing in the ears and loss of hearing
- Symptoms of shock (such as changes in heart rate, breathlessness, cool clammy skin)
- Inflammation of the pancreas (causing pains in your abdomen or back and nausea)
- Changes in the liver causing yellowing of the skin or whites of the eyes
- Skin rashes
Stop taking LASIX 40MG TABLET and consult your doctor immediately if you experience any of the following side effects:
- Severe allergic reactions (such as skin rash, itching, photosensitivity, skin peeling, swelling of the lips, face, tongue or throat or difficulty in breathing or swallowing)
- Symptoms of stevens-johnson syndrome (such as blistering or peeling of the skin around the eyes, nose, mouth or genital, with fever or flu-like symptoms)
- Vasculitis (inflammation of blood vessels)
- Signs of kidney inflammation (such as pain in lower back, blood in the urine, fever, feeling drowsy)
- Blood clot in the legs with pain and swelling
HOW TO MANAGE SIDE EFFECTS
Dry Mouth
Sip water regularly and other sugar free liquids. Do not use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if the symptom does not improve.
Headache
Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve.
Nausea And Vomiting
Stick to simple meals while taking LASIX 40MG TABLET. Avoid eating oily rich, fried or spicy foods. Do not lie down or sleep immediately after eating. Consult your doctor if the symptom does not improve.
Skin Rash Or Itching
Avoid hot showers because hot water can irritate the skin further. Do not rub or scratch the affected area. Use sunscreen and protective clothing when going outdoor. Regularly use moisturizers to soothe and hydrate the affected area. If the symptom still persists, consult your doctor.
WARNING & PRECAUTIONS
PREGNANCY
ContraindicatedLASIX 40MG TABLET is not recommended for use in pregnant women. If you become pregnant while taking this medicine talk to your doctor to check the growth of the baby. Consult your doctor before taking LASIX 40MG TABLET.
BREASTFEEDING
ContraindicatedLASIX 40MG TABLET is not recommended for use in breast-feeding women. Consult your doctor before taking LASIX 40MG TABLET.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any tools or machines if you experience drowsiness, dizziness or blurred vision after taking LASIX 40MG TABLET.
ALCOHOL
Consult your doctorAvoid consumption of alcohol while taking LASIX 40MG TABLET. Consult your doctor for advice.
KIDNEY
Consult your doctorLASIX 40MG TABLET is not recommended for use in patients having anuria (failure of the kidneys to produce urine), severe kidney damage, kidney failure or impaired kidney function due to poisoning by nephrotoxic agents. It should be used with caution in patients with kidney problems. Consult your doctor before taking LASIX 40MG TABLET.
LIVER
Consult your doctorLASIX 40MG TABLET is not recommended for use in patients with liver cirrhosis and liver encephalopathy. It should be used with caution in patients with liver congestion (slowed blood flow through the vessels) or other liver problems. Consult your doctor before taking LASIX 40MG TABLET.
ALLERGY
ContraindicatedDo not take LASIX 40MG TABLET if you are allergic to frusemide (furosemide) or sulphonamide antibiotics (such as sulfamethoxazole).
HEART DISEASE
Use with CautionLASIX 40MG TABLET should be taken with caution in patients with low blood pressure. Consult your doctor before taking LASIX 40MG TABLET.
USE IN PEDIATRICS
Use with CautionLASIX 40MG TABLET should be used with caution in children over 12 years of age. A suitable dosage form is used in children under 12 years of age. Consult your child’s doctor for advice.
USE IN GERIATRICS
Use with CautionLASIX 40MG TABLET should be used with caution in elderly patients. Consult your doctor before taking LASIX 40MG TABLET.
