Search Results (3,327)

This study explores the link between the Sustainable Development Goals (SDGs) and the process of identifying and assessing occupational risks in industrial and organizational environments, highlighting the importance of these goals in promoting a safe, healthy, and sustainable work environment. In the center of this analysis are SDG 3 (“Good Health and Well-Being”) and SDG 8 (“Decent Work and Economic Growth”), which highlight the need to create working conditions that prioritize the safety of workers. The study analyzes the correlation between the implementation of these global objectives and occupational risk management processes. Research results indicate that linking the Sustainable Development Goals (SDGs) to these processes reduces the incidence of accidents and occupational diseases and also contributes to the achievement of global sustainability goals. An integrated approach improves the resilience of organizations, promotes equity in the professional environment, and supports sustainable economic development. The findings of the study offer important insights for policymakers, managers, and researchers, indicating that adopting a common framework for sustainability and occupational safety can bring significant benefits at local and global levels. Thus, the research encourages the widespread application of this integrative model in organizational policies and practices. Full article

In recent years, many studies have been carried out regarding the benefits that nature could bring to people’s well-being. The research presented here applies the Delphi methodology to design a survey aimed at assessing the links between the natural environment, well-being and leisure, enriching the existing body of knowledge. Eighteen experts participated in this study with an integrated approach to sustainability terms. Two rounds of queries were put to the panel of experts between February and July 2021. In the first round, the experts identified the key aspects to be considered when studying the perception of natural environments related to well-being through outdoor activities. In the second query, the experts assessed the importance, relevance and clarity of the questions to be included in the survey. The survey was designed based on the results of these two rounds of queries. This methodology aims to gain a better understanding of the interrelation between people and the natural environment in order to determine the mechanisms by which a relationship with nature can improve people’s health, well-being and sustainable behaviours. The Delphi method could be employed for global research to validate this survey. Full article

The coordinated relationship of new-type urbanization (NU) and the eco-environment (EE) is of great significance for high-quality and healthy development. A multi-dimensional index system of NU and EE was established to measure and compare the coordinated level of 30 Chinese provinces from 2009 to 2020 by the entropy method, coupling coordination degree model, and Markov chain. Furthermore, the regional differences in and distribution dynamic evolution of the coordination level of the four east, west, central, and northeast regions in China were analyzed using the Dagum Gini coefficient and the kernel density estimation method. The results showed that China’s NU and EE was in the low coordination state, and the distribution was uneven. In addition, the coordinated evolution was continuous. The study also revealed that intra-regional differences in coordination level were small and stable in China, and the overall difference in NU and EE coordination was mainly ascribed to inter-regional difference. The national coordination level rose, and the polarization phenomenon gradually disappeared. In the process of NU, the environmental capacity in China should be considered to promote the coordinated development of regions and fully reflect the sustainable development requirements of NU. Full article

Skin aging is the most prominent phenotype of host aging and is the consequence of a combination of genes and environment. Improving skin aging is essential for maintaining the healthy physiological function of the skin and the mental health of the human body. Mitochondria are vital organelles that play important roles in cellular mechanisms, including energy production and free radical balance. However, mitochondrial metabolism, mitochondrial dynamics, biogenesis, and degradation processes vary greatly in various cells in the skin. It is well known that mitochondrial dysfunction can promote the aging and its associated diseases of the skin, resulting in the damage of skin physiology and the occurrence of skin pathology. In this review, we summarize the important role of mitochondria in various skin cells, review the cellular responses to vital steps in mitochondrial quality regulation, mitochondrial dynamics, mitochondrial biogenesis, and mitochondrial phagocytosis, and describe their importance and specific pathways in skin aging. Full article

