Search Results (775)

China aims for high-quality development by balancing energy use and economic growth, leveraging digital infrastructure to foster a resource-efficient, eco-friendly society and boost economic progress. In this context, by using panel data from 279 Chinese cities spanning 2006‒2021, this study employs a multi-phase difference-in-differences (DID) technique to disclose how the Broadband China Pilot Policy (BCPP) affects energy consumption. The results reveal that the BCPP can greatly lower urban energy consumption, which is further validated by robustness tests, including PSM-DID estimation, Bacon decomposition, and placebo testing. Heterogeneity testing shows the BCPP significantly lowers energy consumption in large, eastern, non-resource-based, and high-digital inclusive finance cities compared to smaller, western, resource-based, and low-digital inclusive finance cities. Furthermore, the mechanism analysis indicates that the BCPP contributes to decreased urban energy use by transforming the industrial structure, enhancing financial growth, and improving green technology innovation. To effectively harmonize energy consumption with urban development, it is recommended to accelerate the advancement of digital infrastructure, tailor the industrial structure to meet local needs, and promote greater financial and green innovation development. Full article

Agricultural digitization is crucial for enhancing agricultural productivity and efficiency and promoting green low-carbon development. Based on the provincial panel data of China from 2012 to 2021, this study employs the entropy value method and the GML index based on SBM-DDF to quantify agricultural digitization and agricultural green total factor productivity. It utilizes two-way fixed effects, group regression, and threshold effect models to examine the influence of agricultural digitization in agriculture on the green and carbon-reduction progression of farming practices, as well as to clarify the underlying mechanisms behind these effects. The study finds that agricultural digitalization significantly promotes agricultural green low-carbon development. Green innovation and scale operation mediate the impact path of agricultural digitalization, and there is a threshold effect of digital financial inclusion. Moreover, agricultural digitization has a significant impact on the eastern region and a smaller impact on the central and western areas, and the effect is better in regions with high levels of innovation. The results of the study provide a scientific basis for the synergizing of agricultural digitization and agricultural development that is green and low-carbon, as well as for the construction of relevant subjects for interest cooperation and sharing mechanisms. Full article

This study examines the barriers to implementing sustainable mobility strategies in small municipalities by integrating participatory and multi-criteria decision-making methods. A triangulated approach combines the nominal group technique (NGT), focus groups (FGs), and the fuzzy analytic hierarchy process (FAHP) to systematically identify, refine, and rank key barriers. The NGT enables stakeholders to list and prioritize barriers individually, ensuring balanced participation. FG discussions then refine and contextualize these barriers, addressing qualitative depth. Finally, the FAHP quantitatively ranks the barriers while accounting for uncertainty in stakeholder judgments. The results highlight systemic constraints, such as financial limitations and regulatory inefficiencies, alongside local challenges like inadequate infrastructure and public resistance. Integrating the NGT, FGs, and the FAHP enhances the analytical rigor by merging structured decision-making with participatory engagement. This methodological innovation strengthens the reliability of barrier assessment and offers a replicable framework for urban mobility planning. The findings underscore the need for locally tailored strategies that balance stakeholder inclusion with structured prioritization, contributing to improved governance in sustainable transport planning. Full article

This article offers a clear and approachable introduction to the evolving landscape of money and the frictions developing between traditional government control and decentralized finance (DeFi). Tailored for readers with a basic awareness of cryptocurrency but limited familiarity with its broader implications, the article demystifies DeFi by explaining its core concepts including blockchain, Centralized Bank Digital Currencies (CBDCs), and the historical role of government regulation of money through central banking. Against this backdrop, it examines the transformative potential of DeFi, emphasizing the growing tension between the centralized authority of governments and the decentralized ideals driving this new financial model. While governments seek to maintain stability and control, individuals increasingly gravitate toward the more affordable, efficient, and inclusive solutions promised by DeFi. Designed to empower readers with a better grasp of the forces shaping the future of finance, this article underscores the importance of understanding the delicate interplay between governmental oversight and decentralized innovation. As the digital economy expands, this dynamic struggle will influence not only economic policies but also personal financial choices and access to resources. Full article

