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Search Results (849)

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Keywords = biomimetic materials

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18 pages, 40521 KiB  
Article
The Sound Absorption Performance of Laser-Sintered Composite Biomimetic Wood Porous Structures
by Li Zou, Aitian Zhang, Zhenbo Liu, Pengfei Du and Yanling Guo
Polymers 2024, 16(23), 3290; https://doi.org/10.3390/polym16233290 - 26 Nov 2024
Viewed by 200
Abstract
This study investigates the development of biomimetic sound-absorbing components through laser sintering technology, drawing inspiration from wood’s natural porous structure. Using a pine wood powder/phenolic resin composite, various specimens were fabricated with different structural configurations (solid, fully porous, and varying straight-pore ratios) and [...] Read more.
This study investigates the development of biomimetic sound-absorbing components through laser sintering technology, drawing inspiration from wood’s natural porous structure. Using a pine wood powder/phenolic resin composite, various specimens were fabricated with different structural configurations (solid, fully porous, and varying straight-pore ratios) and cavity thicknesses. Sound absorption performance was evaluated using the impedance tube transfer function method. The effect of different composite structures, placement orientations, and cavity thicknesses on sound absorption performance was evaluated. The results demonstrate that solid laser-sintered samples exhibit inherent sound absorption properties due to microscopic pores, with absorption coefficients exceeding 0.234. The biomimetic wood-like structure, featuring multi-scale porosity at both microscopic and mesoscopic levels, shows enhanced broadband sound absorption, particularly in mid-high frequencies, with characteristic double-peak absorption curves. The study reveals that absorption performance can be optimized by adjusting structural parameters and thickness, enabling targeted frequency-specific sound absorption. This research establishes the feasibility of creating multi-frequency sound-absorbing materials using laser-sintered biomimetic wood structures, providing a foundation for future applications and development in acoustic engineering. Full article
(This article belongs to the Section Biobased and Biodegradable Polymers)
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<p>Preparation of sintered specimens with different pine wood percentages.</p>
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<p>A 200-fold pore morphology on the surface and cross-section of sintered parts of pine/phenolic composite materials with different amounts of pine wood addition: (<b>a</b>) 20%, surface; (<b>b</b>) 30%, surface; (<b>c</b>) 40%, surface; (<b>d</b>) 20%, cross-section; (<b>e</b>) 30%, cross-section; (<b>f</b>) 40%, cross-section.</p>
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<p>Evolution of the porous composite structure of biomimetic wood: (<b>a</b>) Microscopic diagram of the arrangement of wood tracheids; (<b>b</b>) Cell structure; (<b>c</b>) Biomimetic wood porous composite structure.</p>
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<p>Bending strength of standard specimens under 14~20 W laser power.</p>
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<p>Warpage of sintered specimens.</p>
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<p>Step-by-step diagram of the preparation and experimental process of pine/phenolic resin composite powder.</p>
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<p>Sound absorption coefficient of solid laser-sintered specimens.</p>
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<p>Schematic diagram of the impedance tube structure.</p>
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<p>Schematic diagram 1 of the impedance tube testing. D: The d specimens with 1/2 each of straight and porous holes were placed inside the impedance tube, with the porous cells placed in front; B, F: Fully porous b specimens and fully straight hole f specimens were placed inside the impedance tube.</p>
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<p>Sound absorption coefficient of three types of laser-sintered specimen testing.</p>
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<p>Schematic diagram 2 of the impedance tube testing. C: The porous unit cell of the c specimen inside the impedance tube is placed in front; D: The d specimens with 1/2 each of straight and porous holes were placed inside the impedance tube, with the porous cells placed in front; E: The porous unit cell of the e specimen inside the impedance tube is placed in front.</p>
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<p>Sound absorption coefficient of laser-sintered specimens with different porous composite structures.</p>
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<p>Schematic diagram 3 of impedance tube testing. The letter Z stands for straight pore unit cells placed in front; C, D, E: The porous unit cells of specimen c, specimen d, and specimen e in the impedance tube are placed in front; ZC, ZD, ZE: The straight pore cells of specimen c, specimen d, and specimen e in the impedance tube are placed in front.</p>
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<p>Sound absorption coefficient of the porous composite structures with different placements of the specimens.</p>
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<p>Sound absorption coefficient of the porous composite structures with different placements of the d specimens.</p>
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<p>Sound absorption coefficient of the porous composite structures with different placements of the e specimens.</p>
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<p>Absorption coefficient of solid specimens with different cavity thicknesses.</p>
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<p>Sound absorption coefficient of the c specimen under different cavity thicknesses.</p>
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<p>Sound absorption coefficient of the d specimen under different cavity thicknesses.</p>
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18 pages, 3372 KiB  
Article
Hybrid Chitosan Biosorbents: Tunable Adsorption at Surface and Micropore Domains
by Inimfon A. Udoetok, Mohamed H. Mohamed and Lee D. Wilson
Biomimetics 2024, 9(12), 725; https://doi.org/10.3390/biomimetics9120725 - 24 Nov 2024
Viewed by 392
Abstract
Herein, we report a study that provides new insight on the knowledge gaps that relate to the role of biopolymer structure and adsorption properties for chitosan adsorbents that are cross-linked with glutaraldehyde. The systematic modification of chitosan cross-linked with glutaraldehyde (CG) and its [...] Read more.
Herein, we report a study that provides new insight on the knowledge gaps that relate to the role of biopolymer structure and adsorption properties for chitosan adsorbents that are cross-linked with glutaraldehyde. The systematic modification of chitosan cross-linked with glutaraldehyde (CG) and its quaternized forms (QCG) was studied in relation to the reaction conditions: mole ratios of reactants and pH conditions. Complementary adsorbent characterization employed 13C NMR/FTIR spectroscopy, TGA and DSC, point-zero-charge (PZC), solvent swelling, and sorption studies using selected dye probes. The spectral and thermal techniques provide complementary evidence that affirm the key role of cross-linker content and quaternization on variation of the physicochemical properties of chitosan. The PZC results reveal a neutral surface charge for the modified materials between pH 6.0 to 6.3 ± 0.3, as compared with pH 8.7 ± 0.4 for pristine chitosan. Solvent swelling in water decreased with greater cross-linking, while the QCG materials had greater swelling over CG materials due to enhanced hydration. The adsorption results reveal variable dye uptake properties according to the cross-linker content. Similarly, surface versus micropore adsorption was demonstrated, according to the nature and ionization state of the dye for the modified adsorbents, where the CG and QCG materials had tunable sorption properties that exceeded that of unmodified chitosan. A key step in tuning the structure and surface chemical properties of cross-linked chitosan involves pH control during synthesis. The facile tunability of the physicochemical properties of the modified biopolymers reported herein means that they possess features of biomimetics that are relevant to advanced drug delivery, antimicrobial materials for wound healing, biosensors, and biosorbents for biomedical applications. Full article
(This article belongs to the Special Issue Chitin and Chitosan Materials for Tomorrow)
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<p>FTIR spectra of (<b>A</b>) cross-linked chitosan (CG), (<b>B</b>) cross-linked and quaternized chitosan (QCG) and (<b>C</b>) cross-linked chitosan showing the 1660–1800 cm<sup>−1</sup> region (the highlighted section of the spectra shows new IR bands from the cross-linker). The acronyms for sample names are defined in <a href="#biomimetics-09-00725-t001" class="html-table">Table 1</a>.</p>
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<p>(<b>A</b>–<b>C</b>). DTG of cross-linked chitosan (<b>A</b>) and cross-linked and quaternized chitosan (<b>B</b>), and DSC thermograms of CH and its modified forms (<b>C</b>). The acronyms for the sample names are defined in <a href="#biomimetics-09-00725-t001" class="html-table">Table 1</a>.</p>
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<p>(<b>A</b>) <sup>13</sup>C CP-MAS solids NMR spectra of chitosan, CG, and (<b>B</b>) QGC materials at variable levels of cross-linking and quaternization. The acronyms for sample names are defined in <a href="#biomimetics-09-00725-t001" class="html-table">Table 1</a>.</p>
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<p>PZC of CG (<b>A</b>) and QCG (<b>B</b>). The acronyms for sample names are defined in <a href="#biomimetics-09-00725-t001" class="html-table">Table 1</a>.</p>
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<p>Equilibrium water swelling properties of chitosan, CG, and QGC polymers at ambient pH (pH ca. 6.5). The acronyms for sample names are defined in <a href="#biomimetics-09-00725-t001" class="html-table">Table 1</a>.</p>
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<p>(<b>A</b>) Removal efficiency of chitosan (CH), CG, and QGC polymers for methyl orange (MO), reactive black 5 (RB), phenolphthalein (Phth), and methylene blue (MB). (<b>B</b>) Effects of pH on the decolorization of MO by chitosan (CH), CG, and QGC hydrogels. The acronyms for sample names are defined in <a href="#biomimetics-09-00725-t001" class="html-table">Table 1</a>.</p>
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<p>Effect of pH adjustment on (<b>A</b>) swelling properties, (<b>B</b>) thermal stability, and (<b>C</b>) adsorption properties of the CG polymers. The acronyms for the sample names are defined in <a href="#biomimetics-09-00725-t001" class="html-table">Table 1</a>.</p>
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<p>(<b>A</b>) Schematic description of the synthesis of CGx and QCGx polymer materials, and. (<b>B</b>) Reaction of chitosan with glutaraldehyde to yield micropore domains that contain solvent (not drawn to scale) that arise due to cross-linking between the biopolymer chains.</p>
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17 pages, 6487 KiB  
Article
Effect of Photolithographic Biomimetic Surface Microstructure on Wettability and Droplet Evaporation Process
by Zhihao Zhang and Yuying Yan
Biomimetics 2024, 9(12), 724; https://doi.org/10.3390/biomimetics9120724 - 24 Nov 2024
Viewed by 304
Abstract
In nature, engineering technology and daily life, wetting phenomena are widespread and have essential roles and significance. Bionics is becoming increasingly important nowadays and exploring the mechanism that influences biomimetic surface microstructure on droplet wetting process and heat and mass transfer characteristics is [...] Read more.
