Search Results (968)

The inability to accurately predict the occurrence of postoperative cognitive dysfunction (POCD) among open-heart surgery patients leads to concerning increases in POCD cases. Preoperative circulating biomarkers are important to identify as they are non-invasive and could provide an early prediction of POCD development, allowing for earlier and more strategized interventions. However, to date, no robust circulating biomarkers have proven effective for preoperative POCD prediction. This systematic review aims to synthesize current evidence on preoperative protein profiling among POCD patients following open-heart surgery. Thus, a thorough literature search employing PubMed, EBSCOhost, Scopus, and Science Direct was carried out. This combination of keywords was used as part of the search strategy: (“Postoperative cognitive decline” OR “Postoperative cognitive disorders” OR “Postoperative cognitive dysfunction” OR “Postoperative cognitive complications”) AND (“Thoracic Surgery” OR “Cardiac Surgery” OR “Heart Surgery”) AND (“Protein expression” OR proteomic OR “Protein profiling”). Eight hundred and twenty-nine studies were retrieved and only clinical studies reporting the circulating preoperative differentially expressed Proteins (DEPs) in the POCD patients were selected. Six studies were selected following the inclusion and exclusion criteria. Only one preoperative DEP and four immediate postoperative DEPs were extracted from the studies. All four proteins were selected for analysis using DAVID, STRING, and Cytoscape software. Due to the very low number of proteins, no clusters have been identified. This systematic review demonstrates the lack of POCD preoperative biomarkers for open-heart-surgery patients. Thus, it is suggested that more studies can be conducted to fill this gap. Full article

Objective: To evaluate the accuracy of the O-RADS system in differentiating between benign and malignant adnexal masses, as assessed by inexperienced gynecologists. Methods: Ten gynecologic residents attended a 20 h training course on the O-RADS system conducted by experienced examiners. Following the training, the residents performed ultrasound examinations on patients admitted with adnexal masses under supervision, recording the data in a database that included videos and still images. The senior author later accessed this ultrasound database and presented the cases offline to ten residents for O-RADS rating, with the raters being blinded to the final diagnosis. The efficacy of the O-RADS system by the residents and inter-observer variability were assessed. Results: A total of 201 adnexal masses meeting the inclusion criteria were evaluated, consisting of 136 (67.7%) benign masses and 65 (32.3%) malignant masses. The diagnostic performance of the O-RADS system showed a sensitivity of 90.8% (95% CI: 82.2–96.2%) and a specificity of 86.8% (95% CI: 80.4–91.8%). Inter-observer variability in scoring was analyzed using multi-rater Fleiss Kappa analysis, yielding Kappa indices of 0.642 (95% CI: 0.641–0.643). The false positive rate was primarily due to the misclassification of solid components in classic benign masses as O-RADS-4 or O-RADS-5. Conclusions: The O-RADS system demonstrates high diagnostic performance in distinguishing benign from malignant adnexal masses, even when used by inexperienced examiners. However, the false positive rate remains relatively high, mainly due to the over-interpretation of solid-appearing components in classic benign lesions. Despite this, inter-observer variability among non-expert raters was substantial. Incorporating O-RADS system training into residency programs is beneficial for inexperienced practitioners. This study could be an educational model for gynecologic residency training for other systems of sonographic features. Full article

Background/Objectives Older people with functional limitations find it difficult to age in place alone, without cohabiting with relatives. In light of this, this paper aimed to investigate possible gender differences in this respect among seniors living in Italy. Methods: The study presents findings from the IN-AGE (“Inclusive ageing in place”) study carried out in 2019 in this country assessing the ability of seniors aged 65 years and over to carry out basic and instrumental activities of daily living (ADLs and IADLs), in addition to two mobility limitations (going up/down the stairs and bending to pick up an object) and sensory limitations (hearing and eyesight). Qualitative/semi-structured interviews were administered to 120 older people living in three Italian regions (Lombardy, Marche, and Calabria). Quantitative and qualitative analyses were performed by differentiating between genders and among activities carried out autonomously, with help, or not performed (i.e., the senior is “not able”). Possible sources of support were also explored. Results: The main results revealed that cleaning the house, shopping, bathing/showering, and washing the laundry are particularly difficult, with men reporting greater difficulties than women. Moreover, for both genders, the family—especially children—represents the main source of help, in addition to public and private services, but the results differ between males and females. Conclusions: These results can offer insights for policymakers in the development of adequate gender-sensitive policies. Full article

