Search Results (1,518)

Background/Objectives: Artificial sweeteners are commonly used food additives that provide sweetness without calories. Once considered harmless due to their lack of metabolism, recent studies suggest that they may have unintended effects, potentially stimulating appetite and increasing food intake, leading to weight gain. This study aimed to assess consumer perceptions of artificial sweeteners in food, examine consumption frequencies of products containing them, and explore their potential influence on body mass index. Methods: A cross-sectional study was conducted using two voluntary and anonymous surveys administered via Google Forms. Results: The study included 649 participants: 324 parents of preschool and school-aged children and 325 university and secondary school students. A substantial proportion of parents (59.3%) recognized artificial sweeteners as common sugar substitutes in beverages like juices, soft drinks, and protein drinks. Awareness was notably higher among students (88.9%). While most participants held a negative attitude toward artificial sweeteners, their awareness and engagement with food label reading were low. Multivariate linear regression identified significant associations: Male gender (β = 1.17, p < 0.001) and older age (β = 0.42, p < 0.001) were associated with higher BMI. Additionally, participants who rarely or never consumed carbonated soft drinks had a lower BMI (β = −1.48, p = 0.039), while those who occasionally consumed snacks had a higher BMI (β = 0.51, p = 0.039). Conclusions: This research underscores the urgent need for public health initiatives addressing misconceptions, raising food label reading practices, while encouraging healthier consumption habits through educational campaigns. Additionally, the study’s insights will help assess the potential cumulative health impacts of artificial sweetener intake. Full article

Background/Objectives: Sugar-sweetened beverage (SSB) consumption is associated with child obesity, an understudied issue in the southern United States, where obesity rates are the highest in the country. We examined the factors associated with high SSB intakes among children aged 2–12 years in two major cities in Louisiana, New Orleans and Baton Rouge. Methods: We conducted a cross-sectional study using an online survey. The sample consisted of caregivers of children aged 2–12 years who eat restaurant meals (either dine-in, delivery, or take-out) at least once a month and reside in or near New Orleans or Baton Rouge, LA. Multivariable logistic regression was used to examine factors associated with high child SSB intake frequency (≥4 times/week), including restaurant use, caregiver attitudes towards SSB, and their demographics (n = 1006). Results: Most caregivers reported weekly child SSB consumption (74.6% ≥ 1×/week; 38.1% ≥ 4+/week) and restaurant use (58.8% ≥ 1×/week). High SSB frequency (≥4+/week) was associated with a higher frequency of restaurant use, lower caregiver education, agreement with the statement that SSBs are an important part of family meals, and disagreement with the statement that restaurants should not offer SSBs with children’s meals (p < 0.05). Conclusions: Our results revealed a high frequency of SSB consumption among children who dine at restaurants monthly, with significant associations observed between SSB intake, restaurant meals, and pro-SSB attitudes. These findings may support the need for regulations, such as healthy default beverage policies for children’s menus, to potentially reduce SSB intake and shift social norms, particularly in regions with high childhood obesity rates like Louisiana and the southern USA. Full article

Background: Artificially sweetened beverages (ASBs) are commonly recommended as a substitute for sugar-sweetened beverages (SSBs) in dietary counseling. Childhood obesity, associated with comorbidities like type 2 diabetes (T2D), has risen alongside increased consumption of both SSBs and ASBs. Metformin, a common treatment for pediatric T2D, affects GDF-15, a hormone involved in weight regulation. This pilot study examines the impact of ASBs on the therapeutic effects of metformin in pediatric patients with obesity and prediabetes, focusing on growth differentiation factor 15 (GDF-15) as a potential mediator. Methods: Forty-six children aged 10–21 years were randomized into two groups: one consuming non-sweetened beverages (USB) and the other consuming ASBs during a 12-week metformin intervention. Results: While the USB group showed a greater decrease in the point estimate for mean BMI (−0.55 ± 1.49 USB vs. −0.23 ± 1.60 ASB) and an increase in the point estimate for mean GDF-15 (33.40 ± 58.34 in USB vs. 19.77 ± 85.87 in ASB), these differences were not statistically significant (p = 0.6). As a hypothesis-generating exercise, change in insulin resistance was explored. While again lacking statistical power, we observed that more participants in the USB group showed improvements in insulin resistance. Conclusions: Additional studies are needed to fully elucidate the impact of non-nutritive sweeteners on metabolic health and treatment outcomes in pediatric obesity. Full article

