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Epigenetics

Sweet RNA

Nature Chemical Biology volume 20, page 1237 (2024)Cite this article

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By coupling rPAL to enzymatic glycan cleavage and sequential window acquisition of all theoretical mass spectra (SWATH-MS), the team found that acp3U was the most enriched linker (although other putative linker substrates were identified). Importantly, knocking out DTWD2, an enzyme responsible for installing acp3U in tRNAs, reduced glycoRNA levels. This study provides not only a useful tool for glycoRNA detection, but also the first direct evidence of a covalent linkage between a secretory N-glycan and RNA, paving the way for future functional studies.

Original reference: Cell https://doi.org/10.1016/j.cell.2024.07.044 (2024)

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  1. Nature Chemical Biology https://www.nature.com/nchembio/

    Yiyun Song

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Correspondence to Yiyun Song.

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Song, Y. Sweet RNA. Nat Chem Biol 20, 1237 (2024). https://doi.org/10.1038/s41589-024-01746-7

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