Set in the early sixties, THE BRAIN THAT WOULDN'T DIE follows the misadventures of Dr. Bill Cortner (Patrick Green), a brilliant surgeon, whose unorthodox practices produce fantastic results - the reanimation of dead tissue. Bill's father and mentor, William, cautions his son against meddling with the forces of nature, but Bill insists that his work will bring an end to human mortality.
Bill's methods are put to the test when his fiancee, Jan Compton (Rachael Perrell Fosket), is decapitated in a car accident. Absconding with her remains to his secret laboratory, Bill successfully revives Jan's head in a pan. She begs for death but Bill refuses to oblige, promising that he can make her whole again. Putting his assistant, Kurt (Jason Reynolds), in charge of the lab, Bill leaves to find Jan a new body, knowing full well that he will have to murder an innocent woman to do so.
Bill's quest takes him through the seedy underbelly of the city, from smoky cabarets to sleazy swimsuit competitions. Despite his efforts, Bill is foiled at every turn, narrowly avoiding the suspicions of Mancini (Robert Blanche), the hardboiled detective investigating the car accident. However, Bill's luck changes when he chances upon an old flame, Doris Powell (Mia Allen), a vulnerable model with surgical needs.
Meanwhile, Jan, determined to bring an end to the madness, uses her newly discovered psychic abilities to communicate with another of Bill's hideously deformed experiments. Together, they plot their revenge...