In nature, engineering technology and daily life, wetting phenomena are widespread and have essential roles and significance. Bionics is becoming increasingly important nowadays and exploring the mechanism that influences biomimetic surface microstructure on droplet wetting process and heat and mass transfer characteristics is becoming more meaningful. In this paper, based on photolithography technology, SU-8 photoresist was used as raw material to prepare biomimetic surfaces with microstructures in various arrangements. The research results show that the wettability of biomimetic functional surfaces can be regulated by regulating the shape and arrangement of photoresist micro-pillars. At the same time, the effects of surface microstructure configuration and roughness on the heat and mass transfer processes within the droplets were also comprehensively studied. The results show that a biomimetic surface with cylindrical micro-pillars can effectively inhibit the evaporative cooling effect of the liquid–vapour interface. This effect becomes more evident with the increase in roughness, and the interface temperature difference can be reduced by up to 18%. Similarly, the biomimetic surface with cylindrical micro-pillars can also effectively promote the evaporation rate of sessile droplets, which can be increased by about 13%. In addition, the research also shows that regardless of the structure, substrate temperature changes will significantly impact the wetting phenomenon of the biomimetic surface. This study aims to guide the optimal design of biomimetic surfaces prepared based on photoresistance. Full article
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<p>(<b>a</b>) Common bionic prototypes in the biomimetic surface design process (<b>b</b>) raw materials used for surface preparation; and (<b>c</b>) schematic diagram of the three-dimensional structure of photoresist micropillars.</p>
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<p>Photoresist biomimetic surface production process.</p>
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<p>Equipment and operation procedures for the evaporation experiment of sessile droplets on bionic surfaces.</p>
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<p>Changes in contact angle and contact line of a 1.0 μL droplet on SS-1 and CS-3 surfaces at a substrate temperature of (<b>a</b>) 50 °C; (<b>b</b>) 60 °C; (<b>c</b>) 70 °C; (<b>d</b>) 80 °C.</p>
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<p>Changes in contact angle and contact line of a 1.0 μL droplet on SS-1 and CS-3 surfaces at a substrate temperature of (<b>a</b>) 50 °C; (<b>b</b>) 60 °C; (<b>c</b>) 70 °C; (<b>d</b>) 80 °C.</p>
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<p>(<b>a</b>) Dimensionless height of a 1.0 μL droplet over time for different surfaces and substrate temperatures; (<b>b</b>) initial equilibrium contact angle of a 1.0 μL droplet on different surfaces and substrate temperatures.</p>
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<p>(<b>a</b>) Dimensionless height of a 1.0 μL droplet over time for different surfaces and substrate temperatures; (<b>b</b>) initial equilibrium contact angle of a 1.0 μL droplet on different surfaces and substrate temperatures.</p>
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<p>Changes in contact angle and contact line of a 1.0 μL droplet on different surfaces at a substrate temperature of (<b>a</b>) 50 °C; (<b>b</b>) 60 °C; (<b>c</b>) 70 °C; (<b>d</b>) 80 °C.</p>
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<p>Changes in contact angle and contact line of a 1.0 μL droplet on different surfaces at a substrate temperature of (<b>a</b>) 50 °C; (<b>b</b>) 60 °C; (<b>c</b>) 70 °C; (<b>d</b>) 80 °C.</p>
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<p>(<b>a</b>) The initial equilibrium contact angle of the droplet changes under different surface and substrate temperature conditions; (<b>b</b>) the initial adhesion work of the droplet changes under different surface and substrate temperature conditions.</p>
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<p>Temperature distribution in the droplet liquid–vapour interface on the CS-3 and SS-3 surfaces at different periods when the substrate temperature is (<b>a</b>) 50 °C and (<b>b</b>) 80 °C.</p>
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<p>The temperature distribution at the centre-line of the droplet’s liquid–vapour interface at different periods when the substrate temperature of the CS-3 surface is (<b>a</b>) 50 °C, (<b>c</b>) 60 °C, (<b>e</b>) 70 °C or (<b>g</b>) 80 °C; the temperature distribution at the centre line of the droplet’s liquid–vapour interface at different periods when the substrate temperature of the SS-3 surface is (<b>b</b>) 50 °C, (<b>d</b>) 60 °C, (<b>f</b>) 70 °C or (<b>h</b>) 80 °C.</p>
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<p>The temperature distribution at the centre-line of the droplet’s liquid–vapour interface at different periods when the substrate temperature of the CS-3 surface is (<b>a</b>) 50 °C, (<b>c</b>) 60 °C, (<b>e</b>) 70 °C or (<b>g</b>) 80 °C; the temperature distribution at the centre line of the droplet’s liquid–vapour interface at different periods when the substrate temperature of the SS-3 surface is (<b>b</b>) 50 °C, (<b>d</b>) 60 °C, (<b>f</b>) 70 °C or (<b>h</b>) 80 °C.</p>
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<p>(<b>a</b>) Temperature difference at the droplet’s liquid–vapour interface in the initial state under different surface and substrate temperature conditions; (<b>b</b>) variation in the overall average evaporation rate of the droplet with the surface and substrate temperature.</p>
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27 pages, 5768 KiB  
Review
Biomaterial Promotes Triboelectric Nanogenerator for Health Diagnostics and Clinical Application
by Qiliang Zhu, Enqi Sun, Yuchen Sun, Xia Cao and Ning Wang
Nanomaterials 2024, 14(23), 1885; https://doi.org/10.3390/nano14231885 - 23 Nov 2024
Viewed by 386
Abstract
With the growing demand for personalized healthcare services, biomaterial-based triboelectric nanogenerators (BM-TENGs) have gained widespread attention due to their non-toxicity, biocompatibility, and biodegradability. This review systematically examines the working principles, material choices, biomimetic designs, and clinical application scenarios of BM-TENGs, with a focus [...] Read more.
With the growing demand for personalized healthcare services, biomaterial-based triboelectric nanogenerators (BM-TENGs) have gained widespread attention due to their non-toxicity, biocompatibility, and biodegradability. This review systematically examines the working principles, material choices, biomimetic designs, and clinical application scenarios of BM-TENGs, with a focus on the use of natural biomaterials, biocomposites, hydrogels, and other materials in health diagnostics. Biomaterials show significant potential in enhancing TENG performance, improving device flexibility, and expanding application ranges, especially in early disease detection, health monitoring, and self-powered sensing devices. This paper also addresses the current challenges faced by BM-TENG technology, including performance optimization, biocompatibility, and device durability. By integrating existing research and technological advancements, this review aims to deeply analyze the development of BM-TENG technology, propose corresponding solutions, and explore its practical application prospects in the medical field. Full article
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<p>Recent progress of TENG based on biomaterials including biomaterials like silk; reprinted with permission from Ref. [<a href="#B53-nanomaterials-14-01885" class="html-bibr">53</a>]. Copyright 2023, Elsevier; rice gluten and its application as blood vessel and sweat monitoring; reprinted with permission from Ref. [<a href="#B54-nanomaterials-14-01885" class="html-bibr">54</a>]. Copyright 2022, Elsevier; Cellulose; reprinted with permission from Ref. [<a href="#B55-nanomaterials-14-01885" class="html-bibr">55</a>]. Copyright 2022, Elsevier; Bionic tentacle; reprinted with permission from Ref. [<a href="#B56-nanomaterials-14-01885" class="html-bibr">56</a>]. Copyright 2024, Elsevier; Air permeability; reprinted with permission from Ref. [<a href="#B57-nanomaterials-14-01885" class="html-bibr">57</a>]. Copyright 2022, Elsevier; Self-healing; reprinted with permission from Ref. [<a href="#B58-nanomaterials-14-01885" class="html-bibr">58</a>]. Copyright 2021, Elsevier; Stretchability; reprinted with permission from Ref. [<a href="#B59-nanomaterials-14-01885" class="html-bibr">59</a>]. Copyright 2021, Wiley Online Library; Real-time monitoring of Parkinson’s disease; reprinted with permission from Ref. [<a href="#B60-nanomaterials-14-01885" class="html-bibr">60</a>]. Copyright 2021, Elsevier; Cardiac diagnosis; reprinted with permission from Ref. [<a href="#B61-nanomaterials-14-01885" class="html-bibr">61</a>]. Copyright 2023, ACS Publications; Pulse diagnosis; reprinted with permission from Ref. [<a href="#B62-nanomaterials-14-01885" class="html-bibr">62</a>]. Copyright 2023, Elsevier; Exercise Monitoring; reprinted with permission from Ref. [<a href="#B63-nanomaterials-14-01885" class="html-bibr">63</a>]. Copyright 2022, ACS Publications; In vivo monitoring; reprinted with permission from Ref. [<a href="#B64-nanomaterials-14-01885" class="html-bibr">64</a>]. Copyright 2020, Elsevier; Breath monitoring; reprinted with permission from Ref. [<a href="#B65-nanomaterials-14-01885" class="html-bibr">65</a>]. Copyright 2020, ACS Publications.</p>
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<p>The four primary working modes of TENG are (<b>a</b>) vertical contact–separation mode, (<b>b</b>) lateral-sliding mode, (<b>c</b>) single-electrode mode, and (<b>d</b>) freestanding triboelectric-layer mode.</p>
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<p>(<b>a</b>) Structure of HM-TENG: the upper part represents the simulation and SEM of L-cystine and the original nylon 6; the lower part represents the power density of the HM-TENG at different external resistances, with the charge curve of different capacitors. Reprinted with permission from Ref. [<a href="#B90-nanomaterials-14-01885" class="html-bibr">90</a>]. Copyright 2023, Elsevier. (<b>b</b>) Structure and output of nano-gap TENG: right shows its output current density and the voltage signal used to monitor the pulse. Reprinted with permission from Ref. [<a href="#B91-nanomaterials-14-01885" class="html-bibr">91</a>]. Copyright 2020, ACS Publications. (<b>c</b>) Structure design of SNR-TENG and its application in medical monitoring. Reprinted with permission from Ref. [<a href="#B64-nanomaterials-14-01885" class="html-bibr">64</a>]. Copyright 2020, Elsevier. (<b>d</b>) Top shows the preparation process of HA, middle shows the results of the cell viability assay of MC3T3-E1 after being treated with HA membrane for 24 h, and bottom shows the triboelectric outputs of the TENG based on HA and PTFE films under various external resistances. Reprinted with permission from Ref. [<a href="#B92-nanomaterials-14-01885" class="html-bibr">92</a>]. Copyright 2020, Elsevier.</p>
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<p>(<b>a</b>) Source of wood fiber and schematic diagram of the TENG device based on wood fiber substrate. Reprinted with permission from Ref. [<a href="#B55-nanomaterials-14-01885" class="html-bibr">55</a>]. Copyright 2022, Elsevier. (<b>b</b>) Rice gluten films were prepared by the traditional method using NaOH (as shown in the upper diagram) and then fabricated into biocompatible and environmentally friendly triboelectric materials according to structural engineering (as shown in the lower diagram). Reprinted with permission from Ref. [<a href="#B54-nanomaterials-14-01885" class="html-bibr">54</a>]. Copyright 2022, Elsevier. (<b>c</b>) Preparation of CS–glycerin composite film, its output performance as a TENG, and its application in medical health. Reprinted with permission from Ref. [<a href="#B62-nanomaterials-14-01885" class="html-bibr">62</a>]. Copyright 2023, Elsevier. (<b>d</b>) Schematic of the structure of the PVA/SF-based TENG. Reprinted with permission from Ref. [<a href="#B53-nanomaterials-14-01885" class="html-bibr">53</a>]. Copyright 2023, Elsevier. (<b>e</b>) Schematic of the MoS2-based TENG patch for accelerating wound healing. Reprinted with permission from Ref. [<a href="#B96-nanomaterials-14-01885" class="html-bibr">96</a>]. Copyright 2024, Elsevier. (<b>f</b>) Schematic of the GAH-TES for sweat monitoring. TENG voltage response when detecting 0–500 μM glucose in artificial sweat and calibration curve for repeated glucose detection. Reprinted with permission from Ref. [<a href="#B97-nanomaterials-14-01885" class="html-bibr">97</a>]. Copyright 2023, Elsevier. (<b>g</b>) Schematic diagrams of the structure of CZL hydrogel, SEM (Scanning Electron Microscopy), pulse monitoring, and energy harvesting. Reprinted with permission from Ref. [<a href="#B56-nanomaterials-14-01885" class="html-bibr">56</a>]. Copyright 2024, Elsevier.</p>
