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Genetic polymorphisms of folate metabolic enzymes and toxicities of high dose methotrexate in children with acute lymphoblastic leukemia

Ann Hematol. 2007 Aug;86(8):609-11. doi: 10.1007/s00277-007-0274-x. Epub 2007 Feb 24.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antimetabolites, Antineoplastic / adverse effects*
  • Antimetabolites, Antineoplastic / therapeutic use
  • Child
  • Child, Preschool
  • Female
  • Folic Acid / metabolism
  • Folic Acid Antagonists / adverse effects
  • Folic Acid Antagonists / therapeutic use
  • Humans
  • Infant
  • Male
  • Methotrexate / adverse effects*
  • Methotrexate / therapeutic use
  • Methyltransferases / genetics*
  • Methyltransferases / metabolism
  • Polymorphism, Genetic*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / enzymology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*

Substances

  • Antimetabolites, Antineoplastic
  • Folic Acid Antagonists
  • Folic Acid
  • Methyltransferases
  • thiopurine methyltransferase
  • Methotrexate