Mental health challenges among university students and staff are a pressing concern globally and in Aotearoa, New Zealand. Despite adopting frameworks like the Okanagan Charter to promote health and well-being, there is a lack of empirical research on how campus landscapes contribute to mental health promotion. This is a preliminary study based on a Ph.D. research project aiming to investigate the role of campus landscapes in supporting relaxation and internal recovery through everyday activities. We conducted a comparative multi-case study involving 66 participants from the University of Auckland, Lincoln University, and the University of Otago, exploring how they use and prefer campus landscapes for relaxation. Our findings indicate that ‘enjoying nature’ is the most preferred relaxation activity, with participants engaging both actively and passively with various spaces such as gardens, open lawns, and forested areas. Additionally, in campus settings, the proximity of relaxation spaces appears to be more important than design quality because of the limited time during working hours, which points to the importance of thoughtful campus planning. This study also found that university staff are often overlooked in discussions about healthy universities, despite their significant role in the campus setting. Overall, this study highlights the importance of biophilic design principles in creating health-promoting campus environments and offers initial insights for integrating natural elements into campus planning to enhance mental health and well-being. Full article

Background: Despite recent breakthroughs in cancer treatment, non-small cell lung cancer (NSCLC) and breast cancer remain major causes of death from all malignancies. The epidermal growth factor receptor (EGFR) is an important mediator of the pathways involved in cell proliferation, apoptosis, and angiogenesis. Thus, its overexpression triggers several types of cancer, including NSCLC and breast cancer. Methods: In the current study, we synthesized new pyrimidine-tethered compounds (chalcone derivative (B-4), pyrazoline–carbothioamide (B-9), and pyrazoline–thiazole hybrids (BH1-7)). These compounds were then tested for cytotoxicity against A549 NSCLC and MCF-7 breast cancer cells. Results: Of these, B-4 displayed significant cytotoxicity against both cells (IC₅₀ = 6.70 ± 1.02 µM for MCF-7; IC₅₀ = 20.49 ± 2.7 µM for A549) compared to the standard agent lapatinib (IC₅₀ = 9.71 ± 1.12 µM for MCF-7; IC₅₀ = 18.21 ± 3.25 µM for A549). The anticancer potential of B-4 between Jurkat leukemic T cells and peripheral blood mononuclear cells (PBMCs) (healthy) was found to be selective. Mechanistically, 11.9% and 10.2% of A549 and MCF-7 cells treated with B-4, respectively, underwent apoptosis and B-4 produced 46% EGFR inhibition at a concentration of 10 μM. The B-4/EGFR complex obtained after induced fit docking was subjected to 300 ns of molecular dynamics simulation, which confirmed the stability of the complex in a mimicked biological environment. On the other hand, B-4 was shown to have drug-like properties by in silico pharmacokinetic estimation. Conclusions: B-4 is an EGFR inhibitor and apoptosis inducer for future NSCLC and breast cancer studies. Full article

Environmental particulate pollution is a major global environmental health risk factor, which is associated with numerous adverse health outcomes, negatively impacting public health in many countries, including China. Despite the implementation of strict air quality management policies in China and a significant reduction in PM_2.5 concentrations in recent years, the health burden caused by PM_2.5 pollution has not decreased as expected. Therefore, a comprehensive analysis of the health burden caused by PM_2.5 is necessary for more effective air quality management. This study makes an innovative contribution by integrating the Enhanced Vegetation Index (EVI), Normalized Difference Vegetation Index (NDVI), and Soil-Adjusted Vegetation Index (SAVI), providing a comprehensive framework to assess the health impacts of green space coverage, promoting healthy urban environments and sustainable development. Using Nanjing, China, as a case study, we constructed a health impact assessment system based on PM_2.5 concentrations and quantitatively analyzed the spatiotemporal evolution of premature deaths caused by PM_2.5 from 2000 to 2020. Using Multiscale Geographically Weighted Regression (MGWR), we explored the impact of greening improvement on premature deaths attributed to PM_2.5 and proposed relevant sustainable governance strategies. The results showed that (1) premature deaths caused by PM_2.5 in Nanjing could be divided into two stages: 2000–2015 and 2015–2020. During the second stage, deaths due to respiratory and cardiovascular diseases decreased by 3105 and 1714, respectively. (2) The spatial variation process was slow, with the overall evolution direction predominantly from the southeast to northwest, and the spatial distribution center gradually shifted southward. On a global scale, the Moran’s I index increased from 0.247251 and 0.240792 in 2000 to 0.472201 and 0.468193 in 2020. The hotspot analysis revealed that high–high correlations slowly gathered toward central Nanjing, while the proportion of cold spots increased. (3) The MGWR results indicated a significant negative correlation between changes in green spaces and PM_2.5-related premature deaths, especially in densely vegetated areas. This study comprehensively considered the spatiotemporal changes in PM_2.5-related premature deaths and examined the health benefits of green space improvement, providing valuable references for promoting healthy and sustainable urban environmental governance and air quality management. Full article

