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Mechanism of action of suvorexant

CNS Spectr. 2016 Jun;21(3):215-8. doi: 10.1017/S1092852916000225.

Abstract

Suovrexant is a novel hypnotic and is the only agent clinically available that works by blocking orexin-ergic mechanisms.

MeSH terms

  • Arousal / drug effects*
  • Arousal / physiology
  • Azepines / pharmacology*
  • Azepines / therapeutic use
  • Humans
  • Orexin Receptor Antagonists / pharmacology*
  • Orexin Receptor Antagonists / therapeutic use
  • Orexin Receptors / physiology
  • Orexins / physiology
  • Sleep Aids, Pharmaceutical / pharmacology*
  • Sleep Aids, Pharmaceutical / therapeutic use
  • Sleep Initiation and Maintenance Disorders / drug therapy
  • Triazoles / pharmacology*
  • Triazoles / therapeutic use
  • Wakefulness / drug effects*
  • Wakefulness / physiology

Substances

  • Azepines
  • Orexin Receptor Antagonists
  • Orexin Receptors
  • Orexins
  • Sleep Aids, Pharmaceutical
  • Triazoles
  • suvorexant