Nothing Special   »   [go: up one dir, main page]

You seem to have javascript disabled. Please note that many of the page functionalities won't work as expected without javascript enabled.
 
 
Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Article Types

Countries / Regions

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Search Results (10,063)

Search Parameters:
Keywords = mitigation strategy

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
40 pages, 49610 KiB  
Article
Geoinformatics and Machine Learning for Shoreline Change Monitoring: A 35-Year Analysis of Coastal Erosion in the Upper Gulf of Thailand
by Chakrit Chawalit, Wuttichai Boonpook, Asamaporn Sitthi, Kritanai Torsri, Daroonwan Kamthonkiat, Yumin Tan, Apised Suwansaard and Attawut Nardkulpat
ISPRS Int. J. Geo-Inf. 2025, 14(2), 94; https://doi.org/10.3390/ijgi14020094 - 19 Feb 2025
Abstract
Coastal erosion is a critical environmental challenge in the Upper Gulf of Thailand, driven by both natural processes and human activities. This study analyzes 35 years (1988–2023) of shoreline changes using geoinformatics, machine learning algorithms (Random Forest, Support Vector Machine, Maximum Likelihood, Minimum [...] Read more.
Coastal erosion is a critical environmental challenge in the Upper Gulf of Thailand, driven by both natural processes and human activities. This study analyzes 35 years (1988–2023) of shoreline changes using geoinformatics, machine learning algorithms (Random Forest, Support Vector Machine, Maximum Likelihood, Minimum Distance), and the Digital Shoreline Analysis System (DSAS). The results show that the Random Forest algorithm, utilizing spectral bands and indices (NDVI, NDWI, MNDWI, SAVI), achieved the highest classification accuracy (98.17%) and a Kappa coefficient of 0.9432, enabling reliable delineation of land and water boundaries. The extracted annual shorelines were validated with high accuracy, yielding RMSE values of 13.59 m (2018) and 8.90 m (2023). The DSAS analysis identified significant spatial and temporal variations in shoreline erosion and accretion. Between 1988 and 2006, the most intense erosion occurred in regions 4 and 5, influenced by sea-level rise, strong monsoonal currents, and human activities. However, from 2006 to 2018, erosion rates declined significantly, attributed to coastal protection structures and mangrove restoration. The period 2018–2023 exhibited a combination of erosion and accretion, reflecting dynamic sediment transport processes and the impact of coastal management measures. Over time, erosion rates declined due to the implementation of protective structures (e.g., bamboo fences, rock revetments) and the natural expansion of mangrove forests. However, localized erosion remains persistent in low-lying, vulnerable areas, exacerbated by tidal forces, rising sea levels, and seasonal monsoons. Anthropogenic activities, including urban development, mangrove deforestation, and aquaculture expansion, continue to destabilize shorelines. The findings underscore the importance of sustainable coastal management strategies, such as mangrove restoration, soft engineering coastal protection, and integrated land-use planning. This study demonstrates the effectiveness of combining machine learning and geoinformatics for shoreline monitoring and provides valuable insights for coastal erosion mitigation and enhancing coastal resilience in the Upper Gulf of Thailand. Full article
14 pages, 1401 KiB  
Article
Aeroacoustic Study of Synchronized Rotors
by Fabio Del Duchetto, Tiziano Pagliaroli, Paolo Candeloro, Karl-Stéphane Rossignol and Jianping Yin
Aerospace 2025, 12(2), 162; https://doi.org/10.3390/aerospace12020162 - 19 Feb 2025
Abstract
The main goal of the present study is to explore the noise mitigation potential using an active control strategy based on rotor phase synchronization. This work is focused on the effects of the inflow velocity on the noise interference effect. The inflow velocity [...] Read more.
The main goal of the present study is to explore the noise mitigation potential using an active control strategy based on rotor phase synchronization. This work is focused on the effects of the inflow velocity on the noise interference effect. The inflow velocity does not affect the phase at which the interference phenomenon is observed, as expected. On the other hand, the intensity of the pressure fluctuations is influenced by the inflow velocity for all of the rotor phase shift conditions investigated. Specifically, as the inflow velocity increases, maintaining a constant rotational speed, in the Overall Sound Pressure Level graphs, a reduction of approximately 10 dB is observed. This effect also applies to cases of destructive interference, highlighting the remarkable versatility of this noise reduction technique. Full article
28 pages, 4335 KiB  
Article
A Methodological Framework for AI-Assisted Diagnosis of Ovarian Masses Using CT and MR Imaging
by Pratik Adusumilli, Nishant Ravikumar, Geoff Hall and Andrew F. Scarsbrook
J. Pers. Med. 2025, 15(2), 76; https://doi.org/10.3390/jpm15020076 - 19 Feb 2025
Abstract
Background: Ovarian cancer encompasses a diverse range of neoplasms originating in the ovaries, fallopian tubes, and peritoneum. Despite being one of the commonest gynaecological malignancies, there are no validated screening strategies for early detection. A diagnosis typically relies on imaging, biomarkers, and multidisciplinary [...] Read more.