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<p>(<b>a</b>) Schematic diagrams of the manufacturing process of DF-CNF-based TENG and the self-powered biocompatible smart mask for human respiratory sensing and health monitoring. Reprinted with permission from Ref. [<a href="#B65-nanomaterials-14-01885" class="html-bibr">65</a>]. Copyright 2020, ACS Publications. (<b>b</b>) AF-TENG fabricated mask for patient respiratory detection via Wi-Fi and LoRa. Reprinted with permission from Ref. [<a href="#B103-nanomaterials-14-01885" class="html-bibr">103</a>]. Copyright 2023, ACS Publications. (<b>c</b>) Left shows the structure of SF@MXene-TENG and right shows the air permeability of common textile materials and SF@MXene-TENG as well as their corresponding error bars. Structure of SF@MXene-TENG mask fabricated for diagnosing asthma symptoms. Reprinted with permission from Ref. [<a href="#B104-nanomaterials-14-01885" class="html-bibr">104</a>]. Copyright 2023, ACS Publications. (<b>d</b>) SF/CNF scaffold for cardiac motion energy and iPSCs images captured over 14 days. Reprinted with permission from Ref. [<a href="#B61-nanomaterials-14-01885" class="html-bibr">61</a>]. Copyright 2023, ACS Publications. (<b>e</b>) Manufacturing process and structure of NFM-TENG and respiratory monitoring. Reprinted with permission from Ref. [<a href="#B105-nanomaterials-14-01885" class="html-bibr">105</a>]. Copyright 2019, ACS Publications.</p>
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<p>(<b>a</b>) Schematic diagram of WPHM connected to the human body via arc-shaped CS-TENG and its wireless monitoring application. Reprinted with permission from Ref. [<a href="#B108-nanomaterials-14-01885" class="html-bibr">108</a>]. Copyright 2024, Elsevier. (<b>b</b>) Concept and structural schematic of OFS-TENG implanted in the human body. Reprinted with permission from Ref. [<a href="#B63-nanomaterials-14-01885" class="html-bibr">63</a>]. Copyright 2022, ACS Publications. (<b>c</b>) Structural schematic of CCDHG-TENG and real-time monitoring of typical symptoms of Parkinson’s disease. Reprinted with permission from Ref. [<a href="#B60-nanomaterials-14-01885" class="html-bibr">60</a>]. Copyright 2021, Elsevier. (<b>d</b>) Self-powered strain sensor based on GO-PAM hydrogel for monitoring human motion. Reprinted with permission from Ref. [<a href="#B109-nanomaterials-14-01885" class="html-bibr">109</a>]. Copyright 2022, Elsevier.</p>
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<p>(<b>a</b>) Schematic diagrams of the structure of the PLA-TENG self-powered sensor system and the current signals obtained by monitoring the concentration of bacteria. Reprinted with permission from Ref. [<a href="#B110-nanomaterials-14-01885" class="html-bibr">110</a>]. Copyright 2023, ACS Publications. (<b>b</b>) CNT-Arg-based TENG measures Gram-positive bacteria through voltage measurement. Reprinted with permission from Ref. [<a href="#B111-nanomaterials-14-01885" class="html-bibr">111</a>]. Copyright 2022, Elsevier. (<b>c</b>) Top shows the structure of TENG and the surface morphology of Ti orthopedic implants after anodization. Bottom shows the mechanism of action in the antibacterial and osteogenesis-promoting surfaces of the TENG. Reprinted with permission from Ref. [<a href="#B112-nanomaterials-14-01885" class="html-bibr">112</a>]. Copyright 2020, Elsevier. (<b>d</b>) Left shows the structure and working principle of P-TENG and its function as an antibacterial pressure sensor for monitoring human motions; right shows the preparation process of ZnO@paper. Schematic of antimicrobial pressure sensor based on P-TENG for monitoring human motion. Reprinted with permission from Ref. [<a href="#B113-nanomaterials-14-01885" class="html-bibr">113</a>]. Copyright 2021, MDPI.</p>
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17 pages, 4271 KiB  
Article
Efficient Removal of Cationic Dye by Biomimetic Amorphous Calcium Carbonate: Behavior and Mechanisms
by Renlu Liu, Weizhen Ji, Jie Min, Pengjun Wen, Yan Li, Jialu Hu, Li Yin and Genhe He
Molecules 2024, 29(22), 5426; https://doi.org/10.3390/molecules29225426 - 18 Nov 2024
Viewed by 523
Abstract
The search for efficient, environmentally friendly adsorbents is critical for purifying dye wastewater. In this study, we produced a first-of-its-kind effective biomimetic amorphous calcium carbonate (BACC) using bacterial processes and evaluated its capacity to adsorb a hazardous organic cationic dye—methylene blue (MB). BACC [...] Read more.
The search for efficient, environmentally friendly adsorbents is critical for purifying dye wastewater. In this study, we produced a first-of-its-kind effective biomimetic amorphous calcium carbonate (BACC) using bacterial processes and evaluated its capacity to adsorb a hazardous organic cationic dye—methylene blue (MB). BACC can adsorb a maximum of 494.86 mg/g of MB, and this excellent adsorption performance was maintained during different solution temperature (10–55 °C) and broad pH (3–12) conditions. The favorable adsorption characteristics of BACC can be attributable to its hydrophobic property, porosity, electronegativity, and perfect dispersity in aqueous solution. During adsorption, MB can form Cl-Ca, S-O, N-Ca, and H-bonds on the surface of BACC. Since BACC has excellent resistance to adsorption interference in different water bodies and in real dye wastewater, and can also be effectively recycled six times, our study is an important step forward in dye wastewater treatment applications. Full article
(This article belongs to the Special Issue Functional Nanomaterials for Energy and Environmental Sustainability)
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<p>Structural and morphological characteristics of tested BACC. XRD pattern (<b>a</b>), TEM-SAED-EDS (<b>b</b>), FTIR spectra (<b>c</b>), TG-DTG/DSC results (<b>d</b>), SEM image (<b>e</b>), and 3D-AFM image of BACC (<b>f</b>).</p>
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<p>Effect of adsorbent dose (<b>a</b>) and adsorption isotherm at different temperatures on MB adsorption by BACC fitted to Langmuir and Freundlich models (<b>b</b>), comparison of Qm between BACC and reported mineral or carbon-based adsorbents from <a href="#app1-molecules-29-05426" class="html-app">Table S1</a> (<b>c</b>), adsorption as a function of contact time fitted to PFO, PSO (<b>d</b>), and ID models (<b>d</b>), (insert). Data represent the mean ± standard deviation (s.d.) from three independent experiments.</p>
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<p>The Qe of BACC over a pH range of 1–12 (<b>a</b>), the zeta potential of BACC under various pH conditions (<b>b</b>), the Qe of MB by BACC with various coexisting substances (<b>c</b>), and the effect of different water samples on MB adsorption by BACC (<b>d</b>), W1: deionized water, W2: tap water, W3: lake water from Jinggangshan University, W4: Ganjiang River water, W5: lake water from Hangzhou West Lake, W6: real dyeing wastewater from a dyeing and finishing company in Zhejiang Province of China. Data represent the mean ± standard deviation (s.d.) from three independent experiments.</p>
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<p>Regeneration experiment (<b>a</b>), and breakthrough curves of BACC and recovered BACC for MB in real dyeing wastewater (<b>b</b>), the blue line is the broken through point. Data represent the mean ± standard deviation (s.d.) from three independent experiments.</p>
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<p>The XPS spectra of C1s (<b>a</b>) and N1s (<b>b</b>) before and after MB adsorption by BACC, the side (<b>c</b>) and top (<b>d</b>) views of the MB cation on the BACC surface, and differential charge density distributions for MB adsorbed on BACC (<b>e</b>,<b>f</b>), where the isosurface was adjusted to 0.001 electrons/Born3, and yellow and blue colors, respectively, represent gains and losses of electrons.</p>
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<p>The possible mechanisms of efficient MB adsorption by BACC.</p>
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25 pages, 11995 KiB  
Article
Evaluation of the In Vitro Behavior of Electrochemically Deposited Plate-like Crystal Hydroxyapatite Coatings
by Cosmin M. Cotrut, Alexandru Blidisel, Diana M. Vranceanu, Alina Vladescu (Dragomir), Elena Ungureanu, Iulian Pana, Mihaela Dinu, Catalin Vitelaru, Anca C. Parau, Vasile Pruna, Mihai S. Magurean and Irina Titorencu
Biomimetics 2024, 9(11), 704; https://doi.org/10.3390/biomimetics9110704 - 17 Nov 2024
Viewed by 771
Abstract
The purpose of coatings is to protect or enhance the functionality of the substrate material, irrespective of the field in which the material was designed. The use of coatings in medicine is rapidly expanding with the objective of enhancing the osseointegration ability of [...] Read more.
The purpose of coatings is to protect or enhance the functionality of the substrate material, irrespective of the field in which the material was designed. The use of coatings in medicine is rapidly expanding with the objective of enhancing the osseointegration ability of metallic materials such as titanium. The aim of this study was to obtain biomimetic hydroxyapatite (HAp)-based coatings on titanium by using the pulsed galvanostatic method. The morphology of the HAp-based coatings revealed the presence of very thin and wide plate-like crystals, grown perpendicular to the Ti substrate, while the chemical composition highlighted a Ca/P ratio of 1.66, which is close to that of stoichiometric HAp (1.67). The main phases and chemical bonds identified confirmed the presence of the HAp phase in the developed coatings. A roughness of 228 nm and a contact angle of approx. 17° were obtained for the HAp coatings, highlighting a hydrophilic character. In terms of biomineralization and electrochemical behavior, it was shown that the HAp coatings have significantly enhanced the titanium properties. Finally, the in vitro cell tests carried out with human mesenchymal stem cells showed that the Ti samples coated with HAp have increased cell viability, extracellular matrix, and Ca intracellular deposition when compared with the uncoated Ti, indicating the beneficial effect. Full article
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<p>Morphology of the HAp-based coatings obtained by SEM.</p>
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<p>EDS analysis achieved on the HAp with plate-like morphology.</p>
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<p>Diffractograms of 3 different HAp samples with plate-like morphology.</p>
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<p>FTIR spectra of HAp coatings with plate-like morphology.</p>
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<p>Roughness profiles and parameters and the contact angles obtained for the titanium uncoated and coated with hydroxyapatite.</p>
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<p>Tafel plots (<b>a</b>) and the main electrochemical parameters (<b>b</b>) of cp-Ti and the HAp coatings.</p>
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<p>Mass evolution (<b>a</b>), SEM images (<b>b</b>), EDS results (<b>c</b>), and XRD (<b>d</b>) after 1, 2, and 3 weeks of immersion in SBF.</p>
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<p>Fluorescence microscopy images—BMSCs cultured for 5 days on Ti and HAp. Viable cells—green; dead cells—red.</p>
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<p>Viability (<b>a</b>) and proliferation (<b>b</b>) of BMSCs cultured for 5 days on the investigated surfaces (*** <span class="html-italic">p</span> &lt; 0.001).</p>
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<p>Morphology of BMSCs cultivated on the Ti (<b>a</b>–<b>c</b>) substrate and HAp (<b>d</b>–<b>f</b>) coating for 1 day (<b>a</b>,<b>d</b>) and 5 days (<b>b</b>,<b>e</b>) in fluorescent images; SEM images after 5 days on Ti (<b>c</b>) and HAp (<b>f</b>).</p>
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<p>Evidence of collagen type I and fibronectin in BMSCs cultured for 5 days on cp-Ti (<b>a</b>,<b>c</b>) and the HAp coating (<b>b</b>,<b>d</b>).</p>
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<p>Determination of alkaline phosphatase activity in BMSCs cultured for 5 days on the investigated surfaces (*** <span class="html-italic">p</span> &lt; 0.001).</p>
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22 pages, 3147 KiB  
Review
Biocomposite Scaffolds for Tissue Engineering: Materials, Fabrication Techniques and Future Directions
by Naznin Sultana, Anisa Cole and Francine Strachan
Materials 2024, 17(22), 5577; https://doi.org/10.3390/ma17225577 - 15 Nov 2024
Viewed by 535
Abstract
Tissue engineering is an interdisciplinary field that combines materials, methods, and biological molecules to engineer newly formed tissues to replace or restore functional organs. Biomaterials-based scaffolds play a crucial role in developing new tissue by interacting with human cells. Tissue engineering scaffolds with [...] Read more.