OTHERS
LASIX 40MG TABLET is not recommended for use if you:
- Are dehydrated
- Have low levels of sodium, potassium or other electrolytes in the blood
- Have low blood volume
- Have addison’s disease
- Have digitalis poisoning
Before taking LASIX 40MG TABLET, inform your doctor if you:
- Have hypovolaemia (low blood volume)
- Have hypoproteinemia (low levels of proteins in blood) due to kidney damage
- Have prostate trouble or difficulty in passing urine
- Have diabetes
- Have gout (painful or inflamed joints)
- Have an abnormal blood condition
- Are going to undergo any blood or urine test
INTERACTIONS
A. Drug-Drug Interactions:
Before taking LASIX 40MG TABLET, inform your doctor if you are taking any of the following medicines:
- Medicines used to reduce high blood pressure such as ACE inhibitors (Ex. ramipril, enalapril, perindopril), angiotensin II-receptor blockers (Ex. losartan, candesartan, irbesartan), alpha-blockers (Ex. prazosin), thiazide diuretics (Ex. bendroflumethiazide) and potassium sparging diuretics (Ex. amiloride, spironolactone, acetazolamide and metolazone)
- Medicines used to manage irregular heartbeat (Ex. digoxin, amiodarone, sotalol, disopyramide, flecainide, lidocaine, mexiletine dofetilide and ibutilide)
- Medicines used to manage angina (Ex. nitroglycerin or isosorbide dinitrate)
- Medicines used to reduce high cholesterol levels in blood (Ex. clofibrate, colestyramine and colestipol)
- Medicines used to manage diabetes (Ex. insulin and metformin)
- Non-steroidal anti-inflammatory medicines (Ex. aspirin, ibuprofen, ketoprofen or indomethacin)
- Corticosteroids (used to manage pain or inflammation) Ex. dexamethasone, prednisolone
- Medicines used to manage stomach ulcers (Ex. sucralfate or carbenoxolone)
- Medicines used to manage epilepsy (Ex. phenytoin, carbamazepine or phenobarbital)
- Antibiotics (used to manage bacterial infections) such as gentamicin, amikacin, neomycin, netilmicin, tobramycin, vancomycin or cephalosporins such as cefixime
- Medicines used to manage asthma (Ex. terbutaline, salbutamol, salmeterol, formoterol or bambuterol)
- Medicines used to manage nasal congestion (Ex. xylometazoline or ephedrine)
- Medicines used to manage mental problems (Ex. lithium, chlorpromazine, risperidone, amisulpride, sertindole or pimozide)
- Medicines used to manage depression (Ex. reboxetine, amitriptyline and phenelzine)
- Laxatives (used to manage constipation) Ex. lactulose, polyethylene glycol, bisacodyl
- Skeletal muscle relaxants given during operations (Ex. tubocurarine, curarine derivates and succinylcholine)
- Chloral hydrate (a medicine used to induce sleep)
- Theophylline (a medicine used to manage breathing difficulties)
- Immunosuppressants (used to suppress immune system and manage graft rejection) Ex. tacrolimus, ciclosporin or aldesleukin
- Radiocontrast agent (used before X-ray examinations)
- Probenecid (used to manage gout)
- Cisplatin (used to manage certain type of cancers)
- Methotrexate (used to manage severe arthritis or some forms of cancer)
- Aminoglutethimide (used to manage breast cancer or cushing´s syndrome)
- Amphotericin B (used to manage fungal infections)
- Atomoxetine (used for attention deficit hyperactivity disorder)
- Muscle relaxants (Ex. baclofen and tizanidine)
- Antihistamines (used to manage allergies) Ex. cetirizine
- Alprostadil (a medicine used to manage male impotence)
- Oral contraceptives or HRT containing oestrogen and drospirenone (used to manage pregnancy)
- Liquorice (used to manage cough)
- Moxisylyte (a medicine used for raynaud's syndrome)
- Levodopa (used to manage parkinson’s disease)
Overdosage:
If you or anyone else accidentally takes too much of LASIX 40MG TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of LASIX 40MG TABLET includes dehydration and changes in the levels of certain chemicals in the blood.