Background: Ovarian cancer encompasses a diverse range of neoplasms originating in the ovaries, fallopian tubes, and peritoneum. Despite being one of the commonest gynaecological malignancies, there are no validated screening strategies for early detection. A diagnosis typically relies on imaging, biomarkers, and multidisciplinary team discussions. The accurate interpretation of CTs and MRIs may be challenging, especially in borderline cases. This study proposes a methodological pipeline to develop and evaluate deep learning (DL) models that can assist in classifying ovarian masses from CT and MRI data, potentially improving diagnostic confidence and patient outcomes. Methods: A multi-institutional retrospective dataset was compiled, supplemented by external data from the Cancer Genome Atlas. Two classification workflows were examined: (1) whole-volume input and (2) lesion-focused region of interest. Multiple DL architectures, including ResNet, DenseNet, transformer-based UNeST, and Attention Multiple-Instance Learning (MIL), were implemented within the PyTorch-based MONAI framework. The class imbalance was mitigated using focal loss, oversampling, and dynamic class weighting. The hyperparameters were optimised with Optuna, and balanced accuracy was the primary metric. Results: For a preliminary dataset, the proposed framework demonstrated feasibility for the multi-class classification of ovarian masses. The initial experiments highlighted the potential of transformers and MIL for identifying the relevant imaging features. Conclusions: A reproducible methodological pipeline for DL-based ovarian mass classification using CT and MRI scans has been established. Future work will leverage a multi-institutional dataset to refine these models, aiming to enhance clinical workflows and improve patient outcomes. Full article
(This article belongs to the Special Issue Artificial Intelligence Applications in Precision Oncology)
30 pages, 2825 KiB  
Review
Understanding Social Engineering Victimisation on Social Networking Sites: A Comprehensive Review of Factors Influencing User Susceptibility to Cyber-Attacks
by Saad S. Alshammari, Ben Soh and Alice Li
Information 2025, 16(2), 153; https://doi.org/10.3390/info16020153 - 19 Feb 2025
Abstract
The widespread adoption of social networking sites (SNSs) has brought social-engineering victimisation (SEV) to the forefront as a significant concern in recent years. Common examples of social-engineering attacks include phishing websites, fake user accounts, fraudulent messages, impersonation of close friends, and malicious links [...] Read more.
The widespread adoption of social networking sites (SNSs) has brought social-engineering victimisation (SEV) to the forefront as a significant concern in recent years. Common examples of social-engineering attacks include phishing websites, fake user accounts, fraudulent messages, impersonation of close friends, and malicious links shared through comments or posts on SNS platforms. The increasing number of SNS users is closely linked to a rise in SEV incidents. Consequently, it is essential to explore relevant theories, frameworks, and contributing factors to better understand this phenomenon. This study systematises and analyses 47 scholarly works on SEV in SNSs, examining theories, frameworks, and influencing factors. A total of 90 independent variables were identified and grouped into seven perspectives: socio-demographics, personality traits, socio-emotional factors, habitual factors, perceptual/cognitive factors, message characteristics, and sender characteristics; these were considered alongside mediating variables. The correlations between these variables and victimisation outcomes were evaluated, uncovering factors that increase vulnerability and highlighting contradictory findings in existing studies. This systematised analysis emphasises the limitations in current research and identifies future research directions in order to deepen the understanding of the factors influencing SEV. By addressing these gaps, this study aims to advance mitigation strategies and provide actionable insights to reduce SEV in SNS contexts. Full article
(This article belongs to the Special Issue Recent Developments and Implications in Web Analysis)
18 pages, 853 KiB  
Review
Hypertension and Atrial Fibrillation: Bridging the Gap Between Mechanisms, Risk, and Therapy
by Ibrahim Antoun, Georgia R. Layton, Ali Nizam, Joseph Barker, Ahmed Abdelrazik, Mahmoud Eldesouky, Abdulmalik Koya, Edward Y. M. Lau, Mustafa Zakkar, Riyaz Somani and Ghulam André Ng
Medicina 2025, 61(2), 362; https://doi.org/10.3390/medicina61020362 - 19 Feb 2025
Abstract
Background and objectives: Atrial fibrillation (AF), the most prevalent sustained arrhythmia, poses a significant public health challenge due to its links with stroke, heart failure, and mortality. Hypertension, a primary modifiable cardiovascular risk factor, is a well-established risk factor for AF that facilitates [...] Read more.
Background and objectives: Atrial fibrillation (AF), the most prevalent sustained arrhythmia, poses a significant public health challenge due to its links with stroke, heart failure, and mortality. Hypertension, a primary modifiable cardiovascular risk factor, is a well-established risk factor for AF that facilitates structural and electrical changes in the atria, including dilation, fibrosis, and pressure overload. Material and Methods: we conducted a literature search regarding the shared mechanisms, risks and treatments of hypertension and atrial fibrillation. Results: The renin–angiotensin–aldosterone system plays a pivotal role in this remodelling and inflammation, increasing AF susceptibility. Uncontrolled hypertension complicates AF management, diminishing the effectiveness of mainstay treatments, including antiarrhythmic drugs, catheter ablation, and cardioversion. Effective blood pressure management, particularly with therapies targeting the renin–angiotensin–aldosterone system (RAAS), can lower the risk of new-onset AF and reduce the incidence of recurrent AF, enhancing the success of rhythm control strategies. These antihypertensive therapies mitigate myocardial hypertrophy and fibrosis and attenuate both atrial pressure strain and the inflammatory response, mitigating the substrates for AF. Conclusion: This review highlights the urgent need for integrated strategies that combine BP control, AF screening, and lifestyle modifications to minimise the burden of AF and its complications. Future research should investigate the specific mechanisms of cellular-level interactions associated with a hypertensive predisposition to AF, including systematic inflammation and the role of genetics, the impact of blood pressure variations on AF risk, and individualised treatment strategies specifically targeting the shared mechanisms, simultaneously propagating hypertension and AF. Full article
(This article belongs to the Special Issue New Insights into Hypertension and the Cardiovascular System)
Show Figures