Tissue engineering is an interdisciplinary field that combines materials, methods, and biological molecules to engineer newly formed tissues to replace or restore functional organs. Biomaterials-based scaffolds play a crucial role in developing new tissue by interacting with human cells. Tissue engineering scaffolds with ideal characteristics, namely, nontoxicity, biodegradability, and appropriate mechanical and surface properties, are vital for tissue regeneration applications. However, current biocomposite scaffolds face significant limitations, particularly in achieving structural durability, controlled degradation rates, and effective cellular integration. These qualities are essential for maintaining long-term functionality in vivo. Although commonly utilized biomaterials can provide physical and chemical properties needed for tissue regeneration, inadequate biomimetic properties, as well as insufficient interactions of cells-scaffolds interaction, still need to be improved for the application of tissue engineering in vivo. It is impossible to achieve some essential features using a single material, so combining two or more materials may accomplish the requirements. In order to achieve a proper scaffold design, a suitable fabrication technique and combination of biomaterials with controlled micro or nanostructures are needed to achieve the proper biological responses. This review emphasizes advancements in scaffold durability, biocompatibility, and cellular responsiveness. It focuses on natural and synthetic polymer combinations and innovative fabrication techniques. Developing stimulus-responsive 3D scaffolds is critical, as these scaffolds enhance cell adhesion and promote functional tissue formation while maintaining structural integrity over time. This review also highlights the natural polymers, smart materials, and recent advanced techniques currently used to create emerging scaffolds for tissue regeneration applications. Full article
(This article belongs to the Special Issue Advances in Functional Soft Materials—2nd Volume)
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<p>Schematic diagram of Tissue Engineering Construct (Created with <a href="http://BioRender.com" target="_blank">BioRender.com</a>).</p>
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<p>Scanning electron micrograph of pectin/chitosan and Gelatin scaffold fabricated using the technique.</p>
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<p>Morphology of electrospun composite scaffold and HSF cell growth after three days of culture on Polycaprolactone/Gelatin scaffold (reproduced from [<a href="#B38-materials-17-05577" class="html-bibr">38</a>]).</p>
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30 pages, 4171 KiB  
Review
Animal-Morphing Bio-Inspired Mechatronic Systems: Research Framework in Robot Design to Enhance Interplanetary Exploration on the Moon
by José Cornejo, Cecilia E. García Cena and José Baca
Biomimetics 2024, 9(11), 693; https://doi.org/10.3390/biomimetics9110693 - 13 Nov 2024
Viewed by 677
Abstract
Over the past 50 years, the space race has potentially grown due to the development of sophisticated mechatronic systems. One of the most important is the bio-inspired mobile-planetary robots, actually for which there is no reported one that currently works physically on the [...] Read more.
Over the past 50 years, the space race has potentially grown due to the development of sophisticated mechatronic systems. One of the most important is the bio-inspired mobile-planetary robots, actually for which there is no reported one that currently works physically on the Moon. Nonetheless, significant progress has been made to design biomimetic systems based on animal morphology adapted to sand (granular material) to test them in analog planetary environments, such as regolith simulants. Biomimetics and bio-inspired attributes contribute significantly to advancements across various industries by incorporating features from biological organisms, including autonomy, intelligence, adaptability, energy efficiency, self-repair, robustness, lightweight construction, and digging capabilities-all crucial for space systems. This study includes a scoping review, as of July 2024, focused on the design of animal-inspired robotic hardware for planetary exploration, supported by a bibliometric analysis of 482 papers indexed in Scopus. It also involves the classification and comparison of limbed and limbless animal-inspired robotic systems adapted for movement in soil and sand (locomotion methods such as grabbing-pushing, wriggling, undulating, and rolling) where the most published robots are inspired by worms, moles, snakes, lizards, crabs, and spiders. As a result of this research, this work presents a pioneering methodology for designing bio-inspired robots, justifying the application of biological morphologies for subsurface or surface lunar exploration. By highlighting the technical features of actuators, sensors, and mechanisms, this approach demonstrates the potential for advancing space robotics, by designing biomechatronic systems that mimic animal characteristics. Full article
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<p>Adapted PRISMA flow diagram of the search process. CR: Crab, MO: Mole, WO: Worm, LZ: Lizard, SN: Snake. SP: Spider, SF-X: Surface exploration, SSF-X: Subsurface exploration. The numbers mean the quantity of published articles.</p>
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<p>Novel proposal of design methodology for space planetary bio-robots, it starts with the INPUT: Selection of animal-specie, and finishes with the OUTPUT: Prototype. Note: Analog Environment is defined as terrestrial locations that exhibit geological or environmental conditions analogous to celestial bodies, like the Moon or Mars. Source: Original contribution.</p>
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<p><span class="html-italic">Subsurface Exploration</span>: (<b>I</b>) Crab, Emerita Analoga (Standard Copyright Licence transferred to the authors) Adapted with permission from Bandersnatch(1808981506)/<a href="http://Shutterstock.com" target="_blank">Shutterstock.com</a> (accessed on 8 July 2024).—(<b>A</b>) Hardware components and full assembly, including the cuticle design, homing hall effect sensors, and retractable fabric leg design. Reproduced from [<a href="#B48-biomimetics-09-00693" class="html-bibr">48</a>]. CC BY 4.0. (<b>II</b>) Mole, Eremitalpa Granti (Standard Copyright Licence transferred to the authors) Adapted with permission from Anthony Bannister(MFFHY0)/<a href="http://Shutterstock.com" target="_blank">Shutterstock.com</a> (accessed on 9 July 2024).—(<b>B.1</b>) Design of the cable-driven burrowing force amplification mechanism. (<b>B.2</b>) System configuration. Reprinted from [<a href="#B50-biomimetics-09-00693" class="html-bibr">50</a>], Copyright (2023), with permission from IEEE. (<b>B.3</b>) Motion process during burrowing. (<b>B.4</b>) Prototype experiment and model angle measurement. Reprinted from [<a href="#B52-biomimetics-09-00693" class="html-bibr">52</a>], Copyright (2023), with permission from IEEE. Note: The left column shows the animal, while the right column represents the bio-inspired robot.</p>
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<p>Subsurface Exploration: (<b>I</b>) Worm, Eunice Aphroditois (Standard Copyright License transferred to the authors) Adapted with permission from Cingular(1219459138)/<a href="http://Shutterstock.com" target="_blank">Shutterstock.com</a> (accessed on 8 July 2024).—(<b>A.1</b>) Robot is mainly made up of three units: a propulsion unit, an excavation unit, and a discharging unit. The propulsion unit contains three additional propulsion subunits and propels through a borehole by reproducing the peristaltic crawling motion of an earthworm. Moreover, the propulsion unit allows LEAVO to excavate deep underground by supporting the reaction torque/force of the excavation by gripping the wall of the borehole. The excavation unit mainly includes an excavation instrument, namely, an “earth auger”, and a casing pipe covering the earth auger. The excavation unit excavates soil and transports it to the back of the robot. The soil in the back of the robot is discharged out of the borehole using the discharging unit. Reprinted from [<a href="#B59-biomimetics-09-00693" class="html-bibr">59</a>], Copyright (2018), with permission from IEEE. (<b>A.2</b>) Bio-inspired PSA modules are assembled in series using interconnections to form a soft robot with passive setae-like friction pads on its ventral side. (<b>A.3</b>) Working principle of the actuator with positive and negative pressure compared to the muscular motion observed in earthworm segments. Reproduced from [<a href="#B69-biomimetics-09-00693" class="html-bibr">69</a>]. CC BY 4.0. Surface Exploration: (<b>II</b>) Snake, Sonora Occipitalis (Standard Copyright License transferred to the authors) Adapted with permission from Matt Jeppson(86483413)/<a href="http://Shutterstock.com" target="_blank">Shutterstock.com</a> (accessed on 8 July 2024).—(<b>B.1</b>) An overview of the snake robot locomotion experiment. The snake robot is moving on granular terrain. A single DC motor drives the robot to generate sidewinding locomotion. The motion capture system captures the motion data through five reflective markers on the snake robot. (<b>B.2</b>) Fabrication of the continuous snake robot with a single rotary motor. Different mounting holes on the head anchor are used to adjust the slope angle. Basins assemble the body shells. (<b>B.3</b>) A cylindrical helix rod with two coils is made by 3D printing. (<b>B.4</b>) 3D printed body shells are linked to form a robot snake shell. (<b>B.5</b>) the helix rod is put into the body shells to form the snake robot body. (<b>B.6</b>) The snake robot body is filmed with silicone elastomers to improve the friction coefficient; (<b>B.7</b>) Prototype of snake robot after painting. Reprinted from [<a href="#B83-biomimetics-09-00693" class="html-bibr">83</a>], Copyright (2023), with permission from IEEE. Note: The left column shows the animal, while the right column represents the bio-inspired robot.</p>
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<p>Surface Exploration: (<b>I</b>) Lizard, Scincus Scincus (Standard Copyright License transferred to the authors) Adapted with permission from Kurit afshen(2358731213)/<a href="http://Shutterstock.com" target="_blank">Shutterstock.com</a>, (accessed on 8 July 2024).—(<b>A.1</b>) schematic of robot design—top view, and soft-amphibious robot-Reprinted from [<a href="#B77-biomimetics-09-00693" class="html-bibr">77</a>], Copyright (2017), with permission from IEEE. (<b>A.2</b>) fabricated prototype of the lizard-inspired quadruped robot moving on simulated Mars surface terrains. Reproduced from [<a href="#B79-biomimetics-09-00693" class="html-bibr">79</a>]. CC BY 4.0. (<b>II</b>) Spider, Carparachne Aureoflava (Standard Copyright License transferred to the authors) Adapted with permission from Tobias Hauke(1958871052)/<a href="http://Shutterstock.com" target="_blank">Shutterstock.com</a> (accessed on 8 July 2024).—(<b>B.1</b>) 4 legged-system showing the pitch, roll, and yaw servo motors associated with the hemispherical limbs while the robot is in the crawling posture. (<b>B.2</b>) Bio-inspired reconfigurable prototype. Reproduced from [<a href="#B88-biomimetics-09-00693" class="html-bibr">88</a>]. CC BY 4.0. Note: The left column shows the animal, while the right column represents the bio-inspired robot.</p>
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14 pages, 3287 KiB  
Article
Exploring the Role of Skin Pigmentation in the Thermal Regulation of Polar Bears and Its Implications in the Development of Biomimetic Outdoor Apparel
by Arny Leroy, David M. Anderson, Patrick Marshall, David Stark and Haskell W. Beckham
Textiles 2024, 4(4), 507-520; https://doi.org/10.3390/textiles4040029 - 10 Nov 2024
Viewed by 882
Abstract
A popular belief for why polar bears have black skin is to increase solar heat gain from solar radiation that penetrates through a translucent fur layer made of unpigmented hollow hair. To examine the relative importance of skin color on solar heat gain, [...] Read more.