Vinegar, frequently distilled by solid fermentation or liquid processes, was generated through the synergistic effect of a microbial community in open or semi-open environments. Based on the studied raw materials, researchers distributed the vinegar into three classes: grain, fruit and animal, with lactic acid bacteria (LAB) playing a pivotal role in their fermentation and contributing significantly to their functional and sensory qualities. Typically, the natural maturation of fresh vinegar necessitates a long period and vast space, engendering a reduced efficiency. To accelerate the vinegar aging process, some physical methods, viz. micro-oxygenation, ozone, ultrasound, microwave, gamma rays, infrared, electric fields and high pressure, have been developed. Produced or enriched by LAB, key bioactive vinegar components are organic acids, phenolic compounds, melanoidins, and tetramethylpyrazine. These active compounds have antibacterial, antioxidant, anti-inflammatory functions; aid in the regulation of liver protection metabolism and glucose control; and have blood pressure, anti-tumor, anti-fatigue and metabolic regulatory effects. The review explores advancements in vinegar production, including modernized fermentation processes and optimized aging techniques, which enhance these beneficial compounds and ensure product consistency and safety. By examining the LAB variety strains and the bioactive profiles of different vinegar types, this study highlights vinegar’s value beyond a culinary product, as a potential therapeutic agent in human nutrition and health. The findings underscore vinegar’s relevance not only in dietary and preventive healthcare but also as a potential functional food ingredient. Further research is needed to explore the mechanisms of action through which LAB contribute to the development of several new healthy vinegars. Full article

Aging and longevity are shaped by the exposome, a dynamic network of environmental, social, and biological factors. Understanding how these exposures interact with biological mechanisms can inform strategies for healthier aging. Background/Objectives: This review explores the exposome as a dynamic system encompassing both protective and risk factors, with a specific focus on how beneficial environmental exposures, microbiome diversity, lifestyle behaviors, and resilience mechanisms contribute to successful aging. By analyzing high-longevity populations, such as the Blue Zones and Cilento, it aims to identify common determinants of successful aging. Methods: A mixed-method study was conducted, combining a systematic review of the English literature (2003–2024) with a comparative analysis of longevity regions. A structured search was performed in PubMed, Scopus, and Google Scholar using keywords such as “longevity”, “Blue Zones”, “Cilento”, “microbiome”, “environmental factors”, and related terms. Additionally, qualitative and quantitative analysis were applied to assess key protective factors across different aging models. Results: This study identified key factors contributing to successful aging in longevity hotspots, including sustained exposure to biodiverse natural environments, adherence to Mediterranean or plant-based diet rich in polyphenols and probiotics, regular physical activity, strong social networks, and psychological resilience. A novel aspect of this review is the role of the gut microbiome as a mediator between environmental exposures and immune–metabolic health, influencing inflammation modulation and cellular aging. Despite geographic and cultural differences, case studies reveal a shared pattern of protective factors that collectively enhance lifespan and healthspan. Conclusions: The exposome is a critical determinant of aging trajectories, acting through complex interactions between environmental and biological mechanisms. By integrating insights from high-longevity populations, this mixed-method study proposes a comprehensive framework for optimizing microbiome health, enhancing resilience, and promoting protective environmental exposures. These findings provide a translational perspective to guide future interventions in aging research and global health initiatives. Full article

