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IJMS
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Discoveries of Genetic Regulations in Onco-Progression
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Discoveries of Genetic Regulations in Onco-Progression

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 7753

Special Issue Editor

Dr. Marina K. Ibragimova

E-Mail Website
Guest Editor
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk 634009, Russian
Interests: Olaparib; ovarian neoplasms; homologous recombination; clonal evolution; mutation; somatic mutation; human papillomavirus 53; genotype; uterine cervix carcinoma in situ

Special Issue Information

Dear Colleagues,

Tumor progression is one of the most important characteristics of malignant growth and is characterized by a gradual change in the morphological, biochemical, functional and proliferative properties of the transformed cells. This gradual change is associated with the selection and accumulation of genetic changes and contributes to the acquisition of an increasingly aggressive tumor phenotype.

In recent decades, significant efforts have been made to investigate the molecular genetic basis of tumor progression, leading to unique fundamental and clinical data. However, the regulation of causative and resultant genetic changes is not fully understood in relation to tumor cell potential.

This Special Issue aims to present the latest original studies and reviews of molecular genetics regarding the regulation of tumor progression, and to discuss future directions in this field of science.

Dr. Marina K. Ibragimova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tumor progression
  • chromosomes
  • clonal evolution
  • genes
  • immunity
  • genome changes
  • microenvironment
  • molecular mechanisms
  • metastasis

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Published Papers (2 papers)

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Review

15 pages, 738 KiB  
Review
Cancer-Associated Fibroblasts in Gastrointestinal Cancers: Unveiling Their Dynamic Roles in the Tumor Microenvironment
by Noor N. Al-Bzour, Ayah N. Al-Bzour, Obada E. Ababneh, Moayad M. Al-Jezawi, Azhar Saeed and Anwaar Saeed
Int. J. Mol. Sci. 2023, 24(22), 16505; https://doi.org/10.3390/ijms242216505 - 19 Nov 2023
Cited by 6 | Viewed by 2299
Abstract
Gastrointestinal cancers are highly aggressive malignancies with significant mortality rates. Recent research emphasizes the critical role of the tumor microenvironment (TME) in these cancers, which includes cancer-associated fibroblasts (CAFs), a key component of the TME that have diverse origins, including fibroblasts, mesenchymal stem [...] Read more.
Gastrointestinal cancers are highly aggressive malignancies with significant mortality rates. Recent research emphasizes the critical role of the tumor microenvironment (TME) in these cancers, which includes cancer-associated fibroblasts (CAFs), a key component of the TME that have diverse origins, including fibroblasts, mesenchymal stem cells, and endothelial cells. Several markers, such as α-SMA and FAP, have been identified to label CAFs, and some specific markers may serve as potential therapeutic targets. In this review article, we summarize the literature on the multifaceted role of CAFs in tumor progression, including their effects on angiogenesis, immune suppression, invasion, and metastasis. In addition, we highlight the use of single-cell transcriptomics to understand CAF heterogeneity and their interactions within the TME. Moreover, we discuss the dynamic interplay between CAFs and the immune system, which contributes to immunosuppression in the TME, and the potential for CAF-targeted therapies and combination approaches with immunotherapy to improve cancer treatment outcomes. Full article
(This article belongs to the Special Issue Discoveries of Genetic Regulations in Onco-Progression)
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Figure 1

Figure 1
<p>CAFs secrete molecules inducing PD-L1 expression on tumor cells, which binds to PD-1 on T-cells, leading to T-cell dysfunction.</p> Full article ">Figure 2
<p>The activation process of CAFs.</p> Full article ">
15 pages, 1028 KiB  
Review
Organ-Specificity of Breast Cancer Metastasis
by Marina K. Ibragimova, Matvey M. Tsyganov, Ekaterina A. Kravtsova, Irina A. Tsydenova and Nikolai V. Litviakov
Int. J. Mol. Sci. 2023, 24(21), 15625; https://doi.org/10.3390/ijms242115625 - 26 Oct 2023
Cited by 11 | Viewed by 4601
Abstract
Breast cancer (BC) remains one of the most common malignancies among women worldwide. Breast cancer shows metastatic heterogeneity with priority to different organs, which leads to differences in prognosis and response to therapy among patients. The main targets for metastasis in BC are [...] Read more.
Breast cancer (BC) remains one of the most common malignancies among women worldwide. Breast cancer shows metastatic heterogeneity with priority to different organs, which leads to differences in prognosis and response to therapy among patients. The main targets for metastasis in BC are the bone, lung, liver and brain. The molecular mechanism of BC organ-specificity is still under investigation. In recent years, the appearance of new genomic approaches has led to unprecedented changes in the understanding of breast cancer metastasis organ-specificity and has provided a new platform for the development of more effective therapeutic agents. This review summarises recent data on molecular organ-specific markers of metastasis as the basis of a possible therapeutic approach in order to improve the diagnosis and prognosis of patients with metastatically heterogeneous breast cancer. Full article
(This article belongs to the Special Issue Discoveries of Genetic Regulations in Onco-Progression)
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Figure 1

Figure 1
<p>Frequency of metastasis to target organs depending on the molecular subtype of breast tumour. Note: subtypes are grouped into four categories based on the immunohistochemical expression of hormone receptors: oestrogen receptor positive (ER+), progesterone receptor positive (PR+), human epidermal growth factor receptor positive (HER2+) and triple-negative.</p> Full article ">Figure 2
<p>Biomarkers of organ-specificity of distant metastasis occurrence in breast cancer. Note: experimentally confirmed metastasis markers are highlighted in light blue, primary tumour metastasis markers are highlighted in light yellow.</p> Full article ">
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