Search Results (101)

In Vietnam, as in other parts of Asia, rural communities establish ritual markers that delineate the social spacetime in which communal existence takes shape and meaning. These ritual markers evolve according to the socio-economic, political, and ecological challenges that said communities confront. The material for this study comes from a local community of North Vietnam that belongs to the Muong ethnic group. We focus on the various spatial levels—household, village, ethnic territory, and the nation as a whole—according to which this community fashions its sense of identity, asserts its ethos, and delimitates its frontiers. We also examine how these levels take varying importance at different moments in time. Moreover, we show how specific rituals condensate different strata of meaning into one unifying event. Finally, we attempt to unearth the various ways through which an Asian rural community constructs and asserts its agency by activating the ritual resources at its disposal while respecting the constraints that weigh upon their mobilization. Full article

There is research on professional helper education and jobs working in a society with children and youth or supporting vulnerable people, but for academics, working in higher education, and preparing students for these work fields, it is not very common. This research focuses on academics from five European countries who prepare teachers, medical, healthcare, and clergy professionals. The aim is to design a map of pressures and challenges in their work. We hypothesized that academics in professional helper higher education (PHHE) perceive work-related challenges differently. Using explanatory research methodology, we considered higher education responsibilities: the working time and demands of academics. A total of 315 responses were used in our quantitative analyses from Romania, Slovakia, Hungary, Serbia, and Ukraine. The research questions were as follows: Are there differences between academics’ responsibilities and different PHHE scientific fields or work profiles? How do academics cope with work tasks and work time? How is a long hour-working academic’s profile? Statistical analyses using SPSS included cross-tabulation analysis, ANOVA and correlation tests, and factor analysis. We delimited two scientific fields and four academic working profiles: 1. academics in teacher education; 2. academics in medical/healthcare education; 3. leaders; 4. organizers; 5. classic lecturers; and 6. researchers. We designed five work demand patterns: controls and supports, global pressures, performance pressures, multi-role challenges, and lecturer roles. Drawing the map of pressures, we concluded that there are significant differences between those in teacher education in perceiving global (research, grant, and publish) responsibilities and performance pressures. At the same time, classic lecturers have significantly higher scores on perceiving performance challenges, and we deduced a positive and significant relation between multi-role challenges and overworking time. The design of the long hour-working profile of academics in PHHE is significantly associated with the medical and health scientific field. Men and academics from E.U. countries have significantly higher working time scores than females and workers outside E.U. Leaders have the highest working mean-time score comparing all the working fields and profiles. Our results for higher education teachers, researchers, policymakers, and institutional leaders can be useful in identifying work-related difficulties and maintaining a balanced distribution of work in the academic fields. Full article

Neuropathic pain (NP) is a heterogeneous group of conditions characterized by the experience of a number of sensory disturbances including pain, burning sensations, paroxysms of stabbing pain, dysesthesias, allodynia, and hyperalgesia. The above-mentioned sensations may occur in a specific dermatome area or other delimited region of the body. The objective of this review was to analyze the evidence for ketamine in multifactorial neuropathic pain. The research group systematically searched the databases MEDLINE (via PubMed), EMBASE, SCOPUS, the Cochrane Central Register of Controlled Trials, the Cumulative Index to Nursing and Allied Health Literature (Cinahl), and the Web of Science. The findings of this review show that different forms of low doses of ketamine (LDK) do not present statistically significant changes for any of the scales included. In this study, the total symptom score [standardized mean difference (SMD) = −3.59, confidence interval (CI) = −4.16 to −3.02, and p < 0.00001], neuropathy impairment score (SMD = −1.42, CI = −3.68 to 0.84, and p = 0.22), and neuropathy symptom checklist (SMD = −0.09, CI = −0.15 to −0.02, and p = 0.01) were taken into account. For finality compared to the use of a placebo, the findings suggest that LDK does not exhibit significant differences in terms of pain reduction and functionality. Moreover, no specific dosages are identified to support the use of LDK in the reduction in NP. Full article