Background/Objectives: To understand the lived experiences of the informal caregivers of people with chronic noncommunicable diseases and their interpretations of the significance of that care. The perspectives of men and women interacting with people in a situation of chronicity are examined. Methods: This qualitative, phenomenological, hermeneutic study was based on Van Manen’s comprehensive and interpretative vision. Criterion-oriented non-probability random sampling was used. In-depth interviews were used to collect the information. Twenty informal caregivers participated in the study. Results: The following five themes emerged: transformation of the caregiver’s world; uncertainty of care; tireless guardianship and unwavering devotion; isolation and emotional exhaustion; and imbalance between caring for others and the self. Conclusions: The experience of informal caregivers reveals that both men and women face significant challenges, albeit from gender-differentiated perspectives and experiences. Men and women elaborate different meanings of caregiving, reflecting their gender roles and expectations. Therefore, an inclusive and equitable approach that recognizes and addresses these gender differences is essential in order to improve the support and quality of life for all informal caregivers, respecting and valuing their unique voices and experiences. An inclusive and equitable approach that recognizes gender intersections is required to improve support and the quality of life for informal caregivers. Full article

The existence of two positive solutions for an elliptic differential inclusion is established, assuming that the nonlinear term is an upper semicontinuous set-valued mapping with compact convex values having subcritical growth. Our approach is based on variational methods for locally Lipschitz functionals. As a consequence, a multiplicity result for elliptic Dirichlet problems having discontinuous nonlinearities is pointed out. Full article

Background: Rosmarinic acid (ROS) has gained notable attention for its anticancer potential; however, its limited aqueous solubility hinders its effective delivery and application in pharmaceutical formulations. Methods: To overcome this limitation, an inclusion complex of ROS with β-cyclodextrin (β-CD) was prepared using the recrystallization method. The resultant ROS–β-CD complex was comprehensively characterized by powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). Results: The ROS–β-CD complex showed a significant improvement in the solubility and dissolution profile of ROS, underscoring its potential for enhanced bioavailability and therapeutic efficacy in pharmaceutical applications. In vitro assays were performed to assess the effects on cell viability, proliferation, apoptotic pathways, and 3D spheroid tumor models. Conclusions: The results demonstrated that ROS–β-CD exhibited superior anticancer properties compared to free ROS, effectively reducing the viability and proliferation of the MD-MBA-231 cell line and inducing apoptosis. This research signifies a substantial advancement in developing therapeutic strategies for TNBC, leveraging the distinct properties of the ROS–β-CD inclusion complex. Full article

Many industrial processes, from manufacturing to food processing, incorporate rotating elements as principal components in their production chain. Failure of these components often leads to costly downtime and potential safety risks, further emphasizing the importance of monitoring their health state. Vibration signal analysis is now a common approach for this purpose, as it provides useful information related to the dynamic behavior of machines. This research aimed to conduct a comprehensive examination of the current methodologies employed in the stages of vibration signal analysis, which encompass preprocessing, processing, and post-processing phases, ultimately leading to the application of Artificial Intelligence-based diagnostics and prognostics. An extensive search was conducted in various databases, including ScienceDirect, IEEE, MDPI, Springer, and Google Scholar, from 2020 to early 2024 following the PRISMA guidelines. Articles that aligned with at least one of the targeted topics cited above and provided unique methods and explicit results qualified for retention, while those that were redundant or did not meet the established inclusion criteria were excluded. Subsequently, 270 articles were selected from an initial pool of 338. The review results highlighted several deficiencies in the preprocessing step and the experimental validation, with implementation rates of 15.41% and 10.15%, respectively, in the selected prototype studies. Examination of the processing phase revealed that time scale decomposition methods have become essential for accurate analysis of vibration signals, as they facilitate the extraction of complex information that remains obscured in the original, undecomposed signals. Combining such methods with time–frequency analysis methods was shown to be an ideal combination for information extraction. In the context of fault detection, support vector machines (SVMs), convolutional neural networks (CNNs), Long Short-Term Memory (LSTM) networks, k-nearest neighbors (KNN), and random forests have been identified as the five most frequently employed algorithms. Meanwhile, transformer-based models are emerging as a promising venue for the prediction of RUL values, along with data transformation. Given the conclusions drawn, future researchers are urged to investigate the interpretability and integration of the diagnosis and prognosis models developed with the aim of applying them in real-time industrial contexts. Furthermore, there is a need for experimental studies to disclose the preprocessing details for datasets and the operational conditions of the machinery, thereby improving the data reproducibility. Another area that warrants further investigation is differentiation of the various types of fault information present in vibration signals obtained from bearings, as the defect information from the overall system is embedded within these signals. Full article