A popular belief for why polar bears have black skin is to increase solar heat gain from solar radiation that penetrates through a translucent fur layer made of unpigmented hollow hair. To examine the relative importance of skin color on solar heat gain, we measured thermal gradients, heat flux, and solar transmittance through a polar bear pelt under solar irradiation while thermally anchored to a temperature-controlled plate set to 33 °C. We found that for 60–70% of the dorsal region of the pelt where the fur layer is thickest, solar energy cannot reach the skin through the fur (solar transmittance ≤ 3.5 ± 0.2%) and therefore skin color does not meaningfully contribute to solar heat gain. In contrast, skin pigmentation was important in the remaining areas of the pelt that were covered with thinner fur. This information was used to select commercially available materials according to their solar optical properties to build biomimetic outdoor apparel with enhanced solar heat gain by a factor of 3 compared to standard outerwear constructions. Full article
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<p>Polar bear pelt and cross section of hair at three locations signified as short, medium, and long hair regions. A ruler in the insets shows hair length in centimeters.</p>
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<p>(<b>a</b>) Schematic of experimental setup including a solar simulator, a temperature-controlled plate set at 33 °C, a guarded copper block with a heat flux sensor and thermocouple, and a 20-thermocouple tower to measure temperature gradients. (<b>b</b>) Details of the 20-thermocouple tower used to measure temperatures at different depths through the fur. (<b>c</b>) Photograph of the thermocouple tower inserted into the fur for a measurement.</p>
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<p>Temperature versus distance away from the skin at the medium-hair-length region shown in <a href="#textiles-04-00029-f001" class="html-fig">Figure 1</a> without (0 W/m<sup>2</sup>) and with (1000 W/m<sup>2</sup>) solar irradiance. Skin heat fluxes of −73 W/m<sup>2</sup> and 95 W/m<sup>2</sup> were measured without (0 W/m<sup>2</sup>) and with (1000 W/m<sup>2</sup>) sunlight, respectively. Data points with black borders depict the hair-side skin surface temperature, which was modeled based on estimated skin thermal resistance and the measured skin heat flux. The subcutaneous temperature was controlled by a thermoelectric plate to 33 °C.</p>
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<p>(<b>a</b>) Mid-back fur (i.e., the medium-hair-length region shown in <a href="#textiles-04-00029-f001" class="html-fig">Figure 1</a>) temperature versus distance away from the skin with natural dark skin and with painted white skin when exposed to 1000 W/m<sup>2</sup> of sunlight. Skin heat fluxes 95 W/m<sup>2</sup> and 94 W/m<sup>2</sup> were measured with the natural dark and painted white skin, respectively. Patterned data points with black borders depicting the hair-side skin temperature were modeled based on estimated skin thermal resistance and the measured skin heat flux. The subcutaneous temperature was controlled by a thermoelectric plate to 33 °C. (<b>b</b>) Photograph of the pelt with the hair combed open to reveal the natural dark skin (<b>left</b>) and white painted skin (<b>right</b>).</p>
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<p>(<b>a</b>) Experimental setup to measure solar transmittance of polar bear fur. (<b>b</b>) Skin-side view showing the excised skin removed and the overlying hair intact. (<b>c</b>) Hair-side view showing the fur structure intact after removing the skin layer. The red dashed circle shows the location of the removed skin layer. (<b>d</b>) View of the pyranometer, collimator, support plate, and pelt in the experimental setup. All scale bars are 25 mm.</p>
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<p>Fur temperature profiles for short-, medium-, and long-hair regions: (<b>a</b>) with no sunlight, and (<b>b</b>) with 1000 W/m<sup>2</sup> of sunlight. Patterned data points with black borders depict hair-side skin temperature in (<b>a</b>,<b>b</b>) and are modeled based on estimated skin thermal resistance and the measured skin heat flux while the subcutaneous temperature was set to 33 °C by a temperature-controlled plate. (<b>c</b>) Net skin heat flux for the different locations on the pelt without (0 W/m<sup>2</sup>) and with (1000 W/m<sup>2</sup>) sunlight. (<b>d</b>) Examples of hair lengths for the short-, medium-, and long-hair locations.</p>
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<p>Polar-bear-inspired layered material constructions and experimental setup to measure thermal performance under sunlight. The solar transmittance (τ<sub>solar</sub>) of the shell fabrics and sheet insulation is also included.</p>
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<p>Thermal performance of four 3-layer material constructions (shell fabric-sheet insulation-lining fabric) exposed to 1000 W/m<sup>2</sup> sunlight in a 0 °C environment. The 11.5 mm-thick 60 g/m<sup>2</sup> polyester sheet insulation layer was used for all four material constructions.</p>
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15 pages, 11324 KiB  
Article
Scalable O(log2n) Dynamics Control for Soft Exoskeletons
by Julian D. Colorado, Diego Mendez, Andres Gomez-Bautista, John E. Bermeo, Catalina Alvarado-Rojas and Fredy Cuellar
Actuators 2024, 13(11), 450; https://doi.org/10.3390/act13110450 - 9 Nov 2024
Viewed by 630
Abstract
Robotic exoskeletons are being actively applied to support the activities of daily living (ADL) for patients with hand motion impairments. In terms of actuation, soft materials and sensors have opened new alternatives to conventional rigid body structures. In this arena, biomimetic soft systems [...] Read more.
Robotic exoskeletons are being actively applied to support the activities of daily living (ADL) for patients with hand motion impairments. In terms of actuation, soft materials and sensors have opened new alternatives to conventional rigid body structures. In this arena, biomimetic soft systems play an important role in modeling and controlling human hand kinematics without the restrictions of rigid mechanical joints while having an entirely deformable body with limitless points of actuation. In this paper, we address the computational limitations of modeling large-scale articulated systems for soft robotic exoskeletons by integrating a parallel algorithm to compute the exoskeleton’s dynamics equations of motion (EoM), achieving a computation with O(log2n) complexity for the highly articulated n degrees of freedom (DoF) running on p processing cores. The proposed parallel algorithm achieves an exponential speedup for n=p=64 DoF while achieving a 0.96 degree of parallelism for n=p=256, which demonstrates the required scalability for controlling highly articulated soft exoskeletons in real time. However, scalability will be bounded by the n=p fraction. Full article
(This article belongs to the Special Issue Actuators and Robots for Biomedical Applications)
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<p>Hardware in-the-loop approach for computing a large-scale exoskeleton’s multi-body dynamics using parallel computing: a virtual model (digital twin) replicates the hand dynamics (blue section), while a real embedded device executes the control mechanisms (yellow section).</p>
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<p>(<b>a</b>) Former rigid-body mechanism reported in our previous work [<a href="#B19-actuators-13-00450" class="html-bibr">19</a>], composed of 3 under-actuated joints connected to a single actuation input driven by a linear actuator. (<b>b</b>) Soft model implemented in SoRoSim©Matlab™ composed of 512 degrees of freedom that emulate flexible bending [<a href="#B28-actuators-13-00450" class="html-bibr">28</a>]. (<b>c</b>) Proposed novel mechanism based on a semi-soft structure driven by compliant joints.</p>
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<p>Parallel EoM calculation following an <math display="inline"><semantics> <mrow> <mi>O</mi> <mo>(</mo> <mi>l</mi> <mi>o</mi> <msub> <mi>g</mi> <mn>2</mn> </msub> <mi>n</mi> <mo>)</mo> </mrow> </semantics></math> computational complexity. The computing steps (<span class="html-italic">e</span>) for the case of <math display="inline"><semantics> <mrow> <mi>n</mi> <mo>=</mo> <mn>8</mn> </mrow> </semantics></math> degrees of freedom (DoF) are depicted. For higher joints (<math display="inline"><semantics> <mrow> <mi>n</mi> <mo>&gt;</mo> <mo>&gt;</mo> </mrow> </semantics></math>), the same <math display="inline"><semantics> <mrow> <mi>O</mi> <mo>(</mo> <mi>l</mi> <mi>o</mi> <msub> <mi>g</mi> <mn>2</mn> </msub> <mi>n</mi> <mo>)</mo> </mrow> </semantics></math> propagation scheme is maintained. On the left, both the spatial velocities (<span class="html-italic">V</span>) and accelerations (<math display="inline"><semantics> <mover accent="true"> <mi>V</mi> <mo>˙</mo> </mover> </semantics></math>) are computed by following a forward propagation. On the right, the spatial forces (<span class="html-italic">F</span>) are calculated in a backward direction. Computing cores are represented by each node.</p>
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<p>(<b>a</b>) Computational time comparison between the serial <math display="inline"><semantics> <mrow> <mi>O</mi> <mo>(</mo> <mi>n</mi> <mo>)</mo> </mrow> </semantics></math> RNE (cf. Algorithm 1) and the parallel <math display="inline"><semantics> <mrow> <mi>O</mi> <mo>(</mo> <mi>l</mi> <mi>o</mi> <msub> <mi>g</mi> <mn>2</mn> </msub> <mi>n</mi> <mo>)</mo> </mrow> </semantics></math> RNE (cf. Algorithm 2). (<b>b</b>) Close-up of the <math display="inline"><semantics> <mrow> <mi>O</mi> <mo>(</mo> <mi>l</mi> <mi>o</mi> <msub> <mi>g</mi> <mn>2</mn> </msub> <mi>n</mi> <mo>)</mo> </mrow> </semantics></math> response of Algorithm 2), including computational time variations depending on the number of trajectory points (<math display="inline"><semantics> <mrow> <mi>p</mi> <mi>t</mi> </mrow> </semantics></math>) defined for the exoskeleton’s therapy motions. For this test, <math display="inline"><semantics> <mrow> <mi>p</mi> <mi>t</mi> </mrow> </semantics></math> was varied from 500 to 2000 trajectory knot points with a fixed step time of <math display="inline"><semantics> <mrow> <mn>0.01</mn> </mrow> </semantics></math> s (platform: Intel<sup>®</sup>Core™i7 processor with 512 GPU NVIDIA Quadro cores).</p>
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<p>Speedup of the proposed <math display="inline"><semantics> <mrow> <mi>O</mi> <mo>(</mo> <mi>l</mi> <mi>o</mi> <msub> <mi>g</mi> <mn>2</mn> </msub> <mi>n</mi> <mo>)</mo> </mrow> </semantics></math> RNE algorithm compared to Amdahl’s law for several degrees of parallelism ranging from <math display="inline"><semantics> <mrow> <mn>0.8</mn> </mrow> </semantics></math> to <math display="inline"><semantics> <mrow> <mn>0.99</mn> </mrow> </semantics></math> (platform: Intel®Core™i7 processor with 512 GPU NVIDIA Quadro cores).</p>
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<p>(<b>a</b>) Ansys<sup>®</sup>simulation for the proposed semi-soft structure driven by the compliant joint mechanism. (<b>b</b>) Computation time for the soft model implemented in SoRoSim©Matlab™.</p>
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<p>HIL-based <math display="inline"><semantics> <mrow> <mi>O</mi> <mo>(</mo> <mi>l</mi> <mi>o</mi> <msub> <mi>g</mi> <mn>2</mn> </msub> <mi>n</mi> <mo>)</mo> </mrow> </semantics></math> response of Algorithm 2, showing computation time variations based on the number of trajectory points (platform: Nvidia Jetson Orin™Nano with 1024 cores).</p>
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16 pages, 3178 KiB  
Article
Engineering Ion Affinity of Zr-MOF Hybrid PDMS Membranes for the Selective Separation of Na+/Ca2+
by Ahmed S. Abou-Elyazed, Xiaolin Li and Jing Meng
Molecules 2024, 29(22), 5297; https://doi.org/10.3390/molecules29225297 - 9 Nov 2024
Viewed by 811
Abstract
Ion-selective separation, especially Na+/Ca2+ separation, is of significant importance in the realms of biomimetic research and the fabrication of biomimetic devices, underscoring the pivotal role that sodium and calcium ions play in cellular metabolism. However, the analogous ionic radii and [...] Read more.