Figure 1

Figure 1
<p>Mechanism of atrial fibrillation in hypertension patients. AF: atrial fibrillation. BP: blood pressure. persAF: persistent atrial fibrillation. LVH: left ventricular hypertrophy. ↓: decrease. ↑: increase. TGF: transforming growth hormone.</p>
Full article ">Figure 2
<p>Role of the renin–angiotensin–aldosterone system (RAAS) in atrial fibrillation (AF). Ca<sup>2+</sup>: calcium. AF: atrial fibrillation. SR: sinus rhythm. ↓: decrease.</p>
Full article ">
27 pages, 798 KiB  
Article
Longevity Risk and Annuitisation Decisions in the Absence of Special-Rate Life Annuities
by Jorge de Andrés-Sánchez and Laura González-Vila Puchades
Risks 2025, 13(2), 37; https://doi.org/10.3390/risks13020037 - 19 Feb 2025
Abstract
Longevity risk affecting older adults can be transferred to the insurance market by purchasing a lifetime annuity. Special-rate life annuities, which are priced, among other factors, on the basis of health and lifestyle factors, go beyond traditional considerations of age and sex by [...] Read more.
Longevity risk affecting older adults can be transferred to the insurance market by purchasing a lifetime annuity. Special-rate life annuities, which are priced, among other factors, on the basis of health and lifestyle factors, go beyond traditional considerations of age and sex by using modified mortality tables. However, they are not available in many countries. In regions where life annuities are priced solely via standard mortality tables, retirees with below-average life expectancy may face unfair pricing. This study aims to quantify this actuarial unfairness and proposes an alternative annuitisation strategy for these retirees. The strategy allows them to transfer longevity risk by acquiring a life annuity on the basis of their actual mortality probabilities, thereby mitigating actuarial inequities. Additionally, the paper examines how tax incentives can exacerbate actuarial unfairness and, specifically for Spanish tax regulations, compares different alternatives under two scenarios related to the sources used for purchasing life annuities. Full article
(This article belongs to the Special Issue Applied Financial and Actuarial Risk Analytics)
27 pages, 1952 KiB  
Article
Torque Ripple Minimization for Switched Reluctance Motor Drives Based on Harris Hawks–Radial Basis Function Approximation
by Jackson Oloo and Szamel Laszlo
Energies 2025, 18(4), 1006; https://doi.org/10.3390/en18041006 - 19 Feb 2025
Abstract
Switched reluctance motor drives are becoming attractive for electric vehicle propulsion systems due to their simple and cheap construction. However, their operation is degraded by torque ripples due to the salient nature of the stator and rotor poles. There are several methods of [...] Read more.
Switched reluctance motor drives are becoming attractive for electric vehicle propulsion systems due to their simple and cheap construction. However, their operation is degraded by torque ripples due to the salient nature of the stator and rotor poles. There are several methods of mitigating torque ripples in switched reluctance motors (SRMs). Apart from changing the geometrical design of the motor, the less costly technique involves the development of an adaptive switching strategy. By selecting suitable turn-on and turn-off angles, torque ripples in SRMs can be significantly reduced. This work combines the benefits of Harris Hawks Optimization (HHO) and Radial Basis Functions (RBFs) to search and estimate optimal switching angles. An objective function is developed under constraints and the HHO is utilized to perform search stages for optimal switching angles that guarantee minimal torque ripples at every speed and current operating point. In this work, instead of storing the values in a look-up table, the values are passed on to an RBF model to learn the nonlinear relationship between the columns of data from the HHO and hence transform them into high-dimensional outputs. The values are used to train an enhanced neural network (NN) in an adaptive switching strategy to address the nonlinear magnetic characteristics of the SRM. The proposed method is implemented on a current chopping control-based SRM 8/6, 600 V model. Percentage torque ripples are used as the key performance index of the proposed method. A fuzzy logic switching angle compensation strategy is implemented in numerical simulations to validate the performance of the HHO-RBF method. Full article
(This article belongs to the Special Issue Advanced Electric Powertrain Technologies for Electric Vehicles)
17 pages, 484 KiB  
Review
Addressing Cadmium in Cacao Farmland: A Path to Safer, Sustainable Chocolate
by Gina Alexandra García Porras, Jéssica Aires dos Santos, Mariana Rocha de Carvalho, Elberth Hernando Pinzón-Sandoval, Aline Aparecida Silva Pereira and Luiz Roberto Guimarães Guilherme
Agriculture 2025, 15(4), 433; https://doi.org/10.3390/agriculture15040433 - 19 Feb 2025
Abstract
Cacao cultivation is an important economic and social activity for tropical regions worldwide. Elevated cadmium (Cd) concentrations in soil and cacao beans have become a serious concern for producers and consumers, particularly following the implementation of stricter Cd limits for cacao products in [...] Read more.
Cacao cultivation is an important economic and social activity for tropical regions worldwide. Elevated cadmium (Cd) concentrations in soil and cacao beans have become a serious concern for producers and consumers, particularly following the implementation of stricter Cd limits for cacao products in the European Union since 2019. Cadmium is a potentially toxic element that can bioaccumulate in different plant tissues, raising concerns about the future of cacao exports and posing a significant threat to the food chain through consuming products with high Cd concentrations. Therefore, understanding the origins of Cd in cacao-producing countries’ agricultural soils is essential. Equally important is the need to investigate the factors influencing its availability, uptake, translocation, and distribution within the cacao plant, in addition to strategies for mitigating its effects or reducing its concentration in agriculturally relevant tissues. This review aims to contextualize the sources of Cd in the cacao agroecosystems while highlighting recent advances and perspectives in applying essential and beneficial elements, selecting low-accumulator genotypes, and utilizing associated microbiota. These strategies seek to mitigate Cd bioaccumulation and minimize its negative impacts on the cocoa value chain. Full article
(This article belongs to the Special Issue Heavy Metals in Farmland Soils: Mechanisms and Remediation Strategies)
20 pages, 10146 KiB  
Review
Earthquake Risk Severity and Urgent Need for Disaster Management in Afghanistan
by Noor Ahmad Akhundzadah
GeoHazards 2025, 6(1), 9; https://doi.org/10.3390/geohazards6010009 - 19 Feb 2025
Abstract
Afghanistan is located on the Eurasian tectonic plate’s edge, a highly seismically active region. It is bordered by the northern boundary of the Indian plate and influenced by the collisional Arabian plate to the south. The Hindu Kush and Pamir Mountains in Afghanistan [...] Read more.
Afghanistan is located on the Eurasian tectonic plate’s edge, a highly seismically active region. It is bordered by the northern boundary of the Indian plate and influenced by the collisional Arabian plate to the south. The Hindu Kush and Pamir Mountains in Afghanistan are part of the western extension of the Himalayan orogeny and have been uplifted and sheared by the convergence of the Indian and Eurasian plates. These tectonic activities have generated numerous active deep faults across the Hindu Kush–Himalayan region, many of which intersect Afghanistan, resulting in frequent high-magnitude earthquakes. This tectonic interaction produces ground shaking of varying intensity, from high to moderate and low, with the epicenters often located in the northeast and extending southwest across the country. This study maps Afghanistan’s tectonic structures, identifying the most active geological faults and regions with heightened seismicity. Historical earthquake data were reviewed, and recent destructive events were incorporated into the national earthquake dataset to improve disaster management strategies. Additionally, the study addresses earthquake hazards related to building and infrastructure design, offering potential solutions and directions to mitigate risks to life and property. Full article
(This article belongs to the Special Issue Active Faulting and Seismicity—2nd Edition)
Show Figures