The population dynamics of early replicators has revealed numerous puzzles, highlighting the difficulty of transitioning from simple template-directed replicating molecules to complex biological systems. The resolution of these puzzles has set the research agenda on prebiotic evolution since the seminal works of Manfred Eigen in the 1970s. Here, we study the effects of demographic noise on the population dynamics of template-directed (non-enzymatic) and protein-mediated (enzymatic) replicators. We borrow stochastic algorithms from evolutionary game theory to simulate finite populations of two types of replicators. These algorithms recover the replicator equation framework in the infinite population limit. For large but finite populations, we use finite-size scaling to determine the probability of fixation and the mean time to fixation near a threshold that delimits the regions of dominance of each replicator type. Since enzyme-producing replicators cannot evolve in a well-mixed population containing replicators that benefit from the enzyme but do not encode it, we study the evolution of enzyme-producing replicators in a finite population structured in temporarily formed random groups of fixed size n. We argue that this problem is identical to the weak-altruism version of the n-player prisoner’s dilemma, and show that the threshold is given by the condition that the reward for altruistic behavior is equal to its cost. Full article

Recent technological advancements in conservation genetics and genomics have resulted in diverse tools for aiding the conservation of species. The precision and resolution of high throughput sequencing technologies provide valuable insights to aid conservation decisions, but these technologies are often financially unfeasible or unavailable in resource constrained countries. Inter-Simple Sequence Repeat (ISSR) markers, when combined with sensitive automated detection systems, provide a simple, cheap means to investigate genetic diversity and discriminate closely related species. Here, we apply this technology to assess genetic diversity and taxonomic delimitation in the Encephalartos eugene-maraisii species complex, a highly threatened, taxonomically dubious group of cycads in South Africa. Our analyses support the taxonomic singularity of E. dyerianus, E. dolomiticus and E. eugene-maraisii. Relationships between E. nubimontanus and E. cupidus remain uncertain. E. middelburgensis samples showed no clustering but had poor amplification success. This study demonstrates the suitability of automated ISSR fingerprinting as a method for plant conservation studies, especially in resource-constrained countries, and we make recommendations as to how this methodology can be effectively implemented. Full article

Morphometric analyses of male genitalia are routinely used to distinguish genera and species in beetles, butterflies, and flies, but are rarely used in ants, where most morphometric analyses focus on the external morphology of the worker caste. In this work, we performed linear morphometric analysis of the male genitalia to distinguish Monomorium and Syllophopsis in Madagascar. For 80 specimens, we measured 10 morphometric characters, especially on the paramere, volsella, and penisvalvae. Three datasets were made from linear measurements: mean (raw data), the ratios of characters (ratio data), and the Removal of Allometric Variance (RAV data). The following quantitative methods were applied to these datasets: hierarchical clustering (Ward’s method), unconstrained ordination methods including Principal Component Analysis (PCA), Non-Metric Multidimensional Scaling analyses (NMDS), Linear Discriminant Analysis (LDA), and Conditional Inference Trees (CITs). The results from statistical analysis show that the ratios proved to be the most effective approach for genus-level differentiation. However, the RAV method exhibited overlap between the genera. Meanwhile, the raw data facilitated more nuanced distinctions at the species level compared with the ratios and RAV approaches. The CITs revealed that the ratios of denticle length of the valviceps (SeL) to the paramere height (PaH) effectively distinguished between genera and identified key variables for species-level differentiation. Overall, this study shows that linear morphometric analysis of male genitalia is a useful data source for taxonomic delimitation. Full article

Cross-sectional energy benchmarking in the building domain has become crucial for policymakers, energy managers and property owners as they can compare an immovable property performance against its closest peers. For this, Key Performance Indicators (KPIs) are formulated, often relying on multiple and heterogeneous data sources which, combined, can be used to set benchmarks following normalization criteria. Geographically delimited parameters are important among these criteria because they enclose entities sharing key common characteristics the geometrical boundaries represent. Linking georeferenced heterogeneous data is not trivial, for it requires geographical aggregation, which is often taken for granted or hidden within a pre-processing activity in most energy benchmarking studies. In this article, a novel approach for Linked Data (LD) generation is presented as a methodological solution for data integration together with its application in the energy benchmarking use case. The methodology consists of eight phases that follow the best principles and recommend standards including the well-known GeoSPARQL Open Geospatial Consortium (OGC) for leveraging the geographical aggregation. Its feasibility is demonstrated by the integrated exploitation of INSPIRE-formatted cadastral data and the Buildings Performance Certifications (BPCs) available for the Catalonia region in Spain. The outcomes of this research support the adoption of the proposed methodology and provide the means for generating cross-sectional building energy benchmarking histograms from any-scale geographical aggregations on the fly. Full article