Ion-selective separation, especially Na+/Ca2+ separation, is of significant importance in the realms of biomimetic research and the fabrication of biomimetic devices, underscoring the pivotal role that sodium and calcium ions play in cellular metabolism. However, the analogous ionic radii and charge densities shared by sodium and calcium ions significantly impede their effective discrimination, presenting formidable challenges for the precise engineering of ion separation materials, such as separation membranes. In this study, a polydimethylsiloxane (PDMS) separation membrane hybridized with zirconium-based metal–organic frameworks (UiO-66, UiO-66-NO2 and UiO-66-NH2) was constructed. Through the meticulous design of the MOF functional groups, the material’s affinity for specific ions was modulated, thereby achieving efficient Na+/Ca2+ separation. Notably, the PDMS integrated with amino-modified Zr-MOF exhibited an efficacious selective separation of Na+ and Ca2+ ions. The interaction between the amino group of UiO-66-NH2 and Ca2+ gave rise to the observed superior selectivity toward Ca2+ cations and enhanced separation efficiencies of up to 64% compared to pristine PDMS for UiO-66-NH2-embedded membranes. Full article
(This article belongs to the Section Organometallic Chemistry)
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Graphical abstract

Graphical abstract
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<p>XRD patterns of different Zr-MOF@PDMS membranes (<b>a</b>) and SEM images of the membrane surface and cross-section morphologies (<b>b</b>–<b>d</b>).</p>
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<p><span class="html-italic">I–V</span> curves of Zr-MOFs@PDMS membranes and the separation ratio (insert tables) (thickness: 600 ± 0.01 μm, pH = 7.42).</p>
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<p>(<b>a</b>) Hydrated ionic diameter (<span class="html-italic">D</span><sub>h</sub>), ionic diameter (<span class="html-italic">D</span><sub>i</sub>), and hydration-free energy (<span class="html-italic">ΔG</span>) f different metal ions; (<b>b</b>–<b>d</b>) N<sub>2</sub> sorption isotherm of different Zr-MOFs, and pore size distribution of Zr-MOFs (inset figures).</p>
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<p>XRD patterns of different Zr-MOFs after immersing in deionized water, 1 mol L<sup>−1</sup> NaCl, 1 mol L<sup>−1</sup> KCl, and 1 mol L<sup>−1</sup> CaCl<sub>2</sub> solutions for 72 h, (<b>a</b>–<b>c</b>) and transport activation energies of Na<sup>+</sup> and Ca<sup>2+</sup> ions in Zr-MOF-0.05@PDMS and PDMS membranes (<b>d</b>).</p>
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<p>XRD patterns of the three Zr-MOF-0.05@PDMS after immersing in a saline solution for ten days.</p>
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<p>The concentration of Na<sup>+</sup> and Ca<sup>2+</sup> in the receiving solution at different times: (<b>a</b>) PDMS, (<b>b</b>) UiO-66-0.05@PDMS, (<b>c</b>) UiO-66-NO<sub>2</sub>-0.05@PDMS and (<b>d</b>) UiO-66-NH<sub>2</sub>-0.05@PDMS membranes.</p>
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<p>The plots of <span class="html-italic">ln</span> ((<span class="html-italic">C</span><sub>0</sub>−2<span class="html-italic">C</span><sub>t</sub>)/<span class="html-italic">C</span><sub>0</sub>) vs. time. (feed solution: 1.0 mol L<sup>−1</sup> NaCl and 1.0 mol L<sup>−1</sup> CaCl<sub>2</sub>; receiving solution: deionized water, membrane: 600 ± 0.01 μm, (<b>a</b>) PDMS, (<b>b</b>) UiO-66-0.05@PDMS, (<b>c</b>) UiO-66-NO<sub>2</sub>-0.05@PDMS and (<b>d</b>) UiO-66-NH<sub>2</sub>-0.05@PDMS membranes; pH = 7.42).</p>
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<p>Schematic procedure for the synthesis of Zr-MOF@PDMS membranes.</p>
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<p>The photograph of the setup for ion conductivity (<b>a</b>) and schematic diagram of the test of ion separation (<b>b</b>).</p>
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20 pages, 17386 KiB  
Article
Spectral Water Wave Dissipation by Biomimetic Soft Structure
by Garance Marlier, Frédéric Bouchette, Samuel Meulé, Raphaël Certain and Jean-Yves Jouvenel
J. Mar. Sci. Eng. 2024, 12(11), 2004; https://doi.org/10.3390/jmse12112004 - 7 Nov 2024
Viewed by 395
Abstract
Coastal protection solutions can be categorised as grey, hybrid or natural. Grey infrastructure includes artificial structures like dykes. Natural habitats like seagrasses are considered natural protection infrastructure. Hybrid solutions combine both natural and grey infrastructure. Evidence suggests that grey solutions can negatively impact [...] Read more.
Coastal protection solutions can be categorised as grey, hybrid or natural. Grey infrastructure includes artificial structures like dykes. Natural habitats like seagrasses are considered natural protection infrastructure. Hybrid solutions combine both natural and grey infrastructure. Evidence suggests that grey solutions can negatively impact the environment, while natural habitats prevent flooding without such adverse effects and provide many ecosystem services. New types of protective solutions, called biomimetic solutions, are inspired by natural habitats and reproduce their features using artificial materials. Few studies have been conducted on these new approaches. This study aims to quantify wave dissipation observed in situ above a biomimetic solution inspired by kelps, known for their wave-dampening properties. The solution was deployed in a full water column near Palavas-les-Flots in southern France. A one-month in situ experiment showed that the biomimetic solution dissipates around 10% of total wave energy on average, whatever the meteo-marine conditions. Wave energy dissipation is frequency-dependent: short waves are dissipated, while low-frequency energy increases. An anti-dissipative effect occurs for forcing conditions with frequencies close to the eigen mode linked to the biomimetic solution’s geometry, suggesting that resonance should be considered in designing future biomimetic protection solutions. Full article
(This article belongs to the Section Coastal Engineering)
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Figure 1
<p>(<b>a</b>) A map of the study area, where A and B refer to the dyke and the beach in <a href="#sec5dot1-jmse-12-02004" class="html-sec">Section 5.1</a>. (<b>b</b>) A map of the position of the device and the biomimetic structures, composed of ten modules. The black dotted lines forming a rectangle delineate the extension of the biomimetic solution and the domain on which Rabinovitch formalism was used (<a href="#sec5dot1-jmse-12-02004" class="html-sec">Section 5.1</a>). The coloured area represents the bathymetry. (<b>c</b>) The diagram and the photo show one biomimetic structure. (<b>d</b>) A plot of the instrumented transect, where pressure sensors (red diamond) and idealised biomimetic structures are shown. The seabed (black solid line) is placed as a function of the depth measurements (black dots) made at each device.</p>
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<p>Energy spectral density spectra calculated at stations R1 to R5. Each spectrum is calculated by averaging all the spectra calculated over the 30 min long bursts. The dotted vertical lines represent the frequency cuts of the infragravity, the swell and the wind wave bands, clearly identified by relative minima on every mean spectrum.</p>
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<p>Wind and hydrodynamic forcings during the experimentation. The yellow, green and red boxes represent type 1, 2 and 3 conditions, respectively, observed in two periods, a and b. Periods in white are not used in the analysis. The wave characteristics at Sète are offshore conditions. (<b>a</b>) Wave direction (<math display="inline"><semantics> <msub> <mi>θ</mi> <mrow> <mi>s</mi> <mi>e</mi> <mi>t</mi> <mi>e</mi> </mrow> </msub> </semantics></math>) at Sète, wind direction (<math display="inline"><semantics> <msub> <mi>θ</mi> <mrow> <mi>w</mi> <mi>i</mi> <mi>n</mi> <mi>d</mi> </mrow> </msub> </semantics></math>) and wind speed (<math display="inline"><semantics> <msub> <mi>v</mi> <mrow> <mi>w</mi> <mi>i</mi> <mi>n</mi> <mi>d</mi> </mrow> </msub> </semantics></math>) recorded at the Montpellier airport weather station; (<b>b</b>) Significant wave height measured at Sète (<math display="inline"><semantics> <msub> <mi>H</mi> <mrow> <mi>s</mi> <mi>e</mi> <mi>t</mi> <mi>e</mi> </mrow> </msub> </semantics></math>) and at R1 station, and the ratio <math display="inline"><semantics> <mrow> <msub> <mi>H</mi> <mrow> <mn>5</mn> <mo>,</mo> <mi>T</mi> <mi>O</mi> <mi>T</mi> </mrow> </msub> <mo>/</mo> <msub> <mi>H</mi> <mrow> <mn>1</mn> <mo>,</mo> <mi>T</mi> <mi>O</mi> <mi>T</mi> </mrow> </msub> </mrow> </semantics></math>; (<b>c</b>) The mean wave period measured at Sète (<math display="inline"><semantics> <msub> <mi>T</mi> <msub> <mi>m</mi> <mrow> <mi>s</mi> <mi>e</mi> <mi>t</mi> <mi>e</mi> </mrow> </msub> </msub> </semantics></math>) and at the R1 station.</p>
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<p>(<b>a</b>) Plots of mean wave height reduction for <math display="inline"><semantics> <mrow> <mi>T</mi> <mi>O</mi> <mi>T</mi> </mrow> </semantics></math>, <math display="inline"><semantics> <mrow> <mi>I</mi> <mi>G</mi> </mrow> </semantics></math>, <math display="inline"><semantics> <mrow> <mi>S</mi> <mi>S</mi> </mrow> </semantics></math> and <math display="inline"><semantics> <mrow> <mi>W</mi> <mi>W</mi> </mrow> </semantics></math> frequency bands from the R1 to R5 stations for the three types of meteo-marine conditions, including both periods a and b. The coloured envelope represents the standard deviation at each station and for each frequency band. (<b>b</b>) Ternary diagrams of normalised <math display="inline"><semantics> <msub> <mi>E</mi> <mrow> <mi>I</mi> <mi>G</mi> </mrow> </msub> </semantics></math>, <math display="inline"><semantics> <msub> <mi>E</mi> <mrow> <mi>S</mi> <mi>S</mi> </mrow> </msub> </semantics></math> and <math display="inline"><semantics> <msub> <mi>E</mi> <mrow> <mi>W</mi> <mi>W</mi> </mrow> </msub> </semantics></math> by <math display="inline"><semantics> <msub> <mi>E</mi> <mrow> <mi>T</mi> <mi>O</mi> <mi>T</mi> </mrow> </msub> </semantics></math> for the three types of meteo-marine conditions. The two smaller ternary diagrams represent the same information for periods a and b considered separately. Each arrow represents the evolution of the relative contributions of <math display="inline"><semantics> <mrow> <mi>I</mi> <mi>G</mi> </mrow> </semantics></math>, <math display="inline"><semantics> <mrow> <mi>S</mi> <mi>S</mi> </mrow> </semantics></math> and <math display="inline"><semantics> <mrow> <mi>W</mi> <mi>W</mi> </mrow> </semantics></math> to the energy between the R1 and R5 stations for each burst.</p>