Figure 1

Figure 1
<p>Tectonic setting of Afghanistan and the surrounding regions. The bold arrows show the relative direction and velocities of the Eurasian (EU), Arabian (AR), and Indian (IN) plates. The big arrows show the plate’s movement direction and rate, and the small arrows show EU and IN transform boundaries, which are labeled in red.</p>
Full article ">Figure 2
<p>Regional tectonic and geological faults network map with historical earthquakes in Afghanistan and surrounding regions between 1964 and 2004. Magnitude 4 to 7.5 earthquake centers are shown on the map. Most earthquakes, especially the higher-magnitude earthquakes, are recorded around the major faults.</p>
Full article ">Figure 3
<p>Afghanistan’s tectonic zones and major fault systems (adapted from [<a href="#B31-geohazards-06-00009" class="html-bibr">31</a>]). Red lines show the geological faults that crossed different parts of Afghanistan and connected to the surrounding regions. These fault systems parted the country’s four tectonic zones. Sarobi and Spinghar faults are overlapped by the Transpressional Plate Boundary.</p>
Full article ">Figure 4
<p>Historical earthquake magnitudes across Afghanistan’s principal tectonic zones and fault systems (data adapted from [<a href="#B31-geohazards-06-00009" class="html-bibr">31</a>,<a href="#B60-geohazards-06-00009" class="html-bibr">60</a>]). The map highlights clusters of high-magnitude events along the active faults in Badakhshan, Darvaz, and Chaman-Makur, part of the Transpressional Plate Boundary and North Afghan Platform tectonic zones. The largest earthquakes occurred outside Afghanistan’s borders, showing the continuity of the tectonic zones across the region.</p>
Full article ">Figure 5
<p>Historical earthquakes in and around Afghanistan show earthquake magnitudes and focal depths. Earthquake magnitudes are indicated on the map, while the corresponding focal depth ranges are provided in the legend. Notably, most deep-focus earthquakes are concentrated near the Badakhshan fault system in the northern region.</p>
Full article ">Figure 6
<p>Map depicting major faults, tectonic zones, and earthquakes recorded between 1990 and 2022. It clearly shows that recent significant earthquakes are concentrated near the Badakhshan fault system in the northern region. Afghanistan experienced notable seismic activity in areas beyond the immediate boundaries of the Indian and Arabian plates.</p>
Full article ">Figure 7
<p>Afghanistan earthquake hazard map delineating distinct seismic regions (modified after [<a href="#B9-geohazards-06-00009" class="html-bibr">9</a>]. The map was developed based on the locations of active faults and earthquake intensity and magnitude data. The region surrounding the Badakhshan, Darvaz, and Chaman faults is the most seismically active, whereas the Hari Rod fault, though less frequently active, is associated with high-magnitude earthquakes.</p>
Full article ">
22 pages, 3749 KiB  
Review
Microbiota and Inflammatory Markers: A Review of Their Interplay, Clinical Implications, and Metabolic Disorders
by Emiliano Peña-Durán, Jesús Jonathan García-Galindo, Luis Daniel López-Murillo, Alfredo Huerta-Huerta, Luis Ricardo Balleza-Alejandri, Alberto Beltrán-Ramírez, Elsa Janneth Anaya-Ambriz and Daniel Osmar Suárez-Rico
Int. J. Mol. Sci. 2025, 26(4), 1773; https://doi.org/10.3390/ijms26041773 - 19 Feb 2025
Abstract
The human microbiota, a complex ecosystem of microorganisms, plays a pivotal role in regulating host immunity and metabolism. This review investigates the interplay between microbiota and inflammatory markers, emphasizing their impact on metabolic and autoimmune disorders. Key inflammatory biomarkers, such as C-reactive protein [...] Read more.
The human microbiota, a complex ecosystem of microorganisms, plays a pivotal role in regulating host immunity and metabolism. This review investigates the interplay between microbiota and inflammatory markers, emphasizing their impact on metabolic and autoimmune disorders. Key inflammatory biomarkers, such as C-reactive protein (CRP), interleukin-6 (IL-6), lipopolysaccharides (LPS), zonulin (ZO-1), and netrin-1 (Ntn1), are discussed in the context of intestinal barrier integrity and chronic inflammation. Dysbiosis, characterized by alterations in microbial composition and function, directly modulates the levels and activity of these biomarkers, exacerbating inflammatory responses and compromising epithelial barriers. The disruption of microbiota is further correlated with increased intestinal permeability and chronic inflammation, serving as a precursor to conditions like type 2 diabetes (T2D), obesity, and non-alcoholic fatty liver disease. Additionally, this review examines therapeutic strategies, including probiotics and prebiotics, designed to restore microbial balance, mitigate inflammation, and enhance metabolic homeostasis. Emerging evidence positions microbiota-targeted interventions as critical components in the advancement of precision medicine, offering promising avenues for diagnosing and treating inflammatory and metabolic disorders. Full article
(This article belongs to the Special Issue Molecular Progression of Gut Microbiota)
Show Figures

Figure 1

Figure 1
<p>Gut Microbiota: Classification and Impact on Metabolic and Inflammatory Health. Classification of gut microbiota into three categories based on its impact on metabolic and inflammatory health: <span class="html-italic">normal microbiota</span> (essential for metabolic and defense functions, such as <span class="html-italic">Lactobacillus</span> and <span class="html-italic">Bifidobacterium</span>), <span class="html-italic">opportunistic microbiota</span> (can cause inflammation under dysbiosis conditions, such as <span class="html-italic">Candida albicans</span> and <span class="html-italic">Clostridium difficile</span>), and <span class="html-italic">pathogenic microbiota</span> (associated with systemic inflammation and metabolic disorders, such as <span class="html-italic">Salmonella</span> and <span class="html-italic">Yersinia enterocolitica</span>). Maintaining this balance is critical to preventing metabolic and inflammatory diseases.</p>
Full article ">Figure 2