SYNOPSIS
| Drug | : | Frusemide (furosemide) |
| Pharmacological Category | : | Diuretics |
| Therapeutic Indication | : | Fluid retention (edema) |
| Dosage Forms | : | Injection, Tablet, Oral Solution |
MORE INFORMATION
STORAGE
- Keep LASIX 40MG TABLET out of reach of children
- Do not store LASIX 40MG TABLET above 25°C
FAQs ABOUT LASIX 40MG TABLET
Q: What is LASIX 40MG TABLET and why is it prescribed?
A: LASIX 40MG TABLET contains frusemide (furosemide) which belongs to the group of medicines called Diuretics. It is used to manage edema (fluid retention) due to problems with your heart, lungs, kidneys, liver, blood vessels or high blood pressure.
Q: Will LASIX 40MG TABLET make me feel tired?
A: LASIX 40MG TABLET may cause hypotension (decrease in blood pressure) in some individuals and feeling of extreme tiredness or fainting can be attributed to this. Consult your doctor if you experience any unusual symptoms after taking LASIX 40MG TABLET.
Q: Is LASIX 40MG TABLET safe to use in patients with kidney problems?
A: LASIX 40MG TABLET is not recommended for use in patients having anuria (failure of the kidneys to produce urine), severe kidney damage, kidney failure or impaired kidney function due to poisoning by nephrotoxic agents. LASIX 40MG TABLET should be used with caution in patients with kidney problems. Consult your doctor before taking LASIX 40MG TABLET.
Q: Will LASIX 40MG TABLET increase the urge to pass urine?
A: No, although LASIX 40MG TABLET acts by increasing urine output, it only increases the frequency of urine output and not the urge to pass urine. Consult your doctor if you experience any symptoms of urinary incontinence or if you have any bladder problems.
Q: Can LASIX 40MG TABLET be used in pregnant women?
A: LASIX 40MG TABLET is not recommended for use in pregnant women. If you become pregnant while taking LASIX 40MG TABLET talk to your doctor to check the growth of the baby. Consult your doctor before taking LASIX 40MG TABLET.
Q: How does LASIX 40MG TABLET work?
A: LASIX 40MG TABLET contains frusemide which is a loop diuretic. It works by inhibiting the reabsorption of sodium and chloride in the proximal and distal tubules and in the thick ascending loop of Henle by inhibiting the sodium-chloride cotransport system. As a result, it promotes diuresis (urine output) by enhancing the excretion of water along with sodium, chloride, magnesium and calcium.
REFERENCES
1. KD. Tripathi. Diuretics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 579-581.
2. Robert F. Reilley and Edwin K. Jackson. Regulation of renal function and vascular volume. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 682-686.
3. University of Pennsylvania. Furosemide for Accelerated Recovery of Blood Pressure Postpartum (ForBP). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in September 2020] [Accessed on 12th February 2021] https://clinicaltrials.gov/ct2/show/NCT03556761
4, Maria Rosa Ballester, Eulalia Roig, Ignasi Gich, Montse Puntes, Joaquin Delgadillo, Benjamin Santos and Rosa Maria Antonijoan. Randomized, open-label, blinded-endpoint, crossover, single-dose study to compare the pharmacodynamics of torasemide-PR 10 mg, torasemide-IR 10 mg, and furosemide-IR 40 mg, in patients with chronic heart failure. NCBI; PMC US National Library of Medicine, National Institute of Health. August 2015. [Accessed on 12th February 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532344/
5. Elara Pharmaservices Limited. Electronic Medicines Compendium (EMC). [Revised in October 2020] [Accessed on 12th February 2021] https://www.medicines.org.uk/emc/files/pil.12129.pdf
6. Clonmel Healthcare Ltd. Health Products Regulatory Authority (HPRA). [Revised in December 2016] [Accessed on 12th February 2021] https://www.hpra.ie/img/uploaded/swedocuments/2188112.PA0126_008_002.fbf0465a-d44d-4c59-b51b-337dd8586c8e.000001Product%20Leaflet%20Approved.170215.pdf
USEFUL DIAGNOSTIC TESTS
- Kidney Function Test
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