Search Results (26)

According to the requirements of the small double-pulse solid rocket motor, a compartmentalized isolation device has been designed. This device consists of a metal diaphragm and a support frame. An experimental study and numerical simulation were used to verify the bidirectional working process of the metal diaphragm during operation of the double-pulse motor. The results show that the pressure-bearing capacity of the metal diaphragm meets the requirements under the working conditions of pulse I without affecting pulse II, because the metal diaphragm can provide insulation and flame retardancy. The metal diaphragm can be cracked in the direction of the preset V-groove in a relatively short time under the working conditions of pulse II, which allows the gas to flow to the first pulse combustion chamber normally. This indicates that the metal diaphragm can meet the requirements of bidirectional working process in dual-pulse motors. Full article

The power transformer is one of the most crucial pieces of high-voltage equipment in the power system, and its stable operation is crucial to the reliability of power transmission. Partial discharge (PD) is a key factor leading to the degradation and failure of the insulation performance of power transformers. Therefore, online monitoring of partial discharge can not only obtain real-time information on the operating status of the equipment but also effectively predict the remaining service life of the transformer. Meanwhile, accurate localization of partial discharge sources can assist maintenance personnel in developing more precise and efficient maintenance plans, ensuring the stable operation of the power system. Dual partial discharge sources in transformer oil represent a more complex fault type, and piezoelectric transducers installed outside the transformer oil tank often fail to accurately capture such discharge waveforms. Additionally, the sensitivity of the built-in F-P sensors can decrease when installed deep within the oil tank due to the influence of oil pressure on its sensing diaphragm, resulting in an inability to accurately detect dual partial discharge sources in transformer oil. To address the impact of oil pressure on sensor sensitivity and achieve the detection of dual partial discharge sources under high-voltage conditions in transformers, this paper proposes an optical fiber ultrasonic sensor with a pressure-balancing structure. This sensor can adapt to changes in oil pressure environments inside transformers, has strong electromagnetic interference resistance, and can be installed deep within the oil tank to detect dual partial discharge sources. In this study, a dual PD detection system based on this sensor array is developed, employing a cross-positioning algorithm to achieve detection and localization of dual partial discharge sources in transformer oil. When applied to a 35 kV single-phase transformer for dual partial discharge source detection in different regions, the sensor array exhibits good sensitivity under high oil pressure conditions, enabling the detection and localization of dual partial discharge sources in oil and winding interturn without obstruction. For fault regions with obstructions, such as within the oil channel of the transformer winding, the sensor exhibits the capability to detect the discharge waveform stemming from dual partial discharge sources. Overall, the sensor demonstrates good sensitivity and directional clarity, providing effective detection of dual PD sources generated inside transformers. Full article

Duchenne muscular dystrophy (DMD) is one of the most frequent and severe childhood muscle diseases. Its pathophysiology is multifaceted and still incompletely understood, but we and others have previously shown that oxidative stress plays an important role. In particular, we have demonstrated that inhibition of mitochondrial monoamine oxidases could improve some functional and biohumoral markers of the pathology. In the present study we report the use of dystrophic mdx mice to evaluate the efficacy of a dual monoamine oxidase B (MAO-B)/semicarbazide-sensitive amine oxidase (SSAO) inhibitor, PXS-5131, in reducing inflammation and fibrosis and improving muscle function. We found that a one-month treatment starting at three months of age was able to decrease reactive oxygen species (ROS) production, fibrosis, and inflammatory infiltrate in the tibialis anterior (TA) and diaphragm muscles. Importantly, we also observed a marked improvement in the capacity of the gastrocnemius muscle to maintain its force when challenged with eccentric contractions. Upon performing a bulk RNA-seq analysis, PXS-5131 treatment affected the expression of genes involved in inflammatory processes and tissue remodeling. We also studied the effect of prolonged treatment in older dystrophic mice, and found that a three-month administration of PXS-5131 was able to greatly reduce the progression of fibrosis not only in the diaphragm but also in the heart. Taken together, these results suggest that PXS-5131 is an effective inhibitor of fibrosis and inflammation in dystrophic muscles, a finding that could open a new therapeutic avenue for DMD patients. Full article

