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  1. Article ; Online: ACE2

    Asselta, Rosanna / Paraboschi, Elvezia Maria / Mantovani, Alberto / Duga, Stefano

    Aging

    2020  Volume 12, Issue 11, Page(s) 10087–10098

    Abstract: As the outbreak of coronavirus disease 2019 (COVID-19) progresses, prognostic markers for early identification of high-risk individuals are an urgent medical need. Italy has one of the highest numbers of SARS-CoV-2-related deaths and one of the highest ... ...

    Abstract As the outbreak of coronavirus disease 2019 (COVID-19) progresses, prognostic markers for early identification of high-risk individuals are an urgent medical need. Italy has one of the highest numbers of SARS-CoV-2-related deaths and one of the highest mortality rates. Worldwide, a more severe course of COVID-19 is associated with older age, comorbidities, and male sex. Hence, we searched for possible genetic components of COVID-19 severity among Italians by looking at expression levels and variants in
    MeSH term(s) Angiotensin-Converting Enzyme 2 ; COVID-19 ; Cohort Studies ; Coronavirus Infections/genetics ; Female ; Genetic Predisposition to Disease ; Humans ; Male ; Pandemics ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/genetics ; Polymorphism, Single Nucleotide ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism
    Chemical Substances Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Serine Endopeptidases (EC 3.4.21.-) ; TMPRSS2 protein, human (EC 3.4.21.-)
    Keywords covid19
    Language English
    Publishing date 2020-06-05
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.103415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: ACE2

    Bao, Riyue / Hernandez, Kyle / Huang, Lei / Luke, Jason John

    Journal for immunotherapy of cancer

    2020  Volume 8, Issue 2

    Abstract: ... 2) infection is facilitated by the ACE2 receptor and protease TMPRSS2. Modestly sized case series ...

    Abstract Background: Pandemic COVID-19 by severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) infection is facilitated by the ACE2 receptor and protease TMPRSS2. Modestly sized case series have described clinical factors associated with COVID-19, while
    Methods: We performed an integrated study of
    Results: Matched normal tissues generally display higher
    Conclusions: We performed a large-scale integration of
    MeSH term(s) Aged ; Angiotensin-Converting Enzyme 2 ; Betacoronavirus/immunology ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Datasets as Topic ; Female ; Gastrointestinal Microbiome/immunology ; Gene Expression Regulation, Neoplastic/immunology ; HLA Antigens/blood ; HLA Antigens/immunology ; Humans ; Macrophages/immunology ; Male ; Middle Aged ; Neoplasms/blood ; Neoplasms/immunology ; Neoplasms/microbiology ; Neoplasms/pathology ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; RNA-Seq ; SARS-CoV-2 ; Serine Endopeptidases/metabolism
    Chemical Substances HLA Antigens ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Serine Endopeptidases (EC 3.4.21.-) ; TMPRSS2 protein, human (EC 3.4.21.-)
    Keywords covid19
    Language English
    Publishing date 2020-05-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2719863-7
    ISSN 2051-1426 ; 2051-1426
    ISSN (online) 2051-1426
    ISSN 2051-1426
    DOI 10.1136/jitc-2020-001020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: ACE2

    Li Xiao / Hiroshi Sakagami / Nobuhiko Miwa

    Viruses ; Volume 12 ; Issue 5

    The key Molecule for Understanding the Pathophysiology of Severe and Critical Conditions of COVID-19: Demon or Angel?

    2020  

    Abstract: ... of the patients have severe or critical conditions. SARS-CoV-2 exploits ACE2 for host cell entry. ACE2 plays ... blood pressure and fluid balance. ACE2 also protects organs from inflammatory injuries and regulates intestinal ... functions. ACE2 can be shed by two proteases, ADAM17 and TMPRSS2. TMPRSS2-cleaved ACE2 allows SARS-CoV-2 ...

