Extended Data Fig. 2: Scoring of Histopathologic Lesions.

Histopathologic lesions were scored semi-quantitatively and scores plotted as graphs for histologic signs of general inflammation and histologic parameters of bronchiolar, alveolar and vascular lesions at day 2/3 p.i (a) or day 5 p.i. (b). Data are represented as mean values +/- SEM. Number of animals analyzed per treatment group at days 2/3; day 5 p.i.: Ensovibep 0 h: n = 5; 5 / mAb cocktail 0 h: n = 4; 5 / Ensovibep 24 h: n = 5; 5 / mAb cocktail 24 h: n = 6; 6 / Placebo, infected: n = 8; 4 Placebo, non-infected: n = 3; 3. The rational for excluding animals is the identification of animals with low drug exposure, likely due to a failure of i.p. injections.