The dynamic relationship between heart failure and cancer poses a dual challenge. While cardiac remodeling can promote cancer growth and metastasis, tumor development can ameliorate cardiac dysfunction and suppress fibrosis. However, the precise mechanism through which cancer influences the heart and fibrosis is yet to be uncovered. To further explore the interaction between heart failure and cancer, we used the MDX mouse model, which suffers from cardiac fibrosis and cardiac dysfunction. A previous study from our lab demonstrated that tumor growth improves cardiac dysfunction and dampens fibrosis in the heart and diaphragm muscles of MDX mice. We used breast Polyoma middle T (PyMT) and Lewis lung carcinoma (LLC) cancer cell lines that developed into large tumors. To explore whether the aggressiveness of the cancer cell line is crucial for the beneficial phenotype, we employed a PyMT breast cancer cell line lacking integrin β1, representing a less aggressive cell line compared to the original PyMT cells. In addition, we examined immortalized and primary MEF cells. The injection of integrin β1 KO PyMT cancer cells and Mouse Embryo Fibroblasts cells (MEF) resulted in the improvement of cardiac function and decreased fibrosis in the heart, diaphragm, and skeletal muscles of MDX mice. Collectively, our data demonstrate that the cancer line aggressiveness as well as primary MEF cells are sufficient to impose the beneficial phenotype. These discoveries present potential novel clinical therapeutic approaches with beneficial outcome for patients with fibrotic diseases and cardiac dysfunction that do not require tumor growth. Full article

The interplay between heart failure and cancer represents a double-edged sword. Whereas cardiac remodeling promotes cancer progression, tumor growth suppresses cardiac hypertrophy and reduces fibrosis deposition. Whether these two opposing interactions are connected awaits to be determined. In addition, it is not known whether cancer affects solely the heart, or if other organs are affected as well. To explore the dual interaction between heart failure and cancer, we studied the human genetic disease Duchenne Muscular Dystrophy (DMD) using the MDX mouse model. We analyzed fibrosis and cardiac function as well as molecular parameters by multiple methods in the heart, diaphragm, lungs, skeletal muscles, and tumors derived from MDX and control mice. Surprisingly, cardiac dysfunction in MDX mice failed to promote murine cancer cell growth. In contrast, tumor-bearing MDX mice displayed reduced fibrosis in the heart and skeletal and diaphragm muscles, resulting in improved cardiac function. The latter is at least partially mediated via M2 macrophage recruitment to the heart and diaphragm muscles. Collectively, our data support the notion that the effect of heart failure on tumor promotion is independent of the improved cardiac function in tumor-bearing mice. Reduced fibrosis in tumor-bearing MDX mice stems from the suppression of new fibrosis synthesis and the removal of existing fibrosis. These findings offer potential therapeutic strategies for DMD patients, fibrotic diseases, and cardiac dysfunction. Full article

A prototype optical bionic microphone with a dual-channel Mach–Zehnder interferometric (MZI) transducer was designed and prepared for the first time using a silicon diaphragm made by microelectromechanical system (MEMS) technology. The MEMS diaphragm mimicked the structure of the fly Ormia Ochracea’s coupling eardrum, consisting of two square wings connected through a neck that is anchored via the two torsional beams to the silicon pedestal. The vibrational displacement of each wing at its distal edge relative to the silicon pedestal is detected with one channel of the dual-channel MZI transducer. The diaphragm at rest is coplanar with the silicon pedestal, resulting in an initial phase difference of zero for each channel of the dual-channel MZI transducer and consequently offering the microphone strong temperature robustness. The two channels of the prototype microphone show good consistency in their responses to incident sound signals; they have the rocking and bending resonance frequencies of 482 Hz and 1911 Hz, and their pressure sensitivities at a lower frequency exhibit an “8”-shaped directional dependence. The comparison indicates that the dual-channel MZI transducer-based bionic microphone proposed in this work is advantageous over the Fabry–Perot interferometric transducer-based counterparts extensively reported. Full article

A vitrectome is a commonly used instrument in eye surgery, which is used to cut and aspirate the vitreous body out of the eye. The mechanism of the vitrectome consists of miniature components that need to be assembled by hand due to their size. Non-assembly 3D printing, in which fully functional mechanisms can be produced in a single production step, can help create a more streamlined production process. We propose a vitrectome design based on a dual-diaphragm mechanism, which can be produced with minimal assembly steps using PolyJet printing. Two different diaphragm designs were tested to fulfill the requirements of the mechanism: a homogenous design based on ‘digital’ materials and a design using an ortho-planar spring. Both designs were able to fulfill the required displacement for the mechanism of 0.8 mm, as well as cutting forces of at least 8 N. The requirements for the cutting speed of the mechanism of 8000 RPM were not fulfilled by both designs, since the viscoelastic nature of the PolyJet materials resulted in a slow response time. The proposed mechanism does show promise to be used in vitrectomy; however, we suggest that more research into different design directions is required. Full article