The consumer food environment is an important medium for understanding complex interactions regarding food consumption, health outcomes and social vulnerability. We aimed to analyze the diversity, variety and quality of natural and ultra-processed foods in a Brazilian metropolis. We performed a cross-sectional study, analyzing food stores within a buffer (1600 m) area around 18 randomly selected Health Promotion Program units. We used descriptive analyses and regression models, adjusted by the area’s population, to examine associations of consumer food environment variables with the health vulnerability (HVI) of the territory and store type. Low HVI areas had higher fruits and vegetables variety adequacy and better quality, when compared to medium and high/very high HVI areas (p-value < 0.001 and p-value = 0.001). Supermarkets in low HVI areas had almost twice the prevalence of adequate vegetable variety (65.2% vs. 33.3% in high/very high HVI areas, p-value = 0.005). Adjusted by population, areas with high/very high HVI had lower odds of adequate fruit variety when compared to low HVI areas (OR = 0.06; CI 95% = 0.01–0.44; p-value = 0.006). Although consumer preference is important in food acquisition, disparities in quality, diversity and variety within the consumer food environment could lead to difficulties in access to healthy options for vulnerable populations. Full article

Iron uptake plays an important role in the persistence of Escherichia coli in the host and for its survival in the environment, and it is known that E. coli has a variety of siderophore systems for iron uptake. We investigated the ability to produce siderophores, the genetic diversity of the siderophores and their correlation with virulence-associated genes (VAGs), phylogroups and bacteriocin production in E. coli strains isolated from different sources: uropathogenic E. coli (UPEC) from urine of patients with urinary tract infections, avian pathogenic E. coli (APEC) from organs of birds with signs of colibacillosis, fecal E. coli (FEC) from feces of healthy cattle and E. coli from organic fertilizers based on poultry and cattle manure (OFEC). A high variability in siderophore production was found among the UPEC strains studied, while the OFEC strains showed the highest siderophore production among all groups. Genes for aerobactin and yersiniabactin receptors were most frequently found in the UPEC strain, followed by the APEC, FEC and OFEC strains. The greatest diversity of siderophore receptors was found in the APEC strain. We also found that iutA-positive E. coli isolated from animals contained more VAGs than iutA-negative strains. The profiles of the siderophore genes of APEC and OFEC from poultry manure were very similar, indicating that APEC can be transmitted via organic fertilizers, suggesting that poultry manure is an environmental risk. The data obtained complement the information on the prevalence of siderophore producers and contribute to our knowledge on the biodiversity of E. coli pathotypes. Full article

This paper introduces a fatigue detection model specifically designed for immersive virtual reality (VR) environments, aimed at facilitating upper limb rehabilitation for individuals with spinal cord injuries (SCIs). The model’s primary application centers on the Box-and-Block Test, providing healthcare professionals with a reliable tool to monitor patient progress and adapt rehabilitation routines. At its core, the model employs data fusion techniques via ordered weighted averaging (OWA) operators to aggregate multiple metrics captured by the VR rehabilitation system. Additionally, fuzzy logic is employed to personalize fatigue assessments. Therapists are provided with a detailed classification of fatigue levels alongside a video-based visual representation that highlights critical moments of fatigue during the exercises. The experimental methodology involved testing the fatigue detection model with both healthy participants and patients, using immersive VR-based rehabilitation scenarios and validating its accuracy through self-reported fatigue levels and therapist observations. Furthermore, the model’s scalable design promotes its integration into remote rehabilitation systems, highlighting its adaptability to diverse clinical scenarios and its potential to enhance accessibility to rehabilitation services. Full article

