Analytical chemistry articles within Nature Communications

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  • Article
    | Open Access

    Lipid droplets (LDs) and their membrane proteins play essential roles in many biological processes, but the monolayer lipid membrane of LDs has not been extensively studied due to the lack of suitable molecular probes. Here, the authors report an LD membrane labelling pro-probe called LDM, which, upon activation by the HClO/ClO− microenvironment that surrounds LDs, undergoes a color change and releases LDM-OH probe that binds to LD membrane proteins.

    • Lingxiu Kong
    • , Qingjie Bai
    •  & Qixin Chen

  • Article
    | Open Access

    While thermally- and photo-induced valence tautomerism, which is stimulated intramolecular electron transfer between a metal and coordinated redox-active ligand, has been explored extensively, less is known about pressure-induced valence tautomerism. Here, the authors report pressure-triggered valence tautomerism in a thermally inactive cobalt complex.

    • Aston Summers
    • , F. Zahra M. Zahir
    •  & Stephen A. Moggach

  • Article
    | Open Access

    Continuous and long-term monitoring of medicines in biological systems could offer personalized pharmacokinetic reports but is challenging due to the complexity of the biological environment in living organisms. Here, the authors present a photoelectrochemical biosensor with single atom Cu on TiO2-x as recognition unit for selective, precise, long-term tetracycline monitoring in living organisms.

    • Xiankui Xu
    • , Dawei Xu
    •  & Zhonghai Zhang

  • Article
    | Open Access

    Crosslinking mass spectrometry protocols applied directly to cells can distort the spatial proteome. Here, the authors show that prefixing the cell with high concentrations of formaldehyde can prevent this, while simultaneously increasing crosslink yield and supporting the use of any type of crosslinker.

    • Andrew R. M. Michael
    • , Bruno C. Amaral
    •  & David C. Schriemer

  • Article
    | Open Access

    Deuteration of active pharmaceutical ingredients is increasingly applied as the isosteric and isotopic replacement can modulate the pharmacokinetic profile, without necessarily having to alter the overall synthetic strategy toward the compound of interest. Here, the authors show manifold deuterations of piperidines and apply molecular rotational resonance (MRR) spectroscopy as a methodology to distinguish isotopomers within a distribution of products.

    • Jonathan D. Dabbs
    • , Caleb C. Taylor
    •  & W. Dean Harman

  • Article
    | Open Access

    A chemical infrastructure for integrating sensing and memory and exhibiting short- and long-term memory responses to alcohols and aldehydes through an artificial olfactory memory system is realized with conductive metal-organic framework Ce-HHTP.

    • Xiaomeng Yin
    • , Hao Zhang
    •  & Tie Wang

  • Article
    | Open Access

    Electrochemical methods are promising for monitoring neurochemical dynamics, but are limited by inflammation effects from electrode implantation. Here, the authors report the development of a single-atom catalyst that acts both as an antioxidative nanozyme and an electrode material for the inflammation-free sensing of dopamine in the brain.

    • Xiaolong Gao
    • , Huan Wei
    •  & Lanqun Mao

  • Article
    | Open Access

    Physical characterisation of proteins is challenging. Here the authors report single-molecule microfluidic diffusional sizing (smMDS) to enable calibration-free single-molecule diffusional-sizing based monitoring of protein hydrodynamic radii even within heterogenous multicomponent mixtures.

    • Georg Krainer
    • , Raphael P. B. Jacquat
    •  & Tuomas P. J. Knowles

  • Article
    | Open Access

    Protein phosphorylation plays critical roles in myriad cell processes. In this work, the authors apply new mass spectrometer technology to detect and quantify tens of thousands of protein phosphorylation sites within one hour or less of analysis. This technology has potential to greatly accelerate biological discovery.

    • Noah M. Lancaster
    • , Pavel Sinitcyn
    •  & Joshua J. Coon

  • Article
    | Open Access

    The immobilization of one reactant on a solid support makes interfacing of reagents a critical challenge in solid-phase synthesis. Here, authors combine dielectrophoresis and droplet microfluidics to encapsulate and eject individual beads out of reagent droplets for improved reaction fidelity.

    • Punnag Padhy
    • , Mohammad Asif Zaman
    •  & Lambertus Hesselink

  • Article
    | Open Access

    A mechano-fluorescence sensor system using polydiacetylene (PDA) particles monitors mechanical stresses in microchannels mimicking stenotic vessels, with fluorescence varying by fluid viscosity and particle collisions, aiding in in-vitro simulations.

    • Narges Ahmadi
    • , Jieun Lee
    •  & Bum Jun Park

  • Article
    | Open Access

    Second near-infrared (NIR-II) fluorescence imaging is promising for real-time surveillance of surgical operations, but its clinical uses have been limited by the safety and cost concerns associated with lasers or X-rays. Here the authors report the engineering and applications of white-light activatable organic nanomaterials with bright NIR-II emission.

    • Chunbin Li
    • , Jian Du
    •  & Ben Zhong Tang

  • Article
    | Open Access

    Classical theories of electrode kinetics assume a homogeneous electrode-solution interface. Here, authors reveal that electron transfer at a macroscopic electrode exhibits significant spatial inhomogeneity due to nonuniform solution resistance, which can be reduced by a retracted electrode design.

    • Ben Niu
    • , Ruo-Chen Xie
    •  & Wei Wang

  • Article
    | Open Access

    Acute myocardial infarction has become a public health disease threatening public life safety. Here, authors propose a BAS Mem with an ultra-high rectification coefficient, replacing the conventional chromatographic membrane to develop an ultra-fast, highly-sensitive lateral-flow assay for cTnI.

