Recent advances and applications of cyclodextrins in magnetic solid phase extraction

Cyclodextrins (CDs) as a family of cyclic oligosaccharides are toroidal with a hydrophobic interior and a hydrophilic exterior. They are well-known for their ability to form host-guest inclusion complexes with different compounds. They are used as chiral stationary phases in high performance liquid chromatography (HPLC) and gas chromatography (GC) or as chiral reagents in the background electrolyte of capillary electrophoresis (CE). In recent years, they have been used for modification of sorbents or as sorbents in solid phase extraction (SPE) procedures. Magnetic solid-phase extraction (MSPE), as a new type of SPE procedure, has received considerable attention due to its rapid phase separation process as compared to traditional extraction mode. This review covers the synthesis of CD-based magnetic sorbents (such as immobilization of CDs onto the different supports, production of nanosponges, and making hybrid substances with nanomaterials) and the use of these compounds in MSPE of different analytes from biological, environmental, and food samples. Also, prospects of CD-based sorbents for sample pre-treatment are also proposed.