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Search Results (1,241)

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Keywords = early childhood development

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16 pages, 1718 KiB  
Article
Braiding Sámi Diversity and Sámi Pedagogy into Early Childhood Teacher Education: An Example from Norway
by Greta Heim and Veronica Bergan
Educ. Sci. 2024, 14(11), 1212; https://doi.org/10.3390/educsci14111212 - 4 Nov 2024
Viewed by 545
Abstract
The framework plan for kindergartens in Norway emphasizes knowledge of Indigenous Sámi culture among the core values of pedagogical practice. Preservice students in early childhood teacher education (ECTE) are thus obliged to learn about Sámi culture. We explored and developed collaborative teaching interventions [...] Read more.
The framework plan for kindergartens in Norway emphasizes knowledge of Indigenous Sámi culture among the core values of pedagogical practice. Preservice students in early childhood teacher education (ECTE) are thus obliged to learn about Sámi culture. We explored and developed collaborative teaching interventions for Sámi topics. We aimed to “braid” Sámi diversity into our teaching and make the lessons explorative, practical, and student-active, in line with the basics of Sámi pedagogy. The teaching emphasized how Sámi people were historically connected to the land through sustainable livelihoods and respect for natural resources. We developed the teaching interventions through action-based research in three cycles (2022–2024). Our primary material consisted of students’ responses to online surveys and group interviews. The findings show that students gained a broader understanding of diversity within Sámi culture after the interventions. They reported greater interest and better learning outcomes, especially from the active and practical lessons. The Sámi teaching content, structure, and methods explored in this study may be relevant to other ECTE or other teacher education programs, especially those related to teaching Indigenous topics to majority populations. Full article
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<p>Sápmi (the land of the Sámi people), which includes northern parts of Norway, Sweden, Finland, and the Kola Peninsula in Russia (highlighted in blue).</p>
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<p>Overview of the action-based research on teaching content (red, yellow, and green) and collection of data (light blue) from different student groups in 2022, 2023, and 2024. The teaching sessions are marked in boxes: “Sámi land areas and genealogy” (second author, red), “Sámi food culture” (first author, yellow), and “learning by googling (LBG)” (second author, green).</p>
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<p>Students’ responses to questionnaire items (<span class="html-italic">y</span>-axis) rated on a five-point Likert scale indicating their self-reported degree of (<b>A</b>) increased understanding of Sámi diversity, (<b>B</b>) increased interest in Sámi culture, (<b>C</b>) the importance of the teaching interventions, and (<b>D</b>) the importance of self-effort. The results (<span class="html-italic">x</span>-axis) are shown as percentages of students (2022: <span class="html-italic">n</span> = 23; 2023: <span class="html-italic">n</span> = 20; 2024: <span class="html-italic">n</span> = 7). (<b>A</b>,<b>B</b>) shows the students’ evaluations of the teaching content, while (<b>C</b>,<b>D</b>) provides information about the teaching methods.</p>
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<p>Overall changes that aimed to braid and strengthen (<span class="html-italic">nannet</span>) Sámi diversity and pedagogy in our teaching interventions.</p>
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14 pages, 692 KiB  
Article
Characteristics of Children with an Undesirable Motor Competence Development During the Transition from Early to Middle Childhood: Results of a 2-Year Longitudinal Study
by Pim Koolwijk, Ester de Jonge, Remo Mombarg, Teun Remmers, Dave Van Kann, Ingrid van Aart, Geert Savelsbergh and Sanne de Vries
Int. J. Environ. Res. Public Health 2024, 21(11), 1460; https://doi.org/10.3390/ijerph21111460 - 31 Oct 2024
Viewed by 410
Abstract
Objective: Motor competence development from early to middle childhood is accompanied by great variance. This course can be influenced by many factors in the ecosystem. The objective of this study was to examine which individual characteristics are associated with an undesirable motor competence [...] Read more.
Objective: Motor competence development from early to middle childhood is accompanied by great variance. This course can be influenced by many factors in the ecosystem. The objective of this study was to examine which individual characteristics are associated with an undesirable motor competence development during the transition from early to middle childhood. Methods: A longitudinal study was conducted between February 2020 and May 2022. Actual and perceived motor competence and the potential determinants physical activity enjoyment, weight status, and organized sports participation of children (49% boys) aged 4–6 years old at T0 (N = 721) were measured at two points in time, separated by a two-year interval. Associations between potential determinants and AMC, including interactions with time, were analyzed using linear mixed-effect regression models with continuous motor quotient scores as outcome variables. Results: Overweight, obesity, and lack of organized sports participation were associated with lower motor quotient scores over time. Multivariate analyses showed that associations of weight status (overweight and obesity) and sports participation with motor quotient scores remained significant after adjustment for variations in perceived motor competence and physical activity enjoyment. Conclusions: Excessive body weight and lack of sports participation from early childhood are associated with an increased risk of an undesirable motor competence development over time. Full article
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<p>Univariate and multivariate associations of measured determinants: weight status (overweight and obesity), PMC (LOC and OC skills), sports participation, and enjoyment of PA, with the MQ scores. For each determinant, positive regression coefficients (β) reflect associations with higher MQ score and therefore a higher motor competence, whereas negative regression coefficients reflect associations with lower MQ scores. Regression coefficients (and confidence intervals) of the fixed effects represent differences in MQ scores between specified determinant and the reference category.</p>
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16 pages, 2351 KiB  
Review
COVID-19 and Its Potential Impact on Children Born to Mothers Infected During Pregnancy: A Comprehensive Review
by Cristiana Stolojanu, Gabriela Doros, Melania Lavinia Bratu, Iulia Ciobanu, Krisztina Munteanu, Emil Radu Iacob, Laura Andreea Ghenciu, Emil Robert Stoicescu and Mirabela Dima
Diagnostics 2024, 14(21), 2443; https://doi.org/10.3390/diagnostics14212443 - 31 Oct 2024
Viewed by 291
Abstract
Pregnancy is a vulnerable period of time during which pregnant people are prone to infections like COVID-19, which can increase risks for both the mother and fetus. These infections may lead to complications such as preterm birth, developmental delays, and congenital abnormalities. While [...] Read more.