    Abstract Recently, the SARS-CoV-2 induced disease COVID-19 has spread all over the world. Nearly 20% of the patients have severe or critical conditions. SARS-CoV-2 exploits ACE2 for host cell entry. ACE2 plays an essential role in the renin–

    angiotensin–

    aldosterone system (RAAS), which regulates blood pressure and fluid balance. ACE2 also protects organs from inflammatory injuries and regulates intestinal functions. ACE2 can be shed by two proteases, ADAM17 and TMPRSS2. TMPRSS2-cleaved ACE2 allows SARS-CoV-2 cell entry, whereas ADAM17-cleaved ACE2 offers protection to organs. SARS-CoV-2 infection-caused ACE2 dysfunction worsens COVID-19 and could initiate multi-organ failure. Here, we will explain the role of ACE2 in the pathogenesis of severe and critical conditions of COVID-19 and discuss auspicious strategies for controlling the disease.
    Keywords COVID-19 ; ACE2 ; RAAS ; Ang-(1-7) ; SARS-CoV-2 ; ADAM17 ; TMPRSS2 ; B 0 AT1 ; covid19
    Subject code 550
    Language English
    Publishing date 2020-04-28
    Publisher Multidisciplinary Digital Publishing Institute
    Publishing country ch
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: ACE2

    Li Xiao / Hiroshi Sakagami / Nobuhiko Miwa

    Viruses, Vol 12, Iss 491, p

    The key Molecule for Understanding the Pathophysiology of Severe and Critical Conditions of COVID-19: Demon or Angel?

    2020  Volume 491

    Abstract: ... of the patients have severe or critical conditions. SARS-CoV-2 exploits ACE2 for host cell entry. ACE2 plays ... balance. ACE2 also protects organs from inflammatory injuries and regulates intestinal functions. ACE2 ... can be shed by two proteases, ADAM17 and TMPRSS2. TMPRSS2-cleaved ACE2 allows SARS-CoV-2 cell entry ...

    Abstract Recently, the SARS-CoV-2 induced disease COVID-19 has spread all over the world. Nearly 20% of the patients have severe or critical conditions. SARS-CoV-2 exploits ACE2 for host cell entry. ACE2 plays an essential role in the renin–angiotensin–aldosterone system (RAAS), which regulates blood pressure and fluid balance. ACE2 also protects organs from inflammatory injuries and regulates intestinal functions. ACE2 can be shed by two proteases, ADAM17 and TMPRSS2. TMPRSS2-cleaved ACE2 allows SARS-CoV-2 cell entry, whereas ADAM17-cleaved ACE2 offers protection to organs. SARS-CoV-2 infection-caused ACE2 dysfunction worsens COVID-19 and could initiate multi-organ failure. Here, we will explain the role of ACE2 in the pathogenesis of severe and critical conditions of COVID-19 and discuss auspicious strategies for controlling the disease.
    Keywords COVID-19 ; ACE2 ; RAAS ; Ang-(1-7) ; SARS-CoV-2 ; ADAM17 ; Microbiology ; QR1-502 ; covid19
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article ; Online: ACE2

    Xiao, Li / Sakagami, Hiroshi / Miwa, Nobuhiko

    Viruses, 12(5):491

    The key Molecule for Understanding the Pathophysiology of Severe and Critical Conditions of COVID-19: Demon or Angel?

    2020  

    Abstract: ... of the patients have severe or critical conditions. SARS-CoV-2 exploits ACE2 for host cell entry. ACE2 plays ... balance. ACE2 also protects organs from inflammatory injuries and regulates intestinal functions. ACE2 ... can be shed by two proteases, ADAM17 and TMPRSS2. TMPRSS2-cleaved ACE2 allows SARS-CoV-2 cell entry ...

    Abstract Recently, the SARS-CoV-2 induced disease COVID-19 has spread all over the world. Nearly 20% of the patients have severe or critical conditions. SARS-CoV-2 exploits ACE2 for host cell entry. ACE2 plays an essential role in the renin–angiotensin–aldosterone system (RAAS), which regulates blood pressure and fluid balance. ACE2 also protects organs from inflammatory injuries and regulates intestinal functions. ACE2 can be shed by two proteases, ADAM17 and TMPRSS2. TMPRSS2-cleaved ACE2 allows SARS-CoV-2 cell entry, whereas ADAM17-cleaved ACE2 offers protection to organs. SARS-CoV-2 infection-caused ACE2 dysfunction worsens COVID-19 and could initiate multi-organ failure. Here, we will explain the role of ACE2 in the pathogenesis of severe and critical conditions of COVID-19 and discuss auspicious strategies for controlling the disease.
    Keywords COVID-19 ; RAAS ; B0AT1 ; ACE2 ; Ang-(1-7) ; TMPRSS2 ; SARS-CoV-2 ; ADAM17 ; covid19
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  6. Book ; Online: ACE2

    Medina-Enríquez, Miriam Marlene / Carlos-Escalante, José Alberto / Aponte-Torres, Zuleika / Cuapio, Angelica / Lopez-Leon, Sandra / Wegman-Ostrosky, Talia

    THE DOORWAY TO SARS-CoV-2

    2020  

    Abstract: The angiotensin-converting enzyme 2 (ACE2) is the host functional receptor for the new virus SARS ... CoV-2 causing Coronavirus Disease 2019. ACE2 is expressed in 71 different cell types. Some factors ... that can affect the expression of the ACE2 are: sex, environment, lifestyles, comorbidities, medications (e.g ...