Until now, non-specific chronic neck pain has mainly been considered as a musculoskeletal system dysfunction, with associated psychological involvement due to its prolonged or recurrent nature. However, patients with non-specific chronic neck pain frequently additionally exhibit respiratory dysfunction. Emerging evidence suggests that addressing the respiratory dysfunction in these patients will provide additional therapeutic benefits in musculoskeletal and respiratory-related outcomes for several reasons (biomechanical, biochemical, and psychological). Motor control dysfunction of the muscles surrounding the spine (diaphragm included) negatively affects the mechanics and biochemistry of breathing (pH-homeostasis). An impaired and ineffective breathing pattern has been recognized as the primary source of many unexplained symptoms (anxiety, depression, confusion, chest pain, hypocapnia, and breathlessness) in patients with non-specific chronic neck pain. The proposed protocol’s purpose is dual: to assess the relative effectiveness of manual therapy in the cervical spine and the diaphragm, in combination with breathing reeducation exercises, along with cervical spine manual therapy or usual physical therapy care on the underlying dysfunctions in patients with non-specific chronic neck pain via a randomized controlled clinical trial, and to validate part of the outcome measures. Several musculoskeletal and respiratory dysfunction outcomes will be employed to delimit the initial extent and level of dysfunction and its resolution with the treatments under study. Full article

This paper proposes a novel high-sensitivity micro-electromechanical system (MEMS) piezoresistive pressure sensor that can be used for rock mass stress monitoring. The entire sensor consists of a cross, dual-cavity, and all-silicon bulk-type (CCSB) structure. Firstly, the theoretical analysis is carried out, and the relationship between the structural parameters of the sensor and the stress is analyzed by finite element simulation and curve-fitting prediction, and then the optimal structural parameters are also analyzed. The simulation results indicate that the sensor with the CCSB structure proposed in this article obtained a high sensitivity of 87.74 μV/V/MPA and a low nonlinearity error of 0.28% full-scale span (FSS) within the pressure range of 0–200 MPa. Compared with All-Si Bulk, grooved All-Si Bulk, Si-Glass Bulk, silicon diaphragm, resistance strain gauge, and Fiber Bragg grating structure pressure sensors, the designed sensor has a significant improvement in sensitivity and nonlinearity error. It can be used as a new sensor for rock disaster (such as collapse) monitoring and forecasting. Full article

In order to understand the differences between dual synthetic jets (DSJs) and synthetic jets (SJs), particle image velocimetry (PIV) technology is used to capture the basic flow field characteristics of a dual synthetic jet actuator (DSJA) and a synthetic jet actuator (SJA), and then a careful comparison between them is implemented. The results indicate that a cycle of the DSJ is divided into two stages. In the near-field downstream, a pair of synthetic jets entrain fluid around them and interact with each other, making the flow field complex, and the time-periodic diaphragm dominates them. There is an unfavorable phenomenon of “self-support” between the two jets. In the far-field downstream, the two jets merge into a single, more stable SJ with a higher velocity and a double characteristic frequency. The DSJs have also shown good vectoring characteristics, with the vectoring deflection angle (VDA) changing from about −46° to 46°. The above results demonstrate that the DSJA may replace the traditional SJA in all kinds of applications and extend the applying area of the SJ to more active flow control systems, which cannot be qualified by traditional SJA. Full article

In electrohydrostatic drive actuators, there is a demand for temperature and pressure monitoring in complex environments. Fiber Bragg grating (FBG) has become a promising sensor for measuring temperature and pressure. However, there is a cross-sensitivity between temperature and pressure. A gold-plated FBG is proposed and manufactured, and an FBG is used as a reference grating to form a parallel all-fiber sensing system, which can realize the simultaneous measurement of pressure and temperature. Based on the simulation software, the mechanical distribution of the pressure diaphragm is analyzed, and the fixation scheme of the sensor is determined. Using the demodulator to monitor the changes in the reflectance spectrum in real-time, the pressure and ambient temperature applied to the sensor are measured. The experimental results show that the temperature sensitivity of gold-plated FBG is 3 times that of quartz FBG, which can effectively distinguish the temperature changes. The pressure response sensitivity of gold-plated FBG is 0.3 nm/MPa, which is same as the quartz FBG. Through the sensitivity matrix equation, the temperature and pressure dual-parameter sensing measurement is realized. The accuracy of the temperature and pressure measurement is 97.7% and 99.0%, and the corresponding response rates are 2.7 ms/°C and 2 ms/MPa, respectively. The sensor has a simple structure and high sensitivity, and it is promising to be applied in health monitoring in complex environments with a high temperature and high pressure. Full article