<p>The NF-κB pathway activation by tumor necrosis factor α (TNF-α) and its impact on the regulation of inflammation at the cellular level. Tumor necrosis factor-alpha (TNF-α) through the NF-κB pathway and its impact on inflammatory regulation at the cellular level. The following key events are described: Production of TNF-α: Immune cells such as macrophages and lymphocytes release TNF-α in response to inflammatory stimuli. Receptor Interaction: TNF-α binds to the TNF-R receptor located in the plasma membrane, triggering an intracellular signaling cascade. IKK Complex Activation: TNF-α receptor binding recruits and activates the IKK (IκB kinase) complex, responsible for phosphorylating IκB-α, an inhibitory protein associated with the NF-κB transcription factor. IκB-α Degradation: Phosphorylation of IκB-α leads to its ubiquitination and subsequent degradation in the proteasome, releasing NF-κB. Nuclear Translocation of NF-κB: Once released, the NF-κB complex translocates to the nucleus, where it regulates the transcription of proinflammatory genes. Proinflammatory Gene Expression: NF-κB induces the expression of cytokines such as IL-6, IL-1β, and chemokines like MCP-1, which amplify the inflammatory response. Negative Regulation by A20: The diagram includes the role of A20 as a negative regulator of this pathway, inhibiting IKK complex activity to limit inflammatory signaling. Create by <a href="http://BioRender.com" target="_blank">BioRender.com</a>.</p>
Full article ">Figure 3
<p>Inflammatory biomarkers in intestinal dysbiosis. This diagram illustrates the primary factors that disrupt intestinal barrier homeostasis and their systemic repercussions. High-fat diets, obesity, and glycemic dysregulation contribute to dysbiosis, increasing the release of bacterial lipopolysaccharides (LPS). LPS activates Toll-like receptors and the NF-κB pathway, promoting the production of pro-inflammatory cytokines such as interleukin-6 (IL-6), which in turn stimulates hepatic synthesis of C-reactive protein (CRP). These inflammatory responses impair tight junction proteins, including ZO-1, leading to increased intestinal permeability and facilitating bacterial translocation (endotoxemia). Systemically, endotoxemia induces endothelial damage, leukocyte infiltration, and impaired insulin signaling, exacerbating chronic inflammation and metabolic dysfunction. Conversely, Netrin-1 exerts a regulatory effect by limiting immune cell infiltration and preserving the integrity of the intestinal barrier. The imbalance between pro-inflammatory mediators and protective mechanisms highlights the critical role of maintaining barrier function to preserve systemic homeostasis.</p>
Full article ">Figure 4
<p>Impact of probiotics and prebiotics on microbiota. The diagram illustrates the effects of probiotics and prebiotics on gut microbiota and their role in maintaining health. It highlights the causal factors and consequences of microbiota dysbiosis, the key functions of the microbiota–gut axis in health, and the specific benefits of probiotic and prebiotic use. Probiotics contribute to microbial balance, inflammation reduction, and immune modulation, while prebiotics stimulate the growth of beneficial bacteria, enhance mineral absorption, and support intestinal health. The figure also emphasizes the interplay between gut microbiota and systemic processes, including immune responses and neurological conditions.</p>
Full article ">Figure 5
<p>Progression from Healthy Microbiota to Dysbiosis and Inflammation. The figure illustrates the transition from a symbiotic gut microbiota to a state of dysbiosis and its impact on systemic inflammation. In a healthy microbiota, beneficial bacteria produce essential metabolites such as short-chain fatty acids (SCFAs), secondary bile acids, and bacteriocins, which support intestinal barrier integrity, immune regulation, and metabolic health. Dysbiosis disrupts this balance, leading to increased production of harmful substances such as lipopolysaccharides (LPS), microbial antigens, and pro-inflammatory cytokines (e.g., TNF-α, IL-6, IL-1β). This pro-inflammatory response contributes to intestinal barrier damage, immune dysregulation, angiogenesis, and systemic inflammation, increasing the risk of metabolic disorders such as diabetes, rheumatoid arthritis, and non-alcoholic fatty liver disease (NAFLD). Abbreviations: BCAA, branched-chain amino acids; TMAO, trimethylamine N-oxide; iNOS, inducible nitric oxide synthase.</p>
Full article ">
21 pages, 4387 KiB  
Article
Exploring the Genotoxic Stress Response in Primed Orphan Legume Seeds Challenged with Heat Stress
by Andrea Pagano, Conrado Dueñas, Nicolò Bedotto, Amine Elleuch, Bassem Khemakhem, Hanen El Abed, Eleni Tani, Maria Goufa, Dimosthenis Chachalis and Alma Balestrazzi
Genes 2025, 16(2), 235; https://doi.org/10.3390/genes16020235 - 19 Feb 2025
Abstract
Background/Objectives: The increased frequency of extreme weather events related to climate change, including the occurrence of extreme temperatures, severely affects crop yields, impairing global food security. Heat stress resulting from temperatures above 30 °C is associated with poor germination performance and stand establishment. [...] Read more.
Background/Objectives: The increased frequency of extreme weather events related to climate change, including the occurrence of extreme temperatures, severely affects crop yields, impairing global food security. Heat stress resulting from temperatures above 30 °C is associated with poor germination performance and stand establishment. The combination of climate-resilient crop genotypes and tailored seed priming treatments might represent a reliable strategy to overcome such drawbacks. This work explores the potential of hydropriming as a tool to mitigate the heat-stress-mediated impact on germination performance in orphan legumes. Methods: For each tested species (Lathyrus sativus L., Pisum sativum var. arvense and Trigonella foenum-graecum L.), two accessions were investigated. Germination tests were performed at 25 °C, 30 °C, 35 °C and 40 °C to assess the heat stress tolerance threshold. Hydropriming was then applied and germination tests were performed at 40 °C to test the impact of the treatment on the seeds’ ability to cope with heat stress. An alkaline comet assay and Quantitative Real Time-Polymerase Chain Reaction were performed on embryos excised from primed and control seeds. Results: Phenotyping at the germination and seedling development stage highlighted the accession-specific beneficial impact of hydropriming under heat stress conditions. In L. sativus seeds, the alkaline comet assay revealed the dynamics of heat stress-induced DNA damage accumulation, as well as the repair patterns promoted by hydropriming. The expression patterns of genes involved in DNA repair and antioxidant response were consistently responsive to the hydropriming and heat wave conditions in L. sativus accessions. Full article
(This article belongs to the Special Issue DNA Damage Repair and Plant Stress Response)
Show Figures

