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Nutrients
Volume 16
Issue 23
10.3390/nu16234152
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Effects of Pterostilbene on the Cell Division Cycle of a Neuroblastoma Cell Line

by
Francesca Bruno
1,†,
Flores Naselli
2,†,
Desiree Brancato
1,
Sara Volpes
2,
Paola Sofia Cardinale
2,
Salvatore Saccone
1,3,
Concetta Federico
1,3,* and
Fabio Caradonna
2,4
1
Department Biological, Geological, and Environmental Sciences, University of Catania, 95124 Catania, Italy
2
Department Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, 90133 Palermo, Italy
3
CERNUT, Interdepartmental Research Center in Nutraceutics and Health Products, 95125 Catania, Italy
4
NBFC, National Biodiversity Future Center, 90133 Palermo, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to the work.
Nutrients 2024, 16(23), 4152; https://doi.org/10.3390/nu16234152 (registering DOI)
Submission received: 30 October 2024 / Revised: 26 November 2024 / Accepted: 28 November 2024 / Published: 29 November 2024
(This article belongs to the Special Issue The Impact of Nutrition on Cognitive Function: Its Role in Aging and Neurodegenerative Diseases)
Versions Notes

Abstract

Background. The “Cell Cycle Hypothesis” suggests that the abnormal re-entry of neurons into the cell division cycle leads to neurodegeneration, a mechanism supported by in vitro studies on neuronal-like cells treated with the hyperphosphorylating agent forskolin. Pterostilbene, a bioavailable compound found in foods such as blueberries and grapes, may exert neuroprotective effects and could serve as a potential adjunct therapy for neurodegenerative diseases. Methods. In this study, we investigated the effects of pterostilbene on neuronal-like cells derived from the human neuroblastoma SK-N-BE cell line, where cell cycle reactivation was induced by forskolin treatment. We analyzed molecular endpoints associated with differentiated versus replicative cell states, specifically the following: (a) the expression of cyclin CCND1, (b) the Ki67 cell proliferation marker, (c) the AT8 nuclear tau epitope, and (d) genome-wide DNA methylation changes. Results. Our findings indicate that pterostilbene exerts distinct effects on the cell division cycle depending on the cellular state, with neuroprotective benefits observed in differentiated neuronal-like cells, but not in cells undergoing induced division. Additionally, pterostilbene alters DNA methylation patterns. Conclusion. These results suggest that pterostilbene may offer neuroprotective advantages for differentiated neuronal-like cells. However, further studies are required to confirm these effects in vivo by examining specific biomarkers in human populations consuming pterostilbene-containing foods.
Keywords: neurodegeneration; cell cycle re-entry; SK-N-BE neuroblastoma cell line; pterostilbene; stilbenoids; nutrigenomic; DNA methylation; tau protein; cyclin CCND1 neurodegeneration; cell cycle re-entry; SK-N-BE neuroblastoma cell line; pterostilbene; stilbenoids; nutrigenomic; DNA methylation; tau protein; cyclin CCND1

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MDPI and ACS Style

Bruno, F.; Naselli, F.; Brancato, D.; Volpes, S.; Cardinale, P.S.; Saccone, S.; Federico, C.; Caradonna, F. Effects of Pterostilbene on the Cell Division Cycle of a Neuroblastoma Cell Line. Nutrients 2024, 16, 4152. https://doi.org/10.3390/nu16234152

AMA Style

Bruno F, Naselli F, Brancato D, Volpes S, Cardinale PS, Saccone S, Federico C, Caradonna F. Effects of Pterostilbene on the Cell Division Cycle of a Neuroblastoma Cell Line. Nutrients. 2024; 16(23):4152. https://doi.org/10.3390/nu16234152

Chicago/Turabian Style

Bruno, Francesca, Flores Naselli, Desiree Brancato, Sara Volpes, Paola Sofia Cardinale, Salvatore Saccone, Concetta Federico, and Fabio Caradonna. 2024. "Effects of Pterostilbene on the Cell Division Cycle of a Neuroblastoma Cell Line" Nutrients 16, no. 23: 4152. https://doi.org/10.3390/nu16234152

APA Style

Bruno, F., Naselli, F., Brancato, D., Volpes, S., Cardinale, P. S., Saccone, S., Federico, C., & Caradonna, F. (2024). Effects of Pterostilbene on the Cell Division Cycle of a Neuroblastoma Cell Line. Nutrients, 16(23), 4152. https://doi.org/10.3390/nu16234152

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