Access to finance is essential for fostering financial inclusion, improving household economic well-being, and stimulating economic growth. However, if not prudently managed, it can become a double-edged sword, increasing the risk of over-indebtedness, particularly among low-income households. This paper investigates the borrowing behavior of rural households in Egypt, exploring whether it is motivated by the optimization of intertemporal consumption or reflects deeper financial vulnerabilities. The study enhances our understanding of rural households’ financial behavior in Egypt and contributes to the literature by introducing perceived general self-efficacy as a key behavioral factor. The paper employs a quantitative methodology using a probit analysis of the Egypt Labor Market Panel Survey to explore the factors affecting the demand for formal loans, informal borrowing, and Rotating Saving and Credit Associations (RoSCAs). The results show that informal credit plays a dominant role in meeting rural households’ financial needs. A significant positive relationship between formal and informal credit suggests they are complementary. Elderly, married, less educated, and poorer individuals are more likely to seek both forms of credit, with employment stability being a key differentiator. Self-efficacy also has a significant positive effect. No significant regional differences are observed, except in the case of informal borrowing, with rural households in Upper Egypt showing less reliance, suggesting that social image may influence financial behavior in this region. The results suggest that demand for credit is driven by economic and financial vulnerability of rural households. The paper highlights key policy implications. First, to enhance participation in formal credit market, credit policies should offer more affordable, tailored credit relevant to starting a business rather than financing consumption, part of which is conspicuous. Second, the low self-efficacy among the rural poor suggests a need for policies that combine credit access with financial literacy and debt management support to prevent over-indebtedness. Full article

This study aimed to evaluate the effects of the replacement of rice bran oil (RBO) with black soldier fly larvae oil (BSFLO) on growth performance, blood biochemicals, carcass quality, and metabolomics profile of breast muscle of Thai native chickens. A total of 192 1-day-old, mixed-sex, Pradu Hang Dam (Mor Kor 55) chickens were randomly allocated to one of three dietary groups. Each treatment had four replicates with 16 chicks per replicate (8 males and 8 females). Three dietary treatments were used: (T1) the control group, based on a corn–soybean meal with RBO, and two treatment groups that replaced 50% (T2) and 75% (T3) of RBO in the basal diet with BSFLO, respectively. Results showed that BSFLO inclusion at 50% and 75% did not adversely affect the productive performance of Thai native chickens (p > 0.05). Regarding blood profiles, on day 28, chickens fed 75% BSFLO exhibited significant increases in hemoglobin, hematocrit, and MCHC (mean corpuscular hemoglobin concentration) with lower eosinophil percentages compared to the control group (p < 0.05). Additionally, BSFLO supplementation raised glucose levels but decreased globulin and total protein levels (p < 0.05). On day 63, BSFLO inclusion primarily affected MCV (mean corpuscular volume), with higher values in the 50% BSFLO group (p < 0.05). It also increased globulin and HDL (high-density lipoprotein) levels while lowering AST (aspartate transaminase) concentrations (p < 0.05). For carcass and meat quality, BSFLO supplementation did not affect dressing percentage or edible meat yield (p > 0.05). However, it influenced meat pH and shear force (p < 0.05), with a higher pH at 24 h post-mortem in BSFLO-fed chickens. Metabolomics showed that arginine biosynthesis; phenylalanine, tyrosine, and tryptophan metabolism; alanine, aspartate, and glutamate metabolism; arginine and proline metabolism; and taurine and hypotaurine metabolism were the most differentially abundant. These findings suggest that BSFLO can be used for a partial replacement (50 to 75%) for RBO in Thai native chicken diets, potentially offering benefits for animal health and meat quality without compromising growth performance. Full article