Pregnancy is a vulnerable period of time during which pregnant people are prone to infections like COVID-19, which can increase risks for both the mother and fetus. These infections may lead to complications such as preterm birth, developmental delays, and congenital abnormalities. While COVID-19 poses additional risks like placental dysfunction and neonatal infections, studies on long-term effects remain limited. Ongoing research and monitoring are essential to understand and mitigate potential cognitive and developmental challenges in children born to mothers infected with COVID-19. This review aims to guide clinicians in managing these risks throughout childhood. Maternal COVID-19 infection during pregnancy can have significant implications for fetal development, even if the newborn is not infected at birth. The release of inflammatory cytokines may cross the placental barrier, potentially disrupting fetal brain development and increasing the risk of long-term cognitive and behavioral issues, such as ADHD or autism. Placental dysfunction, caused by inflammation or thrombosis, can lead to intrauterine growth restriction (IUGR), preterm birth, or hypoxia, affecting both neurological and respiratory health in newborns. Furthermore, a compromised fetal immune system can increase susceptibility to autoimmune conditions and infections. The early diagnosis and management of infections during pregnancy are crucial in mitigating risks to both the mother and fetus. Swift intervention can prevent complications like preterm birth and long-term developmental challenges, ensuring better health outcomes for both the mother and child. Long-term monitoring of children born to mothers infected with COVID-19 is necessary to understand the full extent of the virus’s impact. This review evaluates the long-term systemic effects of maternal COVID-19 infection during pregnancy on fetuses, newborns, and children, focusing beyond vertical transmission. It highlights the broader impacts on fetal development, offering insights to help clinicians manage potential issues that may arise later in life. Full article
(This article belongs to the Special Issue Diagnosis and Management in Prenatal Medicine, 3rd Edition)
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<p>Algorithm for the literature search.</p>
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<p>VOSviewer map and the study directions.</p>
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<p>The main possible repercussions of maternal COVID-19 in the newborn.</p>
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17 pages, 273 KiB  
Article
Supporting Young Children’s Self-Regulation Through Nature-Based Practices in Preschool
by Julie Ernst and Hannah Stelley
Behav. Sci. 2024, 14(11), 1013; https://doi.org/10.3390/bs14111013 - 31 Oct 2024
Viewed by 355
Abstract
Self-regulation is a crucial skill in early childhood, due to its influence on school readiness and success, as well as its foundational role in promoting wellbeing across the lifespan. Additionally, self-regulation is malleable, particularly during early childhood. This study investigated the impact of [...] Read more.
Self-regulation is a crucial skill in early childhood, due to its influence on school readiness and success, as well as its foundational role in promoting wellbeing across the lifespan. Additionally, self-regulation is malleable, particularly during early childhood. This study investigated the impact of nature-based practices on preschoolers’ self-regulation. The Preschool Self-Regulation Assessment (PSRA) and PSRA Assessor Report were administered to 115 children from nine preschool programs at the beginning and end of the school year. While further research is needed, results suggest the potential for nature-based practices to support SR, in particular hot executive function, and particularly in children from lower socio-economic backgrounds in public preschool. This study contributes to the literature regarding effective practices for supporting self-regulation development in young children and adds to the growing body of research surrounding the impact of nature play on child development and school readiness. Full article
20 pages, 1017 KiB  
Review
Oxidative Stress and Antioxidants in Pediatric Asthma’s Evolution and Management
by Ileana Katerina Ioniuc, Ancuta Lupu, Felicia Dragan, Irina Tarnita, Monica Mihaela Alexoae, Violeta Streanga, Costica Mitrofan, Aye Aung Thet, Alin Horatiu Nedelcu, Delia Lidia Salaru, Stefan Lucian Burlea, Elena Cristina Mitrofan, Vasile Valeriu Lupu and Alice Nicoleta Azoicai
Antioxidants 2024, 13(11), 1331; https://doi.org/10.3390/antiox13111331 - 31 Oct 2024
Viewed by 453
Abstract
Within the pediatric population, bronchial asthma is one of the most prevalent chronic respiratory system diseases. The number of exacerbations, severity, and duration of symptoms all have a significant impact on children’s life quality. In the last decades, the prevention and management strategies [...] Read more.
