Search Results (5)

Information that is complicated and ambiguous entails high cognitive load. Trying to understand such information can involve a lot of cognitive effort. An alternative to expending a lot of cognitive effort is to engage in motivated cognition, which can involve selective attention to new information that matches existing beliefs. In accordance with principles of least action related to management of cognitive effort, another alternative is to give up trying to understand new information with high cognitive load. In either case, high cognitive load can limit potential for understanding of new information and learning from new information. Cognitive Load Theory (CLT) provides a framework for relating the characteristics of information to human cognitive load. Although CLT has been developed through more than three decades of scientific research, it has not been applied comprehensively to improve the explainability, transparency, interpretability, and shared interpretability (ETISI) of machine learning models and their outputs. Here, in order to illustrate the broad relevance of CLT to ETISI, it is applied to analyze a type of hybrid machine learning called Algebraic Machine Learning (AML). This is the example because AML has characteristics that offer high potential for ETISI. However, application of CLT reveals potential for high cognitive load that can limit ETISI even when AML is used in conjunction with decision trees. Following the AML example, the general relevance of CLT to machine learning ETISI is discussed with the examples of SHapley Additive exPlanations (SHAP), Local Interpretable Model-Agnostic Explanations (LIME), and the Contextual Importance and Utility (CIU) method. Overall, it is argued in this Perspective paper that CLT can provide science-based design principles that can contribute to improving the ETISI of all types of machine learning. Full article

The study’s main objective is to identify and analyze the attitude toward prayer of teenagers in a denominational school in Romania and the need to use AI-assisted tools. To find a satisfactory answer, we considered it necessary to identify how they pray, i.e., freely or by calling on the prayer book, and whether they questioned whether artificial intelligence could be an agreeable support. The research also takes into account the documents of the Romanian Orthodox Church from which the attitude of the Hierarchy towards new technologies in general and artificial intelligence in particular emerges. How attentive is the Church to these realities, and how open is it to incorporate them? Does it have any good reason to consider tools like e-rosary in the Catholic world or Alexa Pray in the Anglican world in the near future? The introduction addresses Romania’s socio-political, educational, and theological context, and the discussion focuses on how the literature on digital religion and its subchapters is received in the Romanian theological landscape. The research method includes qualitative, questionnaire, and textual analysis; it is an interdisciplinary approach, namely practical theology and the study of digital religions. The questionnaire was administered to 216 respondents, respecting all research ethics requirements. The results reveal that young people prefer to pray freely, use the prayer book moderately, and have not gathered information regarding artificial intelligence that could help them. However, they are open to a future offers from the Romanian Orthodox Church, including AI-assisted tools. Full article

Aiming at the problem of data sparsity, cold start, and privacy concerns in complex information recommendation systems, such as personalized marketing on Alibaba or TikTok, this paper proposes a mobile social recommendation model integrating users’ personality traits and social relationship strength under privacy concerns (PC-MSPR). Firstly, PC-MSPR focuses on specific personality traits, including openness, extraversion, and agreeableness, and their impacts on mobile users’ online behaviors. A personality traits calculation method that incorporates privacy preferences (PP-PTM) is then introduced. Secondly, a novel method for calculating the users’ relationship strength, based on their social network interactive activities and domain ontologies (AI-URS) is proposed. AI-URS divides the interactive activities into activity domains and calculates the strength of relationships between users belonging to the same activity domain; at the same time, the comprehensive relationship strength of users in the same domain, including direct relationships and indirect relationships, is calculated based on interactive activity documents. Finally, social recommendations are derived by integrating personality traits and social relationships to calculate user similarity. The proposed model is validated using empirical data. The results show the model’s superiority in alleviating data sparsity and cold-start problems, obtaining higher recommendation precision, and reducing the impact of privacy concerns regarding the users’ adoption of personalized recommendation services. Full article