    • Juanhua Li
    • , Yiren Liu
    •  & Jianhua Zhou

  • Article
    | Open Access

    Understanding the intricate relationship between alloying elements and oxidation processes is essential for the integrity and performance of materials. Here, the authors study the effects of atomic size and redox potential to understand the oxidation process and structural changes in surface oxides.

    • Bharat Gwalani
    • , Andrew Martin
    •  & Arun Devaraj

  • Article
    | Open Access

    Molecular computing is an emerging paradigm with a crucial role in clinical diagnosis. Here, authors develop a spatially localized, DNA-integrated circuits-based classifier, DNA IC-CLA, which enables accurate cancer diagnosis for clinical samples in a faster and more effective manner.

    • Linlin Yang
    • , Qian Tang
    •  & Da Han

  • Article
    | Open Access

    Zero to ultralow-field NMR provides chemical information in the absence of a high magnetic field but it is difficult to measure molecules with quadrupolar nuclei due to their fast relaxation. This study examines zero-field J-spectra from isotopologues of ammonium cations, with quadrupolar nuclei, revealing the presence of a primary isotope effect of −58 mHz.

    • Román Picazo-Frutos
    • , Kirill F. Sheberstov
    •  & Danila A. Barskiy

  • Article
    | Open Access

    Chiral recognition of amino acids with luminescence, despite its advantages, is usually slow and lacks generality. Here, the authors demonstrate that L-phenylalanine derived benzamide can manifest the structural difference between the natural, left-handed amino acid and its right-handed counterpart via the difference in room-temperature phosphorescence, irrespective of the specific chemical structure.

    • Xiaoyu Chen
    • , Renlong Zhu
    •  & Guoqing Zhang

  • Article
    | Open Access

    Simultaneously quantifying mitochondrial Cu+ and Cu2+ levels is vital for understanding the molecular mechanism of mitochondria-related biological events. Here the authors report an alkynyl-labeled SERS probe to simultaneously monitor free Cu+ and Cu2+ in mitochondria, and unveil their roles during ischemia and cuproptosis processes.

    • Sihan Zhang
    • , Yuxiao Mei
    •  & Yang Tian

  • Article
    | Open Access

    Electrochemical research often requires stringent combinations of experimental parameters that are demanding to manually locate. Here the authors report an autonomous electrochemical platform that implements an adaptive, closed-loop workflow for mechanistic investigation of molecular electrochemistry.

    • Hongyuan Sheng
    • , Jingwen Sun
    •  & Chong Liu

  • Article
    | Open Access

    Bioimaging with photocontrol and multiplexing capability is vital for studying cellular interactions and dynamics, but multiplexed stimulated Raman scattering (SRS) imaging with reversible photocontrol is elusive. Here, the authors report SRS microscopy with Carbow-switch enabling multiplexed SRS imaging and tracking in live cells with reversible photocontrol and high spatiotemporal selectivity.

    • Yueli Yang
    • , Xueyang Bai
    •  & Fanghao Hu

  • Article
    | Open Access

    Near-infrared small molecule dyes are attractive in biophotonics, but generally rely on expanded aromatic structures to achieve this redshift. Here the authors report the use of a ground state antiaromatic strategy for 14 aminofluorene dyes, and their use in imaging kidney injury.

    • Kui Yan
    • , Zhubin Hu
    •  & Fan Zhang

  • Article
    | Open Access

    Manual data mining for HDX-MS restricts the use of this biophysical technique to a small number of samples run by specialty labs. Enabled by data-independent acquisition methodology, the authors describe an approach that fully automates and standardizes the information extraction process, opening the door to new and challenging applications.

    • Frantisek Filandr
    • , Vladimir Sarpe
    •  & David C. Schriemer

  • Article
    | Open Access

    Natural herbs, which contain pharmacologically active compounds, have been historically used as medicines but the analysis of their chemical components is time-consuming and complex. Here, the authors report a phenylboronic acid appended Mycobacterium smegmatis porin A (MspA) nanopore for sensing a variety of bioactive compounds based on salvianolic acid, without the need for sample separation or purification.

    • Pingping Fan
    • , Shanyu Zhang
    •  & Shuo Huang

  • Article
    | Open Access

    Fruits contain a large variety of cis-diols but their rapid and direct analysis without complex sample pretreatment was not achieved. Here, the authors report a Mycobacterium smegmatis porin A nanopore modified with a phenylboronic acid adapter for recognition of 1,2-diphenols, alditols, α-hydroxy acids and saccharides in fruits.

    • Pingping Fan
    • , Zhenyuan Cao
    •  & Shuo Huang

  • Article
    | Open Access

    Integrated structural data show that the MAP7 microtubule binding domain stabilizes the microtubule lattice through binding along protofilaments. Both strong and weak interactions between MAP7 and the lattice extend beyond a single tubulin dimer and include the tubulin C-terminal tails.

    • Agnes Adler
    • , Mamata Bangera
    •  & Marc Baldus

  • Article
    | Open Access

    Astrocytes adopt diverse states in response to brain injuries. Here, the authors develop a platform for spatially resolved, single-cell transcriptomics and proteomics, called tDISCO (tissue-digital microfluidic isolation of single cells for -Omics) to uncover the spatial boundaries of molecularly distinct reactive astrocyte populations in stroke.

    • Erica Y. Scott
    • , Nickie Safarian
    •  & Maryam Faiz

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