Both palm weevils, the South American (Rhynchophorus palmarum) (SAPW) and the red palm weevil (R. ferrugineus, RPW), are present in South America, affecting commercial, ornamental, and native palms. These pests oviposit and thrive on selected Arecaceae. R. palmarum mainly infests coconut (Cocos nucifera), oil palms (Elaeis guineensis), and other ornamental and native palms in America, causing a significant social impact on growers. The weevils fulfill a significant ectosymbiotic macro- and microorganism role in the first period of larval development, worsening the damage which, during this period, is not yet apparent. Palm protection in the Brazilian context suggests the use of indigenous agents for microbiological biocontrol. This research identifies three Brazilian Beauveria bassiana isolates: CVAD01, CVAD02, and CVAD06. The results suggest that the strain’s impact on R. palmarum can also be compared with that of the commercial strain Beauveria bassiana. Phylogenetic analysis allowed the delimitation of species of Beauveria (Hypocreales). Pathogenicity tests caused significant mortality in R. palmarum. The isolates CVAD01, CVAD02, and CVADO6 showed high pathogenicity between 7 and 21 days, with mortality rates between 90 and 100%, suggesting that they may be effective biological control agents of R. palmarum in the field when used, within available means, to mitigate the impact of R. palmarum and R. ferrugineus in South America. Full article

Among the antiquities of the archaic period of Forest-Steppe Scythia, a group of elite burials of women, possibly endowed with priestly functions during their lifetime, stands out. Until recently, only two unrobbed burial complexes were known to contain the main burials of women of high social rank, in whose graves golden costume elements were found—primarily expressive details of headdresses. The barrows (kurgans) were discovered at the end of the 19th century when amateur excavations were actively carried out on the right bank of the Dnipro. As a result of research conducted by the author at the Skorobir necropolis (in the area of the Bilsk fortified settlement, on the left bank of the Dnipro), two similar graves were recently discovered, which provided new material that significantly expanded the known geographical distribution of this phenomenon. The materials are closely analogous to the previously discovered elite female burials of the Middle Dnipro (barrow 100 near the village of Syniavka, barrow 35 near the village of Bobrytsa) and allow us to highlight a number of stable elements of the funeral costume of noble women and the sets of objects that complemented them. In this article, we consider the social and cultural significance of female attire in elite burials and delimit the chronological framework of this previously understudied phenomenon within the first half of the 6th century BCE. The new finds offer unprecedented insight into the form and meaning of one type of female headdress which researchers have tried to reconstruct for over a century. Full article

Glioblastoma (GB) is a rare but extremely aggressive brain tumor that significantly impacts patient outcomes, affecting both duration and quality of life. The protocol established by Stupp and colleagues in 2005, based on radiotherapy and chemotherapy with Temozolomide, following maximum safe surgical resection remains the gold standard for GB treatment; however, it is evident nowadays that the extreme intratumoral and intertumoral heterogeneity, as well as the invasiveness and tendency to recur, of GB are not compatible with a routine and unfortunately ineffective treatment. This review article summarizes the main challenges in the search for new valuable therapies for GB and focuses on the impact that extracellular vesicle (EV) research and exploitation may have in the field. EVs are natural particles delimited by a lipidic bilayer and filled with functional cellular content that are released and uptaken by cells as key means of cell communication. Furthermore, EVs are stable in body fluids and well tolerated by the immune system, and are able to cross physiological, interspecies, and interkingdom barriers and to target specific cells, releasing inherent or externally loaded functionally active molecules. Therefore, EVs have the potential to be ideal allies in the fight against GB and to improve the prognosis for GB patients. The present work describes the main preclinical results obtained so far on the use of EVs for GB treatment, focusing on both the EV sources and molecular cargo used in the various functional studies, primarily in vivo. Finally, a SWOT analysis is performed, highlighting the main advantages and pitfalls of developing EV-based GB therapeutic strategies. The analysis also suggests the main directions to explore to realize the possibility of exploiting EVs for the treatment of GB. Full article