A targeted and timely treatment can be a beneficial tool for patients with hematological emergencies (particularly acute leukemias). The key challenges in the early diagnosis of leukemias and related hematological disorders are their symptom-sharing nature and prolonged turnaround time as well as the expertise needed in reporting confirmatory tests. The present study made use of the potential morphological and immature fraction-related parameters (research items or cell population data) generated during complete blood cell count (CBC), through artificial intelligence (AI)/machine learning (ML) predictive modeling for early (at the pre-microscopic level) differentiation of various types of leukemias: acute from chronic as well as myeloid from lymphoid. The routine CBC parameters along with research CBC items from a hematology analyzer in the diagnosis of 1577 study subjects with hematological neoplasms were collected. The statistical and data visualization tools, including heat-map and principal component analysis (PCA,) helped in the evaluation of the predictive capacity of research CBC items. Next, research CBC parameter-driven artificial neural network (ANN) predictive modeling was developed to use the hidden trend (disease’s signature) by increasing the auguring accuracy of these potential morphometric parameters in differentiation of leukemias. The classical statistics for routine and research CBC parameters showed that as a whole, all study items are significantly deviated among various types of leukemias (study groups). The CPD parameter-driven heat-map gave clustering (separation) of myeloid from lymphoid leukemias, followed by the segregation (nodding) of the acute from the chronic class of that particular lineage. Furthermore, acute promyelocytic leukemia (APML) was also well individuated from other types of acute myeloid leukemia (AML). The PCA plot guided by research CBC items at notable variance vindicated the aforementioned findings of the CPD-driven heat-map. Through training of ANN predictive modeling, the CPD parameters successfully differentiate the chronic myeloid leukemia (CML), AML, APML, acute lymphoid leukemia (ALL), chronic lymphoid leukemia (CLL), and other related hematological neoplasms with AUC values of 0.937, 0.905, 0.805, 0.829, 0.870, and 0.789, respectively, at an agreeably significant (10.6%) false prediction rate. Overall practical results of using our ANN model were found quite satisfactory with values of 83.1% and 89.4.7% for training and testing datasets, respectively. We proposed that research CBC parameters could potentially be used for early differentiation of leukemias in the hematology–oncology unit. The CPD-driven ANN modeling is a novel practice that substantially strengthens the predictive potential of CPD items, allowing the clinicians to be confident about the typical trend of the “disease fingerprint” shown by these automated potential morphometric items. Full article

luxS is conserved in several bacterial species, including A. hydrophila, which causes infections in prawn, fish, and shrimp, and is consequently a great risk to the aquaculture industry and public health. luxS plays a critical role in the biosynthesis of the autoinducer-2 (AI-2), which performs wide-ranging functions in bacterial communication, and especially in quorum sensing (QS). The prediction of a 3D structure of the QS-associated LuxS protein is thus essential to better understand and control A. hydrophila pathogenecity. Here, we predicted the structure of A. hydrophila LuxS and characterized it structurally and functionally with in silico methods. The predicted structure of LuxS provides a framework to develop more complete structural and functional insights and will aid the mitigation of A. hydrophila infection, and the development of novel drugs to control infections. In addition to modeling, the suitable inhibitor was identified by high through put screening (HTS) against drug like subset of ZINC database and inhibitor ((−)-Dimethyl 2,3-O-isopropylidene-l-tartrate) molecule was selected based on the best drug score. Molecular docking studies were performed to find out the best binding affinity between LuxS homologous or predicted model of LuxS protein for the ligand selection. Remarkably, this inhibitor molecule establishes agreeable interfaces with amino acid residues LYS 23, VAL 35, ILE76, and SER 90, which are found to play an essential role in inhibition mechanism. These predictions were suggesting that the proposed inhibitor molecule may be considered as drug candidates against AI-2 biosynthesis of A. hydrophila. Therefore, (−)-Dimethyl 2,3-O-isopropylidene-l-tartrate inhibitor molecule was studied to confirm its potency of AI-2 biosynthesis inhibition. The results shows that the inhibitor molecule had a better efficacy in AI-2 inhibition at 40 μM concentration, which was further validated using Western blotting at a protein expression level. The AI-2 bioluminescence assay showed that the decreased amount of AI-2 biosynthesis and downregulation of LuxS protein play an important role in the AI-2 inhibition. Lastly, these experiments were conducted with the supplementation of antibiotics via cocktail therapy of AI-2 inhibitor plus OXY antibiotics, in order to determine the possibility of novel cocktail drug treatments of A. hydrophila infection. Full article