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<p>Plots of energy density spectra at R1 to R5 stations for (<b>a</b>) type 1, (<b>b</b>) type 2 and (<b>c</b>) type 3 meteo-marine conditions. Each spectrum is calculated by averaging all elementary spectra calculated over 30 min long bursts for each type of meteo-marine condition.</p>
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<p>A plot of the wavelength <math display="inline"><semantics> <msub> <mi>λ</mi> <mn>1</mn> </msub> </semantics></math> and peak period <math display="inline"><semantics> <msub> <mi>T</mi> <mrow> <mi>p</mi> <mn>1</mn> </mrow> </msub> </semantics></math> defined at the R1 station as a function of <math display="inline"><semantics> <mrow> <msub> <mi>H</mi> <mrow> <mn>5</mn> <mo>,</mo> <mi>T</mi> <mi>O</mi> <mi>T</mi> </mrow> </msub> <mo>/</mo> <msub> <mi>H</mi> <mrow> <mn>1</mn> <mo>,</mo> <mi>T</mi> <mi>O</mi> <mi>T</mi> </mrow> </msub> </mrow> </semantics></math> for each burst. Bursts related to different meteo-marine condition types are represented by different colours. The grey dots represent the burst not related to the different meteo-marine condition types. The wavelength is calculated from each frequency peak for each burst with the approximation of Guo [<a href="#B69-jmse-12-02004" class="html-bibr">69</a>]. The peak period is calculated from the peak frequency. The vertical dashed line separates the dissipative (<math display="inline"><semantics> <mrow> <msub> <mi>H</mi> <mrow> <mn>5</mn> <mo>,</mo> <mi>T</mi> <mi>O</mi> <mi>T</mi> </mrow> </msub> <mo>/</mo> <msub> <mi>H</mi> <mrow> <mn>1</mn> <mo>,</mo> <mi>T</mi> <mi>O</mi> <mi>T</mi> </mrow> </msub> <mo>&lt;</mo> <mn>1</mn> </mrow> </semantics></math>) and anti-dissipative (<math display="inline"><semantics> <mrow> <msub> <mi>H</mi> <mrow> <mn>5</mn> <mo>,</mo> <mi>T</mi> <mi>O</mi> <mi>T</mi> </mrow> </msub> <mo>/</mo> <msub> <mi>H</mi> <mrow> <mn>1</mn> <mo>,</mo> <mi>T</mi> <mi>O</mi> <mi>T</mi> </mrow> </msub> <mo>&gt;</mo> <mn>1</mn> </mrow> </semantics></math>) domains. The horizontal dashed line is placed at <math display="inline"><semantics> <msub> <mi>λ</mi> <mn>1</mn> </msub> </semantics></math> = 37 m (<math display="inline"><semantics> <msub> <mi>T</mi> <mrow> <mi>p</mi> <mn>1</mn> </mrow> </msub> </semantics></math> = 6.47 s), which is roughly equal to the diagonal length of the biomimetic solution.</p>
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<p>Empirical <math display="inline"><semantics> <msub> <mi>C</mi> <mi>D</mi> </msub> </semantics></math> represented as a function of the Reynolds <math display="inline"><semantics> <msub> <mi>R</mi> <mi>e</mi> </msub> </semantics></math> number (<b>a</b>) and the Keulegan–Carpenter <math display="inline"><semantics> <msub> <mi>K</mi> <mi>C</mi> </msub> </semantics></math> number (<b>b</b>) for all bursts. Bursts related to different meteo-marine condition types are represented by different colours. The grey dots represent bursts not related to the different meteo-marine condition types. Empirical <math display="inline"><semantics> <msub> <mi>C</mi> <mi>D</mi> </msub> </semantics></math> laws as a function of (<b>c</b>) <math display="inline"><semantics> <msub> <mi>R</mi> <mi>e</mi> </msub> </semantics></math> and (<b>d</b>) <math display="inline"><semantics> <msub> <mi>K</mi> <mi>C</mi> </msub> </semantics></math> in comparison with other analytical expression of <math display="inline"><semantics> <msub> <mi>C</mi> <mi>D</mi> </msub> </semantics></math> from the literature (see <a href="#jmse-12-02004-t003" class="html-table">Table 3</a>). Dashed lines represent the new empirical <math display="inline"><semantics> <msub> <mi>C</mi> <mi>D</mi> </msub> </semantics></math> laws calculated with the equivalent diameter volume <math display="inline"><semantics> <msub> <mi>D</mi> <mi>V</mi> </msub> </semantics></math>. Empirical <math display="inline"><semantics> <msub> <mi>C</mi> <mi>D</mi> </msub> </semantics></math> is shown as a function of <math display="inline"><semantics> <mrow> <mn>1</mn> <mo>/</mo> <msub> <mi>R</mi> <mi>e</mi> </msub> </mrow> </semantics></math> (<b>e</b>). The colours represent the dissipation intervals over which the new fitted laws are calculated. The optimised parameters associated with each interval are presented in the table next to the plot (<b>f</b>).</p>
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25 pages, 7782 KiB  
Article
Bioactive Hybrids Containing Artificial Cell Membranes and Phyto-Gold–Silver Chloride Bio-Nanoparticles
by Marcela-Elisabeta Barbinta-Patrascu, Cornelia Nichita, Monica Enculescu, Valentin-Adrian Maraloiu, Mihaela Bacalum, Camelia Ungureanu, Catalin Constantin Negrila and Irina Zgura
Int. J. Mol. Sci. 2024, 25(22), 11929; https://doi.org/10.3390/ijms252211929 - 6 Nov 2024
Viewed by 516
Abstract
This research targets the need for eco-friendly strategies in the synthesis of bioactive materials, addressing the importance of valorization of vegetal waste. This study focuses on developing biohybrids containing biomimetic lipid vesicles and phytosynthesized gold–silver chloride nanoparticles (AuAgCl NPs) derived from Achillea millefolium [...] Read more.
This research targets the need for eco-friendly strategies in the synthesis of bioactive materials, addressing the importance of valorization of vegetal waste. This study focuses on developing biohybrids containing biomimetic lipid vesicles and phytosynthesized gold–silver chloride nanoparticles (AuAgCl NPs) derived from Achillea millefolium L. extract. By leveraging the natural antioxidant and antimicrobial properties of the plant, the research proposes a sustainable approach to creating materials with potential biomedical applications. The biomimetic membranes were loaded with chlorophyll a, a natural spectral marker. Three types of bioactive materials (biohybrids) were developed by varying the lipid vesicle/AuAgCl NP ratio. Optical (UV-Vis, fluorescence emission, FTIR), structural (XRD), elemental (EDX, XPS), and morphological (TEM) studies were performed to characterize the bio-developed materials. The hydrophobic/hydrophilic characteristics of the samples were investigated by measuring the water contact angle, and their size was estimated by DLS and TEM. Zeta potential measurements were used to evaluate the physical stability of phyto-developed particles. Antioxidant properties of phyto-particles were investigated through the chemiluminescence technique. The obtained biomaterials exhibited high antioxidant activity and antiproliferative activity against HT-29 and B-16 cancer cells. Therapeutic index values were calculated for each biohybrid. Additionally, the bio-prepared hybrids revealed biocidal action against Staphylococcus aureus and Enterococcus faecalis. The phyto-developed biomaterials are promising in biomedical applications, particularly as adjuvants in cancer therapy. Full article
(This article belongs to the Special Issue Nanoparticles in Nanobiotechnology and Nanomedicine: 2nd Edition)
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Figure 1
<p>Optical characterization of <span class="html-italic">Achillea</span>-derived samples. (<b>a</b>) UV-Vis absorption spectra of yarrow-derived AuAgClNPs and the biohybrids (the spectra were normalized at their characteristic peak). (<b>b</b>) Fluorescence emission spectra of chlorophyll-containing samples (λ<sub>excitation</sub> = 430 nm). The lipid vesicles are in the same concentrations as in the biohybrids. (<b>c</b>) Comparative presentation of FTIR spectra of the obtained samples.</p>
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<p>XRD patterns of the obtained samples. The diffraction peaks are marked using the symbols: ∗ (magenta) for Au; • (red) for AgCl; ◈ (blue) for NaCl.</p>
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<p>CTEM images (<b>a</b>,<b>d</b>,<b>g</b>), HRTEM images (<b>b</b>,<b>e</b>,<b>h</b>), and EDX spectra (<b>c</b>,<b>f</b>,<b>i</b>) obtained on the investigated samples.</p>
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<p>XPS spectra of the AuAgClNP sample: (<b>a</b>) survey spectrum; (<b>b</b>) Ag3s and K2s spectrum; (<b>c</b>) Cl2s spectrum; (<b>d</b>) Au4f spectrum.</p>
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<p>The wetting properties of <span class="html-italic">Achillea</span>-derived samples.</p>
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<p>Antioxidant activity of the obtained samples estimated using the chemiluminescence technique.</p>
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<p>The in vitro antimicrobial activity of developed samples, expressed as diameters of the growth inhibition zone (IGZ, mm) evaluated by the agar well diffusion method.</p>
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<p>Cell viability curves recorded for all samples: (<b>A</b>)—Lipo, (<b>B</b>)—Extract, (<b>C</b>)—AuAgClNPs, (<b>D</b>)—L1, (<b>E</b>)—L2, (<b>F</b>)—L3, following 24 h of treatment for the three cell lines: L929, B16, and HT-29.</p>
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<p>Morphological evaluation by the SEM of L929 cells grown in different conditions for 24 h: (<b>A</b>) control cells and cells treated with liposomes, (<b>B</b>) the extract, (<b>C</b>) AuAgClNPs, (<b>D</b>) L1, (<b>E</b>) L2, (<b>F</b>) and L3 (<b>G</b>). The scale bar is 4 µm.</p>
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<p>Schematic representation of the phyto-design of biohybrids containing yarrow-derived AuAgClNPs. The figure was created with Chemix (<a href="https://chemix.org/" target="_blank">https://chemix.org/</a>, accessed on 27 September 2024), PowerPoint (Windows 10 version), and Paint 3D (Windows 10 version), &amp; Office 365.</p>
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29 pages, 13992 KiB  
Review
External Scaffold for Strengthening the Pulmonary Autograft in the Ross Procedure
by Francesco Nappi, Aubin Nassif and Thibaut Schoell
Biomimetics 2024, 9(11), 674; https://doi.org/10.3390/biomimetics9110674 - 5 Nov 2024
Viewed by 567
Abstract
Despite offering several potential benefits over standard prosthetic aortic valve replacement, the use of the pulmonary autograft has been limited to date due to concerns over the risk of pulmonary autograft expansion and the need for reintervention. Several techniques using materials with biomimetic [...] Read more.
