Illicit psychoactive substance use, heavy use, abuse, and dependence in a US population-based sample of male twins

KS Kendler, LM Karkowski, MC Neale… - Archives of general …, 2000 - jamanetwork.com
Background In order to develop informed approaches to prevention and treatment of illicit
psychoactive substance use, abuse, and dependence, we need to understand the sources
of individual differences in risk. Methods In personal interviews with 1198 male-male twin
pairs (708 monozygotic and 490 dizygotic) ascertained from a population-based registry, we
assessed lifetime use, heavy use, and abuse of and dependence on cannabis, sedatives,
stimulants, cocaine, opiates, and hallucinogens. Twin resemblance was assessed by …