Intravenous ethanol infusion decreases human cortical γ-aminobutyric acid and N-acetylaspartate as measured with proton magnetic resonance spectroscopy at 4 …
BACKGROUND: Ethanol modulates glutamate and γ-aminobutyric (GABA) function.
However, little is known about the acute pharmacologic effects of ethanol on levels of GABA,
glutamate, and other metabolites measurable in the human cortex in vivo with proton
magnetic resonance spectroscopy (1H-MRS). METHODS: Eleven healthy social drinkers
received two intravenous ethanol infusions that raised breath alcohol levels to a clamped
plateau of 60 mg/dL over 60–70 min. The first infusion established tolerability of the …
However, little is known about the acute pharmacologic effects of ethanol on levels of GABA,
glutamate, and other metabolites measurable in the human cortex in vivo with proton
magnetic resonance spectroscopy (1H-MRS). METHODS: Eleven healthy social drinkers
received two intravenous ethanol infusions that raised breath alcohol levels to a clamped
plateau of 60 mg/dL over 60–70 min. The first infusion established tolerability of the …