    Abstract The angiotensin-converting enzyme 2 (ACE2) is the host functional receptor for the new virus SARS-CoV-2 causing Coronavirus Disease 2019. ACE2 is expressed in 71 different cell types. Some factors that can affect the expression of the ACE2 are: sex, environment, lifestyles, comorbidities, medications (e.g. anti-hypertensives) and its interaction with other genes of the renin-angiotensin system and other pathways. All of these factors can affect the risk of infection of SARS-CoV-2 and determine the severity of the symptoms. The ACE2 enzyme is a negative regulator of RAS expressed in various organ systems. It has been seen to be associated with immunity, inflammation, increased coagulopathy, and cardiovascular disease. In this review, we describe the genetic and molecular functions of the ACE2 receptor and its relation with the physiological and pathological conditions to better understand how this receptor is involved in the pathogenesis of COVID-19.
    Keywords covid19
    Publisher Center for Open Science
    Publishing country us
    Document type Book ; Online
    DOI 10.31226/osf.io/bhpx8
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Book ; Online: ACE2

    Gao, Feng / Zheng, Kenneth I. / Fan, Yu-Chen / Targher, Giovanni / Byrne, Christopher / Zheng, Ming-Hua

    a linkage for the interplay between COVID-19 and decompensated cirrhosis

    2020  

    Keywords covid19
    Language English
    Publishing country uk
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: ACE2

    Scialo, F. / Daniele, A. / Amato, F. / Pastore, L. / Matera, M. G. / Cazzola, M. / Castaldo, G. / Bianco, A.

    The Major Cell Entry Receptor for SARS-CoV-2

    2020  

    Abstract: ... more effective treatments for COVID-19. Here, we focus our attention on ACE2, a primary receptor ... given to how the ACE2 soluble form can have a great impact on disease progression and thus be used ... in a potential therapeutic strategy. Furthermore, we will discuss repercussions that SARS-CoV-2/ACE2 binding has ...

    Abstract Despite the unprecedented effort of the scientific community, the novel SARS-CoV-2 virus has infected more than 46 million people worldwide, killing over one million two hundred thousand. Understanding the mechanisms by which some individuals are more susceptible to SARS-CoV-2 infection and why a subgroup of them are prone to experience severe pneumonia, and death should lead to a better approach and more effective treatments for COVID-19. Here, we focus our attention on ACE2, a primary receptor of SARS-CoV-2. We will discuss its biology, tissue expression, and post-translational regulation that determine its potential to be employed by SARS-CoV-2 for cell entry. Particular attention will be given to how the ACE2 soluble form can have a great impact on disease progression and thus be used in a potential therapeutic strategy. Furthermore, we will discuss repercussions that SARS-CoV-2/ACE2 binding has on the renin–angiotensin system and beyond. Indeed, although mostly neglected, ACE2 can also act on [des-Arg 937]-bradykinin of the kinin–kallikrein system regulating coagulation and inflammation. Thorough comprehension of the role that ACE2 plays in different pathways will be the key to assess the impact that SARS-CoV-2/ACE2 binding has on organismal physiology and will help us to find better therapies and diagnostic tools.
    Keywords ACE2 receptor ; COVID-19 ; SARS-CoV-2 ; covid19
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: ACE2

    Rezaei, Mitrasadat / Ziai, Seyed Ali / Fakhri, Sajad / Pouriran, Ramin

    Journal of Cellular Physiology ; ISSN 0021-9541 1097-4652

    Its potential role and regulation in severe acute respiratory syndrome and COVID‐19

    2020  

    Keywords Clinical Biochemistry ; Cell Biology ; Physiology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/jcp.30041
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: ACE2

    Gao, Feng / Zheng, Kenneth I. / Fan, Yu-Chen / Targher, Giovanni / Byrne, Christopher D. / Zheng, Ming-Hua

    American Journal of Gastroenterology

    A Linkage for the Interplay Between COVID-19 and Decompensated Cirrhosis

    2020  Volume 115, Issue 9, Page(s) 1544–1544

    Keywords Hepatology ; Gastroenterology ; covid19
    Language English
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000000780
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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