Within the pediatric population, bronchial asthma is one of the most prevalent chronic respiratory system diseases. The number of exacerbations, severity, and duration of symptoms all have a significant impact on children’s life quality. In the last decades, the prevention and management strategies of this pathology have focused on maintaining or even increasing the pulmonary function to maximum levels in early childhood, as it has been demonstrated that functional deficits at this level occurring before school age cause pathological manifestations later, in adulthood. The epithelium of the airways and implicitly that of the lung is the first barrier against the lesions caused by pro-oxidative factors. Both oxidative and antioxidative factors can be of endogenous origin (produced by the body) or exogenous (from the environment or diet). Good functioning of antioxidant defense mechanisms from the molecular level to the tissue level, and a balance between pro-oxidative factors and anti- oxidative factors, influence the occurrence of compensatory mechanisms at the level of the respiratory epithelium, causing the delay of local responses to the stress induced by chronic inflammation (bronchial remodeling, thickening of airway smooth muscles, bronchoconstriction, bronchial hyper-reactivity). These mechanisms underlie the pathophysiological changes in asthma. Numerous studies carried out among the pediatric population inclusively have demonstrated the effectiveness of antioxidants in the prophylaxis, slowing down and preventing the progression of this pathology. This review complements the scientific articles, aiming at emphasizing the complexity of oxidative physio-pathological pathways and their importance in the occurrence, development, and therapeutic response in asthma, providing a good understanding of the relationship between oxidative and antioxidative factors, and being a source of future therapeutic strategies. Full article
(This article belongs to the Special Issue Oxidative-Stress in Human Diseases—3rd Edition)
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<p>The main molecules involved in antioxidant defense: SOD—superoxide dismutase; MPO—myeloperoxidase; GPX—glutathione peroxidase; NAC—N-acetylcysteine; Nrf2—Erythroid 2 Nuclear factor; NO—nitric oxide; iNO—inducible form of NO.</p>
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<p>Dietary antioxidants.</p>
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15 pages, 742 KiB  
Systematic Review
Trauma-Based Sexually Dimorphic Changes in the Connectome and Its Association with Central Sensitization Syndromes—A Systematic Review
by Nicole Quodling, Shad Groves, Norman Hoffman, Frederick R. Carrick and Monèm Jemni
Brain Sci. 2024, 14(11), 1105; https://doi.org/10.3390/brainsci14111105 - 30 Oct 2024
Viewed by 752
Abstract
Background/Objectives: Chronic pain syndromes pose a significant global health challenge to patients and physicians with a complex relationship of biological and psychosocial factors that are only partly understood. Emerging research suggests an association between prenatal and childhood adversity and the development of somatic [...] Read more.
Background/Objectives: Chronic pain syndromes pose a significant global health challenge to patients and physicians with a complex relationship of biological and psychosocial factors that are only partly understood. Emerging research suggests an association between prenatal and childhood adversity and the development of somatic syndromes, particularly in females. This study aims to explore the relationship between sexual dimorphic epigenetic changes in the connectome and prenatal and early life adversity (ELA). Methods: A review of the existing literature was conducted, examining studies utilizing MRI to identify critical periods of environmental influence on neural phenotypes. Results: The findings indicate a significant association between prenatal and childhood adversity and the emergence of central sensitization syndromes, particularly among females. Notably, alterations in grey matter volume and neural connectivity patterns were observed, suggesting that early adverse experiences can influence pain signaling mechanisms. Conclusions: Understanding the role of sex differences in brain circuitry is crucial for developing personalized pain management strategies. This study highlights the importance of considering both biological and psychosocial factors in addressing chronic pain, as interventions based predominantly on male subjects may be less effective for females. Further research is warranted to explore these differences and refine therapeutic approaches. Full article
(This article belongs to the Section Neuroscience of Pain)
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<p>PRISMA 2020 flow diagram for new systematic reviews which included searches of databases and registers only [<a href="#B49-brainsci-14-01105" class="html-bibr">49</a>] for more information, visit <a href="http://www.prisma-statement.org/" target="_blank">http://www.prisma-statement.org/</a>. * Consider, if feasible to do so, reporting the number of records identified from each database or register searched (rather than the total number across all databases/registers).** If automation tools were used, indicate how many records were excluded by a human and how many were excluded by automation tools.</p>
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15 pages, 664 KiB  
Article
Links Between Attention-Deficit/Hyperactivity Disorder Symptoms, Peer Relationships and Mental Health Outcomes in Western Australian Youth
by Carolyn Maxwell, Stephen Houghton and Elaine Chapman
Children 2024, 11(11), 1321; https://doi.org/10.3390/children11111321 - 30 Oct 2024
Viewed by 306
Abstract
Peer relationships are critical in the development of positive mental health during childhood and adolescence. Attention-deficit/hyperactivity disorder (ADHD) symptoms can adversely affect the development of positive peer relationships, and thus, have significant long-term implications for mental health. This study explored the long-term relationships [...] Read more.
Peer relationships are critical in the development of positive mental health during childhood and adolescence. Attention-deficit/hyperactivity disorder (ADHD) symptoms can adversely affect the development of positive peer relationships, and thus, have significant long-term implications for mental health. This study explored the long-term relationships between ADHD symptoms, peer relationships and mental health in Western Australian adolescents. Participants were drawn from a sample of 1489 young people: n = 623 males with a mean age of 13.79 years (SD = 1.61) and n = 866 females, with a mean age of 14.29 years (SD = 1.51). Data were collected at three timepoints across three successive years, with different numbers of participants contributing data at each timepoint. Participants completed measures of ADHD symptoms and existing peer problems in the first year; five measures of peer relationships in the second year; and four measures of mental health in the third year. Multiple regression and path analyses were used to determine whether ADHD symptoms predicted scores on the peer relationship and mental health measures and whether peer relationships mediated links observed between ADHD symptoms and mental health. ADHD symptoms significantly predicted both long-term problematic peer relationships and long-term adverse mental health outcomes. Three peer relationship variables were significant mediators of relationships between ADHD symptoms and mental health: sense of belonging, friendships and perceived isolation. ADHD symptoms significantly predict poor peer relationships and adverse mental health outcomes in Western Australian youth, regardless of whether a formal diagnosis has been assigned. Early interventions for young people with ADHD symptoms are needed for such individuals to enjoy positive mental health in their adult years. Full article
(This article belongs to the Special Issue Child and Adolescent Psychiatry and Mental Health Progress)
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<p>Significant effects in the model (direct effects solid arrows; indirect effects dashed arrows).</p>
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13 pages, 240 KiB  
Article
Early Childhood Education and Care Services, and Parents’ Work–Life Balance
by Aniela Matei, Mihaela Ghența and Luise Mladen-Macovei
Educ. Sci. 2024, 14(11), 1186; https://doi.org/10.3390/educsci14111186 - 29 Oct 2024
Viewed by 397
Abstract
Parents’ work–life balance represents a major challenge, especially for those who have young children. The present article aims to identify the perceptions of parents relating to the purpose of early childhood education and care (ECEC) services, care responsibilities, and factors that affect the [...] Read more.