Early-onset sepsis (EOS) remains a major cause of neonatal morbidity and mortality worldwide, with significant differences in the incidence and outcome of the disease in Europe. Eastern European countries face particular challenges due to differences in access to healthcare, diagnostic facilities, and prevention strategies. This review summarizes the results of recent research to provide insights into maternal risk factors, regional inequalities in access to healthcare, diagnostic biomarkers, pathogen patterns, and treatment protocols for EOS. This review also examines how healthcare infrastructure and socioeconomic factors influence EOS outcomes in Eastern Europe. Introduction: Early-onset sepsis (EOS) presents a significant health challenge for newborns, characterized by sepsis occurring within the first 72 h of life, primarily caused by the vertical transmission of pathogens from mother to child. Despite advancements in medical care, EOS remains particularly burdensome in resource-poor settings, especially in Eastern Europe, where disparities in healthcare access and maternal health are pronounced. This systematic review aims to provide insights into maternal risk factors, regional inequalities in healthcare access, diagnostic biomarkers, pathogen patterns, and treatment protocols for EOS. Background/Objectives: EOS is increasingly recognized as a public health issue, with outcomes significantly influenced by maternal health, socioeconomic status, and healthcare infrastructure. The review seeks to summarize the existing literature on EOS, particularly focusing on differences between high-income Western and low-resource Eastern European countries. The influence of maternal access to antenatal care, pathogen prevalence, and antibiotic resistance on EOS outcomes across regions will also be examined. Methods: To achieve the review’s objectives, a comprehensive search was conducted across multiple databases including PubMed, Google Scholar, ScienceDirect, and Scopus, adhering to PRISMA guidelines for systematic reviews. The inclusion criteria encompassed studies published within the last 20 years (January 2004–August 2024) that addressed EOS in late preterm or term infants, emphasizing maternal health, risk factors, diagnostic approaches, and treatment protocols pertinent to European populations. Exclusion criteria included non-English publications and studies lacking a focus on maternal and neonatal health. A total of 29 peer-reviewed articles meeting the specified criteria were ultimately included in the analysis. Results: The findings highlight significant regional disparities in EOS management between Western and Eastern Europe. Key issues include maternal risk factors, socioeconomic barriers to healthcare, diagnostic biomarkers, and pathogen resistance trends. Limited access to prenatal screenings and healthcare infrastructure in Eastern European countries, especially in rural regions in Romania, exacerbate the challenges faced by expectant mothers. Financial burdens, such as high out-of-pocket expenses, were shown to further restrict access to necessary maternal care. Conclusions: This systematic review emphasizes the urgent need for targeted investments in maternal healthcare infrastructure in Eastern Europe to mitigate the impacts of EOS. Enhanced screening programs, standardized surveillance systems, and ensuring equitable health policies are essential to improving neonatal outcomes. Additionally, tailored education and awareness campaigns for disadvantaged groups and comprehensive health policy reforms, including universal antenatal care and Group B Streptococcus (GBS), are essential to bridging healthcare gaps. Full article

Background: We examined four potential challenges for the implementation of the European Union (EU) Regulation 2021/2282 on Health Technology Assessment (EU HTAR): interaction with the European Medicines Agency (EMA), expert input, the interface of European health technology assessment (EU HTA) joint procedures with those within Member States, and the management of conflict of interest. This research aims to explore how to address these challenges in a balanced manner and prioritise key actions for effective collaboration in the context of the EU HTA. Methods: The methodology included a pre-convention survey among relevant stakeholders as well as working groups and the plenary ranking of discussion outcomes at the European Access Academy (EAA) Spring Convention 2024. Results: In the survey, 65.5% of respondents indicated that experts are currently not sufficiently included in the upcoming joint scientific consultations and clinical assessments; only 37.9% suggested that the EU HTA joint procedures would accelerate national appraisal decision-making, and 58.6% believed that the principles of ‘transparency’ and ‘competency’ are balanced in the EU HTA position on conflict of interest. The top priority action points identified in the working groups were the involvement of the best available expertise, the early and inclusive involvement of experts, strengthened early scientific dialogue, and the fostering of the political willingness/financial support of EU Member States to increase capacities. Conclusions: The key topics identified were an approach to conflict of interest that balances transparency obligations and the need for expertise, strengthens the involvement of clinical and patient experts, intensifies early interaction between the EMA and EU HTA, and increases the involvement of the EU Member States. Full article