Figure 1

Figure 1
<p>Overview of the experimental systems designed to assess the effects of heat waves on seeds of <span class="html-italic">L. sativus</span> accessions, <span class="html-italic">Pisum sativum</span> var. <span class="html-italic">arvense</span> accessions, and <span class="html-italic">Trigonella foenum-graecum</span> accessions. (<b>a</b>) Schematic representation of the experimental system designed to assess the impact of 4 h heat waves with incremental temperatures (25 °C, 30 °C, 35 °C, and 40 °C) administered after 4 h of imbibition at 24 °C. (<b>b</b>) Experimental system designed to assess the effects of 4 h of heat wave (40 °C) after 4 h of imbibition at 25 °C on unprimed and hydroprimed (8 h) seeds. DS, dry seed; DB, dry back; RH, rehydrated seed; UP, unprimed seeds; HP, hydroprimed seeds; NT, seeds subjected to 8 h of imbibition at 25 °C without heat wave; HW, seeds subjected to 4 h of imbibition at 25 °C followed by 4 h of heat wave at 40 °C.</p>
Full article ">Figure 2
<p>Germination performance of the <span class="html-italic">L. sativus</span> accessions Maleme-107 and Sofades under control and heat wave conditions. (<b>a</b>) Germinability index (G). (<b>b</b>) Mean germination time (MGT). (<b>c</b>) Frequency of seedlings with normal and aberrant phenotypes developed from control and treated seeds. NT, non-treated with heat wave; HW, heat wave. Asterisks indicate statistically significant differences in each heat wave condition compared with the respective non-treated control, as analyzed using a heteroscedastic two-tailed Student’s <span class="html-italic">t</span>-test. *, <span class="html-italic">p</span>-value &lt; 0.05; **, <span class="html-italic">p</span>-value &lt; 0.01; ***, <span class="html-italic">p</span>-value &lt; 0.001.</p>
Full article ">Figure 3
<p>Germination performance of the <span class="html-italic">P. sativum</span> var. <span class="html-italic">arvense</span> accessions Forrimax and Guifredo under control and heat wave conditions. (<b>a</b>) Germinability index (G). (<b>b</b>) Mean germination time (MGT). (<b>c</b>) Frequency of seedlings with normal and aberrant phenotypes developed from control and treated seeds. NT, non-treated with heat wave; HW, heat wave. Asterisks indicate statistically significant differences in each heat wave condition compared with the respective non-treated control, as analyzed using a heteroscedastic two-tailed Student’s <span class="html-italic">t</span>-test. *, <span class="html-italic">p</span>-value &lt; 0.05; **, <span class="html-italic">p</span>-value &lt; 0.01; ***, <span class="html-italic">p</span>-value &lt; 0.001.</p>
Full article ">Figure 4
<p>Germination performance of the <span class="html-italic">T. foenum-graecum</span> accessions Rayhane and Tborsek under control and heat wave conditions. (<b>a</b>) Germinability index (G). (<b>b</b>) Mean germination time (MGT). (<b>c</b>) Frequency of seedlings with normal and aberrant phenotypes developed from control and treated seeds. NT, non-treated with heat wave; HW, heat wave. Asterisks indicate statistically significant differences in each heat wave condition compared with the respective non-treated control, as analyzed using a heteroscedastic two-tailed Student’s <span class="html-italic">t</span>-test. *, <span class="html-italic">p</span>-value &lt; 0.05; **, <span class="html-italic">p</span>-value &lt; 0.01; ***, <span class="html-italic">p</span>-value &lt; 0.001.</p>
Full article ">Figure 5
<p>Germination performance of the <span class="html-italic">L. sativus</span> accessions Maleme-107 and Sofades (unprimed, hydroprimed) under control and heat wave conditions. (<b>a</b>) Germinability index in <span class="html-italic">L. sativus</span> Maleme-107 accession. (<b>b</b>) Mean germination time in <span class="html-italic">L. sativus</span> Maleme-107 accession. (<b>c</b>) Shoot and root length in 7-day-old seedlings in <span class="html-italic">L. sativus</span> Maleme-107 accession. (<b>d</b>) Germinability index in <span class="html-italic">L. sativus</span> Sofades accession. (<b>e</b>) Mean germination time in <span class="html-italic">L. sativus</span> Sofades accession. (<b>f</b>) Shoot and root length in 7-day-old seedlings in <span class="html-italic">L. sativus</span> Sofades accession. UP, unprimed seeds; HP, hydroprimed seeds; US, unstressed seeds (subjected to 8 h of imbibition at 25 °C); HW, heat wave (seeds subjected to 4 h of imbibition at 25 °C followed by 4 h of heat wave at 40 °C). G, germinability index; MGT, mean germination time. Values are indicated as average ± standard deviation. For each parameter of each accession, average values without common letters are significantly different (<span class="html-italic">p</span>-value &lt; 0.05), as analyzed by one-way ANOVA and Duncan’s test.</p>
Full article ">Figure 6
<p>Germination performance of the <span class="html-italic">P. sativum</span> var. <span class="html-italic">arvense</span> accessions Forrimax and Guifredo (unprimed, hydroprimed) under control and heat wave conditions. (<b>a</b>) Germinability index in <span class="html-italic">P. sativum</span> var. <span class="html-italic">arvense</span> Forrimax accession. (<b>b</b>) Mean germination time in <span class="html-italic">P. sativum</span> var. <span class="html-italic">arvense</span> Forrimax accession. (<b>c</b>) Shoot and root length in 7-day-old seedlings in <span class="html-italic">P. sativum</span> var. <span class="html-italic">arvense</span> Forrimax accession. (<b>d</b>) Germinability index in <span class="html-italic">P. sativum</span> var. <span class="html-italic">arvense</span> Guifredo accession. (<b>e</b>) Mean germination time in <span class="html-italic">P. sativum</span> var. <span class="html-italic">arvense</span> Guifredo accession. (<b>f</b>) Shoot and root length in 7-day-old seedlings in <span class="html-italic">P. sativum</span> var. <span class="html-italic">arvense</span> Guifredo accession. UP, unprimed seeds; HP, hydroprimed seeds; US, unstressed seeds (subjected to 8 h of imbibition at 25 °C); HW, heat wave (seeds subjected to 4 h of imbibition at 25 °C followed by 4 h of heat wave at 40 °C). G, germinability index; MGT, mean germination time. Values are indicated as average ± standard deviation. For each parameter of each accession, average values without common letters are significantly different (<span class="html-italic">p</span>-value &lt; 0.05), as analyzed by one-way ANOVA and Duncan’s test.</p>
Full article ">Figure 7
<p>Germination performance of the <span class="html-italic">T. foenum-graecum</span> accessions Rayhane and Tborsek (unprimed, hydroprimed) under control and heat wave conditions. (<b>a</b>) Germinability index in <span class="html-italic">T. foenum-graecum</span> Rayhane accession. (<b>b</b>) Mean germination time in <span class="html-italic">T. foenum-graecum</span> Rayhane accession. (<b>c</b>) Shoot and root length in 7-day-old seedlings in <span class="html-italic">T. foenum-graecum</span> Rayhane accession. (<b>d</b>) Germinability index in <span class="html-italic">T. foenum-graecum</span> Tborsek accession. (<b>e</b>) Mean germination time in <span class="html-italic">T. foenum-graecum</span> Tborsek accession. (<b>f</b>) Shoot and root length in 7-day-old seedlings in <span class="html-italic">T. foenum-graecum</span> Tborsek accession. UP, unprimed seeds; HP, hydroprimed seeds; US, unstressed seeds (subjected to 8 h of imbibition at 25 °C); HW, heat wave (seeds subjected to 4 h of imbibition at 25 °C followed by 4 h of heat wave at 40 °C); G, germinability index; MGT, mean germination time. Values are indicated as average ± standard deviation. For each parameter of each accession, average values without common letters are significantly different (<span class="html-italic">p</span>-value &lt; 0.05), as analyzed by one-way ANOVA and Duncan’s test.</p>