Parents’ work–life balance represents a major challenge, especially for those who have young children. The present article aims to identify the perceptions of parents relating to the purpose of early childhood education and care (ECEC) services, care responsibilities, and factors that affect the balance between caring responsibilities for children and the professional career of parents. Using a database with 825 parents, who have children aged between 0 and 6 years enrolled in the ECEC system (nurseries, kindergartens), we performed a descriptive statistical analysis and a logistic regression to identify factors that affect the balance between caring responsibilities and career. The results indicate an appreciation of the usefulness of ECEC services (nurseries/kindergartens) by parents and underline the importance of parents’ involvement in the activities of ECEC services. Results also show that three factors affect the balance between caring responsibilities for children and professional career as follows: the residence area, the educational level, and the proximity to ECEC services. The need to develop ECEC services in Romania is correlated with the work–family balance field. Policymakers should focus more on structural changes and the development of early childhood education and care services, as well as the expansion of such services in both rural and urban areas. Full article
(This article belongs to the Section Early Childhood Education)
15 pages, 1101 KiB  
Article
A Preliminary Investigation of a Conceptual Model Describing the Associations Between Childhood Maltreatment and Alcohol Use Problems
by Nayani Ramakrishnan, Sujaiya Tiba, Abby L. Goldstein and Suzanne Erb
Brain Sci. 2024, 14(11), 1081; https://doi.org/10.3390/brainsci14111081 - 29 Oct 2024
Viewed by 342
Abstract
Background/Objectives: Childhood maltreatment has been linked to numerous adverse outcomes in adulthood, including problem substance use. However, not all individuals exposed to childhood maltreatment develop substance use problems, indicating the role of other factors in influencing this outcome. Past work suggests that adverse [...] Read more.
Background/Objectives: Childhood maltreatment has been linked to numerous adverse outcomes in adulthood, including problem substance use. However, not all individuals exposed to childhood maltreatment develop substance use problems, indicating the role of other factors in influencing this outcome. Past work suggests that adverse early life experiences, including childhood maltreatment, lead to neurobiological changes in frontolimbic functions that, in turn, result in altered stress and reward responses, heightened impulsivity, affect dysregulation, and, ultimately, increased risk for maladaptive behaviors such as substance use. The aim of this preliminary investigation using cross-sectional data was to test associations between these factors in the relationship between childhood maltreatment and alcohol use problems in a sample of emerging adults. Methods: Emerging adults (18–30 years old) who identified as regular drinkers (i.e., drinking at least 2–4 times in the past month) were recruited from a crowd-sourcing platform (Prolific) as well as community samples. Participants completed online standardized questionnaires assessing reward sensitivity and responsiveness, impulsivity, emotion regulation, and alcohol consequences. Results: Path analyses demonstrated good fit for the data (SRMR = 0.057, RMSEA = 0.096, 90% CI [0.055, 0.142], CFI = 0.957). Childhood maltreatment was associated with reward responsiveness (β = −0.026, Z = −4.222, p < 0.001) and emotion dysregulation (β = 0.669, Z = 9.633, p < 0.001), which in turn was associated with urgency and, subsequently, alcohol consequences (β = 0.758, Z = 7.870, p < 0.001). Conclusions: Although these findings are preliminary, the current study is one of the first to test a comprehensive model addressing the relationship between childhood maltreatment and alcohol use problems. The findings have the potential to inform treatment strategies that target motivation and goal-directed action for reducing and managing consequences associated with childhood maltreatment. Future research should test the model using longitudinal data to address the limitations of a cross-sectional study and assess temporal associations between constructs. Full article
(This article belongs to the Special Issue Hot Topics in Stress-Related Mental Health Disorders)
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<p>Path model depicting the association between childhood maltreatment and alcohol use problems through emotion dysregulation, reward responsiveness, and negative urgency. Model fits for CTQ total [SRMR = 0.057, RMSEA = 0.096, 90% CI [0.055, 0.142], CFI = 0.957]; CTQ threat [SRMR = 0.050, RMSEA = 0.096, 90% CI [0.055, 0.142], CFI = 0.954]; and CTQ deprivation [SRMR = 0.050, RMSEA = 0.081, 90% CI [0.039, 0.128], CFI = 0.969]. The dashed arrow represents a non-significant association.</p>
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<p>Path model depicting the association between childhood maltreatment and alcohol use problems through emotion dysregulation, reward responsiveness, and positive urgency. Model fits for CTQ total [SRMR = 0.079, RMSEA = 0.132, 90% CI [0.092, 0.177], CFI = 0.878]; CTQ threat [SRMR = 0.077, RMSEA = 0.130, 90% CI [0.089, 0.174], CFI = 0.869]; and CTQ deprivation [SRMR = 0.073, RMSEA = 0.125, 90% CI [0.085, 0.170], CFI = 0.890]. The dashed arrow represents a non-significant association.</p>
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13 pages, 1328 KiB  
Review
The Role of Early Child Nutrition in Pulmonary Hypertension—A Narrative Review
by Alina-Costina Luca, Cristina Stoica, Cosmin Diaconescu, Elena Țarcă, Solange Tamara Roșu, Lăcrămioara Ionela Butnariu, Bogdan Aurelian Stana, Bogdan Gafton, Antoanela Curici, Eduard Vasile Roșu and Dana Elena Mîndru
Children 2024, 11(11), 1307; https://doi.org/10.3390/children11111307 - 29 Oct 2024
Viewed by 385
Abstract
Pulmonary hypertension is a complex condition that has distinct characteristics in pediatric populations. This review explores the important role of early childhood nutrition in the growth, progression, and management of pediatric pulmonary hypertension. Nutritional deficiencies, including those of vitamins C, D, and iron, [...] Read more.
