- (September 11, 2001) Perkins' mother, actress/photographer Berry Berenson, was on board the terrorist-hijacked American Airlines flight #11 that crashed into the World Trade Center.
- Named after his paternal grandfather Osgood Perkins, a stage actor who also had character roles in movies in the 1920s and 1930s.
- Great-grandson of famous fashion designer Elsa Schiaparelli.
- Has played the younger version of his father's character, the infamous Norman Bates, in the horror sequel Psycho II (1983).
- Cites Stanley Kubrick and Tim Burton as his early inspirations as well as Rosemary's Baby (1968), which he admires for the movie's literary qualities as much as its cinematic impact.
- Received his Bachelor of Arts degree in English from New York University.
- Great-grandson of art historian Bernard Berenson, who helped assemble some of the greatest art collections in the United States.
- Nephew of actress Marisa Berenson.
- Attended and graduated from Harvard-Westlake School in Los Angeles.
- Father of actors James Perkins and Beatrix Perkins.
- Elder brother of Elvis Perkins. Cousin of Starlite Randall.
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