Full article ">Figure 8
<p>DNA damage (single and double strand breaks) levels in embryos excised from unprimed and hydroprimed orphan legume seeds exposed to 4 h of heat wave at 40 °C. (<b>a</b>) <span class="html-italic">L. sativus</span> accession Maleme-107. (<b>b</b>) <span class="html-italic">L. sativus</span> accession Sofades. (<b>c</b>) <span class="html-italic">P. sativum</span> var. <span class="html-italic">arvense</span> accession Forrimax. (<b>d</b>) <span class="html-italic">P. sativum</span> var. arvense accession Guifredo. (<b>e</b>) <span class="html-italic">T. foenum-graecum</span> accession Rayhane. (<b>f</b>) <span class="html-italic">T. foenum-graecum</span> accession Tborsek. UP, unprimed seeds; HP, hydroprimed seeds; US, unstressed seeds (subjected to 8 h of imbibition at 25 °C); HW, heat wave (seeds subjected to 4 h of imbibition at 25 °C followed by 4 h of heat wave at 40 °C); a.u., arbitrary units. Values are indicated as average ± standard deviation. For each accession, average values without common letters are significantly different (<span class="html-italic">p</span>-value &lt; 0.05), as analyzed by one-way ANOVA and Duncan’s test.</p>
Full article ">Figure 9
<p>Heat maps representing the relative expression profiles of genes involved in the seed repair response, evaluated by <span class="html-italic">q</span>RT-PCR in <span class="html-italic">L. sativus</span> accession. (<b>a</b>) Z-scored relative gene expression in <span class="html-italic">L. sativus</span> Maleme-107. (<b>b</b>) Z-scored relative gene expression in <span class="html-italic">L. sativus</span> Sofades. For each gene of each accession, expression levels without common letters are significantly different (<span class="html-italic">p</span>-value &lt; 0.05), as analyzed by one-way ANOVA and Duncan’s test. DS, dry seed; DB, seeds subjected to hydropriming and dry-back; UP, unprimed seeds; HP, hydroprimed seeds; NT, seeds subjected to 8 h of imbibition at 25 °C without heat wave; HW, seeds subjected to 4 h of imbibition at 25 °C followed by 4 h of heat wave at 40 °C. <span class="html-italic">LsSOD</span>, superoxide dismutase. <span class="html-italic">LsAPX</span>, ascorbate peroxidase. <span class="html-italic">LsMT</span>, metallothionein. <span class="html-italic">LsSPMS</span>, spermine/spermidine synthase. <span class="html-italic">LsSPDS</span>, spermidine synthase. <span class="html-italic">LsSOG1</span>, suppressor of the gamma response <span class="html-italic">1. LsOGG1</span>, 8-oxoguaninglycosylase/lyase. <span class="html-italic">LsFPG</span>, formamidopyrimidine-dna glycosylase. <span class="html-italic">LsLig</span>, DNA ligase. <span class="html-italic">LsTOP</span>, DNA topoisomerase. <span class="html-italic">LsPCNA</span>, proliferating cell nuclear antigen. <span class="html-italic">LsTFIIS</span>, transcription elongation factor <span class="html-italic">IIS. Ls5.8S</span>, <span class="html-italic">5.8S rRNA. Ls5.8S-IS</span>, <span class="html-italic">5.8S rRNA-</span>interspace. <span class="html-italic">Ls</span>, <span class="html-italic">Lathyrus sativus</span>.</p>
Full article ">Figure 10
<p>Principal component analysis of the effects of heat stress on unprimed and hydroprimed <span class="html-italic">L. sativus</span> seeds. (<b>a</b>) Biplot referring to <span class="html-italic">L. sativus</span> accession Maleme-107. (<b>b</b>) Biplot referring to <span class="html-italic">L. sativus</span> accession Sofades. <span class="html-italic">SOD</span>, superoxide dismutase. <span class="html-italic">APX</span>, ascorbate peroxidase. <span class="html-italic">MT</span>, metallothionein. <span class="html-italic">OGG1</span>, 8-oxoguaninglycosylase/lyase. <span class="html-italic">FPG</span>, formamidopyrimidine-dna glycosylase. <span class="html-italic">Lig</span>, <span class="html-italic">DNA</span> ligase. <span class="html-italic">TOP</span>, <span class="html-italic">DNA</span> topoisomerase. <span class="html-italic">TFIIS</span>, transcription elongation factor <span class="html-italic">IIS. SPMS</span>, <span class="html-italic">SPERMINE/SPERMIDINE SYNTHASE. SPDS</span>, spermidine synthase. <span class="html-italic">5.8S</span>, <span class="html-italic">5.8S rRNA. 5.8S-IS</span>, <span class="html-italic">5.8S rRNA-</span>interspace. <span class="html-italic">PCNA</span>, proliferating cell nuclear antigen. <span class="html-italic">SOG1</span>, suppressor of the γ response 1. G, germinability. MGT, mean germination time. SL, shoot length. RL, root length. SB, strand break.</p>
Full article ">
23 pages, 5838 KiB  
Article
Understanding the Dynamics of PM2.5 Concentration Levels in China: A Comprehensive Study of Spatio-Temporal Patterns, Driving Factors, and Implications for Environmental Sustainability
by Yuanlu Miao, Chunmei Geng, Yuanyuan Ji, Shengli Wang, Lijuan Wang and Wen Yang
Sustainability 2025, 17(4), 1742; https://doi.org/10.3390/su17041742 - 19 Feb 2025
Abstract
Over the past decade, China’s air quality has improved significantly. To further mitigate the concentration levels of fine particulate matter (PM2.5), this study analyzed the spatio-temporal evolution of PM2.5 concentrations from 2012 to 2022. Furthermore, the study integrated the generalized [...] Read more.
Over the past decade, China’s air quality has improved significantly. To further mitigate the concentration levels of fine particulate matter (PM2.5), this study analyzed the spatio-temporal evolution of PM2.5 concentrations from 2012 to 2022. Furthermore, the study integrated the generalized additive model (GAM) and GeoDetector to investigate the main driving factors and explored the complex response relationships between these factors and PM2.5 concentrations. The results showed the following: (1) The annual average concentration of PM2.5 in China peaked in 2013. The annual reductions of PM2.5 in each city ranged from 1.48 to 7.33 μg/m3. In each year, the PM2.5 concentrations were always consistently higher in north and east China and lowest in northeast and southwest China. (2) In terms of spatial distribution, the North China Plain, the Middle and Lower Yangtze River Plain, and the Sichuan Basin exhibited the highest PM2.5 concentration levels and showed high aggregation characteristics. (3) The GeoDetector analysis identified the concentrations of SO2, NO2, and CO and the meteorological conditions as important factors influencing the spatial differentiation of PM2.5. The results of the GAM showed that the meteorological factors, such as temperature, atmospheric pressure, wind speed, and precipitation, generally had specific inflection points in their effects on the PM2.5 concentration levels. The relationship of PM2.5 with the gross domestic product and population density followed an inverted U shape. The PM2.5 concentrations under the land use types of cropland, barren, impervious, and water were higher than others. The concentration of PM2.5 decreased significantly under all land use types. Our work can be used as a strong basis for providing insights crucial for developing long-term pollution control strategies and promoting environmental sustainability. Full article
Show Figures