In order to enhance the sensitivity of a Fabry–Perot (F-P) acoustic sensor without the need of fabricating complicated structures of the acoustic-sensitive diaphragm, a mini-type external sound pressure amplification structure (SPAS) with double 10 μm thickness E-shaped diaphragms of different sizes interconnected with a 5 mm length tapered circular rod was developed based on the acoustic sensitive mechanism of the ossicular chain in the human middle ear. The influence of thickness and Young’s modulus of the two diaphragms with the diameters of 15 mm and 3 mm, respectively, on the amplification ratio and frequency response were investigated via COMSOL acoustic field simulation, thereby confirming the dominated effect. Then, three kinds of dual-diaphragm schemes relating to steel and thermoplastic polyurethanes (TPU) materials were introduced to fabricate the corresponding SPASs. The acoustic test showed that the first scheme achieved a high resonant response frequency with lower acoustic amplification due to strong equivalent stiffness; in contrast, the second scheme offered a high acoustic amplification but reduced frequency range. As a result of sensitivity enhancement, adapted with the steel/TPU diaphragm structure, an optical fiber Fabry–Perot sensor using a multilayer graphene diaphragm with a diameter of 125 μm demonstrated a remarkable sensitivity of 565.3 mV/Pa @1.2 kHz due to the amplification ratio of up to ~29.9 in the range of 0.2–2.3 kHz, which can be further improved by miniaturizing structure dimension, along with the use of microstructure packaging technology. Full article

To deeply analyze the influence of diaphragm materials on the temperature and pressure sensitivity of Fabry–Perot interferometer-based dual-parameter fiber sensors, the multiple transfer method was used to fabricate the dual Fabry–Perot cavities, respectively, consisting of the following combinations: epoxy resin AB/polydimethylsiloxane (PDMS), Ecoflex0030 silicone rubber /PDMS, and PDMS/Ecoflex0030 silicone rubber. Experimental results show that the temperature sensitivities are, respectively, 528, 540, and 1033 pm/°C in the range of 40–100 °C. Within the applied pressure range of 100–400 kPa, the pressure sensitivities are, respectively, 16.0, 34.6, and 30.2 pm/kPa. The proposed sensors have advantages of proper sensitivity, simple fabrication, cost-effectiveness, controllable cavity length, and suitability for practical sensing applications. Full article

Helicopter tail rotors adopt a segmented driveline connected by flexible couplings, and dry friction dampers to suppress resonance. Modeling for this system can provide a basic foundation for parameter analysis. In this work, the lateral-torsional vibration equation of the shaft with continuous internal damping is established. The static and dynamic effects caused by flexible diaphragm couplings subject to parallel and angular misalignment is derived. A novel dual rub-impact model between the shaft and dry friction damper with multiple stages is proposed. Finally, a model of a helicopter tail rotor driveline incorporating all the above elements is formulated. Numerical simulations are carried out by an improved Adams–Bashforth method following the design flowchart. The dynamics of multiple vibration suppression, and the static and dynamic misalignment are analyzed to illustrate the accuracy and characteristics of the model. The coeffect of the rub impact and the misalignment on shafts and dampers are presented through the results of simulation and experiment. It provides an accurate and comprehensive mathematical model for the helicopter driveline. Response characteristics of multiple damping stages, static and dynamic misalignment, and their interaction are revealed. Full article

A reflective intensity-modulated fiber-optic sensor based on microelectromechanical systems (MEMS) for pressure measurements is proposed and experimentally demonstrated. The sensor consists of two multimode optical fibers with a spherical end, a quartz tube with dual holes, a silicon sensitive diaphragm, and a high borosilicate glass substrate (HBGS). The integrated sensor has a high sensitivity due to the MEMS technique and the spherical end of the fiber. The results show that the sensor achieves a pressure sensitivity of approximately 0.139 mV/kPa. The temperature coefficient of the proposed sensor is about 0.87 mV/°C over the range of 20 °C to 150 °C. Furthermore, due to the intensity mechanism, the sensor has a relatively simple demodulation system and can respond to high-frequency pressure in real time. The dynamic response of the sensor was verified in a 1 kHz sinusoidal pressure environment at room temperature. Full article