The issue of farmers’ income is a widespread concern in countries worldwide, and the Chinese government has always prioritized promoting the sustainable growth of farmers’ income. The development of digital financial inclusion provides a new opportunity for farmers’ income to achieve sustainable growth. With the implementation of digital financial inclusion, whether it can effectively promote farmers’ income growth deserves in-depth study. Based on the panel data from 30 provinces in China from 2011 to 2021, this study uses a dual fixed effects model to empirically analyse the impact of digital inclusive finance on farmers’ income and further analyses the impact of various dimensions of digital financial inclusion on farmers’ income. From a policy perspective, the DID (difference in differences) method is used to analyse, in general, the impact of the implementation of digital financial inclusion policies on farmers’ income and, in particular, the impact of such inclusion on farmers’ income from the perspective of income structure. The results of this study show that digital financial inclusion can significantly promote farmers’ income growth. The dimensions of the breadth of coverage and depth of use can significantly contribute to the increase in farmers’ income, whereas digitization has a negative effect on this increase. Furthermore, the DID results show that digital financial inclusion policy implementation has a significantly positive effect on farmers’ income growth, that is, it can significantly contribute to their wage income, can contribute to family operating income but at a low level of significance, and does not significantly contribute to their property income. Moreover, regional heterogeneity analysis demonstrates that the marginal contribution of digital financial inclusion to the growth of farmers’ income in the eastern region is less than that in the central and western regions. Therefore, the development of digital inclusive finance in rural areas should be vigorously promoted in order to provide high-quality financial services and achieve sustainable growth in farmers’ incomes. Full article

The advancement of digital technologies has become a transformative driver of economic development. Digitalisation is central to the global economy, enhances productivity, drives innovation, and promotes inclusive growth. Despite this potential, South Africa faces persistent challenges such as skills shortages, unemployment, poverty, and socioeconomic inequality. This study investigates the role of digitalisation in advancing economic complexity, human capital development, and gross national income in South Africa. A digitalisation index, constructed through Principal Component Analysis, ARDL models, and Granger causality analysis, provides insights into the short- and long-term impacts and causal relationship. The findings reveal that digitalisation and education significantly enhance human capital development in the long run, with digital infrastructure also driving immediate gains. For the gross national income model, digitalisation and education pose short-term pressures due to development expenditures, while institutional quality plays an important role in sustaining income. Economic complexity benefits positively from digitalisation over the long term, though short-term impacts stress the role of governance quality and infrastructure. Causality analysis further shows the interconnectedness of these variables, with digitalisation advancing economic complexity and human capital driving national income, reinforcing digitalisation. The results call for policies that align short-term developmental priorities with long-term sustainability. Investments in digital infrastructure, accessible education, and institutional frameworks are critical for building a skilled labour force while enhancing economic complexity and maintaining financial stability. Full article

Climate change has a significant impact on the population’s health and negatively affects the functioning of healthcare systems. Health systems must be operationally prepared to handle the challenges posed by environmental change. Resilience is required to adapt quickly to critical environmental conditions and reduce carbon emissions. In this systematic review strategies, for health system preparedness and resilience are examined to address the impacts of climate change, and the barriers and challenges faced when implementing them. To identify studies, the Scopus, PubMed and Google Scholar databases were searched three times (from April to October 2024, 21 April, 15 June, and 9 September) for the years 2018 to 2024, using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) methodology. Specifically, the search identified 471 articles, of which the specified inclusion and exclusion criteria (secondary studies with inclusion criteria, being in English, etc.) were met by sixteen (16) studies. According to the findings of the studies reviewed, adaptation strategies focus on structural changes, the development of training programs, the development of surveillance systems, and appropriate operational plans. The leader’s ability to motivate employees to achieve defined goals, continuous evaluation of goals and interventions, and learning from previous disasters play an important role in their implementation. Similarly, key policies and strategies for mitigation include the adoption of sustainable practices, such as recycling and cultural change. However, lack of resources (human, material, financial) and increased demand for health services make it difficult to implement adaptation and mitigation strategies. The findings of the review are mainly theoretical in nature and are confirmed by other studies. It is suggested that further research on resilience and preparedness of health systems should be pursued, leading to their sustainability and the formulation of appropriate policies. Full article