Pulmonary hypertension is a complex condition that has distinct characteristics in pediatric populations. This review explores the important role of early childhood nutrition in the growth, progression, and management of pediatric pulmonary hypertension. Nutritional deficiencies, including those of vitamins C, D, and iron, are closely linked to worse outcomes in children with this disease, emphasizing the importance of early intervention to prevent malnutrition and promote growth. Emerging research revealed that promising nutrients like resveratrol, along with modulation of the gut and respiratory microbiomes, may offer therapeutic advances for managing pulmonary hypertension. However, the current literature is limited by a lack of pediatric-specific studies, with much of the data extrapolated from adult populations and animal models, especially rats. This review highlights the need for targeted research to develop effective nutritional interventions aimed at improving outcomes for pediatric patients. Full article
(This article belongs to the Special Issue Infant and Early Childhood Nutrition)
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<p>Influence of nutrition on PAH: The role of dietary factors such as Fe<sup>2+</sup>, vitamins D and C, flavonoids, and other related polyphenols, alongside vitamin D acquired from sunlight exposure, may enhance the quality of life and outcomes of patients suffering from pulmonary arterial hypertension. Each nutritional element operates through its own unique mechanism. Nevertheless, certain effects of these nutrients could be linked to their impact on the immune system via the rejuvenation of T lymphocytes and cytokines, alterations in the gut microbiome and its bacterial metabolites, and the movement of bacteria across barriers [<a href="#B25-children-11-01307" class="html-bibr">25</a>].</p>
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<p>Incidence of undernutrition in pediatric patients with CHD. This chart shows the percentage and severity of undernutrition in congenital heart diseases. As shown, at the pinnacle of the chart are pediatric patients with cyanotic CHD, with more than 40% being severely underweight [<a href="#B35-children-11-01307" class="html-bibr">35</a>].</p>
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<p>Natural products with benefic role in pulmonary hypertension. These extensively researched natural compounds may contribute to the management of pulmonary hypertension (PH) by enhancing anti-inflammatory responses, suppressing oxidative stress, mitigating apoptosis resistance, and modulating dysregulated ion channels and collagen accumulation. These mechanisms can effectively alleviate pulmonary vascular remodeling and right ventricular hypertrophy [<a href="#B59-children-11-01307" class="html-bibr">59</a>].</p>
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15 pages, 285 KiB  
Article
Hong Kong Kindergarten Teachers’ Satisfaction and Engagement in a Music-and-Movement Online Professional Development Course
by Siu-Ping Ng and Alfredo Bautista
Educ. Sci. 2024, 14(11), 1178; https://doi.org/10.3390/educsci14111178 - 28 Oct 2024
Viewed by 509
Abstract
Online professional development (PD) can be a sustainable and easily scalable alternative to provide early childhood teachers with training opportunities. However, there is limited research on teachers’ levels of satisfaction and engagement in online PD initiatives. Understanding teachers’ levels of satisfaction and engagement [...] Read more.
Online professional development (PD) can be a sustainable and easily scalable alternative to provide early childhood teachers with training opportunities. However, there is limited research on teachers’ levels of satisfaction and engagement in online PD initiatives. Understanding teachers’ levels of satisfaction and engagement is crucial, as these may influence the effectiveness of online PD in benefiting teachers and ultimately young children. This study aimed to examine Hong Kong kindergarten teachers’ satisfaction and engagement in a music-and-movement (M&M) online PD course. This study involved 56 participants who received an 11-week online PD course. Questionnaires were administered after course completion. Data were analyzed using descriptive statistics and t-tests. Participants had high levels of satisfaction with the course, particularly those with no or some M&M background, who were more satisfied with the course content and instruction. Participants had moderate-to-high levels of engagement in the course, particularly those with no or some M&M background, who were more emotionally engaged. We conclude that sustainable and easily scalable online PD initiatives can result in high levels of satisfaction and engagement among kindergarten teachers, especially those with limited M&M background. This study supports the idea that online PD can be responsive to teachers’ needs and preferences. Full article
17 pages, 3925 KiB  
Article
Adipose Tissue Macrophages of the Human Fetus
by Ádám Radványi, Katalin Gyurina, Emese Rácz, Ilona Kovács, Gábor Méhes and Tamás Röszer
Cells 2024, 13(21), 1787; https://doi.org/10.3390/cells13211787 - 28 Oct 2024
Viewed by 345
Abstract
Prenatal adipose tissue development affects body composition and growth trajectory in early infancy, therefore it is a key determinant of adiposity in childhood. Childhood overweight and obesity increase the probability of being obese as an adult. After birth and in adulthood, adipose tissue [...] Read more.