The growing global focus on the adverse health conditions associated with excessive sugar consumption has prompted health and policy organizations as well as the public to take a more mindful approach to health and wellness. In response, food and beverage companies have proactively innovated and reformulated their product portfolios to incorporate low and no-calorie sweeteners (LNCSs) as viable alternatives to sugar. LNCSs offer an effective and safe approach to delivering sweetness to foods and beverages and reducing calories and sugar intake while contributing to the enjoyment of eating. The objective of this paper is to enhance the understanding of LNCSs segmentation and definitions, dietary consumption and reduction guidance, front-of-package labeling, taste and sensory perception and physiology, metabolic efficacy and impact, as well as the overall safety of LNCSs and sugar. Full article

Background/Objectives: The high consumption rate of energy drinks among pupils is a serious public health concern in various countries, including South Africa. Excessive consumption of energy drinks that contain elevated caffeine and sugar levels has the potential to lead to the development of addictions, strokes, dehydration, sleeping disorders, mental health and central nervous disorders, hypertension, digestive problems, and anxiety. Most pupils regard energy drinks as regular soft drinks and lack knowledge of the active ingredients contained in energy drinks and their side effects. The objective of this study was to investigate factors influencing energy drink usage amongst pupils in the Mahikeng sub-district, Northwest Province. Methods: A quantitative cross-sectional survey was conducted amongst 505 pupils in the Mahikeng sub-district, Northwest, using self-administered questionnaires. Data were analysed using STATA software version 18 to examine associations between variables. Results: The energy drinks consumed most by pupils were Dragon (38.21%), Switch (28.97%), and Red Bull (14.62%). Factors and reasons influencing energy drink usage among pupils include all-night parties (3.1%), concentration (20.3%), being awake (43.1%), curiosity (2.2%), energy levels (23.1%), exams (13.8%), sports (8.7%), fatigue (6.9%), and health (2.3%). There was a strong association (p ≤ 0.05) between energy drink usage and sports activities amongst pupils. Conclusions: It is concluded that health education and promotion intervention programmes are required to educate pupils about the dangers of energy drink usage to prevent public health risks. Further studies, including research on primary school pupils, are necessary, considering that a substantial number of pupils were exposed to energy drinks at an early age. Full article

Background/Objectives: The 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention recommendations benefit primary prevention and survivor outcomes. This study evaluated the adherence to these recommendations during the year prior to breast cancer diagnosis and identified related clinical and sociodemographic factors. Methods: A total of 915 patients with breast cancer were recruited from eight hospitals in four regions of Spain. The participants completed an epidemiologic questionnaire and a food frequency questionnaire. The compliance with the WCRF/AICR recommendations was assessed using a standardized score based on seven recommendations. Standardized prevalences and standardized prevalence ratios (SPRs) for moderate and high adherence were calculated based on participant characteristics using binary and multinomial logistic regression models. Results: The mean adherence was 3.5 points out of 7. The recommendations with the best and worst adherence were avoiding sugar-sweetened drinks (54.4% adherence) and maintaining a fiber-rich diet (4.4% consumed ≥30 g/day). The overall adherence was better in women aged ≥60 years (SPR = 1.55; 95% CI = 1.09–2.22), and worse in those with a caloric intake ≥2000 kcal/day (SPR = 0.48; 95% CI = 0.37–0.62) or ≥2 comorbidities (SPR = 0.66; 95% CI = 0.49–0.89). The adherence to maintaining a healthy weight was worse in those with ≥2 comorbidities and stage III-IV tumors. The physical activity adherence was worse in working women and those with ≥2 comorbidities. The alcohol restriction adherence was worse in smokers. Younger women, smokers and those with a low calorie intake were less adherent to the fruit/vegetable recommendation. The consumption of fiber and limited consumption of red/processed meat adherence was poor in all the subgroups. The adherence to a limited consumption of fast food and sugary drinks was worse in younger women and high-calorie-diet consumers. Conclusions: The differences in the adherence to recommendations according to patient characteristics justify the design of personalized interventions for breast cancer patients. Full article