The food environment plays a crucial role in shaping people’s eating habits and, in and around schools, this influence becomes even more critical due to the time students spend daily in these spaces. This study aimed to analyze the food and consumer environments inside and around federal institutes in Bahia, Brazil. Ecological study and audit methodologies were combined, with all the 35 federal institutes in Bahia as the sample universe. To delimit the food environment around the school, the establishments were mapped in a 1000 m buffer, with the school as the centroid. The geographic coordinates of schools and food outlets were initially obtained using Google Maps and later confirmed on-site. The data were collected in WGS 84 and converted to UTM zone 23S SIRGAS 2000. To map the consumer environment, establishments found in a 250 m buffer and also canteens within schools were audited, using the ESAO-r instrument that considers the availability and prices of healthy and unhealthy foods; availability of nutritional information near the point of purchase or on the menu; and presence of internal marketing of healthy and unhealthy foods. The healthy meal–restaurant index (HMRI) was also measured. This index ranges from 0 to 8 points and positively scores items related to healthy consumption and fails to score those related to unhealthy consumption and behavior. The establishments were grouped into four categories (healthy, unhealthy, mixed, and supermarkets). The surrounding area with four or more unhealthy establishments within the 250 m buffer was considered a food swamp. Descriptive analyses were carried out with frequency measurements, measures of central tendency (mean and median), and dispersion (standard deviation). Around the analyzed schools, 732 food establishments were identified, 73.8% (n = 540) formal and 26.2% (n = 192) informal. Considering the characteristics of existing commerce, there was a predominance of snack bars (45%), grocery stores (23%), and bars (7.8%), with a smaller number of supermarkets identified (4.1%). School canteens were found in 20 schools analyzed and only 15% had a variety of healthy foods. When evaluating the availability of healthy foods, a median HMRI of 3 (1–7) was observed. When analyzing this index according to the type of establishment, it was found that fruit and vegetables presented higher values (HMRI = 7; P25–P75: 4–8) compared to large chain supermarkets (HMRI = 5; P25–P75: 2–6; p < 0.001) and local markets (HMRI = 4; P25–P75: 2–5; p < 0.001). From the analysis of the food and consumer environments, it was possible to make inferences about the quality of the food offered to students in these locations, as well as the potential health outcomes arising from this exposure and the need to carry out food education activities and nutritional activities. Full article

The aim of this study was to investigate to what extent annular fissures, vertebral and endplate changes, and Modic changes (MCs), coexist in low back pain (LBP) patients by using multiple imaging modalities. Sixty-two LBP patients (mean age 45 years, range 24–63, 53% men) were examined with same-day CT-discography and MRI. Intervertebral discs punctured for discography (n = 204) were evaluated on MRI [Pfirrmann grade, High-Intensity Zone (HIZ)] and on CT-discograms [Modified Dallas Discogram Score (DDS)]. DDS≥ 1, i.e., disc fissures involving the outer annulus were further digitomized into delimitable fissuring (<50% of annulus affected) or non-delimitable annular fissuring. Using both MRI and CT, adjacent vertebrae and endplates were assessed for MC, vertebral sclerosis, and a modified endplate defect score (EPS). In 194 discs the contrast agent was adequately injected during discography, of which 160 (83%) displayed outer annular fissures, with 91 (47%) of the latter being delimitable fissures. Most discs with delimitable fissures were moderately degenerated; 68% Pfirrmann grade ≤3, 71% EPS ≤ 2, and 12% displayed MC. The majority (76%) of MCs were associated with advanced adjacent disc degeneration; 84% Pfirrmann grade ≥4, 76% with non-delimitable annular fissuring, 59% EPS≥ 4, and 34% EPS of 3. A total 95 HIZ (47%) were found, of which 54 had delimitable fissuring, while the remainder displayed non-delimitable fissuring. Vertebral sclerosis was commonly observed (26%), both with MCs (73%) and without MCs (27%), and not specifically linked to MC type 3. A total of 97% of segments with vertebral sclerosis displayed outer annular fissures. These findings were significant (0.046 > p > 0.0001), except between HIZ and adjacent sclerosis (p = 0.303). To conclude, the present study confirmed a close interplay between the disc and adjacent vertebra and endplates. The fact that a majority of discs with delimitable annular fissures did not coexist with pronounced endplate changes and/or MCs, however, supports the theory that disc fissuring is an early event in the degenerative cascade. This was further supported by the fact that MCs were strongly linked to extensive disc fissuring and to advanced endplate damage. Further, vertebral sclerosis was common also in vertebra without MCs and strongly associated to annular fissuring, indicating that sclerosis is a previously underestimated feature of a general degenerative process. Full article