Prenatal adipose tissue development affects body composition and growth trajectory in early infancy, therefore it is a key determinant of adiposity in childhood. Childhood overweight and obesity increase the probability of being obese as an adult. After birth and in adulthood, adipose tissue macrophages (ATMs) are relevant constituents of the fat depots, and they are necessary for physiological adipose tissue development and fat metabolism. In obesity, however, ATMs may induce chronic inflammation leading to insulin resistance, pancreatic beta cell damage and self-immunity. Despite being relevant regulators of adipose tissue development and functioning, it is unknown whether ATMs are present in the fetal adipose tissue, therefore it is elusive whether they may affect the prenatal establishment of fat depots. Here we studied the distribution of ATMs in the human fetus between gestational weeks 17 and 38 and labeled ATMs in the early postnatal life. We found that CD45+/CD14+/CD68+ ATMs infiltrated the fetal adipose tissue from the 17th week of gestation and remained persistent throughout the second and third trimesters. ATMs were phagocytic in the neonate and expressed interleukin-6, along with other pro-inflammatory gene products. These findings show that ATMs colonize the adipose tissue early in gestation, raising the possibility that intrauterine ATM–adipocyte communication may exist, eventually allowing ATMs to affect prenatal adipose tissue development. Full article
(This article belongs to the Special Issue Adipose Tissue, Obesity, and Metabolic Diseases)
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<p>Development of the subcutaneous adipose tissue depot of the abdominal wall in the human fetus. (<b>a</b>) Computed tomography image showing sagittal section of a human fetus in the late third trimester. Abdominal wall at the level of the umbilical cord is indicated in frame. Original image, retrieved from a postmortem computed tomography scan performed in our previous study [<a href="#B25-cells-13-01787" class="html-bibr">25</a>]. (<b>b’</b>) Cross section of the abdominal wall of the human fetus at the 17th week of gestation. ep: epidermis, hf: hair follicle, 1: subcutaneous connective tissue layer with preadipocytes, 2: collagen fibers, 3: muscular wall of the abdomen. Masson’s trichromic staining. Scale bar: 200 μm. (<b>b’’</b>) Cross section of the abdominal wall in the third trimester. ep: epidermis, hf: hair follicle, vs: vesicles, 1: subcutaneous fat layer, 2: collagen fibers, 3: muscular wall of the abdomen. Hematoxylin and eosin staining. Scale bar: 200 μm. (<b>b’’’</b>) Perilipin immunostaining of the developing adipose tissue. From left to right: week 17, week 21 and week 38. ac: adipocyte, lct: loose connective tissue. Scale bar 50 μm. (<b>c</b>) Subcutaneous connective tissue layer of the abdominal wall from the second trimester (17th week) of gestation. cp: capillary, lct: loose connective tissue. Masson’s trichromic staining. Scale bar: 30 μm. (<b>d’</b>) Capillary from the subcutaneous connective tissue at the 20th gestational week. ev: extravasating leukocyte, cp: capillary, ly: lymphocyte, mf: macrophage, scale bar 30 μm. (<b>d’’</b>) Macrophage (mf) in the subcutaneous connective tissue at the 20th gestational week. cp: capillary. Scale bar 5 μm. (<b>e</b>) Subcutaneous adipose tissue at the 21st week of gestation. ac: adipocyte, cp: capillary. Dotted lines mark regions with immune cell infiltration. Masson’s trichromic staining. Scale bar 30 μm. (<b>f</b>) Subcutaneous adipose tissue at the 30th week of gestation. ac: adipocyte, Masson’s trichromic staining. Scale bar 30 μm. (<b>g</b>) Infiltrating immune cells in the subcutaneous adipose tissue at gestational week 23. lct: loose connective tissue, ac: adipocyte, arrowheads label immune cells. Scale bar 50 μm.</p>
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<p>CD45 immunostaining of the abdominal subcutaneous adipose tissue in the human fetus. (<b>a</b>) Subcutaneous connective tissue at gestation week 17. (<b>b</b>) Subcutaneous connective tissue at gestation week 20. (<b>c</b>) Developing subcutaneous adipose tissue depot at gestation week 21. (<b>d</b>) Subcutaneous adipose tissue at gestational week 30. (<b>e</b>) Subcutaneous adipose tissue at gestational week 34. (<b>f</b>) Subcutaneous adipose tissue of a newborn (born at completed gestational week 36). Arrowheads label CD45<sup>+</sup> cells. lct: loose connective tissue, ac: adipocyte, hf: hair follicle. DNA stained with methyl green. Scale bar 30 μm.</p>
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<p>CD68 immunostaining of the abdominal subcutaneous adipose tissue in the human fetus. (<b>a</b>,<b>b</b>) Subcutaneous connective tissue at gestation week 17. Arrowheads label CD68<sup>+</sup> cells. Scale bar 50 μm (<b>a</b>) and 30 μm (<b>b</b>). (<b>c</b>,<b>d</b>) Subcutaneous connective tissue at gestation week 20. Scale bar 50 μm (<b>c</b>) and 30 μm (<b>d</b>). (<b>e</b>) Developing subcutaneous adipose tissue depot at gestation week 21. Scale bar 30 μm. (<b>f</b>) Subcutaneous adipose tissue at gestation week 30. Inset shows a cluster of CD68<sup>+</sup> cells in vicinity of adipocytes. Scale bar 30 μm and 5 μm in the inlet. (<b>g</b>) Subcutaneous adipose tissue at gestational week 34. Scale bar 30 μm. (<b>h</b>,<b>i</b>) Comparison of the distribution pattern of CD68<sup>+</sup> cells in the second trimester (<b>h</b>) and in the newborn (<b>i</b>); scale bar 30 μm. lct: loose connective tissue, ac: adipocyte, hf: hair follicle, sc: subcutis, bv: blood vessel.</p>