Background: There is growing interest in the role of gut microbiota in the pathophysiology of inflammatory bowel diseases (IBDs), including Crohn’s disease (CD). Probiotics have been proposed as a potential adjunct therapy for these conditions by altering the intestinal environment, although studies on their effectiveness have yielded mixed results. Aim: This study aims to evaluate the short-term (2 months) effects of a dietary supplement containing Lactobacilli, Bifidobacteria, and Lactococcus bacillus on disease progression, remission, quality of life, and nutritional intake in Lebanese patients with CD. Method: A multicenter, randomized, single-blind controlled trial was conducted in 2 medical centers in Beirut from 1 April 2024 to 1 August 2024. Recruitment, prescreening, screening, enrollment, and protocol implementation were carried out at both centers. Data were collected from 21 patients with CD, who were randomly assigned to the control group (n = 10) and the intervention group (n = 11). At baseline and after two months, participants underwent clinical assessments, WHOQOL-BREF evaluation, and 24 h dietary recalls. Follow-up visits included surveys on disease progression, quality of life, adherence, and adverse events, along with repeat body composition and anthropometric measurements. Results: Probiotic supplementation over two months did not significantly alter symptoms, flares, or hospitalizations outcomes between the control and intervention groups. However, the intervention group experienced notable increases in body weight (p = 0.01), BMI (p = 0.01), body fat mass (p = 0.04), and arm muscle circumference (p = 0.01). Nutrient intake patterns differed, with the intervention group showing increased consumption of calcium, riboflavin, and folate compared to controls (p = 0.01, p = 0.04, p = 0.013, respectively). Probiotic supplementation led to significant within-group increases in dietary fiber (p = 0.01), total sugar (p = 0.02), and caffeine (p = 0.01) among the intervention participants. Adverse effects in the intervention group were mild, including nausea (18.2%) and abdominal discomfort (9.1%). QOL improved significantly in the intervention group, particularly in physical (p = 0.03), psychological (p = 0.04), and environmental domains (p = 0.003), while the control group exhibited improvements only in psychological health. Conclusions: Overall, the findings suggest that probiotics can enhance body composition, nutrient intake, and certain aspects of QOL among CD patients, despite minimal impact on disease symptoms or dietary patterns. Full article

Introduction: Good eating habits are essential for proper growth and development. The aim of this study was to assess the correlates of eating habits and factors associated with poor food habits (i.e., Food Habits Score <50%) among in-school adolescents. Method: A cross-sectional study was conducted among 423 adolescents enrolled from 10 high schools in Harare, Zimbabwe. A questionnaire was used to collect sociodemographic data, food habits, nutrition knowledge, and physical activity. WHO AnthroPlus was used to calculate weight-for-height z-scores for body mass index values. Pearson’s Chi-square and multinomial logistic regression were used to test for associations and explore factors associated with poor food habits (p < 0.05). Results: There were more girls (n = 225, 53.2%) than boys. Poor food habits were more prevalent than healthy eating habits for both sexes (51.1% and 53.5%, p = 0.619) and in the 14–16-year-old group (59.1%, p = 0.004). Overall, poor food habits were observed across the nutrition status spectrum with a higher percentage among underweight adolescents (58.5%, p = 0.693). Significant associations were found between age groups (14–16-year-olds vs. 17–19-year-olds) and high fat consumption, especially among 14–16-year-olds (54.8%, p = 0.036). Overall, sugar consumption was high among girls and 14–16-year-olds (52.6%, p = 0.278 and 55.1%, p = 0.666), and skipping meals, especially breakfast, was also common among the same sex and age groups (53.1%, p = 0.931 and 55.2%, p = 0.882). Poor food habits were significantly associated with the age group of 14–16 years [OR= 1.582 (1.026–2.440), p= 0.038]; places of residence in particularly high-density areas [OR= 1.816 (1.344–2.454), p = 0.001]; inadequate physical activity [OR = 0.479 (0.311–0.738), p = 0.001]; and inadequate nutrition knowledge [OR = 4.321 (2.242–8.330), p = 0.001]. Conclusions: Food habits were poor across the nutrition status spectrum. Poor food habits were more common among girls and 14–16-year-olds. Age, place of residence, nutrition knowledge, and inadequate physical activity were factors significantly associated with poor food habits. Full article