Energy consumption represents a significant operating expense in the mining and minerals industry. Grinding accounts for more than half of the mining sector’s total energy usage, where the semi-autogenous grinding (SAG) circuits are one of the main components. The implementation of control and automation strategies that can achieve production objectives along with energy efficiency is a common goal in concentrator plants. However, designing such controls requires a proper understanding of process dynamics, which are highly complex, coupled, and have non-deterministic components. This complex and non-deterministic nature makes it difficult maintain a set-point for control purposes, and hence operations focus on an optimal control region, which is defined in terms of desirable behavior. This paper investigates the feasibility of employing machine learning models to delineate distinct operational regions within in an SAG mill that can be used in advanced process control implementations to enhance productivity or energy efficiency. For this purpose, two approaches, namely k-means and self-organizing maps, were evaluated. Our results show that it is possible to identify operational regions delimited as clusters with consistent results. Full article

Early engineering experiences can provide young people with experiences that can contribute to developing longer-term interest in the field and addressing dropout issues faced in engineering internationally. One way to engage young people with engineering is through the creation of personally meaningful sound-making projects with everyday materials and electronic kits. Sound making can make it possible for people to connect to their personal experiences and to represent these personal experiences through artistic means while also performing engineering practices, like asking questions, defining and delimiting problems, and developing and optimizing solutions with physical materials that produce sounds. Such design processes are referred to as engaging in the design of personally meaningful projects. However, it remains underspecified what personally meaningful means and, therefore, what aspects to integrate into engineering educational activity and technology designs to foster personally meaningful design opportunities. Building on constructionist perspectives on learning, this qualitative research investigated engineering practices as middle-school-aged youth used electronic construction kits and personal tangible material objects to create sounds. Iterative and thematic analysis of engineering practices of semi-structured interviews and video-recorded youth workshops showed that sound making with personal objects and electronic construction kits is a context for engineering design practices. This study also showed that integrating personal tangible projects that materialize personal histories can foster engineering practices. The findings contribute to our understanding of the theoretical idea of personally meaningful design in constructionism by presenting the importance of integrating personal histories through the design of personal projects with tangible material objects of a person’s life. Full article

The urban fringe is the transitional area from rural form to urban form, and it is also the urban space reserve land in the Territorial Spatial Plan. However, few researchers predict its overall evolution and guide the implementation of the Territorial Spatial Plan. This study attempts to explore the dynamic evolution law of urban fringe, analyze its driving factors, predict its future development, and put forward management suggestions for the implementation of the Territorial Spatial Plan. In this paper, the land use data of Wuhan in 2000, 2010 and 2020 are applied to delimit the urban fringe area of Wuhan by means of a sliding t-test. Fifteen driving factors are selected from three dimensions, natural factors, socio-economic factors and traffic accessibility, and brought into the Logistic model to explore the driving factors of its spatial evolution. The CA–Markov model is used to predict the fringe area of Wuhan in 2035. The results show that the transformation of rural hinterland into urban fringe is obviously affected by the distance from railway stations, highways, commercial centers and urban main roads. It is predicted that the outer boundary of Wuhan’s fringe area in 2035 will be basically the same as the planned urban development boundary. In order to realize the intention of land space planning, the development and construction of the northwest of the Huangpi District, the East Lake Scenic Area, and the west side of the Jiangxia District should be restricted. From the perspective of the evolution of the fringe area, this paper puts forward some management suggestions for the implementation of the Territorial Spatial Plan and makes a beneficial attempt in theory and method to understand the development characteristics of the fringe area and promote the implementation of the Territorial Spatial Plan. Full article