Active travel modes, such as walking and cycling, are essential for fostering sustainable urban transportation. However, their adoption in environmentally challenging areas—characterised by steep slopes, extreme weather, and rugged terrain—presents significant obstacles. This study addresses these challenges by conducting a systematic literature review of studies published between 2000 and 2024 to identify strategies that promote active travel in such contexts. Using a structured five-step methodology, 62 relevant articles were selected and analysed to explore common challenges and propose tailored solutions. The findings highlight critical barriers, including topographical difficulties, harsh climatic conditions, and adverse weather, all of which hinder walking and cycling. To address these barriers, this study identifies a range of solutions, including infrastructure enhancements such as bike lifts, e-bike systems, shaded walkways, and heated pavements, as well as policy measures like financial incentives and disincentive regulations. Importantly, this study makes a deliberate effort to avoid overgeneralised solutions by emphasising the need for interventions that are context-sensitive and tailored to specific environmental challenges, urban scales, and local conditions. By providing options for actionable strategies, this research offers a comprehensive foundation for developing inclusive and sustainable policies that encourage active travel in diverse and environmentally constrained urban settings. Full article

Prescription digital therapeutics (PDTs) are emerging as a pivotal component of digital healthcare, providing software-based therapies for various diseases. This review aims to analyze the regulatory landscape in the U.S., safety, efficacy, and current challenges of PDTs, focusing on mental health conditions. Relevant articles were searched on PubMed, Google Scholar, ClinicalTrials.gov, and FDA Guidance Documents databases, supplemented by manual searches of reference lists from included studies. Inclusion criteria covered English-language studies on the development and application, therapeutic efficacy, and regulatory guidelines of PDTs in mental health. Data extraction and synthesis were conducted to summarize key findings and trends in the literature. FDA regulatory frameworks for PDTs are evolving through pathways of de novo and 510(k) applications, with patient-centric guidance. Clinical trials and real-world data support PDTs’ safety and efficacy, while highlighting regulatory needs. Challenges include payer coverage, patient accessibility, and data privacy concerns. Mixed patient feedback reveals areas for improvement. Limited healthcare provider engagement and payer coverage contributed to financial challenges for PDT manufacturers. Future trends suggest that PDTs will expand beyond mental health. The evolving landscape underscores the need for continued research, regulatory refinement, and collaborative efforts across stakeholders to ensure the successful integration of PDTs into healthcare. Full article

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by persistent deficits in social communication and interaction, along with restricted and repetitive patterns of behavior, interests, or activities. ASD encompasses a wide spectrum of clinical presentations and functional impairments, ranging from mild to severe. Despite its prevalence, the underlying physiopathological mechanisms of ASD remain largely unknown, resulting in a lack of effective targeted therapeutic interventions, contributing to significant financial and emotional burdens on affected families and the healthcare system. Emerging evidence suggests that dysfunction in the tetrahydrobiopterin (BH4) pathway may impair the activity of monoaminergic and nitric oxide (NO)-dependent neurons in individuals with ASD. To explore this potential mechanism, we conducted a systematic review to analyze such impairments to gather information on whether the off-label use of BH4 could represent a novel pharmacological approach for managing ASD. Following the PRISMA 2020 guidelines, we systematically reviewed the literature from four databases: PubMed, Virtual Health Library, Cochrane Library, and SciELO, from January 1967 to December 2021. The quality of the included studies was assessed using the Newcastle–Ottawa scale. The inclusion criteria for this systematic review focused on identifying articles published in English that contained the following keywords, used in various combinations: autism, ASD, autism spectrum disorder, BH4, tetrahydrobiopterin, neopterin, NO, nitric oxide. The analysis was performed between December 2020 and December 2021. The collected data demonstrated that BH4 metabolism was altered in individuals with ASD. Lower levels of BH4 were reported in biological samples from ASD-affected individuals compared to age- and sex-matched controls. Additionally, neopterin levels were elevated in plasma and urine, but decreased in cerebrospinal fluid, while nitric oxide levels were consistently reported to be higher across studies. Treatment with BH4 has shown potential in improving ASD-related symptoms. The reported increase in neopterin in biological fluids indicates inflammation, while the reduction in BH4 levels suggests a potential shift in its metabolic role. Specifically, BH4 may be diverted from its primary role in neurotransmitter synthesis to function as an antioxidant or to perpetuate inflammation through NO production. Given that BH4 is a critical cofactor in monoaminergic neurotransmission, its dysfunction highlights the molecule’s therapeutic potential. BH4, already FDA-approved for other conditions, emerges as a promising off-label candidate to alleviate ASD symptomatology. Full article