Background and Objectives: Added sugar usage has become an important public health issue nowadays. Therefore, the interest in studying the cognitive and emotional effects associated with sugar consumption has increased. The present study aimed to investigate how the intake of added sugar affects participants’ impulsivity and cognitive functions monitored during the performance of a computerized Go/NoGo task. Materials and Methods: This study included 20 subjects (10 men and 10 women). Quantitative data for this study were collected via self-report questionnaires, including demographics, the Dietary Fat and Free Sugar—Short Questionnaire (DFS), the Yale Food Addiction Scale (YFAS 2.0), and the Barratt impulsiveness scale-11 (BIS-11). Results: Event-related potentials (ERPs) were registered throughout this study. Comparing the results of psychophysiological and neuropsychological evaluations before and after the added sugar consumption reveals differences in ERPs. Specifically, the NoGo-P3 amplitude increased after the intake of added sugar. However, there were no behavioral differences between the two experimental sessions. Conclusions: Overall, the results of our study suggest that added sugar intake was associated with stronger neuronal firing in NoGo trials. One possible explanation for this could be the need for more cognitive endeavors for participants to successfully inhibit their response impulses after added sugar consumption. Full article

This study optimized the extraction process of crude polysaccharides from Panax notoginseng leaves (PNLP) using the ultrasonic-assisted dual-enzyme method through a single-factor combined with response surface experiment. The crude polysaccharides were subsequently purified and isolated with DEAE-Cellulose 52, followed by structural analysis, evaluation of antioxidant activity, and examination of digestive enzyme inhibition. The hypoglycemic effects of the purified components were further clarified. The results indicated that the optimized crude polysaccharide had an extraction yield of 17.13 ± 0.29%. The purified fraction PNLP-3 (eluted with 0.3 M NaCl) was obtained through DEAE-Cellulose 52 chromatography, exhibiting a total sugar content of 81.2% and a molecular weight of 16.57 kDa. PNLP is primarily composed of arabinose, galactose, and galacturonic acid, with molar percentages of 20.24%, 33.54%, and 24.27%, respectively. PNLP-3 is mainly composed of arabinose and galactose, with molar percentages of 29.97% and 49.35%, respectively. In this study of hypoglycemic activity, the IC₅₀ values of PNLP-3 for α-glucosidase and α-amylase inhibition were 1.045 mg/mL and 9.53 mg/mL, respectively. Molecular docking results confirmed that PNLP-3 exhibits better inhibitory activity against α-glucosidase. Furthermore, PNLP-3 alleviated hyperglycemia in insulin-resistant HepG2 cells by enhancing glucose consumption and glycogen synthesis. The antioxidant activity of PNLP-3 exhibited a positive correlation with its concentration, potentially contributing to its hypoglycemic effects by reducing oxidative stress. These findings underscore the therapeutic potential of Panax notoginseng leaf polysaccharides in managing type 2 diabetes and offer new perspectives on the use of natural polysaccharides for regulating blood glucose. Full article