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<p>Distribution of CD14-expressing cells in the abdominal subcutaneous adipose tissue in the human fetus. (<b>a</b>,<b>b</b>) Subcutaneous connective tissue at gestation week 17. Scale bar 50 μm (<b>a</b>) and 30 μm (<b>b</b>), arrowheads label CD14<sup>+</sup> cells. (<b>c</b>,<b>d</b>) Subcutaneous connective tissue at gestation week 20. Arrowheads label CD14<sup>+</sup> cells. Scale bar 30 μm. (<b>e</b>) Developing subcutaneous adipose tissue depot at gestation week 21. ac: adipocyte, arrowheads label CD14<sup>+</sup> cells. Scale bar 30 μm. (<b>f</b>) Subcutaneous adipose tissue at gestation week 30. ac: adipocyte, arrowheads label CD14<sup>+</sup> cells. Scale bar 30 μm. (<b>g</b>) Subcutaneous adipose tissue at gestation week 34. ac: adipocyte, arrowheads label CD14<sup>+</sup> cells. Scale bar 30 μm. (<b>h’</b>,<b>h”</b>) Adipose tissue macrophages in the second trimester (<b>h’</b>) and in the third trimester (<b>h”</b>), methylene blue stained semi-thin sections. Arrowheads label macrophage-like cells. ac: adipocyte, svf: stromal vascular fraction. Scale bar 30 μm. (<b>i</b>) Transmission electron microscopy of the subcutaneous adipose tissue, corresponding to the semi-thin sections shown in panels (<b>h’,h”</b>), at gestation week 38. A cluster of adipocytes, a capillary (cp) and a macrophage-like cell (arrowhead). lp: lipid droplets in adipocytes, cp: capillary, nc: nucleus, vs: vesicles, scale bar 5 μm. (<b>j</b>) Macrophage-like cells attached to adipocytes in the newborn adipose tissue. Scale bar 5 μm.</p>
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<p>Expression of IL-6 in infant ATMs (<b>a</b>) FACS analysis of ATMs in infant adipose tissue. Labeling for CD45, CD68 and CD14. (<b>b</b>) Phagocytosis activity of ATMs was assessed with flow cytometry. ATMs engulfed FITC-conjugated latex beads, and fluorescence intensity was proportional to number of ingested beads. Histogram showing fluorescence intensity of ATMs following engulfing latex beads. Phagocytosing cells (Phago<sup>+</sup>) accumulated latex beads, shown by their intensive FITC fluorescence. Each histogram represents one donor patient. (<b>c</b>) Expression of CD68 and CD36 in cells of the infant adipose tissue (age range 0.3–0.83 year). Percentage of CD68<sup>+</sup> and phagocytosing (Phago<sup>+</sup>) cells in the infant adipose tissue. (<b>d</b>) Relative mRNA expression levels of M1 macrophage activation genes in mouse ATMs, isolated on postnatal day 6 (P6) and on postnatal day 56 (P56). ** <span class="html-italic">p</span> &lt; 0.01, *** <span class="html-italic">p</span> &lt; 0.001, 2-tailed unpaired Student’s <span class="html-italic">t</span>-test. (<b>e</b>) Relative mRNA expression levels of M2 macrophage activation genes in mouse ATMs at P6 and P56. * <span class="html-italic">p</span> &lt; 0.05, *** <span class="html-italic">p</span> &lt; 0.001, 2-tailed unpaired Student’s <span class="html-italic">t</span>-test. (<b>f</b>) Relative mRNA expression levels of M1 macrophage activation genes in adipose tissue of human infants and children. ** <span class="html-italic">p</span> &lt; 0.01, *** <span class="html-italic">p</span> &lt; 0.001, 2-tailed unpaired Student’s <span class="html-italic">t</span>-test. (<b>g</b>) Relative mRNA expression levels of M2 macrophage activation genes in adipose tissue of human infants and children. ** <span class="html-italic">p</span> &lt; 0.01, *** <span class="html-italic">p</span> &lt; 0.001, 2-tailed unpaired Student’s <span class="html-italic">t</span>-test. (<b>h</b>) Interactome map of gene products overrepresented in mouse ATMs on P6 (Left) and in adipose tissue of human infants (Right). (<b>i</b>) Expression of IL-6 in ATMs of human infants. Comparison of IL-6 expression (mean fluorescence intensity, MFI) in adipocytes and ATMs. Adipocytes were defined as CD36<sup>+</sup> cells, ATMs as CD68<sup>+</sup> cells. Each data point represents one patient. *** <span class="html-italic">p</span> &lt; 0.001, 2-tailed unpaired Student’s <span class="html-italic">t</span>-test. (<b>j</b>) Levels of IL-6 in ATMs.</p>
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27 pages, 1316 KiB  
Review
Digital Device Usage and Childhood Cognitive Development: Exploring Effects on Cognitive Abilities
by Vicente Javier Clemente-Suárez, Ana Isabel Beltrán-Velasco, Silvia Herrero-Roldán, Stephanie Rodriguez-Besteiro, Ismael Martínez-Guardado, Alexandra Martín-Rodríguez and Jose Francisco Tornero-Aguilera
Children 2024, 11(11), 1299; https://doi.org/10.3390/children11111299 - 27 Oct 2024
Viewed by 942
Abstract
The increasing ubiquity of digital devices in childhood had outpaced the understanding of their effects on cognitive development, creating a significant research gap regarding their long-term impact. Objective: The present narrative overview explored the complex relationship between digital device usage and cognitive development [...] Read more.