Figure 1

Figure 1
<p>Six regional distributions in China in this study.</p>
Full article ">Figure 2
<p>The average annual concentration of PM<sub>2.5</sub> in China from 2012 to 2022.</p>
Full article ">Figure 3
<p>Average PM<sub>2.5</sub> concentrations of six regions in China from 2012 to 2022.</p>
Full article ">Figure 4
<p>Spatial distribution of the annual average PM<sub>2.5</sub> concentrations in years 2013 (<b>a</b>), 2017 (<b>b</b>), and 2022 (<b>c</b>).</p>
Full article ">Figure 5
<p>Temporal trends in PM<sub>2.5</sub> annual concentrations from 2012 to 2022 in China.</p>
Full article ">Figure 6
<p>Global spatial correlation of PM<sub>2.5</sub> concentrations from 2012 to 2022.</p>
Full article ">Figure 7
<p>Spatial pattern and clustering of PM<sub>2.5</sub> in China in the years 2013 (<b>a</b>), 2017 (<b>b</b>), and 2022 (<b>c</b>).</p>
Full article ">Figure 8
<p>The detection results of the driving factors of PM<sub>2.5</sub> in six regions in 2013 (<b>a</b>), 2017 (<b>b</b>), and 2022 (<b>c</b>) and the average of the three years (<b>d</b>).</p>
Full article ">Figure 9
<p>Response plots of PM<sub>2.5</sub> to driving factors: (<b>a</b>) temperature, (<b>b</b>) atmospheric pressure, (<b>c</b>) wind speed, (<b>d</b>) precipitation, (<b>e</b>) SO<sub>2</sub>, (<b>f</b>) NO<sub>2</sub>, (<b>g</b>) CO, (<b>h</b>) Log_GDP, (<b>i</b>) Log_Population density, and (<b>j</b>) NDVI.</p>
Full article ">Figure 10
<p>Average PM<sub>2.5</sub> concentrations under nine different land use types in 2013, 2017, and 2022.</p>
Full article ">
15 pages, 250 KiB  
Review
Antiviral Surface Coatings: From Pandemic Lessons to Visible-Light-Activated Films
by Plinio Innocenzi
Materials 2025, 18(4), 906; https://doi.org/10.3390/ma18040906 - 19 Feb 2025
Abstract
The increasing need for effective antiviral strategies has led to the development of innovative surface coatings to combat the transmission of viruses via fomites. The aim of this review is to critically assess the efficacy of antiviral coatings in mitigating virus transmission, particularly [...] Read more.
The increasing need for effective antiviral strategies has led to the development of innovative surface coatings to combat the transmission of viruses via fomites. The aim of this review is to critically assess the efficacy of antiviral coatings in mitigating virus transmission, particularly those activated by visible light. The alarm created by the COVID-19 pandemic, including the initial uncertainty about the mechanisms of its spread, attracted attention to fomites as a possible source of virus transmission. However, later research has shown that surface-dependent infection mechanisms need to be carefully evaluated experimentally. By briefly analyzing virus–surface interactions and their implications, this review highlights the importance of shifting to innovative solutions. In particular, visible-light-activated antiviral coatings that use reactive oxygen species such as singlet oxygen to disrupt viral components have emerged as promising options. These coatings can allow for obtaining safe, continuous, and long-term active biocidal surfaces suitable for various applications, including healthcare environments and public spaces. This review indicates that while the significance of fomite transmission is context-dependent, advances in material science provide actionable pathways for designing multifunctional, visible-light-activated antiviral coatings. These innovations align with the lessons learned from the COVID-19 pandemic and pave the way for sustainable, broad-spectrum antiviral solutions capable of addressing future public health challenges. Full article
(This article belongs to the Section Thin Films and Interfaces)
24 pages, 470 KiB  
Article
Firms’ Position in the Supply Chain Network, R&D Input, and Innovation Output: Striving for the Top or Settling in the Corner? Implications for Sustainable Growth and Adaptive Capacity
by Le Cheng and Liyuan Wu
Sustainability 2025, 17(4), 1729; https://doi.org/10.3390/su17041729 - 19 Feb 2025
Abstract
This study examines the potential constraints that firms may face when occupying central positions within supply chain networks, particularly in terms of innovation. While prior research highlights the benefits of centrality for resource acquisition and knowledge flow, our findings suggest that such positioning [...] Read more.
This study examines the potential constraints that firms may face when occupying central positions within supply chain networks, particularly in terms of innovation. While prior research highlights the benefits of centrality for resource acquisition and knowledge flow, our findings suggest that such positioning can, under certain conditions, hinder innovation. Using unbalanced panel data from Chinese A-share listed firms in Shanghai and Shenzhen (2009–2021), we conduct an empirical investigation into this effect, incorporating the mediating role of R&D investment and the moderating influence of ownership structure. The analysis reveals that supply chain network centrality has a significantly negative impact on total innovation output, invention patents, and low-end patents, with all effects statistically significant at the 0.001 level. This adverse impact is particularly pronounced in state-owned enterprises, where dependence on established networks further restrains innovation. These results suggest that supply chain centrality may hinder firms’ long-term innovation capacity, which could, in turn, weaken their sustainability by limiting their ability to adapt to technological change and evolving industrial environments. These findings suggest that policymakers could implement targeted incentives, such as R&D subsidies, to mitigate the innovation constraints faced by central firms. Meanwhile, corporate managers should adopt strategies like open innovation and supply chain diversification to sustain long-term innovation. Full article
Show Figures

Figure 1

Figure 1
<p>Enterprises’ supply chain network position and innovation output.</p>
Full article ">
18 pages, 7794 KiB  
Article
A Hybrid Simulated Annealing–Particle Swarm Optimization Framework for the Enhanced Operational Efficiency of the W23 Underground Gas Storage Facility
by Xuefeng Bai, Tong Gu, Bo Yu, Yun Liu, Jiakun Yang, Famu Huang, Siyuan Zhang, Wen Deng and Zhi Zhong
Processes 2025, 13(2), 590; https://doi.org/10.3390/pr13020590 - 19 Feb 2025
Abstract
Seasonal and industrial fluctuations in natural gas demands require optimized gas storage operations, especially in depleted reservoirs, to ensure a stable supply. This study proposes a novel optimization model for injection–production processes using the simulated annealing–particle swarm optimization (SA-PSO) algorithm. The model focuses [...] Read more.
Seasonal and industrial fluctuations in natural gas demands require optimized gas storage operations, especially in depleted reservoirs, to ensure a stable supply. This study proposes a novel optimization model for injection–production processes using the simulated annealing–particle swarm optimization (SA-PSO) algorithm. The model focuses on minimizing pressure variances across different reservoir blocks during injection–production cycles. The approach is applied to the W23 underground gas storage facility, where a high-precision 3D geological model and numerical simulations were developed. The SA-PSO algorithm effectively reduced pressure differentials during the sixth injection–production cycle, improving reservoir efficiency. During the gas injection period, the optimized pressure difference between blocks was reduced to one-eighth of that in the initial plan. The average formation pressures in Phase I and Phase II decreased by 0.35 MPa and 0.76 MPa, respectively. During the gas production period, the optimized pressure difference between blocks was reduced to one-tenth of that in the initial plan. The average formation pressures in Phase I and Phase II increased by 0.4 MPa and 1.21 MPa, respectively. The optimized injection–production strategy enhances working gas capacity, maintains balanced formation pressures, and mitigates risks such as high pressure and salt precipitation. The findings demonstrate the potential of SA-PSO optimization to improve the operational efficiency and safety of gas storage reservoirs. Full article
(This article belongs to the Special Issue Oil and Gas Drilling Processes: Control and Optimization)
Show Figures

Figure 1

Figure 1
<p>Flowchart of the improved SA-PSO algorithm.</p>
Full article ">Figure 2
<p>Plane distribution map of W23-UGS: (<b>a</b>) layout and well location deployment, (<b>b</b>) fault distribution.</p>
Full article ">Figure 3
<p>W23-UGS modeling process: (<b>a</b>) static data, (<b>b</b>) geological model, (<b>c</b>) numerical model.</p>
Full article ">Figure 4
<p>Comparison of the predicted wellhead pressure from the numerical simulation model for the representative well with the actual pressure.</p>
Full article ">Figure 5
<p>Monthly gas injection and production plan for the 6th cycle of the W23-UGS.</p>
Full article ">Figure 6
<p>Comparison of formation pressure before and after optimization in the 6th injection-production cycle of the W23-UGS: (<b>a</b>) Phase 1, (<b>b</b>) Phase 2.</p>
Full article ">Figure 7
<p>Comparison of numerical model pressure distribution before and after optimization at the end of injection in the 6th injection–production cycle of the W23-UGS: (<b>a</b>) before optimization, (<b>b</b>) after optimization.</p>
Full article ">Figure 8
<p>Comparison of numerical model pressure distribution before and after optimization at the end of production in the 6th injection–production cycle of the W23-UGS: (<b>a</b>) before optimization, (<b>b</b>) after optimization.</p>
Full article ">Figure 9
<p>Comparison of individual well bottomhole pressures in each block before and after optimization at the end of injection in the 6th cycle.</p>
Full article ">Figure 10
<p>Comparison of individual well bottomhole pressures in each block before and after optimization at the end of production in the 6th cycle.</p>
Full article ">Figure 11
<p>Comparison of average pressures in each block before and after optimization at the end of injection and production in the 6th cycle: (<b>a</b>) end of injection, (<b>b</b>) end of production.</p>
Full article ">
Back to TopTop