Background/Objectives: Fructose consumption in children is increasing, as is the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD). Despite evidence linking added sugars to metabolic syndrome, fructose’s impact on liver disease in youth remains unclear, especially in pediatrics. Our study aimed to evaluate the role of fructose intake in metabolic and liver dysfunction in a cohort of pre-school children and adolescents with obesity. Methods: We recruited 41 children and adolescents with obesity (age range: 2.5–16 years, BMI SDS 2.6 ± 0.5 kg/m²). Clinical and biochemical parameters were assessed. Through ultrasound (US), MASLD, hepatorenal index (HRI), subcutaneous adipose tissue (scAT), and visceral adipose tissue (vAT) were assessed. Dietary intake was evaluated using the IDEFICS FFQ and a fructose-specific questionnaire. Results: Pubertal subjects had more scAT and vAT, higher insulin resistance, and higher liver fibrosis parameters than those prepubertal. MASLD was detected in 12 subjects, associated with higher scAT and vAT. Pubertal subjects had lower weekly fructose intake than prepubertal subjects (p < 0.02). However, they consumed less fructose from fruits (p < 0.04) and more from other sugars (p < 0.04) than younger children. Patients with MASLD reported higher fructose intake (p < 0.01), primarily from fruits (p < 0.003), likely due to misreporting, alongside higher consumption of unhealthy food, mainly rich in saturated fats. Conclusions: Fructose intake and unhealthy dietary habits were associated with MASLD in pre-school and adolescents with obesity. Advice to pay attention to fructose intake and foods rich in saturated fats is mandatory to decrease both obesity and MASLD. Further high-powered studies in any pediatric age and different geographical areas are needed to better evaluate the MASLD history. Full article

Waxy maize (Zea mays L. sinensis kulesh) contains a lot of nutrients, and has a long history of cultivation and extensive consumption. In this study, six waxy maize varieties of white (J18 and W2000), yellow (J41 and J7), and black (J10 and J20) were selected as experimental materials, and the functional nutrients and the differences in anthocyanin anabolic pathways in maize kernels at 14, 18, 22, and 26 days after pollination were determined. The result show that the varieties and kernel development stages had significant effect on the carotenoid, soluble sugar, vitamin C, anthocyanin, and mineral element content. The black waxy maize varieties had a higher anthocyanin content, which plays an important role in maize kernel coloration, whereas the yellow and black waxy maize varieties exhibit a greater abundance of mineral elements. Furthermore, the phenylalanine content, as well as the activities of phenylalanine ammonia lyase (PAL), chalcone isomerase (CHI), dihydroflavonol reductase (DFR), and flavonoid 3-glucosyltransferase (UFGT), played a significant role in the anthocyanin biosynthetic pathway. In conclusion, the comprehensive functional quality of waxy maize decreased with the delay of kernel development stage, and the black waxy maize varieties demonstrated superior functional quality. The PAL and CHI played a primary role in the initial phase of anthocyanin accumulation, while UFGT gradually assumed control in the subsequent stages. Full article

Background/Objectives: The consumption of diets with high fat, salt, and sugar content has been associated with increasing the risk of developing a range of pathologies, including cardiovascular disease, obesity, and diabetes. Furthermore, there is growing evidence to suggest a relationship between variation in the nutritional environment and pancreatic dysregulation, which may be a consequence of oxidative stress. This study aimed to examine the effects of a high-fat, high-carbohydrate (obesogenic) maternal diet during pregnancy and lactation on the metabolic health and pancreatic structure of rat offspring. Methods: Pregnant rats were divided into two groups: one fed a standard diet and the other an obesogenic diet. After weaning, male pups from both groups were fed the same diet until they were 30 days old, which is when they were euthanized. Results: Metabolic and murinometric changes: Increased body weight and pancreas size, elevated blood glucose and cholesterol levels, and reduced glucose tolerance (which is indicative of the beginning of insulin resistance). Oxidative stress: Higher levels of oxidative damage markers and decreased antioxidants in the pancreas, suggesting a state of oxidative stress in this organ. Changes in pancreatic structure: Increased size and number of pancreatic islets and decreased size and number of pancreatic acini. Conclusions: A maternal obesogenic diet induces metabolic alterations, increases oxidative stress, and causes changes in the structure of the pancreas in rat offspring, suggesting a higher risk of developing metabolic diseases such as type 2 diabetes in adulthood. Full article