The increasing ubiquity of digital devices in childhood had outpaced the understanding of their effects on cognitive development, creating a significant research gap regarding their long-term impact. Objective: The present narrative overview explored the complex relationship between digital device usage and cognitive development in childhood. Methods: We conducted a comprehensive literature search across multiple databases, including PubMed, Embase, Scopus, and Web of Science, to critically assess cognitive domains such as attention, memory, executive functions, problem-solving skills, and social cognition. Incorporating over 157 peer-reviewed studies published between 2001 and 2024, we used strict inclusion and exclusion criteria to ensure scientific rigor. Results: The review integrated empirical findings with established theoretical frameworks, particularly from cognitive development and media psychology, to highlight both the advantages and risks of early, frequent exposure to technology. The potential for digital devices to enhance cognitive skills, such as multitasking and information processing, was weighed against risks such as cognitive overload, diminished attention spans, and impaired social skills. We also examined psychological and behavioral outcomes, including identity formation, emotional regulation, and maladaptive behaviors associated with excessive screen time. Additionally, we identified strategies to mitigate negative effects, emphasizing structured digital engagement and parental involvement to support healthy cognitive and psychological growth. Our findings provided actionable recommendations for parents, educators, and policymakers, promoting optimal digital practices that enhanced cognitive development while safeguarding against potential harms. Conclusions: The review offered essential insights for stakeholders in child development, education, and policy-making, highlighting the need for balanced integration of digital tools in childhood learning environments. Full article
(This article belongs to the Section Pediatric Neurology & Neurodevelopmental Disorders)
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<p>PRISMA flow diagram.</p>
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<p>The influence of using digital devices on the development of children and the importance of considering the context, content, and duration of this usage.</p>
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<p>Potential Negative Impacts of Excessive Device Use on Children.</p>
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34 pages, 1270 KiB  
Review
Heavy Metals in Umbilical Cord Blood: Effects on Epigenetics and Child Development
by Sudipta Dutta and Douglas M. Ruden
Cells 2024, 13(21), 1775; https://doi.org/10.3390/cells13211775 - 26 Oct 2024
Viewed by 366
Abstract
Heavy metals like arsenic, mercury, cadmium, and lead are harmful pollutants that can change how our genes are regulated without altering the DNA sequence, specifically through a process called DNA methylation (DNAm) at 5-methylcytosine, an epigenetic mark that we will focus on in [...] Read more.
Heavy metals like arsenic, mercury, cadmium, and lead are harmful pollutants that can change how our genes are regulated without altering the DNA sequence, specifically through a process called DNA methylation (DNAm) at 5-methylcytosine, an epigenetic mark that we will focus on in this review. These changes in DNAm are most sensitive during pregnancy, a critical time for development when these modifications can affect how traits are expressed. Historically, most research on these environmental effects has focused on adults, but now there is more emphasis on studying the impacts during early development and childhood. The placenta acts as a protective barrier between the mother and the baby, and by examining it, scientists can identify changes in key genes that might affect long-term health. This review looks at how exposure to heavy metals during pregnancy can cause changes in the gene regulation by DNAm in newborns, as seen in their umbilical cord blood. These changes reflect the baby’s genetic state during pregnancy and can be influenced by the mother’s environment and genetics, as well as the baby’s own genetics. Full article
(This article belongs to the Special Issue Molecular Advances in Prenatal Exposure to Environmental Toxicants)
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Graphical abstract

Graphical abstract
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<p>A growing fetus inside the mother’s uterus showing the umbilical cord and placenta. The structure of the human placenta showing the direction of maternal–fetal transfer. The fetal side of the placenta comprises umbilical arteries (which deliver nutrients and oxygen to the growing fetus) and umbilical veins (which transport back waste products and CO<sub>2</sub> from the fetus to the maternal circulation). The maternal side consists of a basal plate with maternal vessels. The middle portion of the placenta consists of chorionic villi.</p>
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<p>Heavy metal transition from mother to fetus. Heavy metals are released in the environment from several sources, such as mining, oil refineries, combustion by-products, fertilizers, and pesticides. Heavy metals can get easily transmitted via the maternal circulation and affect the growing fetus.</p>
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21 pages, 400 KiB  
Review
The Relationship Between Asthma and Food Allergies in Children
by Daniela Cunico, Giuliana Giannì, Sara Scavone, Enrico Vito Buono and Carlo Caffarelli
Children 2024, 11(11), 1295; https://doi.org/10.3390/children11111295 - 26 Oct 2024
Viewed by 304
Abstract
Asthma and food allergy are two complex allergic diseases with an increasing prevalence in childhood. They share risk factors, including atopic family history, atopic dermatitis, allergen sensitization, and T2 inflammatory pathways. Several studies have shown that in children with a food allergy, the [...] Read more.
Asthma and food allergy are two complex allergic diseases with an increasing prevalence in childhood. They share risk factors, including atopic family history, atopic dermatitis, allergen sensitization, and T2 inflammatory pathways. Several studies have shown that in children with a food allergy, the risk of developing asthma, particularly in early childhood, is high. Food allergen intake or the inhalation of aerosolized allergens can induce respiratory symptoms such as bronchospasm. Patients with both conditions have an increased risk of severe asthma exacerbations, hospitalization, and mortality. The current management of clinical food hypersensitivity primarily involves the dietary avoidance of food allergens and the use of self-injectable adrenaline for severe reactions. Poorly controlled asthma limits the prescription of oral immunotherapy to foods, which has emerged as an alternative therapy for managing food allergies. Biological therapies that are effective in severe asthma have been explored for treating food allergies. Omalizumab improves asthma control and, either alone or in combination with oral immunotherapy, increases the threshold of allergen tolerance. Understanding the interplay between asthma and food allergy is crucial for developing successful treatment approaches and ameliorating patient results. Full article
(This article belongs to the Special Issue Updates on Lung Function, Respiratory and Asthma Disease in Children)
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