Heterozygosity at the TPMT gene locus, augmented by mutated MTHFR gene, predisposes to 6-MP related toxicities in childhood ALL patients

Leukemia. 2009 May;23(5):971-4. doi: 10.1038/leu.2008.317. Epub 2008 Nov 6.

Authors

N Karas-Kuzelicki, J Jazbec, M Milek, I Mlinaric-Rascan

PMID: 18987660
DOI: 10.1038/leu.2008.317

No abstract available

Publication types

Letter

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Child
Drug-Related Side Effects and Adverse Reactions
Female
Hematopoietic Stem Cell Transplantation
Heterozygote
Humans
Male
Mercaptopurine / pharmacology*
Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
Methyltransferases / genetics*
Mutation / genetics*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / enzymology
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy*
Retrospective Studies

Substances

Mercaptopurine
Methylenetetrahydrofolate Reductase (NADPH2)
Methyltransferases
thiopurine methyltransferase