In this study, we use the dynamic programming method introduced by Mirică (2004) to solve the well-known war game of attrition and attack as formulated by Isaacs (1965). By using this modern approach, we extend the classical framework to explore optimal strategies within the differential game setting, offering a complete, comprehensive and theoretically robust solution. Additionally, the study identifies and analyzes feedback strategies, which represent a significant advancement over other strategy types in game theory. These strategies dynamically adapt to the evolving state of the system, providing more robust solutions for real-time decision-making in conflict scenarios. This novel contribution enhances the application of game theory, particularly in the context of warfare models, and illustrates the practical advantages of incorporating feedback mechanisms into strategic decision-making. The admissible feedback strategies and the corresponding value function are constructed through a refined application of Cauchy’s Method of characteristics for stratified Hamilton–Jacobi equations. Their optimality is proved using a suitable Elementary Verification Theorem for the associated value function as an argument for sufficient optimality conditions. Full article

To meet the growing demand for sustainable aquaculture, plant proteins are being explored as alternative sources in fish diets. However, some plant proteins can have adverse health effects on fish, prompting research into functional feed ingredients to mitigate these issues. This study investigated pistachio shell powder (PSP), rich in antioxidants, as a functional feed ingredient for rainbow trout (Oncorhynchus mykiss). The effects of PSP inclusion (0%, 0.5%, 1%, 2%) on growth performance, intestinal health, and gut microbiota were assessed in fish fed either a fishmeal (FM) or plant meal (PM) diet over a 12-week feeding period. The results indicated that PSP inclusion at 1% significantly (p < 0.05) improved weight gain and growth performance in FM treatments, with no impact on growth in PM treatments. No significant differences were observed in other growth parameters, intestinal morphology, or oxidative stress markers, although a trend toward the downregulation of inflammatory genes was noted in PM treatments at 2% PSP inclusion. PSP inclusion did not significantly alter gut microbiota alpha diversity but affected beta diversity at the 0.5% level in the FM treatments (p < 0.05). Differential abundance analysis of gut microbiota revealed taxa-specific responses to PSP, particularly the genus Candidatus arthromitus, increasing in relative abundance with PSP inclusion in both the FM- and PM-based treatments. Overall, PSP inclusion up to 2% did not have significant adverse effects on the growth, intestinal health, or antioxidant status of rainbow trout. Full article

Background: Neurosurgery demands exceptional precision due to the brain’s complex and delicate structures, necessitating precise targeting of pathological targets. Achieving optimal outcomes depends on the surgeon’s ability to accurately differentiate between healthy and pathological tissues during operations. Raman spectroscopy (RS) has emerged as a promising innovation, offering real-time, in vivo non-invasive biochemical tissue characterization. This literature review evaluates the current research on RS applications in intraoperative neurosurgery, emphasizing its potential to enhance surgical precision and patient outcomes. Methods: Following PRISMA guidelines, a comprehensive systematic review was conducted using PubMed to extract relevant peer-reviewed articles. The inclusion criteria focused on original research discussing real-time RS applications with human tissue samples in or near the operating room, excluding retrospective studies, reviews, non-human research, and other non-relevant publications. Results: Our findings demonstrate that RS significantly improves tumor margin delineation, with handheld devices achieving high sensitivity and specificity. Stimulated Raman Histology (SRH) provides rapid, high-resolution tissue images comparable to traditional histopathology but with reduced time to diagnosis. Additionally, RS shows promise in identifying tumor types and grades, aiding precise surgical decision-making. RS techniques have been particularly beneficial in enhancing the accuracy of glioma surgeries, where distinguishing between tumor and healthy tissue is critical. By providing real-time molecular data, RS aids neurosurgeons in maximizing the extent of resection (EOR) while minimizing damage to normal brain tissue, potentially improving patient outcomes and reducing recurrence rates. Conclusions: This review underscores the transformative potential of RS in neurosurgery, advocating for continued innovation and research to fully realize its benefits. Despite its substantial potential, further research is needed to validate RS’s clinical utility and cost-effectiveness. Full article