Background/Objectives: Poor nutrition in early life represents a relevant public health issue globally. The current study aimed to characterize eating habits among preschoolers and investigate the relationship with parents’ nutritional status. Methods: A secondary analysis of a cross-sectional study carried out at the Child Dentistry Clinics of the Istituto Stomatologico Italiano, Milan, Italy, including 171 patients aged 12–71 months and their parents, was conducted. Demographic data, anthropometric measurements, and information on children’s eating habits were collected. Results: The duration of exclusive breastfeeding was 5.9 (±6.8) months in 65% of children, and complementary feeding began at a mean (±SD) of 6.2 (±1.7) months in accordance with present recommendations. In contrast, the consumption of fruit juice 3.2 (±2.9) times/week, a protein intake of 3.0 (±0.6) g/kg, and a sugar intake of 20 (±8)% were over guideline limits. Overweight/obese children were introduced to cow’s milk earlier (p = 0.033) and consumed a higher percentage of total fats (p = 0.026) whilst consuming a lower percentage of carbohydrates (p = 0.050). In terms of children with both parents being obese or overweight, they consumed more carbohydrates (p = 0.048). Finally, we found that birth weight correlated positively with maternal BMI (ρ = 0.159; p < 0.05). The number of offspring correlated positively with the weekly frequency of sugar-sweetened beverage consumption before 24 months (ρ = 0.282; p < 0.001) whilst correlating negatively with the age of cow’s milk introduction (ρ = −0.226; p < 0.01). Conclusions: Our findings, according to recommendations, suggest that the prevention of obesity needs to begin in infancy. As parents play a pivotal role in establishing children’s food choices, nutritional education aimed at families is needed. Full article

The nutrient, amino acid, and fatty acid compositions of Caulerpa lentillifera from various aquaculture regions were assessed to analyze their nutritional characteristics and potential for aquaculture development. The nutrient composition of C. lentillifera was determined according to the standard national nutrient determination methods of the Association of Official Analytical Chemists, and the following data were revealed. (1) The basic nutritional components of C. lentillifera were relatively more abundant in the three aquaculture areas in Guangdong Province. The crude protein content in C. lentillifera was measured at (8.70 ± 0.36)% and (18.57 ± 1.59)% for samples collected from the Dapeng and Daya areas, respectively. These values were significantly higher compared to those obtained from the Beihai, Dongshan, and Nha Trang regions (p < 0.05). Additionally, the crude lipid content of C. lentillifera from the Daya population was measured at (5.10 ± 1.59)%, which was significantly higher than that of samples from the Beihai, Dongshan, and Nha Trang areas (p < 0.05). Furthermore, the total sugar contents in C. lentillifera were quantified as (32.50 ± 4.22)% and (32.87 ± 2.59)% for samples from the Daya and Shanwei regions, respectively. These values were significantly greater (p < 0.05) compared to those observed in the other four populations. (2) The total amino acid (TAA) content of C. lentillifera ranged from 7.05% to 12.37%, with notable concentrations of the fresh amino acids aspartic acid (Asp) and glutamic acid (Glu). Significant variations in the TAA and essential amino acid (EAA) levels were observed among the cultivation regions (p < 0.05), with the Shanwei population exhibiting the highest TAA content of 12.37% and EAA content of 4.65%, surpassing all other populations except for Guangdong Province (p < 0.05). (3) The fatty acid composition analysis revealed that the total fatty acid (TFA) and unsaturated fatty acid (UFA) levels in the long-stemmed grape fern alga from Daya were 2.400% and 1.048%, respectively, and significantly greater than those in the other populations except for Dapeng (p < 0.05). These results imply that the nutritional quality of the Daya population of C. lentillifera is relatively high. C. lentillifera exhibits a palatable flavor profile, making it suitable for consumption and the development into high-quality seafood condiments, thereby contributing to the environmentally sustainable advancement of C. lentillifera aquaculture. Full article