The title comes from a William Goldman quote from his book "Adventures in the Screen Trade", where he says that "the single most important fact, perhaps, of the entire movie industry" is that 'nobody knows anything'. If there is a Roman numeral I to this book, that's it.... Not one person in the entire motion picture field knows for a certainty what's going to work. Every time out it's a guess and, if you're lucky, an educated one."
Second time that Mike Connors reprises his role as Joe Mannix. He also reprised it in an episode of Diagnosis Murder called Hard Boiled Murder.
Last acting role of Wayne Rogers.
Stars Robin Ruzan and Paul Dooley both have their birthday on February 22nd.