The use of C-type natriuretic peptide (CNP) in the interaction with the oocyte and in the temporary postponement of spontaneous meiosis resumption has already been well described. However, its action in pre-implantation developmental-stage embryos is yet to be understood. Thus, our study aimed to detect the presence of the canonical CNP receptor (natriuretic peptide receptor, NPR2) in germinal vesicle (GV)-, metaphase II (MII)-, presumptive zygote (PZ)-, morula (MO)-, and blastocyst (BL)-stage embryos and, later, to observe possible modulations on the embryos when co-cultured with CNP. In Experiment I, we detected and quantified NPR2 on the abovementioned embryo stages. Further, in Experiment II, we intended to test different concentrations (100, 200, or 400 nM of CNP) at different times of inclusion in the in vitro culture (IVC; inclusion from the beginning, i.e., day 1, or from day 5). In Experiment III, 400 nM of CNP was used on day 1 (D1) in the IVC, which was not demonstrated to be embryotoxic, and it showed potentially promising results in the blastocyst production rate when compared to the control. Thus, we analyzed the embryonic development rates of bovine embryos (D7) and hatching kinetics (D7, D8, and D9). Subsequently, morula and blastocyst were collected and evaluated for transcript abundance of their competence and quality (apoptosis, oxidative stress, proliferation, and differentiation) and lipid metabolism. Differences with probabilities less than p < 0.05, and/or fold change (FC) > 1.5, were considered significant. We demonstrate the presence of NPR2 until the blastocyst development stage, when there was a significant decrease in membrane receptors. There was no statistical difference in the production rate after co-culture with 400 nM CNP. However, when we evaluated the abundance of morula transcripts, there was an upregulated transcription in ADCY6 (p = 0.057) and downregulated transcripts in BMP15 (p = 0.013), ACAT1 (p = 0.040), and CASP3 (p = 0.082). In addition, there was a total of 12 transcriptions in morula that presented variation FC > 1.5. In blastocysts, the treatment with CNP induced upregulation in BID, CASP3, SOX2, and HSPA5 transcripts and downregulation in BDNF, NLRP5, ELOVL1, ELOVL4, IGFBP4, and FDX1 transcripts (FC > 1.5). Thus, our study identified and quantified the presence of NPR2 in bovine pre-implantation embryos. Furthermore, 400 nM of CNP in IVC, a concentration not previously described in the literature, modulated some transcripts related to embryonic metabolism, and this was not embryotoxic morphologically. Full article

This study focuses on the development of environmentally sustainable polypropylene (PP)-based composites with the potential for biodegradability by incorporating cellulose and the oligomeric siloxane ES-40. Targeting industrial applications such as fused deposition modeling (FDM) 3D printing, ES-40 was employed as a precursor for the in situ formation of silica particles via hydrolytic polycondensation (HPC). Two HPC approaches were investigated: a preliminary reaction in a mixture of cellulose, ethanol, and water, and a direct reaction within the molten PP matrix. The composites were thoroughly characterized using rotational rheometry, optical microscopy, differential scanning calorimetry, and dynamic mechanical analysis. Both methods resulted in composites with markedly reduced crystallinity and shrinkage compared to neat PP, with the lowest shrinkage observed in blends prepared directly in the extruder. The inclusion of cellulose not only enhances the environmental profile of these composites but also paves the way for the development of PP materials with improved biodegradability, highlighting the potential of this technique for fabricating more amorphous composites from crystalline or semi-crystalline polymers for enhancing the quality and dimensional stability of FDM-printed materials. Full article

UNESCO presently offers a universal regime and policy environment for the identification and management of natural and cultural heritages. However, heritage does not merely signify cultural diversity; it can also facilitate greater equity and equality. The research problem addressed in this article is that in Ghana, the national government perceives and treats the small-scale fishing (SSF) sector as a masculine space and endeavour, ignoring the gendered aspects of this environment, of SSF practice and ocean care. In the article, it is hypothesized that if the SSF sector is treated as a socially differentiated space, and if the concern of ocean care is prioritized as a key imperative in Ghanaian ocean management, it is likely that a more inclusive and sustainable ocean management process and SSF sector will emerge in Ghana. Mindful of the socially differentiated nature of the SSF sector in Ghana, the goal of the research presented in this article is to use mixed qualitative research methods (participant-observation and semi-structured interviews) to investigate gendered knowledge forms and gendered practices in ocean care in the central region of Ghana. A key finding of the research is that gendered ritual practices, including canoe building and use in Ghana, are critical to long-term, sustainable, and inclusive ocean management in the country. Recognition of the gendered dimensions of ocean management in Ghana may also result in more inclusive ocean governance policies and nature management policies in Ghana in general. The conclusion of the article is that ocean governance in Ghana should consider and mainstream a gendered perspective of the SSF sector, to advance transformative, sustainable, and inclusive ocean care. The article draws on theories of intersectionality, African indigenous feminist thought, and critical heritage studies to analyse the data gathered, to support the discussion, and to propose the way forward for the national government. Full article