Background: A high-quality diet is linked to cardiometabolic risk reduction. Culinary medicine interventions are effective in improving nutrition and health outcomes. While personalized nutrition is usually related to improving patient outcomes through knowledge about gene-nutrient interactions, tailoring interventions based on participant motivation and biopsychosocial environment may improve outcomes. The stage of change framework categorized participants based on current behaviors and intentions for future behaviors. Our goal was to assess participant perceptions regarding accomplishments, challenges, and needs up to one year following a culinary medicine program according to their stage of change at entry. Methods: Participant perceptions were collected at (1) the intervention end (open-ended questionnaire), (2) six months (semi-structured interview), and (3) twelve months (open-ended questionnaire). Analysis was performed inductively following a thematic analysis approach. Results: Twenty-four participants completed 70 perspectives (58/12 from participants who entered at a contemplation/action stage of change). Perceptions were related to (1) acquire culinary and nutritional knowledge: improve knowledge about healthy nutrition, use new recipes, and ask for hands-on cooking classes; (2) improve culinary and self-regulatory skills: improve confidence in the kitchen, expand cooking skills, organizing and planning, and creativity and pleasure; (3) adopt home cooking and healthy nutrition: adopt home-cooking habits, spreading home cooking to other family members, improve nutrition habits throughout the day, and decrease consumption of ultra-processed food; and (4) address the sustainability of health changes: achievements in maintaining long-term health changes, challenges in maintaining long-term health changes, and facilitators for a long-term change. Conclusions: These results provide one-year-long information about participant facilitators, barriers, and needs for making home-cooking changes categorized to the participant stage of change at program entry. This information can help reform effective personalized culinary medicine programs. Full article

Background/Objectives: Nurses’ workplaces are critical to both the levels and types of care nurses can deliver as well as to employee retention. The quality of the workplace environment is a significant predictor of employment outcomes, such as improved care and a decrease in nurses’ desire to leave their work. Moreover, a favourable work environment can significantly improve organisational performance. A healthy nursing workplace is a safe, empowering, and fulfilling place of employment in which all healthcare personnel work tirelessly for patients’ optimal health and wellness. The aim of this study is to identify the association between workplace environment and work engagement among nurses in clinical settings. Methods: A descriptive cross-sectional correlational design was used. Convenience sampling was used to recruit 349 nurses from various hospitals in the central northern region of Saudi Arabia. A four-part electronic questionnaire eliciting information on participants’ sociodemographic characteristics, job characteristics, work-related quality of life (WRQoL), and work engagement was collected. All ethical guidelines for scientific research on human beings were strictly followed. Results: The participants had average levels of WRQoL. However, they had generally moderate to high levels of work engagement, which reflects their moderate to low intention to leave work. The findings demonstrated a statistically significant positive link between the WRQoL and work engagement of the participants. Conclusions: When the nurses’ WRQoL improved, their work engagement increased significantly. Improving WRQoL will almost definitely enhance nurses’ work engagement, which will reduce nurses’ intentions to leave their employment. It is advised that nurses enhance their WRQoL in order to increase their engagement in the workplace, have fewer thoughts about leaving, and make fewer plans to leave. Full article

Floating wind turbines (FWTs) operate in offshore environments under harsh and varying operating conditions, making frequent in situ monitoring dangerous for maintenance teams and costly for operators. Remote and automated diagnosis, including the stages of detection, identification, and severity characterization of early stage damages in FWTs through advanced vibration-based structural health monitoring (SHM) methods of the machine learning (ML) type, is evidently critical for timely repairs, extending their operational lifecycle, reducing maintenance costs, and enhancing safety. This study investigates, for the first time, the complete (all stages) damage diagnosis problem by employing well-established ML SHM methods and conducting hundreds of experiments on a lab-scale FWT model operating under different wind speeds and directions, both in healthy and damaged states. The latter include two distinct blade cracks of limited length, two added masses attached to the blade edge simulating possible accumulation of ice, and connection degradation at the mounting of the main tower with the floater. The results indicate that the proper training of advanced ML methods using damage-sensitive feature vectors that represent the structural dynamics within the entire frequency bandwidth of measurements may achieve flawless damage diagnosis, reaching $100\%$ success at all diagnosis stages, even when only a minimal number of vibration signals from a limited number of sensors (a single sensor in this study) are used. Full article