International market openness has long been regarded as critical for economic development, and recent evidence highlights the distinct roles of financial and trade openness, particularly in emerging and developing economies. This study examines the impact of financial and trade openness on economic growth in ten emerging and developing countries from 1970 to 2023. It employs a dynamic panel generalized method of moments (GMM) model, which is selected for its ability to address potential endogeneity and dynamic relationships within panel data. The analysis finds that both financial and trade openness positively influence economic growth and that stable macroeconomic conditions and political stability enhance these growth-promoting effects. In the context of growing geo-economic tensions, trade fairness, and national security concerns, the study underscores the need for policies that balance global integration with national interests. These findings suggest the importance of designing policies that promote greater integration into global financial and trading systems while ensuring sound macroeconomic fundamentals and supportive institutions. The study recommends that policymakers pursue strategic liberalization and strengthen governance structures to achieve sustained and inclusive growth. Full article

The financial technology domain has undertaken significant strides toward more inclusive credit scoring systems by integrating alternative data sources, prompting an exploration of how we can further simplify the process of efficiently assessing creditworthiness for the younger generation who lack traditional credit histories and collateral assets. This study introduces a novel approach leveraging social media analytics and advanced machine learning techniques to assess the creditworthiness of individuals without traditional credit histories and collateral assets. Conventional credit scoring methods tend to rely heavily on central bank credit information, especially traditional collateral assets such as property or savings accounts. We leverage demographics, personality, psycholinguistics, and social network data from LinkedIn profiles to develop predictive models for a comprehensive financial reliability assessment. Our credit scoring methods propose scoring models to produce continuous credit scores and classification models to categorize potential borrowers—particularly young individuals lacking traditional credit histories or collateral assets—as either good or bad credit risks based on expert judgment thresholds. This innovative approach questions conventional financial evaluation methods and enhances access to credit for marginalized communities. The research question addressed in this study is how to develop a credit scoring mechanism using social media data. This research contributes to the advancing fintech landscape by presenting a framework that has the potential to transform credit scoring practices to adapt to modern economic activities and digital footprints. Full article

Portugal’s renewable energy transition plays a pivotal role in addressing climate change, enhancing energy security, and promoting sustainable development. This study examines the socio-economic impacts of renewable energy policies in Portugal from 2014 to 2022, with a focus on financial performance, employment trends, and gender equity. Utilizing financial assessments from the Orbis database and input–output analysis, the research examines three companies—EDP, E-Redes, and Logical Gravity—classified under NACE Rev. 2 code 3513. The study finds that investments in renewable energy improved profitability and solvency, especially during recovery phases, reflecting the sector’s financial resilience. Larger firms like EDP experienced employment growth, while smaller firms faced more volatility, highlighting the need for targeted support. Despite progress, gender disparities and pay gaps persist, underscoring the need for gender-sensitive policies. This research provides valuable insights for policymakers seeking to ensure a just and sustainable energy transition, emphasizing strategic investments, workforce adaptation, and inclusivity. Full article