Despite offering several potential benefits over standard prosthetic aortic valve replacement, the use of the pulmonary autograft has been limited to date due to concerns over the risk of pulmonary autograft expansion and the need for reintervention. Several techniques using materials with biomimetic potential have been developed to reduce this complication. The incidence, risk factors, and pathophysiology of pulmonary autograft dilatation are discussed in this article. This seminar will provide an overview of the techniques of external pulmonary autograft support and their advantages and limitations. It also considers future directions for further investigation and future clinical applications of external pulmonary autograft support. Dilatation of the autograft is more likely to occur in patients with aortic regurgitation and a dilated aortic annulus. External scaffolding may prevent autograft stretching and expansion in these specific cases. However, from a biomimetic point of view, any permanent scaffold potentially restricts the movement of the autograft root. This reduces some of the benefits associated with the use of autologous tissue, which is the priority of the Ross procedure. To address this issue, several bioresorbable matrices could be used to support the root during its initial adaptive phase. Control of blood pressure with aggressive therapy is the first line to avoid this problem in the first year after pulmonary autograft implantation, together with support of the annular and sinotubular junction in some selected cases. This is the best way to maintain stable autograft root dimensions while preserving root dynamics. However, to determine the efficacy of this combined external support and best medical management, it is important to perform regular imaging and clinical follow-up. Full article
(This article belongs to the Special Issue Biomechanics and Biomimetics in Engineering Design)
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Figure 1
<p>Flowchart.</p>
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<p>Composition and function of the extracellular matrix [<a href="#B63-biomimetics-09-00674" class="html-bibr">63</a>,<a href="#B64-biomimetics-09-00674" class="html-bibr">64</a>,<a href="#B65-biomimetics-09-00674" class="html-bibr">65</a>,<a href="#B66-biomimetics-09-00674" class="html-bibr">66</a>,<a href="#B67-biomimetics-09-00674" class="html-bibr">67</a>,<a href="#B68-biomimetics-09-00674" class="html-bibr">68</a>,<a href="#B69-biomimetics-09-00674" class="html-bibr">69</a>,<a href="#B70-biomimetics-09-00674" class="html-bibr">70</a>,<a href="#B71-biomimetics-09-00674" class="html-bibr">71</a>,<a href="#B72-biomimetics-09-00674" class="html-bibr">72</a>,<a href="#B73-biomimetics-09-00674" class="html-bibr">73</a>,<a href="#B74-biomimetics-09-00674" class="html-bibr">74</a>,<a href="#B75-biomimetics-09-00674" class="html-bibr">75</a>,<a href="#B76-biomimetics-09-00674" class="html-bibr">76</a>,<a href="#B77-biomimetics-09-00674" class="html-bibr">77</a>,<a href="#B78-biomimetics-09-00674" class="html-bibr">78</a>,<a href="#B79-biomimetics-09-00674" class="html-bibr">79</a>,<a href="#B80-biomimetics-09-00674" class="html-bibr">80</a>,<a href="#B81-biomimetics-09-00674" class="html-bibr">81</a>,<a href="#B82-biomimetics-09-00674" class="html-bibr">82</a>,<a href="#B83-biomimetics-09-00674" class="html-bibr">83</a>,<a href="#B84-biomimetics-09-00674" class="html-bibr">84</a>].</p>
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<p>Full-thickness wall reconstruction of unreinforced PA (<b>A</b>), PA externally reinforced with non-resorbable polyethylene terephthalate (<b>B</b>), and PA reinforced with externally resorbable polydioxanone (<b>C</b>). Masson’s trichrome staining. Red, smooth muscle cells; blue, collagen fibers; yellow, elastic fibers. Histological analysis of pulmonary autografts with and without remodeling revealed significant differences between non-resorbable and resorbable reinforced PA. (<b>A</b>) The higher systemic pressure determines the intimal denudation and media disruption in the PA without external reinforcement. Smooth muscle cells were visible in the media. These cells had irregular profiles and no discernible alignment and were widely spaced with intervening collagen fibers grouped in thick and dense bundles. Deeper in the media, sparse elastic fibers formed irregular fascicles, and the adventitia was composed of dense connective tissue. (<b>B</b>) The external polyethylene terephthalate promoted the development of a foreign body inflammatory reaction around the material, and the phenomena of transmural and endoluminal migration of the mesh cutting through the PA wall were noted. On histology, a prominent inflammatory infiltrate was seen, and fewer smooth muscle cells with more interstitial connective tissue could be seen in comparison to the control group. (<b>C</b>) External reinforcement with resorbable polydioxanone showed no signs of an inflammatory reaction. Reorganization of the media was evident with preservation of the endothelial lining. Immediately beneath the intima, smooth muscle cells were seen intertwined with collagen fibers, whereas deeper collagen bundles intertwined with elastic fibers, forming a thick, highly organized layer of concentric lamellae. Loose connective tissue with adipocytes formed the tunica adventitia [<a href="#B86-biomimetics-09-00674" class="html-bibr">86</a>,<a href="#B87-biomimetics-09-00674" class="html-bibr">87</a>]. Adapted with permission Order Number 501943363.</p>
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<p>(<b>A</b>). Subcoronary technique. (<b>B</b>) Full root replacement technique [<a href="#B1-biomimetics-09-00674" class="html-bibr">1</a>,<a href="#B52-biomimetics-09-00674" class="html-bibr">52</a>].</p>
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<p>This CT scan shows (<b>A</b>) pulmonary autograft and pulmonary homograft from a Ross operation performed 23 years ago. (<b>B</b>) Measurements of PA were taken at the sinotubular junction, sinuses of Valsalva, and aortic annulus [<a href="#B51-biomimetics-09-00674" class="html-bibr">51</a>,<a href="#B52-biomimetics-09-00674" class="html-bibr">52</a>].</p>
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<p>The PA can be strengthened with the help of external support (<b>A</b>–<b>H</b>). (<b>A</b>,<b>B</b>) Polyethylene terephthalate or poly(ethylene terephthalate), PET, and PETE. (<b>C</b>–<b>E</b>) Polydioxanone (PDS-ethicon). (<b>F</b>–<b>H</b>) Polydioxanone and polyglactin double-interlaced external reinforcement. Abbreviations: PA, pulmonary autograft [<a href="#B86-biomimetics-09-00674" class="html-bibr">86</a>,<a href="#B87-biomimetics-09-00674" class="html-bibr">87</a>]. Adapted with permission Order Number 501943363.</p>
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<p>(<b>A</b>,<b>B</b>) Handmade PDS/PTFE (Gore-Tex) composite reinforcement (WL Gore &amp; Associates, Newark, Del) prior to implantation. (<b>C</b>) Concept and design of a composite resorbable armored bioprosthesis. The specific design of Gore-Tex armor allows for multidirectional growth and resistance to dilatation. The unique weave of the upper armor gradually adapts and functionally compensates for autograft growth characteristics. Bottom red box on the left: initial implantation. Red box in the middle: intermediate phase. Red box on the right: full development. Note the progressive resorption of the resorbable layer and the progressive expansion of the unitary elements that make up the mesh, which is composed of the auxetic material ePTFE [<a href="#B86-biomimetics-09-00674" class="html-bibr">86</a>,<a href="#B87-biomimetics-09-00674" class="html-bibr">87</a>]. Adapted with permission Order Number 501943363.</p>
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<p>(<b>A</b>–<b>F</b>). Macroscopic and microscopic findings of external reinforcement of PA with non-resorbable polyester. (<b>A</b>) Mesh endoluminal transmigration of polypropylene. (<b>B</b>) Mesh endoluminal transmigration of polyethylene terephthalate. (<b>C</b>) Intimal hyperplasia and media with normal thickness and no disruption. (<b>D</b>) Muscular hyperplasia with fiber disorganization. (<b>E</b>,<b>F</b>) Endoluminal migration of the mesh.</p>
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<p>Histologic elastic remodeling of pulmonary autografts with resorbable polyester (polyglactin or polydioxanone) showed preservation of the endothelial lining and reorganization of the tunica media. Immediately beneath the intima, smooth muscle cells were found to be intertwined with collagen fibers. More deeply, the collagen bundles were intertwined with elastic fibers, forming a thick and highly organized layer of concentric lamellae. Loose connective tissue with adipocytes formed the tunica adventitia. (<b>A</b>) Intimal hyperplasia (yellow arrow) and media with normal thickness and no disruption (green arrow) are seen with the use of polyglactin mesh + polydioxanone. (<b>B</b>,<b>C</b>) The use of polydioxanone shows intimal hyperplasia (<b>B</b>) and media showing normal thickness and no disruption (yellow arrow) (<b>C</b>). Note the presence of PDS remnants (green arrow) (<b>D</b>–<b>F</b>). The use of polydioxanone as a reinforced external support favors the overexpression of metalloproteinase-9 in the reinforced group. This suggests an active process of extracellular matrix remodeling (<b>D</b>). (<b>E</b>) Mallory’s staining analysis shows an increase in the content of elastin fibers (pink). (<b>F</b>) Picrosirius red staining shows the formation of a compact collagen organization in the “elastic zone” of the vessel. The cellular infiltrate is less pronounced [<a href="#B86-biomimetics-09-00674" class="html-bibr">86</a>,<a href="#B87-biomimetics-09-00674" class="html-bibr">87</a>].</p>
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<p>A TEVG was implanted in the abdominal aorta. The illustration depicts PLLA (Sigma-Aldrich) electrospun tubular scaffold that has been functionalized with heparin and utilized as a substitute for the abdominal aorta in a rabbit model. Panel (<b>A</b>) depicts an intraoperative photograph of the PLLA-armored scaffold that has been implanted and the ligature of the infrarenal aorta that has been placed between the two anastomoses. Panel (<b>B</b>) presents a three-dimensional reconstruction of the scaffold, created using maximum intensity projection and volume rendering algorithms. Panel (<b>C</b>): Histological analysis. The tissue was then subjected to a hematoxylin and eosin staining procedure. The scaffold exhibited a high degree of cellular colonization, with distinct phenotypic characteristics observed in different regions of the TEVG. The image on the left is a 40× magnification of the inner side of the TEVG. It is noteworthy that the flat, elongated cells with a protruding nucleus in the lumen (arrow) are organized in an endothelial-like fashion. The image on the right is a 40× magnification of the outer side of the TEVG. It is noteworthy that spindle-shaped cells, which are indicative of fibroblasts, can be observed with certainty (see arrow). The symbol F indicates the presence of polymer fibers in both the cross-sectional and longitudinal sections. Abbreviations: PLLA, poly-L-lactide; TEVG, tissue-engineered vascular graft [<a href="#B198-biomimetics-09-00674" class="html-bibr">198</a>].</p>
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12 pages, 8484 KiB  
Article
Fracture Toughness of Short Fibre-Reinforced Composites—In Vitro Study
by Noor Kamourieh, Maurice Faigenblum, Robert Blizard, Albert Leung and Peter Fine
Materials 2024, 17(21), 5368; https://doi.org/10.3390/ma17215368 - 2 Nov 2024
Viewed by 884
Abstract
The development of dental materials needs to be supported with sound evidence. This in vitro study aimed to measure the fracture toughness of a short fibre-reinforced composite (sFRC), at differing thicknesses. In this study, 2 mm, 3 mm and 4 mm depths of [...] Read more.
The development of dental materials needs to be supported with sound evidence. This in vitro study aimed to measure the fracture toughness of a short fibre-reinforced composite (sFRC), at differing thicknesses. In this study, 2 mm, 3 mm and 4 mm depths of sFRC were prepared. Using ISO4049, each preparation was tested to failure. A total of 60 samples were tested: 10 samples for each combination of sFRC and depth. Fractured samples were viewed, and outcomes were analysed. EXF showed greater toughness than EXP, with a mean of 2.49 (95%CI: 2.25, 2.73) MPa.m1/2 compared to a mean of 2.13 (95%CI: 1.95, 2.31) MPa.m1/2, (F(1,54) = 21.28; p < 0.001). This difference was particularly pronounced at 2 mm depths where the mean (95%CI) values were 2.72 (2.49, 2.95) for EXF and 1.90 (1.78, 2.02) for EXP (Interaction F(2,54) = 7.93; p < 0.001). Both materials performed similarly at the depths of 3 mm and 4 mm. The results for both materials were within the accepted fracture toughness values of dentine of 1.79–3.08 MPa.m1/2. Analysis showed crack deflection and bridging fibre behaviour. The optimal thickness at the cavity base for EXF was 2 mm and for EXP 4 mm. Crack deflection and bridging behaviour indicated that restorations incorporating sFRCs are not prone to catastrophic failure and confirmed that sFRCs have similar fracture toughness to dentine. sFRCs could be a suitable biomimetic material to replace dentine. Full article
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<p>PTFE moulds made from PTFE sheets with 2 mm, 3 mm and 4 mm depth CAD CAM-designed rectangular cut outs.</p>
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<p>Shimadzu universal testing machine with a sample loaded in the test rig—3-point bend test jig.</p>
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<p>An example of a 4 mm EXP fractured sample within the 3-point bend test jig after fracture toughness testing showing the protruding fibres within the crack.</p>
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<p>Mean fracture toughness of sFRCs EXF and EXP and depths with 95% CI.</p>
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<p>Fractured samples of EXF 2 mm and 4 mm and EXP 2 mm and 4 mm. Image (<b>a</b>) is EXF 2 mm after fracture; image (<b>b</b>) is EXF 4 mm after fracture; image (<b>c</b>) EXF 4 mm after catastrophic fracture; image (<b>d</b>) is EXP 2 mm after fracture; image (<b>e</b>,<b>f</b>) are EXP 4 mm after fracture.</p>
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<p>SEM image of crack propagation in (<b>a</b>) EXF 2 mm sample, (<b>b</b>) EXF 2 mm sample and (<b>c</b>) EXP 2 mm sample.</p>
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<p>SEM of EXF and EXP fractured fibre diameters.</p>
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<p>Colourised SEM image demonstrating random distribution of fibres in EXF.</p>
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<p>SEM images of fibre behaviour—bridging fibres, fractured fibres and fibre pull out. (<b>a</b>,<b>b</b>) EXP samples demonstrate fibre bridging, (<b>c</b>,<b>d</b>) EXP samples demonstrating potential fibre fracture, (<b>e</b>,<b>f</b>) EXF samples demonstrating fracture pull out.</p>
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