CLOGEN Lozenges 10's

INTRODUCTION

CLOGEN contains Clotrimazole which belongs to the group of medicines called Anti-fungals. It is used in the management of oropharyngeal candidiasis and used as prophylaxis to prevent the incidence of oropharyngeal candidiasis in immunocompromised patients by conditions that include chemotherapy, radiotherapy, or steroid therapy utilized in the management of leukemia, solid tumors or renal transplantation.

Oropharyngeal candidiasis (oral thrush) is a fungal infection affecting the mouth and throat which appears like white patches on the cheeks, mouth, tongue, throat, redness, soreness, loss of taste and pain during swallowing. Your doctor may initiate the management with CLOGEN when confirmed by a KOH smear or culture test prior to the management.

CLOGEN is not recommended for use in patients who are allergic to clotrimazole and in patients with systemic mycoses (fungal infection affecting the internal organs) including systemic candidiasis (fungal infection affecting the skin or mucous membrane).

CLOGEN should be used with caution in patients with liver impairment and your doctor may check your liver function test regularly during and after management with this medicine. It should be used with caution in pregnant women only if clearly advised by the doctor.

CLOGEN is not recommended for use in children (below 3 years of age) due to lack of safety and effectiveness and should be used with caution in elderly patients (aged 65 years and above). Consult your doctor if you experience any unusual side effects.

USES OF CLOGEN

• Prevents and manage fungal infections of the mouth and throat (oropharyngeal candidiasis)

HOW CLOGEN WORKS

CLOGEN acts by specifically inhibiting the biosynthesis of ergosterol and other sterols (enzyme) required for cell membrane production, therefore it inhibits the division and growing of fungi eventually leading to cell death, which further prevents fungal growth.  

DIRECTIONS FOR USE

Take CLOGEN as advised by your physician. Do not crush, chew or swallow the medicine immediately after placing in the mouth. It should be slowly and completely dissolved in the mouth. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and severity of the infection.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking CLOGEN, inform your doctor if you are taking any medicines including prescription, non-prescription medicines and herbals or vitamin supplements.

Overdosage:

If you or anyone else accidentally take more of CLOGEN, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep CLOGEN out of reach of children
• Store at room temperature

FAQs ABOUT CLOGEN

What is CLOGEN used for?

CLOGEN is used in the management of oropharyngeal candidiasis (fungal infection of the mouth and throat) and used as prophylaxis to prevent the incidence of oropharyngeal candidiasis in immunocompromised patients by conditions that include chemotherapy, radiotherapy, or steroid therapy utilized in the management of leukemia, solid tumors or renal transplantation.     

How does CLOGEN work?

CLOGEN acts by specifically inhibiting the biosynthesis of ergosterol and other sterols (enzyme) required for cell membrane production, therefore it inhibits the division and growing of fungi eventually leading to cell death, which further prevents fungal growth.   

How should I take CLOGEN?

Take CLOGEN as advised by your physician. Do not crush, chew or swallow the medicine immediately after placing in the mouth. It should be slowly and completely dissolved in the mouth. Consult your doctor before taking it.

Is CLOGEN safe to use in patients with liver problems?

CLOGEN should be used with caution in patients with liver impairment. Your doctor may check your liver function test regularly during management with this medicine. Consult your doctor before taking it.

Can CLOGEN be used during pregnancy?

CLOGEN should be used with caution in pregnant women only if considered clearly necessary. Consult your doctor before taking CLOGEN if you are pregnant or planning to get pregnant.

REFERENCES

1. K.D. Tripathi. Antimicrobial Drugs Essentials of pharmacology. Seventh edition 2013. Page no- 792.

2. Thamer A Almangour. Keith S. Kaye. Mohammed Alessa. Khalid Eljaaly. Fadilah Sfouq Aleanizy. Aynaa Alsharidi. Fahad M. Al Majid. Naif H. Alotaibi. Abdullah A Alzeer. Faris S. Alnezar. Abdullah A. Alhifany. Efficacy of clotrimazole for the management of oral candidiasis: A meta-analysis of randomized clinical trials. NIH. National Library of Medicine, National center for biotechnology information. Pubmed Central April 2021. [Accessed on 19th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093540/

3. P R Sawyer, R N Brogden, R M Pinder, T M Speight, Avery. Clotrimazole: a review of its antifungal activity and therapeutic efficacy. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 1975. [Accessed on 19th July 2022] https://pubmed.ncbi.nlm.nih.gov/1097234/

4. West-Ward Pharmaceuticals Corp, DailyMed; National Library of Medicine. National Institute of Health. [Revised in July 2021] [Accessed on 19th July 2022] https://dailymed.nlm.nih.gov/dailymed/getFile.cfm?setid=0bc4b876-ddee-4f03-b44f-544348739a26&type=pdf

5. Roxane laboratories Inc. U.S. Food & Drug Administration. [Revised in December 2002] [Accessed on 19th July 2022] https://www.accessdata.fda.gov/drugsatfda_docs/nda/2004/076387_Clotrimazole%20Lozenges_PRNTLBL.pdf

6. Dwdindia. Clenorush torche (Clotrimazole 10 mg). [Accessed on 19th July 2022] http://www.dwdindia.com/CLENORUSH_TROCHE.html